ESR spin-trapping studies on the reaction of Fe2+ ions with H2O2-reactive species in oxygen toxicity in biology.

Fenton's reagent revisited

1975 • 2,778 citations

The deoxyribose method: A simple “test-tube” assay for determination of rate constants for reactions of hydroxyl radicals

1987 • 2,350 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

Spin Trapping: ESR parameters of spin adducts 1474 1528V

1987 • 1,660 citations

Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site.

1984 • 849 citations

Spin trapping. Kinetics of the reaction of superoxide and hydroxyl radicals with nitrones

1980 • 635 citations

The involvement of iron in lipid peroxidation. Importance of ferric to ferrous ratios in initiation.

1986 • 579 citations

The requirement for iron (III) in the initiation of lipid peroxidation by iron (II) and hydrogen peroxide.

1987 • 547 citations

The mechanism of NADPH-dependent lipid peroxidation. The propagation of lipid peroxidation.

1979 • 390 citations

Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo. Identification of hydroxylated derivatives of salicylate in human body fluids

1986 • 374 citations

The oxidizing nature of the hydroxyl radical. A comparison with the ferryl ion (FeO2+)

1984 • 364 citations

Semiquinone free radicals and oxygen. Pulse radiolysis study of one electron transfer equilibria

1973 • 337 citations

The measurement of free radical reactions in humans

1987 • 325 citations

Hydroxyl radical production in body fluids Roles of metal ions, ascorbate and superoxide

1981 • 250 citations

Differential formation of hydroxyl radicals by adriamycin in sensitive and resistant MCF-7 human breast tumor cells: implications for the mechanism of action

1987 • 214 citations

Oxidizing intermediates in the reaction of ferrous EDTA with hydrogen peroxide. Reactions with organic molecules and ferrocytochrome c.

1986 • 197 citations

Hydroxyl free radical formation from hydrogen peroxide by ferrous iron-nucleotide complexes

1983 • 176 citations

The mechanism of iron EDTA catalyzed superoxide dismutation

1983 • 171 citations

Facilitation of Fe(II) antoxidation by Fe(III) complexing agents

1973 • 170 citations

Oxidation of arachidonic acid in micelles by superoxide and hydrogen peroxide.

1981 • 160 citations

An investigation into the role of hydroxyl radical in xanthine oxidase-dependent lipid peroxidation

1982 • 159 citations

Reduction of hydrogen peroxide by the ferrous iron chelate of diethylenetriamine-N,N,N',N",N"-pentaacetate

1988 • 153 citations

Oxygen radicals in chemistry and biology

1985 • 149 citations

On the Nature of Biochemically Generated Hydroxyl Radicals Studies using the Bleaching of p‐Nitrosodimethylaniline as a Direct Assay Method

1979 • 137 citations

Superoxide reaction with nitroxide spin-adducts

1989 • 135 citations

Hydroxyl radical production from hydrogen peroxide and enzymatically generated paraquat radicals: Catalytic requirements and oxygen dependence

1984 • 133 citations

The role of iron chelates in hydroxyl radical production by rat liver microsomes, NADPH-cytochrome P-450 reductase and xanthine oxidase

1984 • 127 citations

Direct demonstration that ferrous ion complexes of di- and triphosphate nucleotides catalyze hydroxyl free radical formation from hydrogen peroxide

1983 • 125 citations

Pulse radiolysis studies of antitumor quinones: Radical lifetimes, reactivity with oxygen, and one-electron reduction potentials

1981 • 124 citations

The effect of pH on the conversion of superoxide to hydroxyl free radicals

1984 • 123 citations

One-electron-transfer reactions in biochemical systems II. The reaction of free radicals formed in the enzymic oxidation

1969 • 113 citations

The reaction between ferrous polyaminocarboxylate complexes and hydrogen peroxide: An investigation of the reaction intermediates by stopped flow spectrophotometry

1987 • 112 citations

Production of hydroxyl radicals from paraquat radicals and H₂O₂

1981 • 98 citations

Oxygen activation: is the hydroxyl radical always biologically relevant?

1984 • 91 citations

Chelated iron-catalyzed OH. formation from paraquat radicals and H2O2: Mechanism of formate oxidation

1984 • 91 citations

An electron spin resonance study of the reduction of peroxides by anthracycline semiquinones

1984 • 90 citations

The production of hydroxyl radical from hydrogen peroxide

1984 • 90 citations

Ethylene from 2-keto-4-thiomethyl butyric acid: The Haber-Weiss reaction

1980 • 88 citations

An Electron Paramagnetic Resonance Study of Alcohol Oxidation by Fenton's Reagent

1965 • 87 citations

A comparison of cobalt(II) and iron(II) hydroxyl and superoxide free radical formation

1989 • 81 citations

Iron and xanthine oxidase catalyze formation of an oxidant species distinguishable from OH.: Comparison with the Haber-Weiss reaction

1986 • 78 citations

Generation of hydroxyl radicals during the enzymatic reductions of the Fe3+-ADP-Phosphate-adriamycin and Fe3+-ADP-EDTA systems

1983 • 76 citations

The fenton reaction between ferrous‐diethylenetriaminepentaacetic acid and hydrogen peroxide

1982 • 75 citations

Oxygen reduction and lipid peroxidation by iron chelates with special reference to ferric nitrilotriacetate

1989 • 75 citations

Kinetic studies on spin trapping of superoxide and hydroxyl radicals generated in NADPH-cytochrome P-450 reductase-paraquat systems. Effect of iron chelates.

1990 • 67 citations

Effect of ferrous ions on microsomal phospholipid peroxidation and related light emission

1974 • 63 citations

Radical driven fenton reactions—Evidence from paraquat radical studies for production of tetravalent iron in the presence and absence of ethylenediaminetetraacetic acid

1987 • 60 citations

Hydroxyl free-radical spin-adduct in rat brain synaptosomes Observations on the reduction of the nitroxide

1983 • 55 citations

The involvement of biological quinones in the formation of hydroxyl radicals via the Haber-Weiss reaction

1987 • 50 citations

Mitochondrial Formation of OH˙ Radicals by an Ubisemiquinone-Dependent Reaction An Alternative Pathway to the Iron-Catalysed Haber-Weiss Cycle

1982 • 46 citations

Methyl viologen radical reactions with several oxidizing agents

1983 • 38 citations

The Rate-Constant of the Reaction of Hydroxyl Radicals With Methanol, Ethanol and (D3)Methanol

1986 • 33 citations

Microsomal interactions between iron, paraquat, and menadione: Effect on hydroxyl radical production and alcohol oxidation

1985 • 27 citations

Importance of Fe2+-ADP and the relative unimportance of OH in the mechanism of mitomycin C-induced lipid peroxidation

1984 • 24 citations

Effects of scavengers of oxygen free radicals on the anaerobic oxidation of 6-hydroxydopamine by H2O2

1985 • 22 citations

Generation of OH radical during enzymatic reduction of 9,10‐anthraquinone‐2‐sulphonate Can semiquinone decompose hydrogen peroxide?

1987 • 19 citations

Chemiluminescence studies on the generation of oxygen radicals from the interaction of NADPH—Cytochrome P-450 reductase with iron

1987 • 7 citations