Structure of the chromosomal gene and cDNAs coding for lactase-phlorizin hydrolase in humans with adult-type hypolactasia or persistence of lactase.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis

1983 • 2,609 citations

[68] Transcription maps of polyoma virus-specific RNA: Analysis by two-dimensional nuclease S1 gel mapping

1980 • 1,430 citations

EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS

1989 • 1,299 citations

Mapping of RNA by a modification of the Berk-Sharp procedure: the 5′ termini of 15 S β-globin mRNA precursor and mature 10 S β-globin mRNA have identical map coordinates

1979 • 1,286 citations

A simple method for DNA restriction site mapping

1976 • 1,025 citations

Base sequence studies of 300 nucleotide renatured repeated human DNA clones

1981 • 605 citations

[15] Isolation of genomic DNA

1987 • 302 citations

Complete primary structure of human and rabbit lactase-phlorizin hydrolase: implications for biosynthesis, membrane anchoring and evolution of the enzyme.

1988 • 264 citations

ISOLATED INTESTINAL LACTASE DEFICIENCY IN THE ADULT

1963 • 188 citations

AUG is the only recognisable signal sequence in the 5′ non-coding regions of eukaryotic mRNA

1978 • 172 citations

Biosynthesis and maturation of lactase-phlorizin hydrolase in the human small intestinal epithelial cells

1987 • 170 citations

Intestinal lactase deficiency and lactose intolerance in adults. Preliminary report.

1968 • 164 citations

Intestinal disaccharidase activities in relation to age, race, and mucosal damage

1978 • 162 citations

Memorial Lecture: Lactose and Lactase—A Historical Perspective

1971 • 152 citations

Control of lactase in human adult-type hypolactasia and in weaning rabbits and rats.

1989 • 99 citations

Coordinate expression of lactase-phlorizin hydrolase mRNA and enzyme levels in rat intestine during development.

1990 • 96 citations

Biosynthesis of intestinal microvillar proteins intracellular processing of lactase-phlorizin hydrolase

1984 • 83 citations

The human lactase‐phlorizin hydrolase gene is located on chromosome 2

1988 • 82 citations

Biogenesis of intestinal lactase-phlorizin hydrolase in adults with lactose intolerance. Evidence for reduced biosynthesis and slowed-down maturation in enterocytes.

1990 • 76 citations

Biosynthesis, glycosylation, and intracellular transport of intestinal lactase-phlorizin hydrolase in rat.

1987 • 73 citations

The biosynthetic basis of adult lactase deficiency.

1990 • 57 citations

Evidence for biosynthesis of lactase-phlorizin hydrolase as a single-chain high-molecular weight precursor

1984 • 57 citations

A strategy for producing single-stranded DNA in the polymerase chain reaction

1989 • 52 citations

Influence of Hydrocortisone on Human Fetal Small Intestine in Organ Culture

1985 • 49 citations

Discrepancy between the intestinal lactase enzymatic activity and mRNA accumulation in sucklings and adults Effect of starvation and thyroxine treatment

1989 • 48 citations

A Second Enzyme Defect in Acquired Lactase Deficiency: Lack of Small-Intestinal Phlorizin-Hydrolase

1972 • 44 citations

Human lactase and the molecular basis of lactase persistence

1985 • 39 citations

Specific expression of lactase in the jejunum and colon during postnatal development and hormone treatments in the rat

1990 • 36 citations

Immunoelectrophoretic studies on human small intestinal brush border proteins--amount of lactase protein in adult-type hypolactasia.

1980 • 31 citations

Ability of L-triiodothyronine to modulate glucocorticoid evoked brush border enzyme activities in cultured fetal rat intestine

1984 • 9 citations