Ketoconazole; Mechanism of Action, Spectrum of Activity, Pharmacokinetics, Drug Interactions, Adverse Reactions and Therapeutic Use

Manual of Clinical Microbiology.

1980 • 14,937 citations

Principles and Practice of Infectious Diseases

1980 • 632 citations

Ketoconazole Blocks Adrenal Steroid Synthesis

1982 • 425 citations

Ketoconazole blocks testosterone synthesis

1982 • 351 citations

Strategies in the Treatment of Systemic Fungal Infections

1980 • 344 citations

Antimycotic imidazoles. Part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent

1979 • 336 citations

In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis

1980 • 282 citations

Ketoconazole

1982 • 270 citations

MULTIPLE EMULSIONS

1965 • 263 citations

ACUTE ATROPINE POISONING

1948 • 224 citations

Fungal Peritonitis in Patients on Continuous Ambulatory Peritoneal Dialysis

1983 • 220 citations

CALCIUM DEPRIVATION IN HYPOPARATHYROIDISM

1960 • 219 citations

Mechanism of Action of Antifungal Drugs, with Special Reference to the Imidazole Derivatives

1980 • 214 citations

FLUORIDE TOXICITY

1973 • 213 citations

Disposition of ketoconazole, an oral antifungal, in humans

1982 • 205 citations

Emanuel Miller. M.A. Cantab., F.R.C.P., D.P.M.

1970 • 198 citations

Treatment of Systemic Mycoses with Ketoconazole: Emphasis on Toxicity and Clinical Response in 52 Patients

1983 • 189 citations

Laboratory and clinical assessment of ketoconazole in deep-seated mycoses

1983 • 172 citations

Hepatic reactions during ketoconazole treatment

1983 • 159 citations

Long-term therapy of chronic mucocutaneous candidiasis with ketoconazole: Experience with twenty-one patients

1983 • 156 citations

Gynecomastia with Ketoconazole

1981 • 155 citations

KETOCONAZOLE VERSUS NYSTATIN PLUS AMPHOTERICIN B FOR FUNGAL PROPHYLAXIS IN SEVERELY IMMUNOCOMPROMISED PATIENTS

1982 • 155 citations

The influence of gastric acidity on the bio-availability of ketoconazole

1980 • 150 citations

Ketoconazole, an oral antifungal: laboratory and clinical assessment of imidazole drugs

1979 • 145 citations

Toxic hepatis during ketoconazole treatment.

1981 • 142 citations

Treatment of Chronic Mucocutaneous Candidiasis with Ketoconazole

1980 • 140 citations

Ketoconazole: A Novel and Rapid Treatment for Advanced Prostatic Cancer

1983 • 133 citations

An Evaluation of Two Years of Clinical Experience with Ketoconazole

1980 • 132 citations

High-Dose Ketoconazole for Treatment of Fungal Infections of the Central Nervous System

1983 • 101 citations

Ketoconazole in the Management of Fungal Disease

1982 • 97 citations

Oral Ketoconazole in the Treatment of Leishmaniasis

1982 • 97 citations

Improvement of Psoriasis of the Scalp With Ketoconazole

1982 • 95 citations

The antifungal activity of ketoconazole

1983 • 94 citations

Pharmacokinetics of ketoconazole in normal subjects

1981 • 88 citations

Impairing effect of food on ketoconazole absorption

1982 • 87 citations

The activity in vitro and in vivo of a new imidazole antifungal, ketoconazole

1980 • 86 citations

Primary site of action of ketoconazole on Candida albicans

1982 • 86 citations

Miconazole in Coccidioidomycosis. I. Assays of Activity in Mice and in Vitro

1975 • 84 citations

Human Blastomycosis After a Dog Bite

1983 • 81 citations

Treatment of paracoccidioidomycosis with ketoconazole: A three-year experience

1983 • 79 citations

Chronic Mucocutaneous Candidosis and Other Superficial and Systemic Mycoses Successfully Treated with Ketoconazole

1980 • 77 citations

Ketoconazole in the Treatment of Paracoccidioidomycosis and Histoplasmosis

1980 • 77 citations

Promotion of pseudomycelium formation of Candida albicans in culture: a morphological study of the effects of miconazole and ketoconazole

1979 • 75 citations

Effect of pH on Disintegration and Dissolution of Ketoconazole Tablets

1983 • 72 citations

Pityrosporum folliculitis and ketoconazole

1982 • 70 citations

In Vitro Studies of Amphotericin B in Combination with the Imidazole Antifungal Compounds Clotrimazole and Miconazole

1978 • 69 citations

Treatment of Coccidioidomycosis with Ketoconazole: Clinical and Laboratory Studies of 18 Patients

1980 • 67 citations

Paracoccidioidomycosis in the immunosuppressed host: report of a case and review of the literature.

