A mutant of 7SL RNA in Yarrowia lipolytica affecting the synthesis of a secreted protein.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

[10] 5-Fluoroorotic acid as a selective agent in yeast molecular genetics

1987 • 1,375 citations

Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum

1982 • 766 citations

Secretory protein translocation across membranes—the role of the ‘docking protein’

1982 • 648 citations

Phenotypic analysis of temperature-sensitive yeast actin mutants

1985 • 512 citations

Mechanism of Protein Translocation Across the Endoplasmic Reticulum Membrane

1986 • 509 citations

Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum.

1980 • 502 citations

Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor.

1982 • 478 citations

Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle.

1986 • 337 citations

The signal sequence of nascent preprolactin interacts with the 54K polypeptide of the signal recognition particle

1986 • 336 citations

The methionine-rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence.

1990 • 256 citations

Each of the activities of signal recognition particle (SRP) is contained within a distinct domain: Analysis of biochemical mutants of SRP

1988 • 248 citations

E. coli 4.5S RNA is part of a ribonucleoprotein particle that has properties related to signal recognition particle

1990 • 212 citations

[25] Primer extension analysis of RNA

1989 • 188 citations

SRP-RNA sequence alignment and secondary structure

1991 • 181 citations

Elongation arrest is not a prerequisite for secretory protein translocation across the microsomal membrane.

1985 • 179 citations

Human SRP RNA and E. coli 4.5S RNA contain a highly homologous structural domain

1988 • 178 citations

Fungal small nuclear ribonucleoproteins share properties with plant and vertebrate U-snRNPs.

1987 • 171 citations

The 54-kD protein of signal recognition particle contains a methionine-rich RNA binding domain.

1990 • 170 citations

Signal recognition particle mediates a transient elongation arrest of preprolactin in reticulocyte lysate.

1989 • 148 citations

Cloning of the LYS5 gene encoding saccharopine dehydrogenase from the yeast Yarrowia lipolytica by target integration

1988 • 125 citations

Binding sites of the 19-kDa and 68/72-kDa signal recognition particle (SRP) proteins on SRP RNA as determined in protein-RNA "footprinting".

1988 • 112 citations

Identification of an essential Schizosaccharomyces pombe RNA homologous to the 7SL component of signal recognition particle.

1988 • 84 citations

Small ribonucleoproteins in Schizosaccharomyces pombe and Yarrowia lipolytica homologous to signal recognition particle.

1988 • 80 citations

Deletion of a yeast small nuclear RNA gene impairs growth.

1985 • 79 citations

Intracellular precursors and secretion of alkaline extracellular protease of Yarrowia lipolytica.

1988 • 72 citations

7SL RNA from Schizosaccharomyces pombe is encoded by a single copy essential gene

1988 • 70 citations

Functional dissection of the signal recognition particle

1988 • 70 citations

Common structural features between eukaryotic 7SL RNAs, eubacterial 4.5S RNA and scRNA and archaebacterial 7S RNA

1988 • 69 citations

Role of the proregion in the production and secretion of the Yarrowia lipolytica alkaline extracellular protease

1991 • 63 citations

Disassembly and domain structure of the proteins in the proteins in the signal-recognition particle

1987 • 47 citations

Improvement of sporulation in the yeastYarrowia lipolytica

1985 • 38 citations

The yeast Yarrowia lipolytica has two, functional, signal recognition particle 7S RNA genes

1990 • 28 citations

Genetic analysis of Schizosaccharomyces pombe 7SL RNA: a structural motif that includes a conserved tetranucleotide loop is important for function.

1989 • 24 citations

Two genes encode 7SL RNAs in the yeast Yarrowia lipolytica

1989 • 21 citations