The Biotin‐Dependent Enzymes

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

A Correlation of Reaction Rates

1955 • 3,425 citations

Catalysis in chemistry and enzymology

1969 • 3,236 citations

The kinetics of enzyme-catalyzed reactions with two or more substrates or products

1963 • 1,885 citations

The kinetics of enzyme-catalyzed reactions with two or more substrates or products

1963 • 836 citations

The kinetics of enzyme-catalyzed reactions with two or more substrates or products

1963 • 774 citations

The Regulation of Glycolysis and Gluconeogenesis in Animal Tissues

1968 • 635 citations

Biochemistry: The Molecular Basis of Cell Structure and Function

1970 • 606 citations

The Metabolic Basis of Inherited Disease.

1966 • 547 citations

The properties of streptavidin, a biotin-binding protein produced by Streptomycetes

1964 • 504 citations

Renal gluconeogenesis. The effect of diet on the gluconeogenic capacity of rat-kidney-cortex slices

1963 • 493 citations

Factors Influencing the Rates of Long-Chain Fatty Acid Oxidation and Synthesis in Mammalian Systems

1961 • 479 citations

AVIDIN. 1. THE USE OF [14C]BIOTIN FOR KINETIC STUDIES AND FOR ASSAY

1963 • 476 citations

Pyruvate Carboxylase

1963 • 439 citations

A Spectrophotometric Assay for Avidin and Biotin Based on Binding of Dyes by Avidin

1965 • 438 citations

Mechanism of fatty acid synthesis

1961 • 434 citations

Revised linkage map of Escherichia coli

1967 • 428 citations

Studies on the mechanism of fatty acid synthesis

1960 • 408 citations

Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver.

1966 • 388 citations

ACYL ADENYLATES: AN ENZYMATIC MECHANISM OF ACETATE ACTIVATION

1956 • 355 citations

Variations in tissue contents of coenzyme A thio esters and possible metabolic implications

1964 • 343 citations

A MALONIC ACID DERIVATIVE AS AN INTERMEDIATE IN FATTY ACID SYNTHESIS

1958 • 338 citations

Methylmalonic aciduria. An inborn error of metabolism leading to chronic metabolic acidosis.

1967 • 337 citations

The Mechanism of Tricarboxylic Acid Cycle Regulation of Fatty Acid Synthesis

1962 • 333 citations

Studies on the Mechanism of Activation of Acetyl Coenzyme A Carboxylase by Citrate

1963 • 333 citations

Biochemistry: A Functional Approach.

1971 • 332 citations

Pyruvate Carboxylase

1963 • 324 citations

The Control of Lipid Metabolism

1963 • 298 citations

Quaternary Structure of Proteins

1970 • 297 citations

Steady-state concentrations of coenzyme A, acetyl-coenzyme A and long-chain fatty acyl-coenzyme A in rat-liver mitochondria oxidizing palmitate

1965 • 285 citations

The role of biotin-dependent carboxylations in biosynthetic reactions

1967 • 283 citations

Evidence for the participation of biotin in the enzymic synthesis of fatty acids

1958 • 282 citations

AVIDIN. 3. THE NATURE OF THE BIOTIN-BINDING SITE

1963 • 267 citations

THE BIOSYNTHESIS OF FATTY ACIDS IN RAT LIVER

1957 • 264 citations

Regulation of phosphofructokinase activity by citrate in normal and diabetic muscle

1963 • 254 citations

Liver acetyl CoA carboxylase and fatty acid synthetase: Relative activities in the normal state and in hereditary obesity

1967 • 253 citations

Studies on the Mechanism of Fatty Acid Synthesis

1962 • 246 citations

Die biochemische Funktion des Biotins

1959 • 243 citations

The Active Species of “CO2” Utilized by Ribulose Diphosphate Carboxylase

1969 • 238 citations

The Croonian Lecture, 1963 Gluconeogenesis

1964 • 233 citations

Paths of carbon in gluconeogenesis and lipogenesis: the role of mitochondria in supplying precursors of phosphoenolpyruvate.

1965 • 230 citations

Paths of Carbon in Gluconeogenesis and Lipogenesis

1966 • 229 citations

Fatty acid synthesis during fat-free refeeding of starved rats

1965 • 227 citations

METHYLMALONIC ACID EXCRETION: AN INDEX OF VITAMIN-B12 DEFICIENCY

1962 • 225 citations

PREVIOUS NUTRITIONAL STATE AND GLUCOSE CONVERSION TO FATTY ACIDS IN LIVER SLICES

1950 • 225 citations

METABOLISM OF PROPIONIC ACID IN ANIMAL TISSUES

1957 • 224 citations

Determination of Biotin with Lactobacillus arabinosus

1944 • 224 citations

MECHANISM OF ACTION OF OXALACETIC CARBOXYLASE

1954 • 224 citations

Studies in relation to Biosynthesis. I. Some possible routes to derivatives of Orcinol and Phloroglucinol

1953 • 220 citations

Acetyl Coenzyme A Carboxylase

1969 • 218 citations

Participation of acyl?coa in carbon chain biosynthesis

1959 • 211 citations

Pyruvate Carboxylase

1965 • 209 citations

Formation of Oxaloacetate from Pyruvate and CO2

1960 • 208 citations

BIOSYNTHESIS OF FATTY ACIDS BY CELL-FREE OR WATER-SOLUBLE ENZYME SYSTEMS

1952 • 207 citations

The Utilization of Carbohydrates by Human Cell Cultures

1958 • 206 citations

Gluconeogenesis in the perfused liver

1966 • 200 citations

Inhibition of citrate-synthase by palmityl-coenzyme A

1963 • 199 citations

PURIFICATION OF OXALACETIC CARBOXYLASE FROM CHICKEN LIVER

1954 • 198 citations

PURIFICATION AND PROPERTIES OF ENZYMES INVOLVED IN THE PROPIONIC ACID FERMENTATION

1964 • 197 citations

Thermodynamics of the binding of biotin and some analogues by avidin

1966 • 194 citations

Studies on the mechanism of fatty acid synthesis V. Bicarbonate requirement for the synthesis of long-chain fatty acids

1958 • 194 citations

Liver Acetyl Coenzyme A Carboxylase

1968 • 192 citations

ON THE MECHANISM OF FATTY ACID SYNTHESIS¹

1959 • 192 citations

Intramolecular Hydrogen Transfer in the Phosphoglucose Isomerase Reaction

1961 • 191 citations

ACCELERATION OF RENAL GLUCONEOGENESIS BY KETONE BODIES AND FATTY ACIDS

1965 • 191 citations

THE PARTICIPATION OF CARBON DIOXIDE IN THE CARBOHYDRATE CYCLE

1941 • 190 citations

THE ENZYMATIC SYNTHESIS OF FATTY ACIDS BY ALDOL CONDENSATION

1958 • 188 citations

THE SUCCINATE-GLYCINE CYCLE

1955 • 185 citations

Biosynthese von 6‐Methylsalicylsäure

1970 • 183 citations

The utilisation of CO2 in the dissimilation of glycerol by the propionic acid bacteria

1936 • 176 citations

STUDIES OF THE ROLE OF THE LIVER IN HUMAN CARBOHYDRATE METABOLISM BY THE VENOUS CATHETER TECHNIC. II. PATIENTS WITH DIABETIC KETOSIS, BEFORE AND AFTER THE ADMINISTRATION OF INSULIN 12

1949 • 172 citations

THE ROLE OF CO₂ FIXATION IN CARBOHYDRATE UTILIZATION AND SYNTHESIS

1959 • 171 citations

Studies on the mechanism of fatty acid synthesis II. Cofactor requirements of the soluble pigeon liver system

1957 • 171 citations

OLEIC ACID AND RELATED COMPOUNDS AS GROWTH FACTORS FOR LACTIC ACID BACTERIA

1947 • 170 citations

STUDIES IN CARBOHYDRATE METABOLISM

1944 • 170 citations

Pyruvate Carboxylase

1966 • 169 citations

Single-step purification of avidin from egg white by affinity chromatography on biocytin-Sepharose columns

1968 • 167 citations

A derangement in B12 metabolism leading to homocystinemia, cystathioninemia and methylmalonic aciduria

1969 • 166 citations

Studies on the Mechanism of Fatty Acid Synthesis

1966 • 165 citations

STUDIES ON THE CYCLOPHORASE SYSTEM

1948 • 165 citations

Die Geschwindigkeit der Hydratation von SO ₂ in wäßriger Lösung

1961 • 161 citations

FASTING AND HEPATIC LIPOGENESIS FROM C14-ACETATE

1952 • 159 citations

Comprehensive Biochemistry

1964 • 159 citations

THE POSITION OF FIXED CARBON IN GLUCOSE FROM RAT LIVER GLYCOGEN

1945 • 158 citations

LIPOGENESIS IN PARTICLE-FREE EXTRACTS OF RAT LIVER

1957 • 157 citations

A PROTEOLYTIC ENZYME OF STREPTOMYCES GRISEUS

1960 • 156 citations

Regulation of Hepatic Lipogenesis: The Influence of Dietary Fats

1958 • 153 citations

Metabolism of Propionic Acid in Animal Tissues

1955 • 153 citations

EFFECT OF CORTISONE UPON RATES OF GLUCOSE PRODUCTION AND OXIDATION IN THE RAT

1952 • 151 citations

Fat Metabolism in Higher Plants

1961 • 150 citations

LIPOGENESIS AND GLUCOSE OXIDATION IN THE LIVER OF THE ALLOXAN-DIABETIC RAT

1950 • 150 citations

Über das Bios-Problem. Darstellung von krystallisiertem Biotin aus Eigelb. 20. Mitteilung über pflanzliche Wachstumsstoffe

