Development of a common 3D pharmacophore for delta-opioid recognition from peptides and non-peptides using a novel computer program.

Cloning of a Delta Opioid Receptor by Functional Expression

1992 • 1,225 citations

Molecular cloning and functional expression of a mu opioid receptor from rat brain

1994 • 805 citations

Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.

1993 • 614 citations

Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists.

1992 • 233 citations

Recent developments in the design of receptor specific opioid peptides

1989 • 225 citations

Probes for Narcotic Receptor Mediated Phenomena. 19. Synthesis of (+)-4-[(.alpha.R)-.alpha.-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80): A Highly Selective, Nonpeptide .delta. Opioid Receptor Agonist

1994 • 203 citations

TIPP[.psi.]: a highly potent and stable pseudopeptide .delta. opioid receptor antagonist with extraordinary .delta. selectivity

1993 • 145 citations

Pharmacological profiles of fentanyl analogs at μ, δ and κ opiate receptors

1992 • 133 citations

Constrained search of conformational hyperspace

1989 • 120 citations

The conformational properties of the delta opioid peptide [cyclic] [D-pen2,D-pen5]enkephalin in aqueous solution determined by NMR and energy minimization calculations

1988 • 118 citations

Development of a Model for the .delta. Opioid Receptor Pharmacophore. 1. Conformationally Restricted Tyr1 Replacements in the Cyclic .delta. Receptor Selective Tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13)

1994 • 89 citations

A selective .delta.1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for .delta.1 opioid receptor agonists and antagonists

1993 • 72 citations

Proposal for the biologically active conformation of opiates and enkephalin.

1977 • 65 citations

Comparative analysis of various proposed models of the receptor‐bound conformation of H‐tyr‐Tic‐Phe OH related δ‐opioid antagonists

1995 • 39 citations

Development of a model for the δ-opioid receptor pharmacophore: 3. Comparison of the cyclic tetrapeptide Tyr-c[D-Cys-Phe-D-Pen] OH with other conformationally constrained δ-receptor selective ligands

1998 • 36 citations

Conformational analysis of enkephalin analogs contaIntng a disulfide bond Models for delta‐ and mu‐receptor opioid agonists

1989 • 36 citations

Conformational determinants of high affinity delta receptor binding of opioid peptides.

1988 • 31 citations

Characterization of the bioactive form and molecular determinants of recognition of cyclic enkephalin peptides at the δ‐opioid receptor

1993 • 25 citations

Electrophilic N-Benzylnaltrindoles as .delta. Opioid Receptor-Selective Antagonists

1995 • 22 citations

.delta. Opioid receptor selectivity induced by conformational constraints in linear enkephalin-related peptides: proton 400-MHz NMR study and theoretical calculations

1989 • 20 citations

7'-Substituted amino acid conjugates of naltrindole. Hydrophilic groups as determinants of selective antagonism of .delta.1 opioid receptor-mediated antinociception in mice

1995 • 18 citations

Theoretical study of the flexibility and solution conformation of the cyclic opioid peptides [D-Pen2,D-Pen5]enkephalin and [D-Pen2,L-Pen5]enkephalin.

1991 • 17 citations

Characterization of the bioactive form of linear peptide antagonists at the δ-opioid receptor

1996 • 14 citations

Molecular mechanism of delta-selectivity of indole analogs of nonpeptide opioids.

1993 • 13 citations

Binding of BW 373U86, a non-peptidic δ opioid receptor agonist, is not regulated by guanine nucleotides and sodium

1993 • 12 citations