Platelets circulate in an activated state in inflammatory bowel disease

Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal

1962 • 4,273 citations

A SIMPLE INDEX OF CROHN'S-DISEASE ACTIVITY

1980 • 2,735 citations

Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells.

1984 • 944 citations

PADGEM protein: A receptor that mediates the interaction of activated platelets with neutrophils and monocytes

1989 • 878 citations

Detection of activated platelets in whole blood using activation- dependent monoclonal antibodies and flow cytometry

1987 • 736 citations

Clinical, biological, and endoscopic picture of attacks of Crohn's disease

1990 • 709 citations

Vascular Complications of Inflammatory Bowel Disease

1986 • 649 citations

PATHOGENESIS OF CROHN'S DISEASE: MULTIFOCAL GASTROINTESTINAL INFARCTION

1989 • 589 citations

Cultured human endothelial cells generate tissue factor in response to endotoxin.

1983 • 516 citations

Plasma levels of beta-thromboglobulin and platelet factor 4 as indices of platelet activation in vivo

1981 • 511 citations

A NEW METHOD FOR THE QUANTITATIVE DETECTION OF PLATELET AGGREGATES IN PATIENTS WITH ARTERIAL INSUFFICIENCY

1974 • 494 citations

Platelet factor 4 is chemotactic for neutrophils and monocytes.

1981 • 444 citations

Chemiluminescence assay of mucosal reactive oxygen metabolites in inflammatory bowel disease

1992 • 342 citations

Studies with a monoclonal antibody against activated platelets: evidence that a secreted 53,000-molecular weight lysosome-like granule protein is exposed on the surface of activated platelets in the circulation

1987 • 282 citations

Chemotactic activity of platelet alpha granule proteins for fibroblasts.

1983 • 275 citations

Articular indices of joint inflammation in rheumatoid arthritis. Correlation with the acute‐phase response

1987 • 268 citations

Special Report The Complexity of Endothelial Cells: A Review

1989 • 233 citations

Thromboembolism in inflammatory bowel disease: role of platelets.

1993 • 232 citations

von Willebrand factor is an acute phase reactant in man

1989 • 221 citations

Increased Factor VIII/von Willebrand Factor Antigen and von Willebrand Factor Activity in Scleroderma and in Raynaud's Phenomenon

1981 • 220 citations

Role of platelet-activating factor in ulcerative colitis

1988 • 198 citations

In vivo profiles of eicosanoids in ulcerative colitis, Crohn's colitis, and Clostridium difficile colitis

1988 • 185 citations

Ischemic heart disease and platelet aggregation. The Caerphilly Collaborative Heart Disease Study.

1991 • 182 citations

Vascular biology and medicine in the 1990s: scope, concepts, potentials, and perspectives.

1993 • 147 citations

Activated platelets induce endothelial secretion of interleukin-8 in vitro via an interleukin-1-mediated event

1993 • 143 citations

Mucosal capillary thrombi in rectal biopsies

1992 • 133 citations

Platelet responses and metabolism

1986 • 133 citations

β-Thromboglobulin - a Specific Marker of In-Vivo Platelet Release Reaction

1980 • 124 citations

Do Platelets Have Anything To Do With Diabetic Microvascular Disease?

1983 • 124 citations

Platelets as inflammatory cells

1989 • 123 citations

Evidence for the Platelet Specificity of β‐Thromboglobulin and Studies on its Plasma Concentration in Healthy Individuals

1979 • 122 citations

Endotoxaemia in active Crohn's disease. Treatment with whole gut irrigation and 5-aminosalicylic acid.

1986 • 119 citations

Platelet count: a simple measure of activity in Crohn's disease.

1983 • 100 citations

Increased platelet aggregate formation in patients with chronic airflow obstruction and hypoxaemia.

1991 • 82 citations

Aspirin-Sensitive Asthma: Abnormal Platelet Response to Drugs Inducing Asthmatic Attacks

1985 • 77 citations

Circulating von Willebrand factor in inflammatory bowel disease.

1992 • 75 citations

Fixation with formaldehyde induces expression of activation dependent platelet membrane glycoproteins, P selectin (CD62) and GP53 (CD63)

1993 • 44 citations

Raised plasma concentrations of platelet factor 4 (PF4) in Crohn's disease.

1987 • 40 citations

Human platelet aggregation is initiated by peripheral blood mononuclear cells exposed to bacterial lipopolysaccharide in vitro.

1986 • 38 citations

Plasma and Serum Von Willebrand Factor Antigen Concentrations in Connective Tissue Disorders

1992 • 36 citations

Endotoxin-Induced Platelet Activation in Human Whole Blood In Vitro

1988 • 19 citations