Slow-binding inhibition of NAD+ glycohydrolase by arabino analogues of beta-NAD.

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

1997 • 662 citations

Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.

1996 • 604 citations

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

1997 • 547 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

IEX -1L, an Apoptosis Inhibitor Involved in NF-κB-Mediated Cell Survival

1998 • 417 citations

Protein kinase C ζ isoform is critical for mitogenic signal transduction

1993 • 383 citations

The Product of par-4, a Gene Induced during Apoptosis, Interacts Selectively with the Atypical Isoforms of Protein Kinase C

1996 • 367 citations

Activation of IκB Kinase β by Protein Kinase C Isoforms

1999 • 366 citations

Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.

1995 • 271 citations

A Novel Repressor, par-4, Modulates Transcription and Growth Suppression Functions of the Wilms’ Tumor Suppressor WT1

1996 • 254 citations

The Activation of p38 and Apoptosis by the Inhibition of Erk Is Antagonized by the Phosphoinositide 3-Kinase/Akt Pathway

1998 • 252 citations

Localization of Atypical Protein Kinase C Isoforms into Lysosome-Targeted Endosomes through Interaction with p62

1998 • 230 citations

A Dominant Negative Protein Kinase C ζ Subspecies Blocks NF-κ B Activation

1993 • 223 citations

Protein Kinase C-ζ Mediates Angiotensin II Activation of ERK1/2 in Vascular Smooth Muscle Cells

1997 • 220 citations

Fibroblast Growth Factor-2 Suppression of Tumor Necrosis Factor α-Mediated Apoptosis Requires Ras and the Activation of Mitogen-activated Protein Kinase

1996 • 213 citations

Expression and Function of the Leucine Zipper Protein Par-4 in Apoptosis

1997 • 205 citations

Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 smallt to promote cell growth and NF-kappa B activation

1997 • 194 citations

Atypical Protein Kinase C ι Protects Human Leukemia Cells against Drug-induced Apoptosis

1997 • 175 citations

Positioning Atypical Protein Kinase C Isoforms in the UV-Induced Apoptotic Signaling Cascade

1997 • 164 citations

Evidence for a Role of Protein Kinase C ζ Subspecies in Maturation of Xenopus laevis Oocytes

1992 • 162 citations

Inhibition of Protein Kinase C ζ Subspecies Blocks the Activation of an NF-Kappa B-Like Activity in Xenopus laevis Oocytes

1993 • 131 citations

Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma

1999 • 123 citations

Lambda-Interacting Protein, A Novel Protein That Specifically Interacts with the Zinc Finger Domain of the Atypical Protein Kinase C Isotype λ/ι and Stimulates Its Kinase Activity In Vitro and In Vivo

1996 • 121 citations

Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes

1996 • 82 citations

Diacylglycerol generated by exogenous phospholipase C activates the mitogen-activated protein kinase pathway independent of Ras- and phorbol ester-sensitive protein kinase C: dependence on protein kinase C-ζ

1997 • 75 citations

Reversion of Ras- and Phosphatidylcholine-hydrolyzing Phospholipase C-mediated Transformation of NIH 3T3 Cells by a Dominant Interfering Mutant of Protein Kinase C λ Is Accompanied by the Loss of Constitutive Nuclear Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Activity

1997 • 75 citations

Evidence for a Bifurcation of the Mitogenic Signaling Pathway Activated by Ras and Phosphatidylcholine-hydrolyzing Phospholipase C

1995 • 73 citations

Transcriptional activation of c-fos by oncogenic Ha-Ras in mouse mammary epithelial cells requires the combined activities of PKC-λ, ε and ζ

1998 • 69 citations

Interleukin-1β Activates Protein Kinase Cζ in Renal Mesangial Cells

1996 • 60 citations