Contribution of the innate immune system to autoimmune myocarditis: a role for complement

C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity

1996 • 1,172 citations

CD19: Lowering the Threshold for Antigen Receptor Stimulation of B Lymphocytes

1992 • 673 citations

THE ROLE OF COMPLEMENT AND COMPLEMENT RECEPTORS IN INDUCTION AND REGULATION OF IMMUNITY

1998 • 607 citations

Regulation of B Lymphocyte Responses to Foreign and Self-Antigens by the CD19/CD21 Complex

2000 • 513 citations

Cardiac myosin induces myocarditis in genetically predisposed mice.

1987 • 507 citations

Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2.

1996 • 477 citations

Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma

2000 • 387 citations

Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease.

1995 • 367 citations

ROLE OF COMPLEMENT IN INDUCTION OF ANTIBODY PRODUCTION IN VIVO

1974 • 357 citations

Myosin-induced acute myocarditis is a T cell-mediated disease.

1991 • 332 citations

Complement deficiency and disease

1991 • 316 citations

Expression of Complement Receptors 1 and 2 on Follicular Dendritic Cells Is Necessary for the Generation of a Strong Antigen-Specific IgG Response

1998 • 314 citations

Dependence of Germinal Center B Cells on Expression of CD21/CD35 for Survival

1998 • 277 citations

Suppression of the Immune Response by a Soluble Complement Receptor of B Lymphocytes

1991 • 242 citations

Expression of CR2 (the C3dg/EBV receptor, CD21) on normal human peripheral blood T lymphocytes.

1991 • 239 citations

Autoantibodies specific for the cardiac myosin isoform are found in mice susceptible to Coxsackievirus B3-induced myocarditis.

1987 • 224 citations

Interleukin 1 or tumor necrosis factor can promote Coxsackie B3-induced myocarditis in resistant B10.A mice.

1992 • 207 citations

Variations in the susceptibility to Coxsackievirus B3-induced myocarditis among different strains of mice.

1986 • 203 citations

B Cells of HIV-1–Infected Patients Bind Virions through Cd21–Complement Interactions and Transmit Infectious Virus to Activated T Cells

2000 • 197 citations

Coxsackievirus B3-Induced Myocarditis

1998 • 174 citations

Experimental Autoimmune Myocarditis in A/J mice Is an Interleukin-4-Dependent Disease with a Th2 Phenotype

2001 • 171 citations

Monoclonal antibodies to mouse complement receptor type 1 (CR1). Their use in a distribution study showing that mouse erythrocytes and platelets are CR1-negative.

1988 • 162 citations

Antibody-mediated autoimmune myocarditis depends on genetically determined target organ sensitivity.

1995 • 155 citations

Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis.

1985 • 148 citations

Role of IL-1 and tumor necrosis factor in coxsackie virus-induced autoimmune myocarditis.

1993 • 138 citations

Coxsackievirus B-3 myocarditis. Identification of different pathogenic mechanisms in DBA/2 and Balb/c mice.

1986 • 138 citations

Purification of cardiac myosin

1975 • 128 citations

Expression of myosin-class II major histocompatibility complexes in the normal myocardium occurs before induction of autoimmune myocarditis.

1992 • 126 citations

Coxsackievirus B-3 myocarditis. Acute and chronic forms of the disease caused by different immunopathogenic mechanisms.

1987 • 120 citations

Complement Deficiencies

1992 • 116 citations

Lysis of infected myofibers by coxsackievirus B-3-immune T lymphocytes.

1980 • 114 citations

Differential regulation of complement factor H and C3 production in human umbilical vein endothelial cells by IFN-gamma and IL-1.

1990 • 94 citations

Viral Myocarditis Leading to Cardiomyopathy: Do Cytokines Contribute to Pathogenesis?

1993 • 93 citations

Central Nervous System-Targeted Expression of the Complement Inhibitor sCrry Prevents Experimental Allergic Encephalomyelitis

1999 • 93 citations

A Single Gene Controlling Hemolytic Complement and a Serum Antigen in the Mouse

1964 • 78 citations

A further link between innate and adaptive immunity: C3 deposition on antigen-presenting cells enhances the proliferation of antigen-specific T cells.

1998 • 73 citations

Characterization of murine complement receptor type 2 and its immunological cross-reactivity with type 1 receptor

1990 • 71 citations

Detachment of Human Immunodeficiency Virus Type 1 from Germinal Centers by Blocking Complement Receptor Type 2

2000 • 68 citations

C3 Production of Cultured Human Epidermal Keratinocytes in Enhanced by IFNγ and TNFα through Different Pathways

1997 • 57 citations

Modulation of the Humoral Immune Response by Antibody-Mediated Antigen Targeting to Complement Receptors and Fc Receptors

1999 • 55 citations

Inhibition of immunological memory and T‐independent humoral responses by monoclonal antibodies specific for murine complement receptors

1991 • 55 citations

Immunoglobulin Isotype Determines Pathogenicity in Antibody-Mediated Myocarditis in Naïve Mice

2000 • 55 citations

Cellular infiltrate, major histocompatibility antigen expression and immunopathogenic mechanisms in cardiac myosin-induced myocarditis.

1991 • 54 citations

Autoimmunity in heart disease: mechanisms and genetic susceptibility

1996 • 46 citations

Characterization of Murine Autoimmune Myocarditis Induced by Self and Foreign Cardiac Myosin

1999 • 45 citations

Coxsackievirus B3-induced myocarditis. Autoimmunity is L3T4+ T helper cell and IL-2 independent in BALB/c mice.

1987 • 45 citations

Expression, molecular association, and functions of C3 complement receptors CR1 (CD35) and CR2 (CD21) on the human T cell line HPB-ALL.

1992 • 43 citations

Nasal administration of cardiac myosin suppresses autoimmune myocarditis in mice

2000 • 43 citations

CR1(CD35) and CR2(CD21) complement C3 receptors are expressed on normal human thymocytes and mediate infection of thymocytes with opsonized human immunodeficiency virus

1994 • 42 citations

Phagocytosis by human monocyte-derived macrophages. Independent function of receptors for C3b (CR1) and iC3b (CR3).

1984 • 29 citations

Phagocytosis by Human Monocyte-Derived Macrophages

1984 • 23 citations

Influence of cytokines and immunosuppressive drugs on major histocompatibility complex class I/II expression by human cardiac myocytes in vitro

1991 • 19 citations