The nature and action of granulocyte-macrophage colony stimulating factors

Human bone marrow colony growth in agar‐gel

1970 • 1,317 citations

Factors regulating macrophage production and growth. Purification and some properties of the colony stimulating factor from medium conditioned by mouse L cells.

1977 • 740 citations

Purification and properties of colony-stimulating factor from mouse lung-conditioned medium.

1977 • 624 citations

Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukaemia

1978 • 593 citations

Differentiation of a cell line of myeloid leukemia

1969 • 520 citations

Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue

1977 • 438 citations

Stimulation by human placental conditioned medium of hemopoietic colony formation by human marrow cells

1977 • 394 citations

Identification of megakaryocytes, macrophages, and eosinophils in colonies of human bone marrow containing neurtophilic granulocytes and erythroblasts

1979 • 392 citations

Human Blood Monocytes: Stimulators of Granulocyte and Mononuclear Colony Formation in vitro

1972 • 374 citations

Human erythroid burst-forming unit: T-cell requirement for proliferation in vitro.

1978 • 324 citations

Partial replacement of serum by selenite, transferrin, albumin and lecithin in haemopoitec cell cultures

1976 • 319 citations

Identification of the colony-stimulating cell in human peripheral blood

1972 • 301 citations

Identification of lactoferrin as the granulocyte-derived inhibitor of colony-stimulating activity production.

1978 • 293 citations

Specific interaction of murine colony-stimulating factor with mononuclear phagocytic cells.

1980 • 265 citations

Effect of Endotoxin on Granulopoiesis and Colony-Stimulating Factor

1972 • 248 citations

Role for monocyte-macrophage-derived colony-stimulating factor and prostaglandin E in the positive and negative feedback control of myeloid stem cell proliferation

1978 • 234 citations

Stimulation by Granulocyte-Macrophage Colony-Stimulating Factor of Leishmania Tropica Killing by Macrophages

1979 • 227 citations

Regulation of macrophage and granulocyte proliferation. Specificities of prostaglandin E and lactoferrin

1979 • 216 citations

Production of Colony-Stimulating Factor in Mitogen-Stimulated Lymphocyte Cultures

1974 • 213 citations

Hematopoietic Stem Cells

1979 • 212 citations

Acute antigen-induced elevation of serum colony stimulating factor (CFS) levels.

1971 • 206 citations

In Vitro Growth of Granulocytic and Mononuclear Cell Colonies From Blood of Normal Individuals

1971 • 202 citations

Hemopoietic colonies: in vitro cloning of normal and leukemic cells.

1977 • 202 citations

Separation of functionally distinct human granulocyte-macrophage colony- stimulating factors

1979 • 200 citations

Production of colony-stimulating activity by human lymphocytes

1974 • 192 citations

Self-renewal in culture of proliferative blast progenitor cells in acute myeloblastic leukemia

1979 • 190 citations

Direct stimulation by purified GM-CSF of the proliferation of multipotential and erythroid precursor cells

1980 • 188 citations

FACTORS FROM MOUSE TISSUES STIMULATING COLONY GROWTH OF MOUSE BONE MARROW CELLS IN VITRO

1971 • 187 citations

Erythroid colony formation in cultures of human marrow: Effect of leukocyte conditioned medium

1977 • 163 citations

Colony-stimulating factor (CSF) radioimmunoassay: detection of a CSF subclass stimulating macrophage production.

1979 • 162 citations

Secretion of plasminogen activator by bone marrow-derived mononuclear phagocytes and its enhancement by colony-stimulating factor

1978 • 161 citations

Specificity and modulation of the action of lactoferrin, a negative feedback regulator of myelopoiesis

1980 • 142 citations

Purification and properties of L cell-derived colony-stimulating factor.

1979 • 138 citations

Colony Formation <italic>In Vitro</italic> by Myelomonocytic Leukemic Cells<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1969 • 138 citations

Further studies on the differentiation of a cell line of myeloid leukemia

1970 • 135 citations

Human cell lines that elaborate colon-stimulating activity for the marrow cells of man and other species

1978 • 133 citations

Separation and functional characterization of human neutrophil subpopulations

1978 • 132 citations

Granulocyte/macrophage-, megakaryocyte-, eosinophil- and erythroid-colony-stimulating factors produced by mouse spleen cells

1980 • 132 citations

In Vitro Colony Formation by Normal and Leukemic Human Hematopoietic Cells: Interaction Between Colony-Forming and Colony-Stimulating Cells2

1973 • 131 citations

Proliferative state of blast cell progenitors in acute myeloblastic leukemia (AML)

1978 • 127 citations

Production by spleen and lymph node cells of conditioned medium with erythroid and other hemopoietic colony‐stimulating activity

1978 • 124 citations

Colony stimulating factor and the regulation of granulopoiesis and macrophage production.