1984 • 65 citations

Treatment of disseminated and progressive cavitary histoplasmosis with ketoconazole

1983 • 65 citations

Experience with ketoconazole in three major manifestations of progressive coccidioidomycosis

1983 • 65 citations

Ketoconazole: A Major Innovation for Treatment of Fungal Disease

1980 • 63 citations

Ketoconazole for Treatment of Disseminated Coccidioidomycosis

1982 • 63 citations

ANTAGONISM BETWEEN MICONAZOLE AND AMPHOTERICIN B

1976 • 62 citations

Variability of Agar Dilution-Replicator Method of Yeast Susceptibility Testing

1979 • 61 citations

Treatment of Pityriasis Versicolor with Ketoconazole

1980 • 61 citations

Ketoconazole in griseofulvin-resistant dermatophytosis

1982 • 60 citations

Ketoconazole Therapy for Fungal Urinary Tract Infections

1983 • 56 citations

Septic Arthritis due to Candida Species in Patients with Cancer: Report of Five Cases and Review of the Literature

1982 • 55 citations

Ketoconazole inhibition of testicular secretion of testosterone and displacement of steroid hormones from serum transport proteins

1983 • 54 citations

Oral ketoconazole. An effective and safe treatment for dermatophytosis

1981 • 54 citations

Hepatitis and ketoconazole therapy

1981 • 54 citations

Treatment of Paracoccidioidomycosis, Candidiasis, Chromomycosis, Lobomycosis, and Mycetoma with Ketoconazole

1980 • 53 citations

Ketoconazole: A New Drug for the Treatment of Paracoccidioidomycosis

1980 • 53 citations

Therapy of Disseminated or Pulmonary Coccidioidomycosis with Ketoconazole

1980 • 51 citations

Ketoconazole and Candidiasis: A Controlled Study

1983 • 51 citations

Oral Ketoconazole Therapy for Keratomycosis

1983 • 50 citations

Ketoconazole Treatment of Chronic Mucocutaneous Candidiasis

1980 • 50 citations

Sensitive bioassay for ketoconazole in serum and cerebrospinal fluid

1981 • 49 citations

Progressive Disseminated Histoplasmosis: Favorable Response to Ketoconazole

1981 • 48 citations

Ketoconazole treatment of nonprimary coccidioidomycosis

1982 • 47 citations

Multiple dose pharmacokinetics of ketoconazole and their effects on antipyrine kinetics in man

1983 • 47 citations

Effects of pH on the Activity of Ketoconazole Against Candida albicans

1983 • 46 citations

Anaphylactic reactions to ketoconazole.

1983 • 45 citations

Failure of Ketoconazole in Cryptococcal Meningitis

1982 • 44 citations

Effect of ketoconazole on isolated mitochondria from Candida albicans

1982 • 44 citations

Combined treatment with ketoconazole and luteinising hormone releasing hormone analogue: a novel approach to resistant progressive prostatic cancer.

1983 • 44 citations

Determination of the antifungal agent, ketoconazole, in human plasma by high-performance liquid chromatography

1980 • 43 citations

Treatment of Fungal Infections in the Bones and Joints with Ketoconazole

1983 • 43 citations

The successful treatment of pityriasis versicolor by systemic ketoconazole

1982 • 42 citations

The treatment of patients with chronic mucocutaneous candidosis and Candida onychomycosis with ketoconazole

1982 • 42 citations

Ketoconazole in the treatment of fungal infection

1983 • 42 citations

Successful treatment of chronic mucocutaneous candidiasis with ketoconazole

1980 • 41 citations

Ketoconazole, amphotericin B, and amphotericin B methyl ester: comparative in vitro and in vivo toxicological effects on neutrophil function

1981 • 40 citations

Treatment of chromomycosis with ketoconazole and 5-fluorocytosine

1983 • 38 citations

Treatment of Chronic Mucocutaneous Candidosis with Ketoconazole: A Study of 12 Cases