1936 • 149 citations

A possible role for acetyl coa in the control of gluconeogenesis

1964 • 149 citations

Pyruvate Carboxylase

1965 • 149 citations

THE ENZYMATIC CLEAVAGE OF β-HYDROXY-β-METHYLGLUTARYL COENZYME A TO ACETOACETATE AND ACETYL COENZYME A

1955 • 148 citations

The Enzymatic Carboxylation of Phosphoenolpyruvate

1966 • 148 citations

Biosynthesis of fatty acids in cell-free preparations. 5. Synthesis of fatty acids from acetate in extracts of lactating-rat mammary gland

1962 • 147 citations

The utilization of acetic, propionic and butyric acids by fattening sheep

1957 • 147 citations

Biosynthesis of fatty acids in cell-free preparations. 2. Synthesis of fatty acids from acetate by a soluble enzyme system prepared from rat mammary gland

1955 • 146 citations

The effect of starvation and alloxan-diabetes on the contents of citrate and other metabolic intermediates in rat liver

1968 • 146 citations

Methylmalonic Aciduria: Metabolic Block Localization and Vitamin B ₁₂ Dependency

1968 • 146 citations

THE EFFECTS OF CITRATE AND COENZYME A ON FATTY ACID METABOLISM

1956 • 145 citations

X-Ray Induced Growth Factor Requirements in Bacteria

1944 • 145 citations

Pyruvate Carboxylase

1967 • 144 citations

The role of biotin and vitamin B12 coenzyme in propionate metabolism

1960 • 144 citations

Regulation of fatty acid synthesis at the acetyl-CoA carboxylation step

1965 • 142 citations

Selective dampening of lipogenic enzymes of liver by exogenous polyunsaturated fatty acids

1970 • 142 citations

The Carboxylation of Phosphoenolpyruvate and Pyruvate

1968 • 141 citations

Enzymic isomerization of Δ5-3-ketosteroids

1955 • 139 citations

Transcarboxylase

1969 • 139 citations

THE RÔLE OF CARBOXYL-LABELED ACETIC, PROPIONIC, AND BUTYRIC ACIDS IN LIVER GLYCOGEN FORMATION

1943 • 138 citations

Pyruvate Carboxylase

1966 • 138 citations

Mechanism of the Propionyl Carboxylase Reaction

1961 • 137 citations

Location of the Maltose A and B Loci on the Genetic Map of Escherichia coli

1966 • 135 citations

Molecular characteristics of liver acetyl CoA carboxylase.

1966 • 134 citations

The Effect of Desiccation upon the Nutritive Properties of Egg-white

1927 • 132 citations

THE CONCENTRATION AND ASSAY OF AVIDIN, THE INJURY-PRODUCING PROTEIN IN RAW EGG WHITE

1941 • 132 citations

Inhibition of mammary gland acetyl CoA carboxylase by fatty acids

1963 • 130 citations

Studies on the portal blood of sheep. 2. Absorption of volatile fatty acids from the rumen of the sheep

1957 • 129 citations

The anaplerotic fixation of carbon dioxide by Escherichia coli

1966 • 128 citations

THE ROLE OF TRANSCARBOXYLATION IN PROPIONIC ACID FERMENTATION

1960 • 126 citations

Action of glucocorticoid as inducer and insulin as suppressor of biosynthesis of hepatic gluconeogenic enzymes

1965 • 126 citations

Mechanism of the Propionyl Carboxylase Reaction

1962 • 124 citations

Studies on the Anaerobic Micrococci

1948 • 123 citations

The utilization of CO2 by the propionic acid bacteria

1938 • 122 citations

Egg White Avidin

1971 • 122 citations

Renal gluconeogenesis

1963 • 121 citations

Chelation as a Driving Force in Organic Reactions. IV.¹ Synthesis of α-Nitro Acids by Control of the Carboxylation-Decarboxylation Equilibrium²

1963 • 120 citations

The stimulation of fatty acid synthesis by isocitrate and malonate

1962 • 120 citations

MAMMALIAN METHYLMALONYL ISOMERASE AND VITAMIN B ₁₂ COENZYMES

1960 • 119 citations

Studies in relation to biosynthesis. VII. 2-Hydroxy-6-methylbenzoic acid in Penicillium griseofulvum Dierckx

1955 • 118 citations

Substrate synergism and phosphoenzyme formation in catalysis by succinyl coenzyme A synthetase

1968 • 116 citations

THE RÔLE OF INSULIN IN CARBOHYDRATE METABOLISM

1940 • 116 citations

Intracellular Localization of Pyruvate Carboxylase and Phosphoenolpyruvate Carboxykinase in Rat Liver

1969 • 115 citations

Metabolism of Propionic Acid in Animal Tissues

1961 • 115 citations

Fatty Acid Synthesis in Human Adipose Tissue

1969 • 114 citations

Pyruvate Carboxylase

1965 • 114 citations

Properties and Function of Yeast Pyruvate Carboxylase

1965 • 114 citations

Citrate Cleavage Enzyme in Livers of Obese and Nonobese Mice

1964 • 113 citations

PARTICIPATION OF ADENYL-ACETATE IN THE ACETATE-ACTIVATING SYSTEM¹

1955 • 113 citations

AVIDIN. 2. PURIFICATION AND COMPOSITION

1963 • 113 citations

Carbonic anhydrase as a tool in studying the mechanism of reactions involving H2CO3, CO2 or HCO3−

1948 • 113 citations

Some Recent Developments in the Chemistry of Phosphate Esters of Biological Interest

1962 • 112 citations

The Enzymatic Synthesis of Holotranscarboxylase from Apotranscarboxylase and (+)-Biotin

1964 • 111 citations

THE FIXATION OF CARBON DIOXIDE AND THE INTERRELATIONSHIPS OF THE TRICARBOXYLIC ACID CYCLE

1946 • 111 citations

The Enzymatic Synthesis of Holotranscarboxylase from Apotranscarboxylase and (+)-Biotin

1964 • 110 citations

Factors involved in synthesis of fatty acids from acetate by a soluble fraction obtained from lactating rat mammary gland

1961 • 109 citations

Liver Acetyl Coenzyme A Carboxylase

1968 • 108 citations

Effects of Fatty Acids, Glucagon and Anti-insulin Serum on the Control of Gluconeogenesis and Ketogenesis in Rat Liver

1967 • 108 citations

Effects of glucagon and long chain fatty acids on glucose production by isolated perfused rat liver

1966 • 108 citations

Lipid Metabolism

1964 • 107 citations

Localization of the stimulating effect of isocitrate on fatty acid synthesis by rat liver homogenate fractions

1962 • 107 citations

Effects of Magnesium Ions, Adenosine Triphosphate, Palmitoylcarnitine, and Palmitoyl Coenzyme A on Acetyl Coenzyme A Carboxylase

1968 • 106 citations

ISOLATION OF AN ANTIBIOTIN FACTOR FROM EGG WHITE

1942 • 106 citations

Studies on the mechanism of fatty acid synthesis VIII. The participation of protein-bound biotin in the biosynthesis of fatty acids

1960 • 105 citations

CONGENITAL METHYLMALONIC ACIDEMIA: ENZYMATIC EVIDENCE FOR TWO FORMS OF THE DISEASE

1969 • 105 citations

Acetyl CoA carboxylase. I. Requirement for two protein fractions.

1968 • 105 citations

AVIDIN. 4. STABILITY AT EXTREMES OF PH AND DISSOCIATION INTO SUB-UNITS BY GUANIDINE HYDROCHLORIDE

1963 • 104 citations

Conjugative Effects of Methylsulfonyl and Methylthio Groupings¹

1952 • 104 citations

A PROTEOLYTIC ENZYME OF STREPTOMYCES GRISEUS

1960 • 104 citations

Genetic and Biochemical Analysis of the Biotin Loci ofEscherichia coliK-12

1968 • 98 citations

Mode of Action of Glucocorticoids

1964 • 98 citations

THE STRUCTURE OF BIOTIN: A STUDY OF DESTHIOBIOTIN

1942 • 98 citations

Citrate content of liver and kidney of rat in various metabolic states and in fluoroacetate poisoning

1967 • 96 citations

Pyruvate carboxylase. XIII. Reversible inactivation by cold

1969 • 96 citations

Biological synthesis of oxaloacetic acid from pyruvic acid and carbon dioxide

1940 • 95 citations

Metabolic Functions of Biotin

1953 • 93 citations

Egg-White Injury as the Result of Nonabsorption or Inactivation of Biotin

1941 • 93 citations

THE ENZYMATIC CARBOXYLATION OF ACETYL COENZYME A

1959 • 93 citations

Fatty Acid Synthesis from Acetate by Normal and Diabetic Rat Liver Homogenate Fractions

