The identification of an eukaryotic initiation factor 4D precursor in spermidine-depleted Chinese hamster ovary cells.

Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

1978 • 998 citations

Two dimensional gel electrophoresis and computer analysis of proteins synthesized by clonal cell lines.

1979 • 759 citations

Anti-proliferative properties of DL-α-difluoromethyl ornithine in cultured cells. A consequence of the irreversible inhibition of ornithine decarboxylase

1978 • 398 citations

Polyamines as physiological substrates for transglutaminases.

1980 • 310 citations

Identification of hypusine, an unusual amino acid, in a protein from human lymphocytes and of spermidine as its biosynthetic precursor.

1981 • 267 citations

Identification of the hypusine-containing protein hy+ as translation initiation factor eIF-4D.

1983 • 205 citations

The biosynthesis of protein-bound hypusine (N epsilon -(4-amino-2-hydroxybutyl)lysine). Lysine as the amino acid precursor and the intermediate role of deoxyhypusine (N epsilon -(4-aminobutyl)lysine).

1982 • 154 citations

Hypusine, a new amino acid occurring in bovine brain

1971 • 113 citations

Large deletions in the cytoplasmic kinase domain of the epidermal growth factor receptor do not affect its laternal mobility.

1986 • 97 citations

Recent Progress in Polyamine Research

1987 • 96 citations

Hypusine formation in protein by a two-step process in cell lysates.

1987 • 80 citations

Post-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells

1986 • 74 citations

Relationship between inhibition of polyamine biosynthesis and DNA replication in activated lymphocytes.

1979 • 73 citations

Initiation of eukaryotic protein synthesis

1981 • 60 citations

Decreased protein-synthetic activity is an early consequence of spermidine depletion in rat hepatoma tissue-culture cells

1984 • 57 citations

The biosynthesis of hypusine (N epsilon-(4-amino-2-hydroxybutyl)lysine). Alignment of the butylamine segment and source of the secondary amino nitrogen.

1984 • 54 citations

Changes in eIF-4D hypusine modification or abundance are not correlated with translational repression in HeLa cells.

1986 • 50 citations

Regulation of biosynthesis of hypusine in Chinese hamster ovary cells. Evidence for eIF-4D precursor polypeptides.

1987 • 47 citations

The mammalian hypusine-containing protein, eukaryotic initiation factor 4D. Structural homology of this protein from several species.

1984 • 43 citations

Dissociation of the early antiproliferative action of methylglyoxal bis(guanylhydrazone) from polyamine depletion

1979 • 37 citations

Eukaryotic initiation factor 4D. Purification from human red blood cells and the sequence of amino acids around its single hypusine residue.

1986 • 37 citations

Irreversible inhibition of the early increase in ornithine decarboxylase activity following growth stimulation is required to block Ehrlich ascites tumor cell proliferation in culture

1980 • 37 citations

Polyamine depletion results in impairment of polyribosome formation and protein synthesis before onset of DNA synthesis in mitogen-activated human lymphocytes

1985 • 34 citations

Hypusine formation in eukaryotic initiation factor 4D is not reversed when rates or specificity of protein synthesis is altered.

1987 • 25 citations