5-Azacytidine and RNA secondary structure increase the retrovirus mutation rate

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

High efficiency transformation of E.coli by high voltage electroporation

1988 • 2,789 citations

Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidine

1979 • 1,101 citations

A restriction enzyme cleavage map of Tn5 and location of a region encoding neomycin resistance

1979 • 577 citations

New procedure for DNA transfection with polycation and dimethyl sulfoxide.

1984 • 481 citations

Genetic consequences of packaging two RNA genomes in one retroviral particle: pseudodiploidy and high rate of genetic recombination.

1990 • 477 citations

5-Methylcytosine, Gene Regulation, and Cancer

1983 • 425 citations

Selection, recombination, and G----A hypermutation of human immunodeficiency virus type 1 genomes

1991 • 339 citations

Specificity and Mechanism of Error-prone Replication by Human Immunodeficiency Virus-1 Reverse Transcriptase

1989 • 316 citations

The base substitution fidelity of eucaryotic DNA polymerases. Mispairing frequencies, site preferences, insertion preferences, and base substitution by dislocation.

1986 • 301 citations

Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: substitutions, frameshifts, and hypermutations.

1990 • 282 citations

Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia.

1970 • 260 citations

Mutation Frequencies at Defined Single Codon Sites in Vesicular Stomatitis Virus and Poliovirus Can Be Increased Only Slightly by Chemical Mutagenesis

1990 • 256 citations

Genetic Characteristics of Conditional Lethal Mutants of Vesicular Stomatitis Virus Induced by 5-Fluorouracil, 5-Azacytidine, and Ethyl Methane Sulfonate

1970 • 227 citations

New Procedure for DNA Transfection with Polycation and Dimethyl Sulfoxide

1984 • 217 citations

Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: deletions and deletions with insertions.

1990 • 214 citations

Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro.

1989 • 189 citations

High mutation rate of a spleen necrosis virus-based retrovirus vector.

1986 • 157 citations

The tumorigenicity of 5-azacytidine in the male Fischer rat

1984 • 143 citations

5-Azacytidine: A New Active Agent for the Treatment of Acute Leukemia

1973 • 138 citations

Thermodynamic origins of specificity in the lac repressor-operator interaction

1985 • 121 citations

Induction of the metastatic phenotype in a mouse tumor model by 5-azacytidine, and characterization of an antigen associated with metastatic activity.

1984 • 110 citations

Characterization of large deletions occurring during a single round of retrovirus vector replication: novel deletion mechanism involving errors in strand transfer

1991 • 106 citations

Mutagenicity of 5-azacytidine and related nucleosides in C3H/10T 1/2 clone 8 and V79 cells.

1982 • 98 citations

Genetic effects of 5-azacytidine in Saccharomyces cerevisiae

1984 • 79 citations

High Mutation Rate of a Spleen Necrosis Virus-Based Retrovirus Vector

1986 • 74 citations

5-Azacytidine as a mutagen for arboviruses

1968 • 34 citations

Effects of 5-azacytidine on transfer RNA methyltransferases.

1979 • 32 citations

Destructive processing of the 45-S ribosomal precursor in the presence of 5-azacytidine

1973 • 31 citations

Induction of a Step in Carcinogenesis That Is Normally Associated with Mutagenesis by Nonmutagenic Concentrations of 5-Azacytidine

1984 • 29 citations

5-azacytidine and 5-azadeoxycytidine inhibit human immunodeficiency virus type 1 replication in vitro

1990 • 26 citations

Mutagenic effects of 5-azacytidine in bacteria

1965 • 26 citations

The mutagenicity of 5-azacytidine and other inhibitors of replicative DNA synthesis in the L5178Y mouse lymphoma cell

1987 • 25 citations

Effect of 5-azacytidine (5-azaC) on the induction of chromatid aberrations (CA) and sister-chromatid exchanges (SCE)

1985 • 21 citations

Studies of mutagenicity and clastogenicity of 5-azacytidine in human lymphoblasts and Salmonella typhimurium

1986 • 20 citations