1960 • 92 citations

Methylmalonate Excretion in a Patient with Pernicious Anemia

1963 • 92 citations

SOME PROPERTIES OF OXALACETIC CARBOXYLASE

1954 • 91 citations

Acetyl Coenzyme A Carboxylase: Filamentous Nature of the Animal Enzymes

1969 • 90 citations

Stereochemistry of Pyruvate Kinase, Pyruvate Carboxylase, and Malate Enzyme Reactions

1970 • 90 citations

Metabolism of Propionic Acid in Animal Tissues

1959 • 90 citations

LIVER ACETYL COA CARBOXYLASE: THE DISSOCIATION-REASSOCIATION PROCESS AND ITS RELATION TO CATALYTIC ACTIVITY

1966 • 89 citations

FATTY ACID OXIDATION BY A SOLUBLE ENZYME SYSTEM FROM MITOCHONDRIA

1953 • 89 citations

Studies on the ketogenic effect of glucagon in intact rat liver

1966 • 89 citations

Enzymatic regulation of liver acetyl-CoA metabolism in relation to ketogenesis

1964 • 89 citations

Studies on the genetics of biotin-transducing, defective variants of bacteriophage λ

1968 • 88 citations

Pyruvate Metabolism and Control: Factors Affecting Pyruvic Carboxylase Activity

1964 • 88 citations

BIOTIN AND CARBON DIOXIDE FIXATION IN LIVER

1947 • 87 citations

A CONSTITUENT OF RAW EGG WHITE CAPABLE OF INACTIVATING BIOTIN IN VITRO

1940 • 86 citations

TRACER EXPERIMENTS ON THE MECHANISM OF CITRIC ACID FORMATION BY ASPERGILLUS NIGER

1954 • 86 citations

Methylmalonyl Isomerase

1964 • 86 citations

Studies on the Perfused Rat Liver: II. Effect of Glucagon on Gluconeogenesis

1966 • 86 citations

FUNCTION OF BIOTIN IN THE METABOLISM OF LACTOBACILLUS ARABINOSUS

1950 • 85 citations

Optical rotatory dispersion, circular dichroism and far-ultraviolet spectra of avidin and streptavidin

1966 • 85 citations

OLEIC ACID AS A GROWTH STIMULANT FOR LACTOBACILLUS CASEI

1946 • 85 citations

Inhibition of Hepatic Acetyl Coenzyme A Carboxylase by Hypolipidemic Agents

1969 • 85 citations

FIXATION OF CARBON DIOXIDE BY PIGEON LIVER IN THE DISSIMILATION OF PYRUVIC ACID

1942 • 84 citations

SYNTHESIS OF SUCCINATE FROM PROPIONATE AND BICARBONATE BY SOLUBLE ENZYMES FROM LIVER MITOCHONDRIA

1956 • 84 citations

CHARACTERIZATION OF THE FUNCTIONAL GROUPS OF BIOTIN

1941 • 84 citations

An Adenosine Triphosphate-dependent, Avidin-sensitive Enzymatic Cleavage of Urea in Yeast and Green Algae

1968 • 84 citations

THE CHEMISTRY OF GLUCONEOGENESIS

1913 • 83 citations

ON THE MECHANISM OF THE COBAMIDE COENZYME DEPENDENT ISOMERIZATION OF METHYLMALONYL COA TO SUCCINYL CoA

1960 • 83 citations

ENZYMATIC CARBOXYLATION OF β-HYDROXYISOVALERYL COENZYME A

1956 • 83 citations

Pyruvate Carboxylase. X. The Demonstration of Direct Coordination of Pyruvate and α-Ketobutyrate by the Bound Manganese and the Formation of Enzyme-Metal-Substrate Bridge Complexes^*

1967 • 82 citations

A PROTEOLYTIC ENZYME OF STREPTOMYCES GRISEUS

1960 • 82 citations

Cortisol induzierter Anstieg der Pyruvatcarboxylaseaktivität in der Rattenleber

1963 • 81 citations

Effect of Methylmalonyl Coenzyme A, a Metabolite Which Accumulates in Vitamin B12 Deficiency, on Fatty Acid Synthesis

1970 • 81 citations

Changes in the level of the fatty acid synthesizing enzymes during starvation

1962 • 80 citations

The Fixation of Carbon Dioxide by Rat Liver Mitochondria and Its Relation to Gluconeogenesis

1965 • 79 citations

Studies on brain metabolism

1937 • 79 citations

Studies of the Acetyl Coenzyme A Synthetase Reaction

1963 • 78 citations

Vitamin B12 dependent methylmalonicaciduria: Defective B12 metabolism in cultured fibroblasts

1969 • 77 citations

ACETYL COA CARBOXYLASE, II. DEMONSTRATION OF BIOTIN-PROTEIN AND BIOTIN CARBOXYLASE SUBUNITS

1969 • 77 citations

HEAVY CARBON AS A TRACER IN HETEROTROPHIC CARBON DIOXIDE ASSIMILATION

1941 • 76 citations

THE ENZYMATIC DEGRADATION OF SOLUBLE BOUND BIOTIN

1954 • 76 citations

THE RÔLE OF BIOTIN IN BICARBONATE UTILIZATION BY BACTERIA

1947 • 75 citations

STUDIES ON AN OXALACETIC CARBOXYLASE FROM LIVER MITOCHONDRIA

1956 • 75 citations

Synthesis of 7-Oxo-8-Aminopelargonic Acid, a Biotin Vitamer, in Cell-free Extracts of Escherichia coli Biotin Auxotrophs

1968 • 75 citations

Egg White Avidin

1970 • 74 citations

Mechanism for the Stimulation in vivo of Hepatic Gluconeogenesis by Glucagon

1966 • 73 citations

Biochemistry of Biotin

1964 • 73 citations

THE MECHANISM OF CARBON DIOXIDE FIXATION IN CELL-FREE EXTRACTS OF PIGEON LIVER

1943 • 72 citations

THE METABOLIC FATE OF THE ISOPROPYL GROUP OF LEUCINE

1950 • 72 citations

Pyruvate Carboxylase. VIII. The Subunit Structure as Examined by Electron Microscopy^*

1966 • 72 citations

Properties and Purification of Mitochondrial Propionyl Carboxylase

1960 • 72 citations

Stable carbonium ions. LXIX. Protonation of ureas, guanidines, and biotin in super acid solution

1968 • 72 citations

Biotin-requiring mutants of Escherichia coli K-12

1967 • 72 citations

Studies on the mechanism of fatty acid synthesis III. Products of enzymic synthesis of fatty acids

1957 • 71 citations

Metabolism of Propionic Acid in Animal Tissues

1962 • 71 citations

CHELATION AS A DRIVING FORCE IN SYNTHESIS. II. USE OF MAGNESIUM METHYL CARBONATE IN THE CARBOXYLATION AND ALKYLATION OF KETONES

1959 • 71 citations

Interrelationships between liver composition, plasma glucose and ketones, and hepatic acetyl-CoA and citric acid during prolonged starvation in the male rat

1968 • 71 citations

Rat Mammary Acetyl Coenzyme A Carboxylase

1969 • 70 citations

Uber das Katalyseprinzip der Malat-synthase

1967 • 70 citations

Further Studies on the Properties of Liver Propionyl Coenzyme A Holocarboxylase Synthetase and the Specificity of Holocarboxylase Formation

1966 • 69 citations

NUTRITIONAL FACTORS IN FATTY ACID SYNTHESIS BY TISSUE SLICES IN VITRO

1952 • 69 citations

The Absolute Configuration of Methylmalonyl Coenzyme A and Stereochemistry of the Methylmalonyl Coenzyme A Mutase Reaction

1966 • 69 citations

The Possible Identity of Vitamin H with Biotin and Coenzyme R

1940 • 68 citations

The Purification and Properties of Dethiobiotin Synthetase

1970 • 68 citations

Gluconeogenesis: pathways and hormonal regulation.

1966 • 68 citations

Insulin Action in Alloxan Diabetes Modified by Actinomycin D

1964 • 68 citations

Synthesis and properties of palmityl adenylate, palmityl coenzyme A, and palmityl glutathione

1958 • 68 citations

Enzymatic Carboxylation of Biotin: Molecular and Catalytic Properties of a Component Enzyme of Acetyl CoA Carboxylase

1970 • 67 citations

A FUNCTION FOR BIOTIN

1947 • 67 citations

The role of CO2 fixation in metabolism.