1980 • 37 citations

Ketoconazole for Treatment of Chronic Pulmonary Coccidioidomycosis

1982 • 37 citations

Oral Ketoconazole

1981 • 37 citations

Susceptibility of zygomycetes to amphotericin B, miconazole, and ketoconazole

1981 • 32 citations

The Activity of Ketoconazole in the Treatment of Onychomycosis

1980 • 31 citations

Cardiovascular risk factors in middle-aged men in 24 towns

1981 • 29 citations

Treatment of mycoses in cancer patients

1983 • 29 citations

Measurement of ketoconazole, a new antifungal agent, by high-performance liquid chromatography

1982 • 29 citations

Severe hepatitis associated with ketoconazole therapy for chronic mucocutaneous candidiasis.

1982 • 29 citations

Relapse of Candida parapsilosis Endocarditis After Long-Term Suppression with Flucytosine: Retreatment with Valve Replacement and Ketoconazole

1980 • 28 citations

Liquid chromatographic assay of ketoconazole

1981 • 27 citations

Treatment of chronic dermatophyte infections. The use of ketoconazole in griseofulvin treatment failures

1982 • 27 citations

Therapeutic Evaluation of Ketoconazole in Patients with Coccidioidomycosis

1980 • 27 citations

Treatment of coccidioidomycosis with ketoconazole: An evaluation utilizing a new scoring system

1983 • 26 citations

Hepatitis and ketoconazole therapy.

1981 • 24 citations

Fungal arthritis simulating juvenile rheumatoid arthritis.

1982 • 24 citations

Pharmacokinetics of ketoconazole in patients with neoplastic diseases

1982 • 24 citations

Chromohyphomycosis. Treatment wit ketoconazole

1981 • 22 citations

Ketoconazole therapy for systemic fungal infections: inadequacy of standard dosage regimens.

1982 • 22 citations

Therapy of chronic mucocutaneous candidiasis

1983 • 20 citations

Chromoblastomycosis treatment with ketoconazole.

1982 • 20 citations

Ketoconazole in Vulvovaginal Candidosis

1980 • 20 citations

Systemic treatment of tinea versicolor with Ketoconazole in forty-four patients

1981 • 17 citations

Treatment of Chronic Mucocutaneous Candidosis with Ketoconazole: Preliminary Results of a Controlled, Double-Blind Clinical Trial

1980 • 17 citations

The Use of Ketoconazole to Treat Systemic Blastomycosis Presenting as Acute Epididymitis

1983 • 17 citations

Quantitation of Imidazoles by Agar-Disk Diffusion

1978 • 17 citations

Activity of Ketoconazole and Its Deacyl Derivative Against Plasmodium falciparum and Candida Isolates

1982 • 16 citations

Chromohyphomycosis

1981 • 16 citations

Apparent Ketoconazole Failure in Candidal Cholecystitis

1982 • 11 citations

Combined activity of ketoconazole and 5-fluorocytosine on potentially pathogenic yeasts

1982 • 9 citations

Hepatotoxic potential of ketoconazole under investigation.

1982 • 8 citations

Postoperative Peritonitis Due to Saccharomyces Cerivisiae—Treated with Ketoconazole

1982 • 8 citations

Ketoconazole Therapy and Exfoliative Erythroderma

1983 • 7 citations

Comparison of ceftazidime and N-formimidoyl thienamycin against gentamicin-susceptible and resistant Pseudomonas aeruginosa

1983 • 5 citations

Influence of pH on ketoconazole activity against Candida parapsilosis and Candida albicans.

1982 • 3 citations

Ketoconazole in a case of chronic mucocutaneous candidiasis

1982 • 2 citations

An evaluation of two years of clinical experience with ketoconazole.

1982 • 2 citations

Superficial Mycoses: Ketoconazole Treatment Oberflächliche Mykosen: Ketoconazol‐Behandlung

1982 • 2 citations

An Evaluation of two Years of Clinical Experience with Ketoconazole: Die Auswertung der klinischen Erfahrungen mit Ketoconazol über zwei Jahre

1982 • 2 citations

The successful treatment of mycotic infections in immunosuppressed renal transplant recipients with ketoconazole.

1982 • 1 citations

Ketoconazole absorption

1983 • 1 citations