Oligothymidylate analogues having stereoregular, alternating methylphosphonate/phosphodiester backbones. Synthesis and physical studies.

Physicochemical studies on polydeoxyribonucleotides containing defined repeating nucleotide sequences

1970 • 550 citations

Studies on Polynucleotides. XXIV.¹ The Stepwise Synthesis of Specific Deoxyribopolynucleotides (4).² Protected Derivatives of Deoxyribonucleosides and New Syntheses of Deoxyribonucleoside-3″ Phosphates³

1963 • 397 citations

Staphylococcal nuclease: Proposed mechanism of action based on structure of enzyme—thymidine 3′,5′-bisphosphate—calcium ion complex at 1.5-Å resolution

1979 • 375 citations

Structures for the polynucleotide complexes Poly(dA)·Poly(dT) and Poly (dT)·Poly(dA)·Poly(dT)

1975 • 369 citations

Statistical thermodynamics of nucleic acid melting transitions with coupled binding equilibria

1971 • 253 citations

Arylsulfonyltetrazoles, new coupling reagents and further improvements in the triester method for the synthesis of deoxyribooligonucleotides¹

1977 • 235 citations

Nonionic nucleic acid analogs. Synthesis and characterization of dideoxyribonucleoside methylphosphonates

1979 • 186 citations

Conformation and interaction of dinucleoside mono- and diphosphates. V. Syntheses and properties of adenine and thymine nucleoside alkyl phosphotriesters, the neutral analogs of dinucleoside monophosphates

1971 • 141 citations

Structures for Poly(U).poly(A).poly(U) Triple Stranded Polynucleotides

1973 • 127 citations

The structure of a DNA-RNA hybrid.

1967 • 123 citations

Oligodeoxythymidylate: polydeoxyadenylate and oligodeoxyadenylate: polydeoxythymidylate interactions

1969 • 123 citations

Improved triester approach for the synthesis of pentadecathymidylic acid

1975 • 110 citations

Conformations and structural transitions in polydeoxynucleotides

1975 • 92 citations

Molecular and crystal structure of the polynucleotide complex: Polyinosinic acid plus polydeoxycytidylic acid

1970 • 87 citations

Alkyl phosphotriesters of dinucleotides and oligonucleotides. 4. Synthesis of oligodeoxyribonucleotide ethyl phosphotriesters and their specific complex formation with transfer ribonucleic acid

1974 • 84 citations

Effects of a trinucleotide ethyl phosphotriester, G^mp(Et)G^mp(Et)U, on mammalian cells in culture

1977 • 77 citations

Synthesis and enzymatic properties of deoxyribooligonucleotides containing methyl and phenylphosphonate linkages

1979 • 71 citations

Proton nuclear magnetic resonance studies on dideoxyribonucleoside methylphosphonates

1980 • 61 citations

Alkyl phosphotriesters of dinucleotides and oligonucleotides. 5. Inhibitory effect of complex formation with oligodeoxyribonucleotide ethyl phosphotriesters on transfer ribonucleic acid aminoacylation

1974 • 57 citations

Chemical synthesis of a self-complementary octanucleotide, dG-G-T-T-A-A-C-C by a modified triester method

1978 • 52 citations

On the helix-coil equilibrium in two- and three-stranded complexes involving complementary poly- and oligonucleotides

1970 • 49 citations

Staphylococcal nuclease reviewed: A Prototypic study in contemporary enzymology. II. Solution studies of the nucleotide binding site and the effects of nucleotide binding.

1979 • 49 citations

Duplex formation of a nonionic oligo(deoxythymidylate) analog [heptadeoxythymidylyl-(3'-5')-deoxythymidine heptaethyl ester (d-[Tp(Et)]₇T)]with poly(deoxyadenylate). Evaluation of the electrostatic interaction

1977 • 47 citations

Staphylococcal Nuclease: Size and Specificity of the Active Site

1968 • 47 citations

Oligonucleotide syntheses utilizing .beta.-benzoylpropionyl, a blocking group with a trigger for selective cleavage

1967 • 46 citations

Protonated polynucleotide structures. 16. Thermodynamics of the melting of the acid form of polycytidylic acid

1975 • 40 citations

Fluoride ion promoted deprotection and transesterification in nucleotide triesters

1979 • 36 citations

Zur Chemie der „energiereichen Phosphate”︁, VIII. Carbamylphosphate

1959 • 31 citations

Attempts to suppress internucleotide cleavage during unblocking of oligonucleotide phosphotriester intermediates

1977 • 23 citations

Alkyl phosphotriesters of dinucleotides and oligonucleotides. 2. Hydrogen-bonded complexes of adenine and thymine nucleoside alkyl phosphotriesters in deuteriochloroform

1973 • 16 citations

CD studies on the conformation of some deoxyoligonucleotides containing adenine and thymine residues

1974 • 16 citations