1965 • 66 citations

Purification and crystallization of avidin

1970 • 66 citations

Carbon Dioxide Fixation by Cell-free Extracts of Aspergillus niger

1960 • 66 citations

THE CURATIVE FACTOR (VITAMIN H) FOR EGG WHITE INJURY, WITH PARTICULAR REFERENCE TO ITS PRESENCE IN DIFFERENT FOODSTUFFS AND IN YEAST

1939 • 66 citations

METABOLIC FUNCTIONS OF BIOTIN

1949 • 66 citations

Effects of cortisol on the levels of metabolites and enzymes controlling glucose production from pyruvate

1968 • 66 citations

Acyl Carrier Protein

1969 • 65 citations

Further Studies on Mitochondrial Propionyl Carboxylase

1960 • 65 citations

Studies on the mechanism of fatty acid synthesis VI. Spectrophotometric assay and stoichiometry of fatty acid synthesis

1959 • 65 citations

CONVERSION OF PROPIONATE TO LIVER GLYCOGEN IN THE INTACT RAT, STUDIED WITH ISOTOPIC PROPIONATE

1950 • 65 citations

Mechanism of Propionic Acid Formation by Propionibacterium pentosaceum

1948 • 65 citations

The mechanism of synthesis of fatty acids by the pigeon liver enzyme system

1970 • 65 citations

Propionyl Holocarboxylase Synthesis

1962 • 64 citations

The Biochemistry of B Vitamins

1950 • 64 citations

Studies of the Mechanism of Biotin Catalysis

1965 • 64 citations

THE BIOCHEMICAL FUNCTION OF BIOTIN, VI. CHEMICAL STRUCTURE OF THE CARBOXYLATED ACTIVE SITE OF PROPIONYL CARBOXYLASE

1963 • 64 citations

Liver acetyl CoA carboxylase: insight into the mechanism of activation by tricarboxylic acids and acetyl CoA.

1967 • 64 citations

INVOLVEMENT OF BIOTIN IN THE BIOSYNTHESIS OF OXALACETIC AND α-KETOGLUTARIC ACIDS

1947 • 64 citations

Transcarboxylase

1963 • 63 citations

BIOTIN AND PROPIONYL CARBOXYLASE

1960 • 62 citations

Arginosuccinic Acid from Chlorella

1952 • 62 citations

Oxalacetate Decarboxylase of Aerobacter aerogenes. I. Inhibition by Avidin and Requirement for Sodium Ion^*

1967 • 62 citations

LEVELS OF ACIDS OF THE CITRIC ACID CYCLE IN TISSUES OF NORMAL AND DIABETIC RATS

1951 • 62 citations

On the Identity of Vitamin H with Biotin

1940 • 61 citations

Mechanism of Biotin Action

1970 • 61 citations

The Pyruvate Carboxylase of Aspergillus niger

1962 • 61 citations

Metabolic Changes in Liver Associated with Spontaneous Ketosis and Starvation in Cows

1968 • 61 citations

SOME ASPECTS OF THE METABOLISM OF LEUCINE AND VALINE

1944 • 60 citations

THE FERMENTATION OF THREE CARBON SUBSTRATES BY CLOSTRIDIUM PROPIONICUM AND PROPIONIBACTERIUM

1955 • 60 citations

Transcarboxylase

1969 • 60 citations

Transcarboxylase

1969 • 60 citations

REQUIREMENT FOR BICARBONATE IN FATTY ACID SYNTHESIS¹

1958 • 59 citations

CHELATION AS A DRIVING FORCE IN SYNTHESIS. A NEW ROUTE TO α-NITRO ACIDS AND α-AMINO ACIDS

1959 • 59 citations

The relationship of bacterial utilization of CO2 to succinic acid formation

1940 • 59 citations

Activation of acetyl-CoA carboxylase and associated alteration of sedimentation characteristics of the enzyme

1962 • 59 citations

METHYLMALONYL ISOMERASE, II. PURIFICATION AND PROPERTIES OF THE ENZYME FROM PROPIONIBACTERIA

1961 • 59 citations

Methylmalonyl Coenzyme A Decarboxylase

1968 • 58 citations

METABOLIC FUNCTIONS OF BIOTIN

1949 • 58 citations

Studies on the Mechanism of Fatty Acid Synthesis

1970 • 58 citations

THE DIGESTIBILITY AND UTILIZATION OF EGG PROTEINS

1916 • 58 citations

Aspartic Acid as a Partial Substitute for the Growth-Stimulating Effect of Biotin on Torula cremoris.

1942 • 58 citations

A preliminary crystallographic investigation of avidin

1970 • 57 citations

Metal ion complexes with biotin and biotin derivatives. Participation of sulfur in the orientation of divalent cations

1969 • 57 citations

Effect of diet on individual volatile fatty acids in the rumen of sheep, with particular reference to the effect of low rumen pH and adaptation on high-starch diets

1957 • 57 citations

Biotin in fermentation, respiration, growth and nitrogen assimilation by yeast.

1944 • 57 citations

Egg White Avidin

1971 • 57 citations

STUDIES ON THE INTERMEDIARY METABOLISM OF AMINO-ACIDS

1913 • 56 citations

Studies on pyruvate carboxylase activity in alloxan diabetic and normal animals

1964 • 56 citations

THE METABOLISM OF PROPIONATE BY RAT LIVER SLICES AND THE FORMATION OF ISOSUCCINIC ACID¹

1955 • 55 citations

THE POSITION OF CARBON DIOXIDE CARBON IN SUCCINIC ACID SYNTHESIZED BY HETEROTROPHIC BACTERIA

1941 • 55 citations

ENZYMATIC FIXATION OF CARBON DIOXIDE IN OXALACETATE

1943 • 55 citations

BIOTIN ACTIVATION OF CERTAIN DEAMINASES

1947 • 55 citations

STUDIES ON THE METABOLISM OF UREA AND OTHER NITROGENOUS COMPOUNDS IN CHLORELLA ELLIPSOIDEA

1957 • 55 citations

METABOLISM OF PROPIONIC ACID IN ANIMAL TISSUES

1958 • 55 citations

INCORPORATION OF THE CARBONS OF ACETONE, FORMATE, AND CARBONATE INTO ACETOACETATE

1950 • 54 citations

BIOTIN AND THE METABOLISM OF LACTOBACILLUS ARABINOSUS

1948 • 54 citations

THE STRUCTURE OF BIOTIN: THE FORMATION OF THIOPHENEVALERIC ACID FROM BIOTIN

1942 • 54 citations

A Further Note on the Identity of Vitamin H with Biotin

1940 • 54 citations

Citrate and the conversion of carbohydrate into fat. Citrate cleavage in obesity and lactation

1966 • 54 citations

Studies on the Anaerobic Micrococci

1948 • 54 citations

Acetyl-CoA carboxylase from rat adipose tissue

1969 • 53 citations

Metabolism of Propionic Acid in Animal Tissues

1963 • 53 citations

The intermediate metabolism of propionic acid bacteria

1937 • 53 citations

Some Enzymic Properties of Mitochondrial Propionyl Carboxylase

1962 • 53 citations

A Respiration Coenzyme

1933 • 53 citations

ISOTOPE STUDIES ON THE METABOLISM OF VALINE

1955 • 53 citations

Studies of an in Vitro Effect of Glucocorticoids on Gluconeogenesis

1962 • 53 citations

CONVERSION OF C14-LABELED PROPIONATE, LACTATE, AND PYRUVATE TO ACETYL GROUPS IN THE RAT

1952 • 53 citations

THE MECHANISM OF THE REVERSIBLE CARBOXYLATION OF PHOSPHOENOLPYRUVATE

1956 • 53 citations

The Molecular Weight of Avidin

1964 • 53 citations

Pyruvate Carboxylase* *The unpublished data described here were obtained by research supported in part by Contract AT (11-1)—1242 of the U.S. Atomic Energy Commission and by U.S. Public Health Service grants AM-09760, AM-11712, and 5-TI-GM35.

1969 • 52 citations

Ruminant Digestion

1948 • 52 citations

THE ENZYMATIC CARBOXYLATION OF BUTYRYL COENZYME A

1959 • 52 citations

The effect of biotin deficiency on the synthesis of fatty acids by yeast

1963 • 51 citations

Butyryl adenylate and its possible function in the fatty acid activating system

1956 • 51 citations

CO2 Fixation and the Involvement of Allophanate in the Biotin-Enzyme-catalyzed Cleavage of Urea

1970 • 51 citations

Characterization of the Biotin Transport System in Saccharomyces cerevisiae

1969 • 51 citations

The Isolation, Purification, and Properties of Methylmalonyl Racemase

1963 • 51 citations

Citrate and the conversion of carbohydrate into fat. The regulation of fatty acid synthesis by rat liver extracts

1967 • 50 citations

Conjugative Effects in Divalent Sulfur Groupings¹

1956 • 50 citations

Some factors regulating the rate of gluconeogenesis in animal tissues

1964 • 50 citations

Identification of the sites of binding of acetyl and malonyl groups to the pigeon liver fatty acid synthetase complex

1970 • 50 citations

The terminal amino groups of conalbumin, ovomucoid and avidin

1952 • 50 citations

The regulation of yeast pyruvate carboxylase by acetyl-coenzyme A and l-aspartate

1968 • 50 citations

Studies on Experimental Diabetes

1963 • 50 citations

FURTHER STUDIES ON LIPIDE STIMULATION OF LACTOBACILLUS CASEI

1947 • 49 citations

The fixation of CO2 by cell suspensions of Propionibacterium pentosaceum

1940 • 49 citations

Pyruvate carboxylase. XI. Nuclear magnetic resonance studies of the properties of the bound manganese after interaction of the biotin residues with avidin

1968 • 49 citations

STUDIES ON THE CYCLOPHORASE SYSTEM

1948 • 49 citations

Studies on the Mechanism of Action of Acetyl Coenzyme A Carboxylase

1963 • 48 citations

Regulation of Pyruvate Carboxylase Formation from the Apo-enzyme and Biotin in a Thermophilic Bacillus

