New Aspects of Glutathione Metabolism and Translocation in Mammals

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

The Metabolic Basis of Inherited Diseases

1972 • 1,762 citations

Glutathione and Related γ-Glutamyl Compounds: Biosynthesis and Utilization

1976 • 846 citations

Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione.

1975 • 729 citations

Interaction of γ-Glutamyl Transpeptidase with Amino Acids, Dipeptides, and Derivatives and Analogs of Glutathione

1974 • 541 citations

Enzymic transpeptidation reactions involving γ-glutamyl peptides and α-amino-acyl peptides

1952 • 268 citations

Oxidation in the NADP system and release of GSSG from hemoglobin‐free perfused rat liver during peroxidatic oxidation of glutathione by hydroperoxides

1972 • 257 citations

The fate of extracellular glutathione in the rat☆

1978 • 245 citations

Translocation of intracellular glutathione to membrane-bound γ-glutamyl transpeptidase as a discrete step in the γ-glutamyl cycle: Glutathionuria after inhibition of transpeptidase

1979 • 244 citations

Identity of maleate-stimulated glutaminase with gamma-glutamyl transpeptidase in rat kidney.

1975 • 222 citations

Effects of glutathione-oxidizing agents on microtubule assembly and microtubule-dependent surface properties of human neutrophils.

1976 • 220 citations

Serine-borate complex as a transition-state inhibitor of gamma-glutamyl transpeptidase.

1978 • 216 citations

Reduced and oxidized glutathione efflux from liver

1978 • 196 citations

Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase.

1979 • 173 citations

gamma-Glutamylcysteine synthetase. Further purification, "half of the sites" reactivity, subunits, and specificity.

1977 • 151 citations

Glutathione Synthetase Deficiency, an Inborn Error of Metabolism Involving the γ-Glutamyl Cycle in Patients with 5-Oxoprolinuria (Pyroglutamic Aciduria)

1974 • 150 citations

Glutathionuria: Inborn error of metabolism due to tissue deficiency of gamma-glutamyl transpeptidase

1975 • 148 citations

Pyroglutamic Aciduria — a New Inborn Error of Metabolism

1970 • 147 citations

Metabolism of glutathione and a glutathione conjugate by isolated kidney cells.

1979 • 140 citations

Evidence that the gamma-glutamyl cycle functions in vivo using intracellular glutathione: effects of amino acids and selective inhibition of enzymes.

1978 • 137 citations

Enzymatic Conversion of 5-Oxo-L-Proline (L-Pyrrolidone Carboxylate) to L-Glutamate Coupled with Cleavage of Adenosine Triphosphate to Adenosine Diphosphate, a Reaction in the γ-Glutamyl Cycle

1971 • 137 citations

Changes in enzyme levels accompanying differentiation of intestinal epithelial cells

1969 • 127 citations

Theγ-Glutamyl Cycle

1974 • 124 citations

Specificity of a particulate rat renal peptidase and its localization along with other enzymes of mercapturic acid synthesis

1978 • 124 citations

gamma-Glutamyl transpeptidase, a lymphoid cell-surface marker: relationship to blastogenesis, differentiation, and neoplasia.

1976 • 123 citations

Glutathione synthetase. Purification from rat kidney and mapping of the substrate binding sites.

1979 • 113 citations

Interrelationships between the binding sites for amino acids, dipeptides, and gamma-glutamyl donors in gamma-glutamyl transpeptidase.

1977 • 109 citations

Affinity labeling of gamma-glutamyl transpeptidase and location of the gamma-glutamyl binding site on the light subunit.

1977 • 103 citations

Glutathione Turnover in the Kidney; Considerations Relating to the γ-Glutamyl Cycle and the Transport of Amino Acids

1974 • 99 citations

Membrane-Bound γ-Glutamyl Transpeptidase

1976 • 82 citations

Decrease in glutathione levels of kidney and liver after injection of methionine sulfoximine into rats

1975 • 76 citations

Enzymic Formation of Pyrrolidone Carboxylic Acid from γ-Glutamyl Peptides

1956 • 75 citations

Subunit structure and isozymic forms of gamma-glutamyl transpeptidase.

1976 • 75 citations

Translocation of glutathione from lymphoid cells that have markedly different gamma-glutamyl transpeptidase activities.

1979 • 73 citations

Formation and metabolism of a glutathione-S-conjugate in isolated rat liver and kidney cells

1978 • 70 citations

Glutathione and gamma-glutamyl cycle enzymes in crypt and villus tip cells of rat jejunal mucosa.

1976 • 65 citations

5-Oxo-L-prolinase (L-pyroglutamate hydrolase). Purification and catalytic properties.

1975 • 64 citations

Accumulation of 5-Oxoproline in Mouse Tissues After Inhibition of 5-Oxoprolinase and Administration of Amino Acids: Evidence for Function of the γ-Glutamyl Cycle

1974 • 62 citations

Inhibition of 5-Oxoprolinase by 2-Imidazolidone-4-Carboxylic Acid

1973 • 51 citations

Subcellular localization of rat kidney phosphate independent glutaminase

1975 • 51 citations

Selective inhibition of gamma-glutamyl-cycle enzymes by substrate analogs.

1977 • 47 citations

The Metabolic Formation and Utilization of 5‐Oxo‐ <scp>L</scp> ‐proline ( <scp>L</scp> ‐Pyroglutamate, <scp>L</scp> ‐Pyrrolidone Carboxylate)

1975 • 46 citations

γ-glutamyl transpeptidase and related enzyme activities in the reproductive system of the male rat

1977 • 43 citations

Conversion of glutathione to glutathione disulfide by cell membrane-bound oxidase activity.

1979 • 42 citations

gamma-Glutamyl cyclotransferase from rat kidney. Sulfhydryl groups and isolation of a stable form of the enzyme.

1978 • 41 citations

THE EFFECT OF pH ON THE FORMATION OF PYRROLIDONECARBOXYLIC ACID AND GLUTAMIC ACID DURING ENZYMATIC HYDROLYSIS OF GLUTATHIONE BY RAT KIDNEY EXTRACT

1942 • 38 citations

ENZYMATIC OXIDATION OF GLUTATHIONE

1945 • 33 citations

Mechanism and significance of the mammalian pathway for elimination of D-glutamate; inhibition of glutathione synthesis by D-glutamate

1976 • 27 citations

The Biosynthesis of Glutathione

1954 • 22 citations

Rapid purification of rat kidney brush borders enriched in γ‐glutamyl transpeptidase

1979 • 19 citations

Serum protein changes in coal workers' pneumoconiosis

1975 • 17 citations

Current Status of the γ-Glutamyl Cycle

1978 • 15 citations

ENZYMATIC OXIDATION AND HYDROLYSIS OF GLUTATHIONE BY DIFFERENT TISSUES

1947 • 15 citations

Glutathione and Glutathione Conjugate Metabolism in Isolated Liver and Kidney Cells

1978 • 11 citations

γ-GLUTAMYL TRANSPEPTIDASE: PROPERTIES IN RELATION TO ITS PROPOSED PHYSIOLOGICAL ROLE

1975 • 9 citations