1975 • 122 citations

Similar molecular properties of granulocyte-macrophage colony-stimulating factors produced by different mouse organs in vitro and in vivo.

1979 • 119 citations

Heterogeneity of in vitro colony‐ and cluster‐forming cells in the mouse marrow: Segregation by velocity sedimentation

1975 • 117 citations

Analysis of rat hemopoietic cells on the fluorescence-activated cell sorter. I. Isolation of pluripotent hemopoietic stem cells and granulocyte-macrophage progenitor cells

1980 • 107 citations

Purification of a colony-stimulating factor from cultured pancreatic carcinoma cells.

1979 • 107 citations

In vivo induction of normal differentiation in myeloid leukemia cells

1978 • 103 citations

Clonal analysis of the action of GM‐CSF on the proliferation and differentiation of myelomonocytic leukemic cells

1979 • 101 citations

IN VITRO PRODUCTION OF COLONY‐STIMULATING ACTIVITY. I. EXPOSURE OF MOUSE PERITONEAL CELLS TO ENDOTOXIN

1974 • 99 citations

Clonal extinction of myelomonocytic leukemic cells by serum from mice injected with endotoxin

1980 • 98 citations

Release of colony-stimulating activity from thymus-derived lymphocytes.

1975 • 97 citations

Control of normal differentiation of myeloid leukemic cells. VIII. Induction of differentiation to mature granulocytes in mass culture

1975 • 96 citations

Regulation of granulocyte and monocyte-macrophage proliferation by colony stimulating factor (CSF): a review.

1973 • 96 citations

Peritoneal exudate cells. I. Growth requirement of cells capable of forming colonies in soft agar

1974 • 93 citations

Differentiation of Mouse Bone Marrow Precursor Cells into Neutrophil Granulocytes by an Activity Separation from WEHI-3 Cell-Conditioned Medium

1978 • 87 citations

Responsiveness of Human Granulocytic Leukemic Cells to Colony-stimulating Factor

1974 • 84 citations

Monocyte Production of Colony Stimulating Factor in Familial Cyclic Neutropenia

1974 • 83 citations

Colony formation in vitro by leukaemic cells in acute myelogenous leukaemia with phytohaemagglutinin as stimulating factor

1976 • 83 citations

Tumor-Promoting Phorbol Esters Stimulate Hematopoietic Colony Formation in Vitro

1980 • 83 citations

The isolation and properties of granulocytic colony-stimulating activities from medium conditioned by human peripheral leucocytes

1975 • 82 citations

Cytochemical and Morphologic Identification of Macrophages and Eosinophils in Tissue Cultures of Normal Human Bone Marrow

1974 • 81 citations

Isolation and surface labeling of murine polymorphonuclear neutrophils

1979 • 81 citations

Heterogeneity in human neutrophil, macrophage and eosinophil progenitor cells demonstrated by velocity sedimentation separation

1977 • 81 citations

Purification and some properties of colony-stimulating factor from normal human urine

1978 • 77 citations

Studies on the bone marrow colony stimulating factor (CSF): Relation of tissue CSF to serum CSF

1972 • 77 citations

Growth stimulation of human bone marrow cells in agar culture by vascular cells

1975 • 74 citations

Preparation of colony stimulating factors from human placental conditioned medium

1978 • 72 citations

Prolongation of survival time of mice inoculated with myeloid leukemia cells by inducers of normal differentiation.

