Squamous cell carcinoma and precursor lesions of the oral cavity: epidemiology and aetiology

Global cancer statistics

2011 • 55,498 citations

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

2010 • 21,372 citations

Global Cancer Statistics, 2002

2005 • 17,966 citations

Cancer Statistics, 2008

2008 • 10,165 citations

Estimates of the cancer incidence and mortality in Europe in 2006

2007 • 4,128 citations

Global epidemiology of oral and oropharyngeal cancer

2008 • 3,062 citations

Case–Control Study of Human Papillomavirus and Oropharyngeal Cancer

2007 • 2,615 citations

Estimates of cancer incidence and mortality in Europe in 2008

2010 • 2,247 citations

HPV-associated head and neck cancer: a virus-related cancer epidemic

2010 • 1,740 citations

Nomenclature and classification of potentially malignant disorders of the oral mucosa

2007 • 1,605 citations

Tobacco carcinogens, their biomarkers and tobacco-induced cancer

2003 • 1,447 citations

A review of human carcinogens—Part E: tobacco, areca nut, alcohol, coal smoke, and salted fish

2009 • 1,043 citations

Oral leukoplakia and malignant transformation. A follow-up study of 257 patients

1984 • 1,040 citations

Tobacco smoking and cancer: A meta‐analysis

2007 • 896 citations

Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management

2008 • 860 citations

Tongue and tonsil carcinoma

2005 • 736 citations

Natural history of potentially malignant oral lesions and conditions: an overview of the literature

2007 • 611 citations

Global epidemiology of areca nut usage

2002 • 592 citations

Risk factors for squamous cell carcinoma of the oral cavity in young people — a comprehensive literature review

2001 • 576 citations

P<scp>rognosis of</scp> O<scp>ral</scp> P<scp>re-malignant</scp> L<scp>esions:</scp> S<scp>ignificance of</scp> C<scp>linical,</scp> H<scp>istopathological, and</scp> M<scp>olecular</scp> B<scp>iological</scp> C<scp>haracteristics</scp>

2003 • 546 citations

The epidemiology of mouth cancer: a review of global incidence

2000 • 476 citations

Alert for an epidemic of oral cancer due to use of the betel quid substitutes gutkha and pan masala: a review of agents and causative mechanisms

2004 • 456 citations

Long-term treatment outcome of oral premalignant lesions

2005 • 433 citations

Risk factors for oral cancer in Brazil: A case‐control study

1989 • 429 citations

Oral Health and Risk of Squamous Cell Carcinoma of the Head and Neck and Esophagus: Results of Two Multicentric Case-Control Studies

2007 • 388 citations

Pooled estimate of world leukoplakia prevalence: a systematic review

2003 • 378 citations

Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: a systematic review

2011 • 373 citations

Lifestyle risk factors for oral cancer

2008 • 370 citations

Head and Neck Cancer Incidence Trends in Young Americans, 1973-1997, With a Special Analysis for Tongue Cancer

2002 • 354 citations

The causes of cancer.

2001 • 335 citations

Association between fruit and vegetable consumption and oral cancer: a meta-analysis of observational studies1,2

2006 • 331 citations

Health effects associated with smokeless tobacco: a systematic review

2003 • 327 citations

Causes of oral cancer – an appraisal of controversies

2009 • 320 citations

Oral lichen planus – a demographic study

1987 • 301 citations

Oral cancer in India: An epidemiologic and clinical review

1990 • 301 citations

An analysis of risk factors for oral cancer in young people: a case-control study

2003 • 300 citations

NUTRITIONAL MUSCULAR DYSTROPHY AND HUMAN MYOCARDIAL INFARCTION

1973 • 280 citations

Global Oral Health Inequalities in Incidence and Outcomes for Oral Cancer

2011 • 248 citations

Phase II Randomized, Placebo-Controlled Trial of Green Tea Extract in Patients with High-Risk Oral Premalignant Lesions

2009 • 240 citations

Incidence and survival of squamous cell carcinoma of the tongue in Scandinavia, with special reference to young adults

2002 • 240 citations

Oral mucosal lesions in a representative cross‐sectional study of aging Germans

2000 • 234 citations

Tobacco, oral cancer, and treatment of dependence

2005 • 229 citations

Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort study

2007 • 226 citations

Food groups and risk of oral and pharyngeal cancer

1998 • 221 citations

Tobacco-specific and betel nut-specific N-nitroso compounds: occurrence in saliva and urine of betel quid chewers and formation in vitro by nitrosation of betel quid

1985 • 203 citations

Trends of head and neck cancers in urban and rural India.

