Lipoxygenase products of arachidonic acid modulate biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human neutrophils via phospholipase A2.

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

LEUKOCYTE-DEPENDENT HISTAMINE RELEASE FROM RABBIT PLATELETS

1972 • 1,214 citations

Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators).

1979 • 1,203 citations

Arachidonic acid metabolism in polymorphonuclear leukocytes

1979 • 812 citations

Antihypertensive activity of an alkyl ether analog of phosphatidylcholine

1979 • 562 citations

Binding of trifluoperazine to the calcium-dependent activator of cyclic nucleotide phosphodiesterase.

1977 • 544 citations

Activation of human neutrophils with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycerol-3-phosphorylcholine (platelet activating factor).

1981 • 390 citations

Enzymatic synthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a hypotensive and platelet-aggregating lipid.

1980 • 321 citations

Metabolism of arachidonic acid in ionophore-stimulated neutrophils. Esterification of a hydroxylated metabolite into phospholipids.

1979 • 297 citations

Release and metabolism of arachidonic acid in human neutrophils.

1981 • 281 citations

Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) from 1-alkyl-2-acyl-sn-glycero-3-phosphocholine by rat alveolar macrophages. Phospholipase A2 and acetyltransferase activities during phagocytosis and ionophore stimulation.

1983 • 266 citations

Structural analysis of purified platelet-activating factor by lipases

1977 • 262 citations

Human neutrophil-derived platelet activating factor.

1980 • 260 citations

Platelet‐activating factor and macrophages. I. Evidence for the release from rat and mouse peritoneal macrophages and not from mastocytes

1979 • 244 citations

Aggregation of rabbit platelets by platelet-activating factor is independent of the release reaction and the arachidonate pathway and inhibited by membrane-active drugs.

1979 • 217 citations

Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid.

1982 • 202 citations

Platelet activating factor. Stimulation of the lipoxygenase pathway in polymorphonuclear leukocytes by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine.

1982 • 194 citations

Biosynthesis of platelet-activating factor

1982 • 185 citations

Metabolic, membrane, and functional responses of human polymorphonuclear leukocytes to platelet-activating factor

1982 • 177 citations

Acetyl glyceryl ether phosphorylcholine stimulates leukotriene B4 synthesis in human polymorphonuclear leukocytes.

1982 • 177 citations

Preparation and purification of arachidonic acid hydroperoxides of biological importance

1979 • 161 citations

Biosynthesis of platelet activating factor in rabbit polymorphonuclear neutrophils.

1983 • 160 citations

Activation of 1-alkyl-2-lysoglycero-3-phosphocholine. Acetyl-CoA transferase during phagocytosis in human polymorphonuclear leukocytes.

1982 • 158 citations

Biosynthesis of platelet-activating factor (PAF-acether) II. Involvement of phospholipase A2 in the formation of PAF-acether and lyso-PAF-acether from rabbit platelets

1982 • 142 citations

Identification of phospholipid platelet-activating factor (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human amniotic fluid and urine

1983 • 140 citations

Ionophores stimulate prostaglandin and thromboxane biosynthesis

1977 • 133 citations

Mono- and dihydroxyeicosatetraenoic acids alter calcium homeostasis in rabbit neutrophils.

1981 • 110 citations

Platelet-activating factor today

1983 • 102 citations

Esterification of an endogenously synthesized lipoxygenase product into granulocyte cellular lipids

1981 • 93 citations

Mechanism of arachidonic acid release in human polymorphonuclear leukocytes

1983 • 93 citations

Evidence for multiple metabolic pools of phosphatidylinositol in stimulated platelets.

1982 • 73 citations

Phospholipase A activity associated with membranes of human polymorphonuclear leucocytes

1977 • 67 citations

Biosynthesis of platelet-activating factor (PAF)acether). III. Formation of PAF-acether from synthetic substrates by stimulated murine macrophages.

1982 • 65 citations

5-L-hydroxy-6,8,11,14-eicosatetraenoate potentiates the human neutrophil degranulating action of platelet-activating factor

1983 • 62 citations

Phospholipase A₂ activity in the plasma membrane of human polymorphonuclear leukocytes

1981 • 50 citations

The lipoxygenase product, 5-hydroperoxy-arachidonic acid, augments chemotactic peptide-stimulated arachidonic acid release from HL60 granulocytes

1982 • 30 citations

Calmodulin antagonists inhibit formation of platelet-activating factor in stimulated human neutrophils

1984 • 21 citations