Simian virus 40 large T antigen induces or activates a protein kinase which phosphorylates the transformation-associated protein p53

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

1987 • 1,391 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

1984 • 761 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse.

1979 • 736 citations

The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

1987 • 649 citations

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

1984 • 606 citations

Growth regulation of a cellular tumour antigen, p53, in nontransformed cells

1984 • 524 citations

The Approaching Era of the Tumor Suppressor Genes

1987 • 468 citations

Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct sublcasses of large T antigen and for similarities among nonviral T antigens

1980 • 430 citations

Construction and analysis of viable deletion mutants of simian virus 40

1976 • 355 citations

Activating Mutations for Transformation by p53 Produce a Gene Product That Forms an hsc70-p53 Complex with an Altered Half-Life

1988 • 298 citations

Microinjection of monoclonal antibody to protein p53 inhibits serum-induced DNA synthesis in 3T3 cells.

1982 • 279 citations

Detection of a common feature in several human tumor cell lines--a 53,000-dalton protein.

1981 • 263 citations

In vitro mutagenesis of a putative DNA binding domain of SV40 large-T

1984 • 248 citations

Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells

1980 • 222 citations

Role of the p53 protein in cell proliferation as studied by microinjection of monoclonal antibodies.

1984 • 216 citations

When the products of oncogenes and anti-oncogenes meet

1989 • 213 citations

Simian Virus 40 Large T Antigen Is Phosphorylated at Multiple Sites Clustered in Two Separate Regions

1982 • 193 citations

The SV40 a gene product is required for the production of a 54,000 MW cellular tumor antigen

1979 • 179 citations

A region of SV40 large T antigen can substitute for a transforming domain of the adenovirus E1A products

1988 • 167 citations

Different forms of p53 detected by monoclonal antibodies in non-dividing and dividing lymphocytes

1984 • 126 citations

Mutations in the phosphorylation sites of simian virus 40 (SV40) T antigen alter its origin DNA-binding specificity for sites I or II and affect SV40 DNA replication activity

1988 • 125 citations

Immunologically Distinct p53 Molecules Generated by Alternative Splicing

1986 • 120 citations

Genetic and biochemical analysis of transformation-competent, replication-defective simian virus 40 large T antigen mutants

1985 • 110 citations

Inhibition of cell growth mediated by plasmids encoding p53 anti-sense.

1987 • 99 citations

Trans-activation of RNA polymerase II and III promoters by SV40 small t antigen

1988 • 98 citations

Altered Patterns of Protein Synthesis in Infection by SV40 Mutants

1974 • 89 citations

Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells.

1988 • 77 citations

Mapping of phosphomonoester and apparent phosphodiester bonds of the oncogene product p53 from simian virus 40-transformed 3T3 cells.

1986 • 76 citations

p53 transformation-related protein: detection of an associated phosphotransferase activity.

1981 • 67 citations

A Short-Lived Nuclear Phosphoprotein Encoded by the Human ets-2 Proto-Oncogene Is Stabilized by Activation of Protein Kinase C

1988 • 66 citations

Role of the p53 Protein in Cell Proliferation as Studied by Microinjection of Monoclonal Antibodies

1984 • 64 citations

Evidence for free and metabolically stable p53 protein in nuclear subfractions of simian virus 40-transformed cells.

1986 • 62 citations

Modulation of p53 Protein Expression During Cellular Transformation with Simian Virus 40

1987 • 56 citations

Evidence for Simian Virus 40 (SV40) Coding of SV40 T-Antigen and the SV40-Specific Proteins in HeLa Cells Infected with Nondefective Adenovirus Type 2-SV40 Hybrid Viruses

1977 • 56 citations

The structural relationships between 54,000-molecular-weight cellular tumor antigens detected in viral- and nonviral-transformed cells

1981 • 55 citations

Biological and Molecular Analysis of P53 Cellular-Encoded Tumor Antigen

1985 • 55 citations

Overproduction of protein p53 contributes to simian virus 40-mediated transformation.

1986 • 45 citations

Simian virus 40 T antigen alters the binding characteristics of specific simian DNA-binding factors.

1988 • 39 citations

Phosphorylation of threonine in the proline-rich carboxy-terminal region of simian virus 40 large T antigen

1981 • 33 citations

Site-directed mutagenesis of the simian virus 40 large T-antigen gene: replication-defective amino acid substitution mutants that retain the ability to induce morphological transformation

1985 • 32 citations

Phosphorylation of p53 in Normal and Simian Virus 40-Transformed NIH 3T3 Cells

1988 • 30 citations

Evidence for Free and Metabolically Stable p53 Protein in Nuclear Subfractions of Simian Virus 40-Transformed Cells

1986 • 29 citations

Cellular mutation mediates T-antigen-positive revertant cells resistant to simian virus 40 transformation but not to retransformation by polyomavirus and adenovirus type 2

1987 • 27 citations

Simian Virus 40 T Antigen Alters the Binding Characteristics of Specific Simian DNA-Binding Factors

1988 • 21 citations

Overproduction of Protein p53 Contributes to Simian Virus 40-Mediated Transformation

1986 • 19 citations

Enhanced protein phosphorylation in SV40-transformed and -infected cells

1987 • 16 citations

Protein kinase activities in immune complexes of simian virus 40 large T-antigen and transformation-associated cellular p53 protein.

1984 • 15 citations

Protein Kinase Activities in Immune Complexes of Simian Virus 40 Large T-Antigen and Transformation-Associated Cellular p53 Protein

1984 • 9 citations

SV40 Large T Antigen Induces a Protein Kinase Responsible for Phosphorylation of the Cellular Protein p53

1989 • 8 citations