1979 • 72 citations

Differential expression of lectin receptors during hemopoietic differntiation: Enrichment for granulocyte‐macrophage progenitor cells

1980 • 71 citations

Control of macrophage and granulocyte colony formation by two different factors

1977 • 67 citations

Characterization of colony-stimulating activity produced by human monocytes and phytohemagglutinin-stimulated lymphocytes

1977 • 65 citations

Molecular and biological properties of a macrophage colony-stimulating factor from mouse yolk sacs

1978 • 62 citations

Preparation and neutralization characteristics of an anti-CSF antibody

1975 • 62 citations

A Con A-stimulated T-cell hybridoma releases factors affecting haematopoietic colony-forming cells and B-cell antibody responses

1980 • 61 citations

The effect of colony stimulating factor on the synthesis of ribonucleic acid by mouse bone marrow cells in vitro

1977 • 60 citations

Purification of hemopoietic progenitor cells from human marrow using a fucose-binding lectin and cell sorting

1980 • 59 citations

Eosinophil colony formation in semisolid cultures of human bone marrow cells

1977 • 57 citations

Separation of subpopulations of in vitro colony forming cells from mouse marrow by equilibrium density centrifugation

1975 • 57 citations

Production of colony-stimulating factor in mixed leucocyte cultures.

1974 • 54 citations

In vitro differentiation of Rauscher‐virus‐induced myeloid leukemia cells

1976 • 53 citations

Lipid A, the active part of bacterial endotoxins in inducing serum colony stimulating activity and proliferation of splenic granulocyte/macrophage progenitor cells

1976 • 53 citations

Modulation of myelopoiesis by different bacterial cell-wall components: Induction of colony-stimulating activity (by pure preparations, low-molecular-weight degradation products and a synthetic low-molecular analog of bacterial cell-wall components) in vitro

1978 • 51 citations

Inhibition in vivo of mouse granulopoiesis by cell-free activity derived from human polymorphonuclear neutrophils

1978 • 51 citations

The maturation state of three types of granulocyte/macrophage progenitor cells from mouse bone marrow

1980 • 49 citations

Endotoxin-Induced Release of Colony-Stimulating Activity in Man

1975 • 49 citations

Interacting populations affecting proliferation of leukemic cells in culture

1975 • 48 citations

Colony-Stimulating Factors in Cultures of Human Peripheral Blood Cells<xref ref-type="fn" rid="fn2"><sup>2</sup></xref>

1974 • 48 citations

Marrow adherent cell colony-stimulating activity production in acute myeloid leukemia

1978 • 48 citations

Heterogeneity of human colony-forming cells

1978 • 47 citations

LOCAL AND SYSTEMIC CONTROL OF GRANULOCYTIC AND MACROPHAGE PROGENITOR CELL REGENERATION AFTER IRRADIATION

1973 • 46 citations

Release of Bone Marrow Colony Stimulating Activity during Immunological Reactions in vitro

1973 • 46 citations

Characterization of factors stimulating differentiation of mouse myeloid leukemia cells from a Yoshida sarcoma cell line cultured in serum-free medium.

1979 • 38 citations

Purification and characterization of a colony stimulating factor from human lung

1978 • 38 citations

T-cell hybridoma secreting hemopoietic regulatory molecules: Granulocyte-macrophage and eosinophil colony-stimulating factors

1979 • 36 citations

Common pattern of two distinct types of colony-stimulating factor in human tissues and cultured cells.

1980 • 35 citations

Inhibition of Diffusion Chamber (DC) Granulopoiesis by Anti-CSF Serum

1978 • 32 citations

Development of a radioimmunoassay for colony stimulating factor.

1979 • 32 citations

Stimulation of Human Haemopoietic Cells by Colony Stimulating Factors: Sensitivity of Leukaemic Cells

1979 • 32 citations

Characterization of a differentiation-stimulating factor for mouse myeloid leukemia cells.

1977 • 31 citations

Human Cyclic Neutropenia: Urinary Colony-stimulating Factor and Erythropoietin Levels

1974 • 31 citations

Inhibition of agar colony formation by partially purified granulocyte extracts (chalone)

1977 • 31 citations

Serum half-life and organ distribution of radiolabeled colony stimulating factor in mice.

1977 • 31 citations

Heterogeneity of molecules with low molecular weight isolated from media conditioned by human leukocytes and capable of stimulating colony formation by human granulopoietic progenitor cells

1974 • 30 citations

Stimulation by human urine or plasma of granulopoiesis by human marrow cells in agar.

1974 • 28 citations

Inhibition of RNA and protein syntheses makes non‐differentiating mouse myeloid leukemia cells sensitive to a factor(s) stimulating differentiation

1977 • 28 citations

Physiologic distribution of colony-stimulating factor in vivo

1979 • 28 citations

Preparation of colony stimulating activity from large batches of human urine and production of antisera against it

1978 • 27 citations

Heterogeneity of human colony-forming cells (CFU-C): differences in size, rate of colony formation, and responsiveness to colony-stimulating factor.