2006 • 193 citations

Risk factors for oral cancer in newly diagnosed patients aged 45 years and younger: a case–control study in Southern England

2004 • 191 citations

Incidence of oral and oropharyngeal cancer in United Kingdom (1990–1999)—recent trends and regional variation

2006 • 189 citations

The role of alcohol in oral carcinogenesis with particular reference to alcohol‐containing mouthwashes

2008 • 188 citations

Poor dental status increases acetaldehyde production from ethanol in saliva: a possible link to increased oral cancer risk among heavy drinkers

2001 • 187 citations

Racial Disparities in Patients With Head and Neck Squamous Cell Carcinoma

2006 • 182 citations

Trends in oral cancer mortality in Europe

2003 • 170 citations

Cancer mortality in the European Union, 1970–2003, with a joinpoint analysis

2008 • 163 citations

A national epidemiological survey of oral mucosal lesions in Malaysia

1997 • 161 citations

Chemoprevention of oral leukoplakia with vitamin A and beta carotene: an assessment

1997 • 155 citations

The epidemiology of tongue cancer: a review of global incidence

2000 • 153 citations

Family history of cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

2008 • 152 citations

Oral precancerous disorders associated with areca quid chewing, smoking, and alcohol drinking in southern Taiwan

2005 • 152 citations

Occurrence of leukoplakia and some other oral white lesions among 20 333 adult Swedish people

1987 • 151 citations

Risk factors for oral soft tissue lesions in an adult Spanish population

2002 • 138 citations

Ethnicity and oral cancer

2000 • 138 citations

Evidence That Smokeless Tobacco Use Is a Gateway for Smoking Initiation in Young Adult Males

2001 • 137 citations

Dietary factors and oral and pharyngeal cancer risk

2008 • 134 citations

Carcinoma of the lip

1980 • 132 citations

Environmental and dietary risk factors for nasopharyngeal carcinoma: a case-control study in Zangwu County, Guangxi, China

1994 • 130 citations

Indoor air pollution from solid fuels and risk of hypopharyngeal/laryngeal and lung cancers: a multicentric case-control study from India

2008 • 129 citations

Squamous cell carcinoma of the buccal mucosa: An aggressive cancer requiring multimodality treatment

2005 • 129 citations

Oropharyngeal carcinoma in non-smokers and non-drinkers: A role for HPV

2008 • 126 citations

Cultural and dietary risk factors of oral cancer and precancer — a brief overview

2001 • 124 citations

Disparities in oral and pharyngeal cancer incidence, mortality and survival among black and white Americans

2006 • 117 citations

Oral micro-organisms in the etiology of cancer

2008 • 115 citations

Cancer of the buccal mucosa: Are margins and T-stage accurate predictors of local control?

2001 • 112 citations

Short‐term exposure to alcohol increases the permeability of human oral mucosa

2001 • 111 citations

A meta-analysis of alcohol drinking and oral and pharyngeal cancers. Part 1: Overall results and dose-risk relation

2010 • 106 citations

Endogenous Formation of Nitrosamines and Oxidative DNA-Damaging Agents in Tobacco Users

1996 • 104 citations

Oropharyngeal cancer incidence and mortality in Scotland: are rates still increasing?

2002 • 102 citations

Betel-quid chewing with or without tobacco is a major risk factor for oral potentially malignant disorders in Sri Lanka: A case-control study

2010 • 101 citations

Epidemiological study of oral leukoplakia based on mass screening for oral mucosal diseases in a selected Japanese population

1991 • 100 citations

Nutrition and oral cancer

1996 • 100 citations

Good tumor control and survivals of squamous cell carcinoma of buccal mucosa treated with radical surgery with or without neck dissection in Taiwan

2006 • 99 citations

Randomized Trial of 13-cis Retinoic Acid Compared With Retinyl Palmitate With or Without Beta-Carotene in Oral Premalignancy

2008 • 96 citations

Aetiology of oral cancer: alcohol

1998 • 96 citations

Mouthwash and oral cancer risk: An update

2008 • 95 citations

Chemical and analytical aspects of areca nut

2002 • 94 citations

Oral Cancer and Mouthwash Use: Evaluation of the Epidemiologic Evidence

1995 • 92 citations

Gender-related hormonal risk factors for oral cancer

2007 • 91 citations

Cancer incidence among Finnish farmers, 1979-93.

1997 • 89 citations

Prevalence study of oral precancerous lesions within a complex screening system in Hungary

1991 • 87 citations

Tomatoes, tomato-rich foods, lycopene and cancer of the upper aerodigestive tract: a case-control in Uruguay

2000 • 86 citations

Use of wood stoves and risk of cancers of the upper aero-digestive tract: a case-control study

1998 • 86 citations

Solar radiation, lip protection, and lip cancer risk in Los Angeles County women (California, United States)

1996 • 85 citations

Betel quid not containing tobacco and oral cancer: A report on a case–control study in Papua New Guinea and a meta‐analysis of current evidence

2006 • 85 citations

An epidemiologic study of oral cancer in a statewide network

1986 • 82 citations

Cancer risks among male farmers in Sweden

1995 • 82 citations

Regression of experimental oral carcinomas by local injection of β‐carotene and canthaxanthin

1988 • 77 citations

A meta-analysis of alcohol drinking and oral and pharyngeal cancers. Part 2: Results by subsites

2010 • 75 citations

Oral cancer survival in young people in South East England

2007 • 75 citations

Mortality from major cancer sites in the European Union,1955–1998

2003 • 74 citations

Squamous cell carcinoma of the lips in a northern Greek population. Evaluation of prognostic factors on 5-year survival rate—I

1995 • 73 citations

Surgical treatment outcomes of localized squamous carcinoma of buccal mucosa

2004 • 73 citations

Arecoline-stimulated connective tissue growth factor production in human buccal mucosal fibroblasts: Modulation by curcumin

2009 • 73 citations

Oral cancers in Mumbai, India: a fifteen years perspective with respect to incidence trend and cumulative risk.

