Restriction landmark genomic scanning (RLGS-M)-based genome-wide scanning of mouse liver tumors for alterations in DNA methylation status.

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma.

1996 • 587 citations

Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma

1989 • 540 citations

Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene.

1991 • 467 citations

A genomic scanning method for higher organisms using restriction sites as landmarks.

1991 • 351 citations

CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene.

1993 • 317 citations

HUMAN TUMOR SUPPRESSOR GENES

1990 • 266 citations

Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation.

1996 • 251 citations

Identification of an imprinted U2af binding protein related sequence on mouse chromosome 11 using the RLGS method

1994 • 219 citations

Hypermethylation of the p16 gene in nasopharyngeal carcinoma.

1996 • 193 citations

Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA.

1997 • 174 citations

Restriction landmark genomic scanning method and its various applications

1993 • 159 citations

Methylation profiles of genomic DNA of mouse developmental brain detected by restriction landmark genomic scanning (RLGS) method

1993 • 112 citations

T antigen expression and tumorigenesis in transgenic mice containing a mouse major urinary protein/SV40 T antigen hybrid gene.

1989 • 77 citations

Insights into X chromosome inactivation from studies of species variation, DNA methylation and replication, and vice versa

1990 • 51 citations