1978 • 25 citations

Humoral Regulation of Granulopoiesis

1979 • 25 citations

Production of a colony‐stimulating factor following differentiation of leukemic myeloblasts to macrophages

1980 • 24 citations

The exceptional responsiveness of certain human myeloid leukemia cells to colony-stimulating activity

1979 • 24 citations

Cell surfaces and the regulation of hemopoiesis.

1978 • 24 citations

Modulation of granulopoiesis: opposing roles of prostaglandins F and E.

1978 • 22 citations

Prognostic Value of Colony‐stimulating and Colony‐forming cells in Peripheral Blood in Acute Non‐lymphoblastic Leukemia

1977 • 21 citations

Production of Colony Stimulating Factors by Lymphoid Tissues

1979 • 21 citations

The effects of erythropoietin in vitro on spleen colony‐forming cells

1977 • 21 citations

Contamination of erythropoietin by endotoxin: in vivo and in vitro effects on murine erythropoiesis

1979 • 20 citations

Effects of fibroblasts on the growth of erythroid progenitor cells in vitro.

1977 • 20 citations

The role of colony‐stimulating factor in granulopoiesis

1980 • 19 citations

Serum of lipopolysacharide‐treated mice contains two types of colony‐stimulating factor, separable by affinity chromatography

1980 • 18 citations

Colony-Stimulating Factor and the Differentiation of Granulocytes and Macrophages

1977 • 18 citations

Sources and nature of granulocyte-macrophage colony stimulating factor in fetal mice.

1978 • 18 citations

Colony-stimulating factors active on human bone marrow cells from a Yoshida sarcoma cell line

1978 • 16 citations

Isolation of a granulocyte colony inhibitory factor derived from human polymorphonuclear neutrophils

1978 • 16 citations

Granulocyte modulation of endotoxin-stimulated colony-stimulating activity (CSA) production

1978 • 16 citations

Sensitization of resistant myeloid leukemia clone cells by anti-cancer drugs to factor-stimulating differentiation.

1979 • 16 citations

Adherent Cell Dependent Colony‐Stimulating Activity in Human Serum: A Granulopoietic Regulator?

1980 • 16 citations

Human placenta-conditioned medium for stimulation of human granulopoietic precursor cell (CFU-C) colony growth in vitro

1978 • 14 citations

Cross reactivity of human beta2-microglobulin with human granulocyte colony-stimulating activity.

1976 • 13 citations

Properties and separation of T lymphocyte growth stimulatory activity (TL‐GSA) and of granulocyte‐macrophage colony stimulatory activity (GM‐CSA) produced separately from two human T lymphocyte subpopulations

1979 • 11 citations

Granulopoiesis inhibiting factor chalone purification and chemical composition

1980 • 10 citations

In Vitro Colony Growth of Acute Myelogenous Leukemia

1976 • 8 citations

Characteristics of the in Vitro Monocyte-Macrophage Colony-Forming Cells Detected within Mouse Thymus and Lymph Nodes

1977 • 8 citations

Colony stimulating factor (CSF) in human mixed lymphocyte cultures: effect on human and mouse progenitor cells.

1978 • 7 citations

Endotoxin‐Induced Colony Stimulating Activity in Normal and Myeloid Leukaemic Subjects

1979 • 6 citations

The effect of various sources of colony-stimulating activity on normal human marrow in agar culture

1977 • 6 citations

The role of macrophages in stimulation of immune induction and myelopoiesis. I: Comparison of activity of macrophage-derived factors in granulopoiesis and immunostimulation

1979 • 5 citations

The role of macrophages in stimulation of immune induction and myelopoiesis. II: Analysis of genetic restriction involved in the stimulation of granulocyte colony precursors or mature lymphocytes using factors prepared from different recombinant inbred strains of mice

1979 • 4 citations

The effect of cyclic AMP on human colony forming cell and colony stimulating factor production

1977 • 4 citations

Cytotoxicity of anti-beta 2-microglobulin xenoantisera to human and murine myeloid progenitor cells and lack of cross-reactivity with colony-stimulating activity.

1980 • 3 citations