2004 • 73 citations

Dietary Patterns and Risk of Cancer of the Oral Cavity and Pharynx in Uruguay

2005 • 72 citations

Racial Disparity in Survival of Patients with Squamous Cell Carcinoma of the Oral Cavity and Pharynx

2001 • 69 citations

Racial Differences in Stage and Survival in Head and Neck Squamous Cell Carcinoma

2007 • 68 citations

Serum antioxidant micronutrients and the risk of oral leukoplakia among Japanese

2000 • 68 citations

Carcinoma of the Buccal Mucosa

2000 • 66 citations

Oral nitric oxide during plaque deposition

2001 • 66 citations

Outcome following a population screening programme for oral cancer and precancer in Japan

2000 • 66 citations

Systematic review of the relation between smokeless tobacco and non-neoplastic oral diseases in Europe and the United States

2008 • 65 citations

Mouthwash in the etiology of oral cancer in Puerto Rico.

2001 • 62 citations

Carcinogenic tobacc-specific nitrosamines are present at unusually high levels in the saliva of oral snuff users in Sudan

1992 • 62 citations

Risk factors for oral squamous cell carcinoma in young and older Brazilian patients: a comparative analysis.

2008 • 61 citations

Potentially malignant oral lesions in Northern Ireland: size (extent) matters

2003 • 55 citations

Diet diversity and the risk of laryngeal cancer: A case–control study from Italy and Switzerland

2008 • 52 citations

Betel quid not containing tobacco and oral leukoplakia: A report on a cross‐sectional study in Papua New Guinea and a meta‐analysis of current evidence

2008 • 50 citations

Low prevalence of oral leukoplakia in a representative sample of the US population

2003 • 49 citations

Genetic polymorphisms in cytochrome P450 genes are associated with an increased risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population

2009 • 48 citations

Cancers of the lip and oropharynx in different social and occupational groups in Finland

1994 • 48 citations

Prevention of experimental cancer and immunostimulation by vitamin E (immunosurveillance)

1990 • 47 citations

The role of foods and nutrients on oral and pharyngeal cancer risk.

2009 • 45 citations

Oral squamous cell carcinoma incidence by subsite among diverse racial and ethnic populations in California

2008 • 44 citations

Age-standardized incidence and mortality rates of oral and pharyngeal cancer in Puerto Rico and among Non-Hispanics Whites, Non-Hispanic Blacks, and Hispanics in the USA

2009 • 44 citations

Prevalence study of oral white lesions with special reference to a new definition of oral leucoplakia

1996 • 41 citations

Life time risk for development of ten major cancers in India and its trends over the years 1982 to 2000

2008 • 41 citations

Dyskeratosis congenita

2005 • 41 citations

Indoor air pollution by emissions of fossil fuel single stoves: Possibly a hitherto underrated risk factor in the development of carcinomas in the head and neck

1995 • 39 citations

Incidence of oral cancer among 30,000 villagers in India in a 7‐year follow‐up study of oral precancerous lesions

1975 • 36 citations

Control of oral cancer in developing countries. A WHO meeting.

1984 • 36 citations

Oral and pharyngeal cancer in South Asians and non-South Asians in relation to socioeconomic deprivation in South East England

2008 • 33 citations

The Administration of Beta Carotene to Prevent and Regress Oral Carcinoma in the Hamster Cheek Pouch and the Associated Enhancement of the Immune Response

1990 • 32 citations

Comparison of Oral and Pharyngeal Cancer Mortality in five Countries: France, Italy, Japan, UK and USA from the WHO Mortality Database (1960–2000)

2005 • 31 citations

Food, nutrition and oral cancer

2009 • 28 citations

Analysis of the epidemiological features of oral cancer in the city of Buenos Aires.

2005 • 28 citations

Untitled

2002 • 26 citations

Incidence of cancers of the oral cavity and pharynx among American Indians and Alaska Natives, 1999-2004

2008 • 23 citations

Lip cancer in South Australia, 1977–1996

2001 • 23 citations

The urban/rural divide in head and neck cancer?the effect of atmospheric pollution

1993 • 17 citations

Lip cancer in Northern Finland: changing incidence and clinical characteristics

2000 • 17 citations

Trends in lip cancer incidence in Vaud, Switzerland

1993 • 13 citations

Indoor air pollution by emissions of fossil fuel single stoves: Possibly a hitherto underrated risk factor in the development of carcinomas in the head and neck

1995 • 12 citations

Candida of the Larynx

2003 • 7 citations