Mutations within the 5' nontranslated RNA of cell culture-adapted hepatitis A virus which enhance cap-independent translation in cultured African green monkey kidney cells

The scanning model for translation: an update.

1989 • 3,525 citations

Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.

1986 • 2,118 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

1988 • 1,884 citations

Improved free-energy parameters for predictions of RNA duplex stability.

1986 • 1,472 citations

A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation

1988 • 1,325 citations

A Controlled Trial of a Formalin-Inactivated Hepatitis A Vaccine in Healthy Children

1992 • 532 citations

A functional ribonucleoprotein complex forms around the 5′ end of poliovirus RNA

1990 • 494 citations

La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate

1993 • 485 citations

Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein.

1990 • 428 citations

Protection Against Hepatitis A by an Inactivated Vaccine

1994 • 408 citations

Propagation of Human Hepatitis A Virus in Cell Culture in Vitro

1979 • 391 citations

Type A Viral Hepatitis

1985 • 338 citations

A cytoplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding protein.

1993 • 327 citations

A cellular protein that binds to the 5'-noncoding region of poliovirus RNA: implications for internal translation initiation.

1989 • 271 citations

Sequence and structural elements that contribute to efficient encephalomyocarditis virus RNA translation

1992 • 229 citations

The 5' nontranslated region of hepatitis A virus RNA: secondary structure and elements required for translation in vitro

1991 • 203 citations

Cytoplasmic expression system based on constitutive synthesis of bacteriophage T7 RNA polymerase in mammalian cells.

1990 • 195 citations

Complete nucleotide sequence of an attenuated hepatitis A virus: comparison with wild-type virus.

1987 • 159 citations

In vitro characterization of an internal ribosomal entry site (IRES) present within the 5' nontranslated region of hepatitis A virus RNA: comparison with the IRES of encephalomyocarditis virus

1994 • 153 citations

The involvement of a spliceosome component in internal initiation of human rhinovirus RNA translation

1993 • 134 citations

Structure and stability of mRNA synthesized by vaccinia virus-encoded bacteriophage T7 RNA polymerase in mammalian cells

1989 • 133 citations

Low efficiency of the 5' nontranslated region of hepatitis A virus RNA in directing cap-independent translation in permissive monkey kidney cells

1994 • 118 citations

Complete nucleotide sequence of a cell culture-adapted variant of hepatitis a virus: Comparison with wild-type virus with restricted capacity for in vitro replication

1988 • 118 citations

Sequences within the poliovirus internal ribosome entry segment control viral RNA synthesis.

1994 • 114 citations

Safety and Immunogenicity of a Live Attenuated Hepatitis A Virus Vaccine in Seronegative Volunteers

1991 • 99 citations

Nucleotide sequence of wild-type hepatitis A virus GBM in comparison with two cell culture-adapted variants

1994 • 85 citations

2B and 2C Mutations Are Essential but Mutations throughout the Genome of HAV Contribute to Adaptation to Cell Culture

1993 • 81 citations

Identification of the Hepatitis A Virus Internal Ribosome Entry Site: In Vivo and in Vitro Analysis of Bicistronic RNAs Containing the HAV 5′ Noncoding Region

1993 • 78 citations

Studies of Prototype Live Hepatitis A Virus Vaccines in Primate Models

1988 • 77 citations

Mutations in both the 2B and 2C genes of hepatitis A virus are involved in adaptation to growth in cell culture

1992 • 72 citations

Mutations within the 5' nontranslated region of hepatitis A virus RNA which enhance replication in BS-C-1 cells

1992 • 72 citations

Attenuated hepatitis A virus: genetic determinants of adaptation to growth in MRC-5 cells

1994 • 70 citations

Translational efficiency of poliovirus mRNA: mapping inhibitory cis-acting elements within the 5' noncoding region

1988 • 67 citations

Cell type-specific proteins which interact with the 5' nontranslated region of hepatitis A virus RNA

1993 • 64 citations

Pyrimidine tract binding protein strongly stimulates in vitro encephalomyocarditis virus RNA translation at the level of preinitiation complex formation

1994 • 59 citations

Recent advances in hepatitis A vaccine development

1990 • 46 citations

Clinical and laboratory observations following oral or intramuscular administration of a live attenuated hepatitis A vaccine candidate

1992 • 43 citations

Large deletion mutations involving the first pyrimidine-rich tract of the 5' nontranslated RNA of human hepatitis A virus define two adjacent domains associated with distinct replication phenotypes

1994 • 37 citations

Nucleotide Sequence of High-passage Hepatitis A Virus Strain HM175: Comparison with Wild-type and Cell Culture-adapted Strains

1989 • 25 citations

Temperature-sensitive hepatitis A virus mutants with deletions downstream of the first pyrimidine-rich tract of the 5' nontranslated RNA are impaired in RNA synthesis

1995 • 23 citations

Attenuation Phenotype of a Cell Culture-Adapted Variant of Hepatitis A Virus (HM175/p16) in Susceptible New World Owl Monkeys

1993 • 17 citations