1969 • 48 citations

Further evidence for polymeric structure of liver acetyl CoA carboxylase

1966 • 48 citations

A Simple Synthesis of dl-Desthiobiotin and Related Substances

1945 • 48 citations

FACTORS AFFECTING THE FIXATION OF C14O2 BY ANIMAL TISSUES

1951 • 48 citations

Propionyl holocarboxylase formation: Covalent bonding of biotin to apocarboxylase lysyl ϵ-amino groups

1962 • 48 citations

Glucose-6-phosphate Dehydrogenase from Rat Liver II. Effect of Diet on Enzyme Activity in vivo, and Inhibition by Long Chain Fatty Acids in vitro

1967 • 48 citations

METABOLISM OF LACTIC ACID CONTAINING RADIOACTIVE CARBOXYL CARBON

1941 • 48 citations

Ketogenesis-antiketogenesis

1935 • 47 citations

The Enzymatic Isomerization of β-Methylvinylacetyl Coenzyme A and the Specificity of a Bacterial β-Methylcrotonyl Coenzyme A Carboxylase

1960 • 47 citations

Methylmalonyl Isomerase: A Study of the Mechanism of Isomerization

1962 • 47 citations

Crystal Structure of Biotin

1956 • 47 citations

DESTHIOBIOTIN IN THE BIOSYNTHESIS OF BIOTIN

1945 • 47 citations

Wirkstoffprinzip und Pflanzenwachstum

1937 • 47 citations

Biotin. V. Synthesis of dl-Biotin, dl-Allobiotin and dl-epi-Allobiotin

1945 • 46 citations

OCCURRENCE OF AVIDIN IN THE OVIDUCT AND SECRETIONS OF THE GENITAL TRACT OF SEVERAL SPECIES

1942 • 46 citations

Enzymatic Activation of Biotin

1964 • 46 citations

The Absolute Configuration of Biotin^*

1966 • 46 citations

THE FORMATION OF KETONE BODIES FROM ISOVALERIC ACID

1950 • 46 citations

A Biosynthesis of Biotin

1942 • 46 citations

Synthetic Biotin

1943 • 45 citations

The Carboxyl Transferase Component of Acetyl CoA Carboxylase: Structural Evidence for Intersubunit Translocation of the Biotin Prosthetic Group

1971 • 45 citations

Fat Metabolism in Higher Plants

1969 • 45 citations

TRANSCARBOXYLASE, II. PURIFICATION AND PROPERTIES OF METHYLMALONYL-OXALOACETIC TRANSCARBOXYLASE

1961 • 45 citations

STUDIES ON THE CONVERSION OF RADIOACTIVE LEUCINE TO ACETOACETATE

1949 • 45 citations

Lipogenesis in biotin deficiency

1968 • 44 citations

Induction of Avidin Formation in the Avian Oviduct by Stilbestrol Plus Progesterone

1943 • 44 citations

Pyruvate carboxylase of Rhizopus nigricans and its role in fumaric acid production

1969 • 44 citations

The Vitamins. Chemistry, Physiology, Pathology, Methods

1969 • 44 citations

Studies of the Mechanism of Action of the Condensing Enzyme

1959 • 43 citations

The Growth-Stimulating Effect of Biotin for the Diphtheria Bacillus in the Absence of Pimelic Acid

1942 • 43 citations

THE RÔLE OF BIOTIN AND ADENYLIC ACID IN AMINO ACID DEAMINASES

1948 • 43 citations

Regulation of Biotin Transport in Saccharomyces cerevisiae

1969 • 42 citations

Fat feeding and cholesterol synthesis

1967 • 42 citations

ENZYMATIC INCORPORATION OF C14-BICARBONATE INTO ACETOACETATE IN THE PRESENCE OF VARIOUS SUBSTRATES

1951 • 42 citations

Inhibition of hyperlipogenesis with puromycin or actinomycin D

1965 • 42 citations

Avidin. 5. Quenching of fluorescence by dinitrophenyl groups

1964 • 42 citations

BIOTIN AND THE SYNTHESIS OF ASPARTIC ACID BY MICROORGANISMS

1947 • 42 citations

Fat metabolism in higher plants

1966 • 42 citations

Carboxylation of β-methylcrotonyl coenzyme A by a purified enzyme from chicken liver

1959 • 42 citations

The Mechanism of Propionic Acid Formation by Succinate Decarboxylation

1953 • 42 citations

Egg-White Injury in Chicks and Its Relationship to a Deficiency of Vitamin H (Biotin)

1940 • 42 citations

The absolute configuration of methylmalonyl-CoA

1964 • 41 citations

Purification and properties of pyruvate carboxylase from Baker's yeast

1967 • 41 citations

THE PREPARATION OF FREE CRYSTALLINE BIOTIN

1941 • 41 citations

CO ₂ Assimilation by Proprionic Acid Bacteria Studied by the Use of Radioactive Carbon

1940 • 41 citations

The Enzymatic Carboxylation of Propionyl Coenzyme A

1968 • 41 citations

Enzymatic Synthesis and Reactions of Amino Acyl Adenylates

1960 • 40 citations

STUDIES ON KETOSIS

1935 • 40 citations

The effect of CO2 on the production of succinic acid by Bact. coli commune

1938 • 40 citations

CARBON DIOXIDE FIXATION IN HEART EXTRACTS BY β-HYDROXYISOVALERYL COENZYME A¹

1954 • 40 citations

THE PHYSIOLOGICAL EFFECTS OF DIETS RICH IN EGG WHITE

1931 • 39 citations

Biotin. II. Synthesis of Biotin

1944 • 38 citations

Gluconeogenesis in biotin deficiency: In vivo synthesis of pyruvate holocarboxylase in biotin deficient rat liver

1969 • 38 citations

Liver acetyl coenzyme A carboxylase: activation of model partial reactions by tricarboxylic acids.

1968 • 38 citations

ピオチンの生化学的機能 VIII カルボキシル化アセチル-CoAカルボキミラーゼにおける炭酸結合

1964 • 38 citations

The pathway of propionate oxidation

1953 • 37 citations

Bacterial Biotinidase

1963 • 37 citations

Structure of the Bis-p-bromoanilide of Carbon Dioxide Biotin^*

1965 • 37 citations

Arterial infarction of the liver in man

1955 • 37 citations

Streptavidin—A substance with avidin-like properties produced by microorganisms

1964 • 37 citations

ON THE STRUCTURE OF BIOTIN

1942 • 37 citations

Biochemistry of Fungi

1944 • 37 citations

THE CHEMICAL NATURE OF FAT-SOLUBLE MATERIALS WITH BIOTIN ACTIVITY IN HUMAN PLASMA

1948 • 36 citations

Enzymatic Participation of Enzyme-bound Amino Acyl Adenylates in Amino Acid Incorporation into Protein

1960 • 36 citations

Metabolism of Biotin and Oxybiotin by Lactobacillus pentosus 124-2

1948 • 36 citations

ON THE MECHANISM OF PYRIMIDINE METABOLISM BY YEASTS

1952 • 36 citations

TRANSCARBOXYLASE, VIII. ISOLATION AND PROPERTIES OF A BIOTIN-CARBOXYL CARRIER PROTEIN

1969 • 36 citations

Effect of varying temperature and pH upon the predicted rate of “CO2” utilization by car☐ylases

1970 • 36 citations

Studies on the Control of Fatty Acid Synthesis

1967 • 35 citations

Adaptive enzyme formation during hyperlipogenesis

1966 • 35 citations

MICROBIOLOGICAL ACTIVITY OF SYNTHETIC BIOTIN, ITS OPTICAL ISOMERS, AND RELATED COMPOUNDS

1945 • 35 citations

BIOTIN BIOSYNTHESIS I

1963 • 35 citations

Effect of insulin on pyruvate carboxylase in alloxan diabetic animals

1964 • 35 citations

Requirement for HCO3− by ATP: Urea amido-lyase in yeast

1970 • 35 citations

Studies on the mechanism of fatty acid synthesis

1957 • 35 citations

A Nuclear Magnetic Resonance Investigation of Biotin. The Biotin Sulfonium Ion^*

1966 • 35 citations

Studies on the Mechanism of Action of Acetyl Coenzyme A Carboxylase

1963 • 34 citations

The Carboxylation and Formylation of Certain 2-Tetralones^1,2

1966 • 34 citations

Propionyl apocarboxylase activation catalyzed by cell-free enzyme extracts

1961 • 34 citations

Pyruvate Carboxylase from Bakers' Yeast

1970 • 34 citations

Nutritional Studies with Clostridium parabotulinum Type A

1954 • 34 citations

SUCCINIC ACID DECARBOXYLATION SYSTEM IN PROPIONIBACTERIUM PENTOSACEUM AND VEILLONELLA GAZOGENES I

1956 • 33 citations

The biosynthesis of biotin in microorganisms

1965 • 33 citations

Studies on methylmalonyl isomerase

1962 • 33 citations

The control of gluconeogenesis by adrenal cortical hormones

1965 • 33 citations

The absolute configuration of methylmalonyl CoA and stereochemistry of the methylmalonyl CoA mutase reaction

1964 • 33 citations

Cure of Egg-White Injury in Rats by the "Toxic" Fraction (Avidin) of Egg White Given Parenterally

