Barstar is electrostatically optimized for tight binding to barnase.

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

1983 • 14,615 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

[26] Raster3D: Photorealistic molecular graphics

1997 • 3,784 citations

A Hot Spot of Binding Energy in a Hormone-Receptor Interface

1995 • 1,943 citations

Calculating the electrostatic potential of molecules in solution: Method and error assessment

1988 • 1,096 citations

Backbone-dependent Rotamer Library for Proteins Application to Side-chain Prediction

1993 • 910 citations

The structure of protein-protein recognition sites.

1990 • 825 citations

Do salt bridges stabilize proteins? A continuum electrostatic analysis

1994 • 629 citations

Rapid, electrostatically assisted association of proteins

1996 • 562 citations

Energetics of protein-protein interactions: Analysis ofthe Barnase-Barstar interface by single mutations and double mutant cycles

1995 • 559 citations

Mechanism of specificity in the Fos-Jun oncoprotein heterodimer

1992 • 422 citations

Protein-protein recognition: Crystal structural analysis of a barnase-barstar complex at 2.0-.ANG. resolution

1994 • 359 citations

Are buried salt bridges important for protein stability and conformational specificity?

1995 • 323 citations

Interaction of barnase with its polypeptide inhibitor barstar studied by protein engineering

1993 • 283 citations

Simulation of the diffusional association of barnase and barstar

1997 • 273 citations

Free Energy Determinants of Secondary Structure Formation: I. α-Helices

1995 • 220 citations

Stability and function: two constraints in the evolution of barstar and other proteins

1994 • 168 citations

Direct measurement of salt-bridge solvation energies using a peptide model system: implications for protein stability.

1996 • 130 citations

Predicting the rate enhancement of protein complex formation from the electrostatic energy of interaction 1 1Edited by B. Honig

1999 • 124 citations

Electrostatic interactions in the GCN4 leucine zipper: Substantial contributions arise from intramolecular interactions enhanced on binding

1999 • 124 citations

Directed mutagenesis and barnase-barstar recognition

1993 • 104 citations

Effects of salt bridges on protein structure and design

1998 • 86 citations

Optimizing electrostatic affinity in ligand–receptor binding: Theory, computation, and ligand properties

1998 • 83 citations

Optimization of electrostatic binding free energy

1997 • 72 citations

Discrepancies between the NMR and X-ray Structures of Uncomplexed Barstar: Analysis Suggests That Packing Densities of Protein Structures Determined by NMR Are Unreliable^,

1998 • 63 citations

Energetic decomposition of the α-helix-coil equilibrium of a dynamic model system

1998 • 21 citations