From academic vision to clinical reality

Turnover of adenosine in plasma of human and dog blood

1989 • 524 citations

Protective effects of adenosine in myocardial ischemia.

1992 • 410 citations

Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury.

1989 • 203 citations

Coronary bypass surgery: Is the operation different today?

1991 • 203 citations

Adenosine and the anti-infarct effects of preconditioning

1993 • 160 citations

Use of survival analysis to determine the clinical significance of new Q waves after coronary bypass surgery.

1983 • 143 citations

The changing pattern of coronary artery bypass surgery.

1989 • 132 citations

Metabolism of 5-amino-4-imidazolecarboxamide riboside in cardiac and skeletal muscle. Effects on purine nucleotide synthesis.

1982 • 102 citations

Accelerated repletion of ATP and GTP pools in postischemic canine myocardium using a precursor of purine de novo synthesis.

1982 • 101 citations

AICA‐Riboside: Safety, Tolerance, and Pharmacokinetics of a Novel Adenosine‐Regulating Agent

1991 • 98 citations

Effect of adenosine and AICAR on ATP content and regional contractile function in reperfused canine myocardium

1985 • 96 citations

Adenosine attenuates reperfusion injury following regional myocardial ischaemia

1993 • 91 citations

Retroviral Vector-Mediated Gene Transfer into Human Hematopoietic Progenitor Cells

1985 • 83 citations

Effects of ATP precursors on ATP and free ADP content and functional recovery of postischemic hearts

1989 • 64 citations

Sustained protection by acadesine against ischemia- and reperfusion-induced injury. Studies in the transplanted rat heart.

1992 • 59 citations

Acadesine and myocardial protection. Studies of time of administration and dose-response relations in the rat.

1992 • 57 citations

Neutrophil and endothelial changes in reperfusion injury

1991 • 55 citations

Mortality after coronary angioplasty and coronary artery bypass surgery (the national Medicare experience)

1992 • 53 citations

Acadesine lowers temporal threshold for the myocardial infarct size limiting effect of preconditioning

1993 • 47 citations

The protection of the ischemic myocardium: Surgical success v clinical failure?

1988 • 44 citations

Acadesine (AICA-riboside) improves postischemic cardiac recovery

1992 • 37 citations

Protective Effects of AICAriboside in the Globally Ischemic Isolated Cat Heart

1985 • 33 citations

Acadesine: Prototype adenosine regulating agent for treating myocardial ischemia‐reperfusion injury

1993 • 32 citations

Dissociation between early recovery of regional function and purine nucleotide content in postischaemic myocardium in the conscious dog

1987 • 31 citations

Mortality of coronary artery bypass grafting before and after the advent of angioplasty

1989 • 26 citations

The acute effects of AICAR on purine nucleotide metabolism and postischemic cardiac function

1988 • 25 citations

Failure of AICA Riboside to Limit Infarct Size During Acute Myocardial Infarction in Rabbits

1992 • 19 citations

Progressive cardiac dysfunction with repeated pacing-induced ischemia: protection by AICA-riboside

1991 • 18 citations

Glial cells metabolically cooperate: a potential requirement for gene replacement therapy.

1985 • 12 citations

Acadesine regulates adenosine to improve post-ischemic function in the isolated heart

1992 • 10 citations

Acadesine prevents oxidant-induced damage in the isolated guinea pig heart.

1993 • 9 citations

Acadesine preserves cardiac function and enhances coronary blood flow in isolated, blood perfused rabbit hearts with repeated ischemia and reperfusion

1991 • 5 citations

Functional improvement with AICA riboside in the post ischemic guinea pig heart

1990 • 1 citations