1941 • 33 citations

Mode of action of lipid-lowering agents. II. In vitro inhibition of acetyl coenzyme A carboxylase by a hypolipidemic drug

1970 • 33 citations

Studies on the Relationship betweeen Activity and Structure of Liver Acetyl‐CoA Carboxylase

1967 • 32 citations

METABOLIC FUNCTIONS OF BIOTIN

1949 • 32 citations

The Enzymatic Synthesis of Propionyl Coenzyme A Holocarboxylase from d-Biotinyl 5'-Adenylate and the Apocarboxylase

1965 • 32 citations

Spectroscopic evidence for the participation of tryptophan residues in the binding of biotin by avidin

1962 • 32 citations

Biotin and the Synthesis of Aspartic Acid by Microorganisms

1947 • 32 citations

Mechanism of biotin catalysis. II

1967 • 32 citations

The incorporation of 1,7 C14 pimelic acid into biotin vitamers

1962 • 32 citations

The Extraction of Biotin from Tissues

1941 • 31 citations

THE EFFECT OF ADRENAL CORTICAL HORMONE ON THE SYNTHESIS OF CARBOHYDRATE IN LIVER SLICES

1941 • 31 citations

GLYCOGEN FORMATION FROM GLUCOSE IN THE PRESENCE OF RADIOACTIVE CARBON DIOXIDE

1942 • 31 citations

Inhibition of yeast pyruvate carboxylase by L-aspartate and oxaloacetate

1966 • 31 citations

Fatty acid biosynthesis and RNA function in fasting, aging and diabetes

1966 • 31 citations

Isolation of Crystalline Biocytin from Yeast Extract

1952 • 31 citations

PROPIONIC ACID METABOLISM IN MOUSE LIVER SLICES

1952 • 31 citations

Effect of Bicarbonate on the Enzymic Synthesis of Long Chain Fatty Acids.

1958 • 31 citations

METABOLISM OF LACTIC ACID CONTAINING RADIOACTIVE CARBON IN THE α OR β POSITION

1942 • 31 citations

THE CHEMISTRY OF GLUCONEOGENESIS

1912 • 31 citations

The mechanism of allantoin catabolism by yeast

1953 • 31 citations

Avidin. II. Composition and mode of action of avidin A

1952 • 31 citations

A BIOTIN FUNCTION IN SUCCINIC ACID DECARBOXYLATION BY PROPIONIBACTERIUM PENTOSACEUM

1950 • 31 citations

Mechanism of tricarboxylic acid cycle regulation of fatty acid synthesis

1962 • 30 citations

The participation of acetyl-CoA in pyruvate carboxylase

1966 • 30 citations

Purification and crystallization of acetyl CoA carboxylase

1967 • 30 citations

The effect of univalent cations of activities catalyzed bovine-liver propionyl-CoA carboxylase

1967 • 30 citations

Dethiobiotin Synthesis from 7,8-Diaminopelargonic Acid in Cell-free Extracts of a Biotin Auxotroph of Escherichia coli K-12

1969 • 30 citations

PIMELIC ACID AS A GROWTH ACCESSORY FOR THE DIPHTHERIA BACILLUS

1937 • 30 citations

Enzymatic Activation of Carbon Dioxide

1958 • 30 citations

Possible Biochemical Implications of the Crystal Structure of Biotin

1959 • 30 citations

A New Enzyme in the Conversion of Propionyl Coenzyme A to Succinyl Coenzyme A

1961 • 30 citations

Biotin-Bound CO ₂ and the Mechanism of Enzymatic Carboxylation Reactions

1970 • 30 citations

The Structure of Biotin

1942 • 30 citations

The relationship of dermatitis in chicks to lack of vitamin B2 and to dietary egg-white

1934 • 30 citations

POLYPHASIC RESPONSE OF RESPIRATION AND AEROBIC PHOSPHORYLATION TO 2,4-DINITROPHENOL

1954 • 29 citations

The formation of phosphopyruvate by washed suspensions of sheep kidney particles

1954 • 29 citations

Biotin in the assimilation of heavy carbon in Oxalacetate.

1950 • 29 citations

THE EFFECT OF HEATING EGG WHITE ON CERTAIN CHARACTERISTIC PELLAGRA-LIKE MANIFESTATIONS PRODUCED IN RATS BY ITS DIETARY USE

1933 • 29 citations

Transcarboxylase

1970 • 29 citations

An intramolecular rearrangement in the methylmalonyl isomerase reaction as demonstrated by positive and negative ion mass analysis of succinic acid

1962 • 29 citations

Zur Struktur der CO₂‐Biotinenzyme

1962 • 29 citations

Apparent co-operative effect of acetyl-CoA on sheep kidney pyruvate carboxylase

1966 • 29 citations

The vitamin B complex

1951 • 29 citations

Propionyl-CoA holocarboxylase synthesis from biotinyl adenylate and the apocarboxylase in the presence of an activating enzyme

1963 • 29 citations

Restoration of biotin-deficiency-induced depression of propionyl carboxylase activity invivo and invitro

1961 • 29 citations

Effect of magnesium ions and adenosine triphosphate on the activity of acetyl coenzyme a carboxylase

1967 • 28 citations

Crystalline Avidin

1942 • 28 citations

Studies on Cultural Requirements of Bacteria

1937 • 28 citations

Biotin l-Sulfoxide. I. The Occurrence of a Previously Unrecognized Form of Biotin in Certain Fermentation Sources

1954 • 28 citations

The effects of palmitylcarnitine on hepatic fatty acid synthesis and on acetyl CoA carboxylase activity

1966 • 27 citations

beta-Methylcrotonyl-CoA-Carboxylase. Kristallisation und einige physikalische Eigenschaften

1970 • 27 citations

OLEIC ACID AS A GROWTH FACTOR FOR VARIOUS LACTOBACILLI

1947 • 27 citations

THE EFFECT OF 2,4-DINITROPHENOL ON THE FORMATION OF PHOSPHOENOLPYRUVATE BY LIVER MITOCHONDRIA

1954 • 27 citations

Stereochemie der enzymatischen Carboxylierung von (2R)‐2‐³H‐Propionyl‐Coenzym A

1966 • 27 citations

An Improved Method for the Preparation of Benzenediazonium Salts

1942 • 27 citations

Studies on the Mechanism of Fatty Acid Synthesis

1970 • 27 citations

THE ROLE OF SUCCINATE AS A PRECURSOR OF PROPIONATE IN THE PROPIONIC ACID FERMENTATION

1956 • 27 citations

ATTEMPTS TO ISOLATE THE FACTOR (VITAMIN H) CURATIVE OF EGG WHITE INJURY

1939 • 27 citations

Evidence for a Genetic Relationship between Avidins and Lysozymes

1968 • 27 citations

THE DETERMINATION OF OXYBIOTIN IN THE PRESENCE OF BIOTIN

1945 • 26 citations

Cortisone and the Regulation of Hepatic Gluconeogenesis¹

1962 • 26 citations

Studies with Acetyl Coenzyme A and Condensing Enzyme in D2O

1958 • 26 citations

In VitroEffect of Adrenal Steroids on Carbohydrate Synthesis in Liver

1964 • 26 citations

An Observation on the Value of Egg-White as the Sole Source of Nitrogen for Young Growing Rats

1924 • 26 citations

Synthesis of Biocytin

1952 • 26 citations

Studies on the mechanism of fatty acid synthesis. XXIV. The acetyl- and malonyltransacylase activities of pigeon liver fatty acid synthetase.

1970 • 26 citations

COFACTOR REQUIREMENTS FOR THE DECARBOXYLATION OF SUCCINATE

1953 • 26 citations

The Microbiological Activity of an Oxygen Analog of Biotin

1945 • 26 citations

The Mechanism of Propionic Acid Formation by Succinate Decarboxylation

1953 • 26 citations

RELEASE OF FREE AND BOUND FORMS OF BIOTIN FROM PROTEINS

1949 • 26 citations

Pyruvate carboxylase from sheep kidney. I. Purification and some properties of the enzyme.

1966 • 25 citations

The Elucidation of Biocytin

1951 • 25 citations

Intermediates of fatty acid synthesis: Sites of binding to the pigeon liver fatty acid synthetase

1970 • 25 citations

THE RELATION OF α-METHYLBUTYRATE TO ISOLEUCINE METABOLISM

1952 • 25 citations

Effects of Triamcinolone on Carbohydrate Synthesis by Rat Liver Slices

1963 • 25 citations

In vivo Inhibition of Lipogenesis by Biotin Deficiency.

