The future of cytotoxic therapy: selective cytotoxicity based on biology is the key

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

Gene expression profiling predicts clinical outcome of breast cancer

2002 • 9,314 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

A Gene-Expression Signature as a Predictor of Survival in Breast Cancer

2002 • 6,428 citations

Efficacy and Safety of Trastuzumab as a Single Agent in First-Line Treatment of HER2-Overexpressing Metastatic Breast Cancer

2002 • 2,968 citations

Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

1995 • 1,973 citations

Efficacy and Safety of Trastuzumab as a Single Agent in First-Line Treatment of HER2-Overexpressing Metastatic Breast Cancer

2002 • 1,771 citations

Paclitaxel (Taxol)

1995 • 1,747 citations

Insulin-Like Growth Factor-I Receptor Signaling and Resistance to Trastuzumab (Herceptin)

2001 • 868 citations

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

2000 • 587 citations

Ras Protein Farnesyltransferase: A Strategic Target for Anticancer Therapeutic Development

1999 • 538 citations

Linkage of Rapid Estrogen Action to MAPK Activation by ERα-Shc Association and Shc Pathway Activation

2002 • 403 citations

Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K.

2001 • 360 citations

Anticancer Agents Targeting Signaling Molecules and Cancer Cell Environment: Challenges for Drug Development?

1999 • 206 citations

The ErbB receptor family: a therapeutic target for cancer

2002 • 204 citations

Involvement of steroid hormone and growth factor cross-talk in endocrine response in breast cancer.

1999 • 161 citations

Discovering novel chemotherapeutic drugs for the third millennium

1999 • 140 citations

Farnesyl transferase inhibitors--a novel therapy for breast cancer.

2001 • 37 citations

Beatson: hormones and the management of breast cancer.

1982 • 10 citations

Deleted Work

1955 • 0 citations