Expression and characterization of recombinant human angiotensin I-converting enzyme. Evidence for a C-terminal transmembrane anchor and for a proteolytic processing of the secreted recombinant and plasma enzymes.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung

1971 • 2,569 citations

Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.

1982 • 1,333 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME

1956 • 994 citations

Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.

1988 • 741 citations

Angiotensin-Converting Enzyme: Vascular Endothelial Localization

1976 • 644 citations

Biochemistry of the glycosyl-phosphatidylinositol membrane protein anchors

1987 • 604 citations

A dipeptidyl carboxypeptidase that converts angiotensin I and inactivates bradykinin

1970 • 533 citations

Enzymes of the Renin-Angiotensin System and their Inhibitors

1982 • 465 citations

A continuous spectrophotometric assay for angiotensin converting enzyme

1979 • 416 citations

Localization of angiotensin converting enzyme (kininase II). II. Immunocytochemistry and immunofluorescence

1976 • 348 citations

[Angiotensin-I converting enzyme].

1995 • 335 citations

Complete primary structure of human and rabbit lactase-phlorizin hydrolase: implications for biosynthesis, membrane anchoring and evolution of the enzyme.

1988 • 264 citations

Complete amino acid sequence of human intestinal aminopeptidase N as deduced from cloned cDNA

1988 • 241 citations

Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA.

1987 • 238 citations

Ectoenzymes of the kidney microvillar membrane. Differential solubilization by detergents can predict a glycosyl-phosphatidylinositol membrane anchor

1988 • 216 citations

Biochemical regulation of blood pressure

1981 • 201 citations

Molecular cloning and amino acid sequence of rat enkephalinase

1987 • 190 citations

Proteins of the kidney microvillar membrane. The amphipathic form of dipeptidyl peptidase IV

1979 • 182 citations

Angiotensin I converting enzyme in human intestine and kidney

1986 • 166 citations

Identification of the pH-dependent membrane anchor of carboxypeptidase E (EC 3.4.17.10).

1990 • 163 citations

Angiotensin-Converting Enzyme in Epithelial and Neuroepithelial Cells

1983 • 148 citations

Pig kidney angiotensin converting enzyme. Purification and characterization of amphipathic and hydrophilic forms of the enzyme establishes C-terminal anchorage to the plasma membrane

1987 • 132 citations

Ectoenzymes of the kidney microvillar membrane Aminopeptidase P is anchored by a glycosyl‐phosphatidylinositol moiety

1988 • 115 citations

Method for determination of angiotensin-converting enzyme activity in blood and tissue by high-performance liquid chromatography

1982 • 108 citations

Purification of angiotensin-converting enzyme from rabbit lung and human plasma by affinity chromatography.

1985 • 108 citations

Renal dipeptidase is one of the membrane proteins released by phosphatidylinositol-specific phospholipase C.

1987 • 107 citations

Serum angiotensin-converting enzyme. Isolation and relationship to the pulmonary enzyme.

1977 • 100 citations

Inhibition of rabbit lung angiotensin-converting enzyme by N alpha-[(S)-1-carboxy-3-phenylpropyl]L-alanyl-L-proline and N alpha-[(S)-1-carboxy-3-phenylpropyl]L-lysyl-L-proline.

1985 • 93 citations

Measurement of human converting enzyme level by direct radioimmunoassay.

1983 • 78 citations

Angiotensin-converting enzyme: Accumulation in medium from cultured endothelial cells

1978 • 69 citations

Purification and characterization of human converting enzyme (kininase II)

1981 • 63 citations

Isolation and Characterization of Renin-Producing Human Chorionic Cells in Culture

1988 • 42 citations

The amino acid sequence of the hydrophobic anchor of rabbit intestinal brush border aminopeptidase N

1982 • 40 citations

Rapid affinity chromatographic purification of human lung and kidney angiotensin-converting enzyme with the novel N-carboxyalkyl dipeptide inhibitor N-[1(S)-carboxy-5-aminopentyl]glycylglycine

1986 • 36 citations

Measurement of Angiotensin II Concentration in Rat Plasma: Pathophysiological Applications

1989 • 30 citations

Evidence for a single active site in the human angiotensin I-converting enzyme from inhibitor binding studies with [3H] RU 44 403: Role of chloride

1989 • 27 citations