1964 • 24 citations

Factors affecting fatty acid synthesis in cell-free preparations from Saccharomyces cerevisiae

1965 • 24 citations

Metabolism of Acetate and Propionate in the Ruminant

1950 • 24 citations

Assimilation of Carbon Dioxide in Oxalate and Citrate by Aspergillus Niger

1951 • 24 citations

THE RELATION OF "COENZYME R" TO BIOTIN

1939 • 24 citations

Alterations in the sensitivity to effectors of rat liver acetyl-CoA carboxylase following trypsin treatment

1969 • 24 citations

Distribution of Biotin and Avidin in Hen's Egg

1942 • 24 citations

Methylmalonyl-CoA decarboxylase: Partial purification and enzymatic properties

1968 • 24 citations

CO2 turnover in the fermentation of 3, 4, 5 and 6 carbon compounds by the propionic acid bacteria

1953 • 23 citations

BIOCYTIN, A NATURALLY-OCCURRING COMPLEX OF BIOTIN

1950 • 23 citations

THE METABOLISM OF OXYBIOTIN IN YEAST

1947 • 23 citations

Endocrinological Aspects of Avidin Formation in the Avian Oviduct

1944 • 23 citations

THE BIOTIN ACTIVITY OF A VACCENIC ACID FRACTION

1947 • 23 citations

A Theory Concerning the Mechanism of Fatty Acid Oxidation and of Carbon Dioxide Fixation

1952 • 23 citations

Conversion of Desthiobiotin Into Biotin or Biotinlike Substances by Some Microorganisms

1945 • 23 citations

Studies on carbon dioxide fixation in normal and alloxan-diabetic animals

1963 • 23 citations

The Production-of Fatty Acids in the Alimentary Tract of the Dog

1947 • 23 citations

Structure Determination of Biocytin as ε-N-Biotinyl-L-lysine

1952 • 23 citations

THE IN VITRO TURNOVER OF DICARBOXYLIC AMINO ACIDS IN LIVER SLICE PROTEINS

1947 • 22 citations

Amides and Amino Acid Derivatives of Biotin: Microbiological Studies

1951 • 22 citations

THE EFFECT OF CERTAIN REAGENTS ON THE ACTIVITY OF BIOTIN

1941 • 22 citations

Ueber das Verhalten phosphorhaltiger Eiweisskörper im Stoffwechsel

1898 • 22 citations

In vivo oxidation of glucose-C14 to C14O2 in biotin deficiency

1965 • 21 citations

Direct Evidence for the Conversion of Dethiobiotin to Biotin in Aspergillus niger

1966 • 21 citations

Formation of methylmalonyl-CoA and succinyl-CoA by extracts of Mycobacterium smegmatis

1962 • 21 citations

Zur Chemie des Biotins. Nachweis eines Harnstoffrings. 28. Mitteilung über pflanzliche Wachstumsstoffe

1941 • 21 citations

Studies on the Mechanism of Action of Acetyl Coenzyme A Carboxylase

1966 • 21 citations

Metabolism of Propionic Acid in Animal Tissues

1965 • 21 citations

THE AVIDIN-BIOTIN EQUILIBRIUM

1951 • 21 citations

RESYNTHESIS OF BIOTIN FROM A DEGRADATION PRODUCT

1941 • 20 citations

Yeast-Growth-Promoting Effect of Diaminocarboxylic Acid Derived from Biotin.

1942 • 20 citations

The biosynthesis of biotin in microorganisms

1965 • 20 citations

Isolated Fat Cells: Morphology and Possible Role of Released Lipoprotein Lipase in Deposition of Lipoprotein Fatty Acid

1969 • 20 citations

The activation of rat liver acetyl-CoA carboxylase by trypsin.

1967 • 20 citations

Studies on Mechanism of Glucose Synthesis in Diabetic and Normal Rat Liver

1966 • 20 citations

A ROLE OF BIOTIN IN THE INTERACTION OF ORNITHINE AND CARBAMYL PHOSPHATE

1956 • 20 citations

Citrate metabolism in diabetes

1967 • 19 citations

Enzymic carboxylation of butyryl coenzyme A

1959 • 19 citations

Heat Stability of Avidin and Avidin-Biotin Complex and Influence of Ionic Strength on Affinity of Avidin for Biotin.

1964 • 19 citations

Biosynthesis of biotin in microorganisms

1966 • 19 citations

Synthesis of chicken liver pyruvate holocarboxylase in vivo and in vitro

1970 • 19 citations

THE MICROBIOLOGICAL ACTIVITY OF dl-OXYBIOTIN AND RELATED COMPOUNDS

1945 • 19 citations

Zur Chemie des Biotins. Nachweis eines schwefelhaltigen Ringes. 29. Mitteilung über pflanzliche Wuchsstoffe

1941 • 18 citations

THE CONDENSATION OF PHENANTHRENEQUINONE WITH THE DIAMINOCARBOXYLIC ACID DERIVED FROM BIOTIN

1942 • 18 citations

Radioactive Carbon as an Indicator of Carbon Dioxide Utilization

1941 • 18 citations

SYNTHESIS OF A 3,4-DIAMINOTETRAHYDROTHIOPHENE AND A COMPARISON OF ITS STABILITY WITH THE DIAMINOCARBOXYLIC ACID DERIVED FROM BIOTIN

1942 • 18 citations

Effect of Biotin-Sparing Substances on Growth of Biotin-Deficient Saccharomyces cerevisiae and on the Synthesis of Nucleic Acids and Protein

1962 • 18 citations

THE EFFECTS OF ADENINE NUCLEOTIDES ON PYRUVATE METABOLISM IN RAT LIVER

1965 • 18 citations

Pyruvate carboxylase: Nuclear magnetic resonance studies of the enzyme-manganese-oxalacetate and enzyme-manganese-pyruvate bridge complexes

1970 • 18 citations

A role for carnitine and long chain acylcarnitine in the regulation of lipogenesis

1968 • 18 citations

The essential thiol group of propionyl-Coa carboxylase

1967 • 18 citations

THE AMINO ACID NUTRITION OF YEAST IN RELATIONSHIP TO BIOTIN DEFICIENCY

1954 • 18 citations

Effects of biotin deficiency on carbohydrate metabolism

1963 • 18 citations

THE NATURE OF THE COENZYME OF ASPARTIC ACID, SERINE, AND THREONINE DEAMINASES

1949 • 17 citations

INVESTIGATIONS ON THE STABILITY OF AVIDIN

1942 • 17 citations

Amide Metabolism in Yeasts

1962 • 17 citations

An early intermediate in the biosynthesis of biotin: Incorporation studies with [1,7-14C2]pimelic acid

1966 • 17 citations

BIOTIN-LIKE ACTIVITY OF POSITIONAL AND STEREOISOMERS OF OCTADECENOIC ACIDS

1951 • 17 citations

Transcarboxylation and CO2 “exchange” catalyzed by purified propionyl carboxylase

1960 • 17 citations

Further studies on the mechanism of the enzymic carboxylation of propionyl-CoA

1961 • 17 citations

Carbon Dioxide Fixation by Extracts of Streptococcus faecalis var. liquefaciens

1970 • 16 citations

Urea as a carbon source for Chlorella and Scenedesmus

1955 • 16 citations

Biotin. IV. Synthesis of 4-Benzamido-3-ketotetrahydrothiophene

1944 • 16 citations

SUCCINIC ACID DECARBOXYLATION SYSTEM IN PROPIONIBACTERIUM PENTOSACEUM AND VEILLONELLA GAZOGENES

1956 • 16 citations

Enzyme catalyzed exchange of 1-C14-propionyl CoA and methylmalonyl CoA

1961 • 16 citations

INTERCONVERSION OF PROPIONATE AND SUCCINATE BY PROPIONIBACTERIUM PENTOSACEUM

1951 • 16 citations

Amide metabolism in yeasts. II. The uptake of amide and amide like compounds by yeast.

1962 • 16 citations

Biotin- and adenosine triphosphate-dependent activation of propionyl apocarboxylase

1963 • 16 citations

The basicity of biotin

1968 • 16 citations

Biosynthesis of Desthiobiotin in Cell-free Extracts of Escherichia coli

1969 • 16 citations

Control of gluconeogenesis in biotin-deficient rat liver

1969 • 16 citations

ELEVATION OF BIOTIN ACTIVITY IN THE SERUM OF ESTROGEN TREATED CHICKS; RELATIONSHIP TO HORMONE-INDUCED AVIDIN FORMATION IN THE OVIDUCT

1949 • 15 citations

Position of the Carbon Dioxide-Carbon in Propionic Acid Synthesized by Propionibacterium.

1941 • 15 citations

The Liberation of Biotin from the Avidin-Biotin Complex (AB)

1943 • 15 citations

PARTICIPATION OF CHELATING METALS IN CARBOXYLATION REACTIONS

1960 • 15 citations

Effects of α-Glycerophosphate and of Palmityl-Coenzyme A on Lipid Synthesis in Yeast Extracts

1966 • 15 citations

PROPIONIC ACID METABOLISM: MECHANISM OF THE METHYLMALONYL ISOMERASE REACTION AND THE REDUCTION OF ACRYLYL COENZYME A TO PROPIONYL COENZYME A IN PROPIONIBACTERIA

1962 • 15 citations

An in vitro effect of cortisol on pyruvate carboxylase and gluconeogenesis

1964 • 15 citations

THE PRELIMINARY CHARACTERIZATION OF TWO BIOTIN-CONTAINING FRACTIONS IN BEEF LIVER

1950 • 15 citations

Biotin and bacterial growth. II. Avidin and the response of Lactobacillus arabinosus to oleic acid

1953 • 15 citations

The biosynthesis of biotin in microorganisms

1965 • 15 citations

Utilization of Acetic and Propionic Acids in Sheep

1950 • 15 citations

Quantitative Determination of Free and Conjugated Bilirubin by Diazo Coupling and a Liquid-Extraction and Column-Chromatographic Technique

1967 • 15 citations

Regulation of acetyl-CoA carboxylase of Saccharomyces cerevisiae

1967 • 15 citations

Substitution of -Alanine, Nicotinic Acid, and Pimelic Acid for Meat Extract in Growth of Diphtheria Bacillus

1937 • 15 citations

Synthesis of Desthiobiotin from 7,8-Diaminopel-argonic Acid in Biotin Auxotrophs of Escherichia coli K-12

1969 • 14 citations

THE TRANSFER OF CARBON FROM PROPIONATE TO AMINO ACIDS IN INTACT COWS

1958 • 14 citations

Biotin basicity

1969 • 14 citations

Restoration of gluconeogenesis in biotin-deficient rats

1969 • 14 citations

Biosynthesis of Biotin in Microorganisms VI. Further Evidence for Desthiobiotin as a Precursor in Escherichia coli

1967 • 14 citations

Biocytin as a constituent of methylmalonyl-oxaloacetic transcarboxylase and propionyl CoA carboxylase of bacterial origin

1964 • 13 citations

Coenzyme repression of acetyl-CoA carboxylase by (+)-biotin

1969 • 13 citations

Biosynthesis of Biotin in Microorganisms V. Control of Vitamer Production

1967 • 13 citations

On the mechanism of action of enzyme-bound biotin

1962 • 13 citations

The incorporation of pimelic acid as a unit in the biosynthesis of biotin

1963 • 13 citations

Investigation of the mechanism of enzymatic carboxylation of phosphoenolpyruvate

1962 • 13 citations

Mechanism of Pyruvate Carboxylase Formation from the Apo-Enzyme and Biotin in a Thermophilic Bacillus

1970 • 13 citations

Phosphoric-Carbonic Anhydrides.¹ The Hydrolysis of Dibenzyl p-Nitrocarbobenzoxy Phosphate

1965 • 13 citations

The activation of rat liver acetyl-CoA carboxylase by incubation

1968 • 13 citations

The effect of N-bromosuccinimide on the sub-unit structure of avidin and its complexes with biotin

1968 • 13 citations

Requirements for Mn++ and Mg++ in rat liver acetyl-CoA carboxylase and fatty acid biosynthesis activities

1968 • 12 citations

Enzyme reactions for carbon dioxide fixation in baker's yeast

1965 • 12 citations

A study of biotin sulfone.

1944 • 12 citations

THE NUCLEIC ACID OF AVIDIN

1950 • 12 citations

Relation Between Ovarian Function and Avidin Content in the Oviduct of the Hen

1943 • 12 citations

Desthiobiotin in the Biosynthesis of Biotin

1954 • 12 citations

Isolation and identification of 7-oxo-8-aminopelargonic acid, a biotin intermediate

1970 • 12 citations

"O-Heterohkrtin " a biologically active oxygen analog of biotin.

1945 • 12 citations

Net synthesis of methylmalonyl-CoA by ADP-, ATP-, and Mg-independent transcarboxylation catalyzed by propionyl carboxylase

1961 • 12 citations

Affinity of Avidin for Biocytin

1950 • 11 citations

Crystallization of Biotin Carboxylase, a Component Enzyme of the Acetyl-CoA Carboxylase System fromEscherichia coli

1971 • 11 citations

Biological Precursors of Biotin and/or Biotin L-Sulfoxide

1955 • 11 citations

BIOTIN. III. cis and trans FORMS RELATED TO dl-BIOTIN

1944 • 11 citations

Regulation of pyruvate carboxylase by coenzyme A and acyl coenzyme A thio esters

1968 • 11 citations

The metabolism of [1-14C]glucose in an enzyme system from Propionibacterium

1956 • 11 citations

Metabolism of -Methyl-C5 Fatty Acids by Mitochondria of Rat Liver: Effect of Biotin Nutriture.

1955 • 11 citations

Utilization of Aspartic Acid and Asparagine by Yeast

1950 • 11 citations

DNA of biotin-transducing λ bacteriophage

1969 • 11 citations

Production of vitamers of biotin by Corynebacterium xerose

1956 • 10 citations

Determination of Avidin by Use of Radioactive Biotin and Sephadex Chromatography.

1964 • 10 citations

CARBON DIOXIDE ASSIMILATION IN CELL-FREE LIVER EXTRACTS

1942 • 10 citations

The biosynthesis of biotin in growing yeast cells: The formation of biotin from an early intermediate

1966 • 10 citations

ADIPIC ACID AS AN OXIDATION PRODUCT OF THE DIAMINOCARBOXYLIC ACID DERIVED FROM BIOTIN

1942 • 10 citations

Die Fixierung von [¹⁴C]‐Biotin an die Leberproteine des Hühnchens

1962 • 10 citations

A STUDY OF THE BASIS OF SELECTIVITY OF ACTION OF ANTIMETABOLITES WITH ANALOGUES OF PIMELIC ACID

1950 • 10 citations

Studies on mechanism of gluconeogenesis in diabetes

1965 • 10 citations

Combinability of avidin and streptavidin with analogs of biotin

1965 • 10 citations

THE FORMATION OF ADIPIC ACID BY THE OXIDATIVE DEGRADATION OF THE DIAMINOCAR-BOXYLIC ACID DERIVED FROM BIOTIN

1941 • 10 citations

An Early Intermediate in the Biosynthesis of Biotin: Incorporation Studies with [35S]Sulphate

1966 • 10 citations

A MASS ANALYSIS STUDY OF THE METABOLISM OF PROPIONATE BY PROPIONIBACTERIUM ARABINOSUM

1958 • 9 citations

Effect of succinate on amino acid incorporation in biotin deficiency

1961 • 9 citations

FURTHER STUDIES ON THE BIOTIN COENZYME

1950 • 9 citations

Separation and differential sensitivity toward avidin of carbamyl phosphate synthetase and urea amidolyase

1969 • 9 citations

Structural requirements for substrate binding to propionyl-CoA carboxylase

1966 • 9 citations

Chemical Reactivity of Models Related to a Proposed CO2~Biotin Enzyme Complex II

1964 • 9 citations

THE HYDROLYSIS OF BIOTIN SULFONE

1942 • 8 citations

Some Properties of Avidin-uncombinable Unknown Biotin-Vitamer Produced byBacillussp. and its Role in Biosynthesis of Desthiobiotin

1966 • 8 citations

Activation of Mitochondrial Propionyl-CoA Carboxylase.

1963 • 8 citations

The Indirect Role of Biotin in the Synthesis of the Malic Enzyme

1961 • 8 citations

Studies on the biosynthesis of biotin. Production of biotin and biotin-like compounds by a pseudomonad

1965 • 8 citations

Effects of Biotin Deficiency on Pyruvate Metabolism.

1966 • 7 citations

Effect of Carbon Dioxide on the Aspartic Acid Requirement for Proteinase Biosynthesis by Streptococcus faecalis var. liquefaciens

1969 • 7 citations

THE EFFECT OF BIOS ON THE NITROGEN METABOLISM OF YEAST

1940 • 7 citations

Water Soluble Vitamins

1949 • 7 citations

Adrenocortical hormones and carbohydrates synthesis in liver

1965 • 7 citations

DURCHBLUTUNGSVERSUCHE DES MAGENS

1933 • 7 citations

Enzymic carboxylation of butyryl coenzyme A. I. Conversion of butyryl coenzyme A to 2-ethylmalonyl coenzyme A

1961 • 6 citations

Reaktivierung der Fettsäuresynthese beim Biotinmangelhühnchen durch Biotinzugabe in vitro

1963 • 6 citations

The biological activity of oxybiotin for the rat and the chick.

1945 • 6 citations

A MASS ANALYSIS STUDY OF FORMALDEHYDE FIXATION AND CLEAVAGE OF LACTATE BY PROPIONIBACTERIUM ARABINOSUM

1958 • 5 citations

The endogenous formation of phosphoenolpyruvate by rat-liver mitochondria

1960 • 5 citations

Über die Aktivierung des Biotins

1964 • 5 citations

The Vitamins

1948 • 5 citations

The Influence of Univalent Cations on Crystalline Propionyl CoA Carboxylase.

1963 • 5 citations

Affinity of Avidin for Certain Analogs of Biotin

1947 • 5 citations

A specific requirement for biotin in the synthesis of ornithine carbamoyltransferase by yeast

1966 • 5 citations

Biotin Nutriture and the Enzymatic Incorporation of NaHC14O3 into Acetoacetate

1951 • 4 citations

Protection of chicken liver pyruvate carboxylase by sulphate ions against avidin inhibition

1970 • 4 citations

Über die Aktivierung des Biotins und die Bildung der Acetyl‐CoA‐Holocarboxylase in der Leber de Hühnchens

1964 • 3 citations

[79] Methylmalonyl CoA isomerase

1962 • 3 citations

The Carboxylation of 3-Phenyl-2,4-oxazolidinedione

1965 • 3 citations

[61] Enzymes of branched-chain amino acid metabolism

1962 • 2 citations

Biological activity of oxybiotin in the chick.

1946 • 2 citations

ADAPTIVE BEHAVIOR OF CITRATE CLEAVAGE ENZYME**Supported by NSF GB 3412.

1965 • 2 citations