Neurochemical Aspects of Tolerance to and Physical Dependence on Alcohol

Handbook of Experimental Pharmacology.

1971 • 1,547 citations

Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the “dopamine receptor”

1972 • 1,022 citations

Induction of physical dependence upon ethanol and the associated behavioral changes in rats

1975 • 740 citations

EFFECT OF TEMPERATURE ON THE COMPOSITION OF FATTY ACIDS IN ESCHERICHIA COLI

1962 • 735 citations

Dopamine Receptor Binding Enhancement Accompanies Lesion-Induced Behavioral Supersensitivity

1977 • 716 citations

Über die Bildung von Isochinolin‐derivaten durch Einwirkung von Methylal auf Phenyl‐äthylamin, Phenyl‐alanin und Tyrosin

1911 • 651 citations

On the specificity of naloxone as an opiate antagonist

1979 • 611 citations

HIGH AFFINITY TRANSPORT OF CHOLINE INTO SYNAPTOSOMES OF RAT BRAIN¹

1973 • 585 citations

Alcohol, Amines, and Alkaloids: A Possible Biochemical Basis for Alcohol Addiction

1970 • 558 citations

An Experimental Study of the Etiology of “Rum Fits” and Delirium Tremens

1955 • 518 citations

High Blood Acetaldehyde Levels after Ethanol Administration

1975 • 514 citations

Drug Tolerance in Biomembranes: A Spin Label Study of the Effects of Ethanol

1977 • 511 citations

Alcohol Intoxication and Withdrawal

1976 • 481 citations

Evidence for Boundary Lipid in Membranes

1973 • 461 citations

Effects of low concentrations of ethanol on the fluidity of spin-labeled erythrocyte and brain membranes.

1977 • 458 citations

Alkaloids from Catecholamines in Adrenal Tissue: Possible Role in Alcoholism

1970 • 441 citations

Alteration of ethanol self-administration by naltrexone

1980 • 402 citations

Free Tryptophan in Plasma and Brain Tryptophan Metabolism

1972 • 380 citations

Biphasic action of ethanol

1977 • 373 citations

Role of brain norepinephrine in audiogenic seizure in the rat.

1973 • 363 citations

Regulation of allosteric membrane-bound enzymes through changes in membrane lipid composition

1975 • 355 citations

Brain acetylcholine: Increase after systematic choline administration

1975 • 338 citations

Effect of ethanol on the hydroxylation of tyrosine and tryptophan in rat brain in vivo

1973 • 312 citations

The metabolism of ethanol and its metabolic effects.

1972 • 291 citations

Bioenergetics Bulletin Prospers

1970 • 281 citations

Perspectives in Neuropharmacology

1973 • 261 citations

Increased cholesterol content of erythrocyte and brain membranes in ethanol-tolerant mice

1978 • 248 citations

Alcohol and Aldehyde Metabolizing Systems-IV

1980 • 241 citations

β-Adrenergic Receptor Involvement in 6-Hydroxydopamine-Induced Supersensitivity in Rat Cerebral Cortex

1976 • 238 citations

Involvement of cholinergic presynaptic receptors of nicotinic and muscarinic types in the control of the spontaneous release of dopamine from striatal dopaminergic terminals in the rat.

1977 • 237 citations

ALTERATIONS IN THE TURNOVER OF BRAIN NOREPINEPHRINE AND DOPAMINE IN ALCOHOL‐DEPENDENT RATS

1974 • 231 citations

Alcohol Withdrawal Syndrome in Mice.

1969 • 222 citations

Gaba agonists and antagonists

1979 • 222 citations

The Effect of Fatty Acids on the Binding of Tryptophan to Plasma Protein

1973 • 221 citations

Fermentativer Abbau von l-Dioxyphenylalanin (Dopa) durch Niere

1938 • 217 citations

Influence of fatty acid and sterol composition on the lipid phase transition and activity of membrane-bound enzymes in Acholeplasma laidlawii

1973 • 217 citations

Alcohol withdrawal reactions in mice: effects of drugs that modify neurotransmission.

1973 • 213 citations

A review of methods to induce alcohol addiction in animals

1973 • 210 citations

The Role of Cyclic AMP and Calcium in Cell Activatio

1972 • 209 citations

Inhibition of synaptosomal calcium uptake by ethanol.

1980 • 203 citations

Morphine and Ethanol: Selective Depletion of Regional Brain Calcium

1974 • 203 citations

Effects of ethanol on neurotransmitter release by rat brain cortical.

1975 • 199 citations

Conditioning and extinction of tolerance to the hypothermic effect of ethanol in rats.

1980 • 197 citations

Alterations in phospholipid-dependent (Na++K+)-ATPase activity due to lipid fluidity

1975 • 196 citations

Studies on plasma membranes

1972 • 191 citations

Effects of ethanol on central and peripheral noradrenergic neurons.

1974 • 188 citations

Alterations in γ‐Aminobutyric Acid Receptor Sensitivity Following Acute and Chronic Ethanol Treatments

1980 • 188 citations

Alcohol Drinking: Abnormal Intake Caused by Tetrahydropapaveroline in Brain

1977 • 183 citations

Effects of single doses and chronic administration of ethanol on experimental seizures in mice.

1958 • 177 citations

Synaptosomal membrane lipids of mice during continuous exposure to ethanol

1977 • 169 citations

Direct effects of ethanol on the nervous system.

1975 • 169 citations

Brain acetaldehyde after ethanol administration

1976 • 169 citations

A study of the alcohol-tolerance effect and an introduction of a new behavioural technique

1968 • 166 citations

Relevance of free tryptophan in serum to tissue tryptophan concentrations

1974 • 161 citations

Supersensitivity and Subsensitivity of the β-Adrenergic Receptor in Pineal Gland Regulated by Catecholamine Transmitter

1973 • 161 citations

Corticosterone concentrations in mice during ethanol drinking and withdrawal

1978 • 159 citations

Stimulation of Dopamine Synthesis in Caudate Nucleus by Intrastriatal Enkephalins and Antagonism by Naloxone

1978 • 157 citations

Dopamine-Related Tetrahydroisoquinolines: Significant Urinary Excretion by Alcoholics After Alcohol Consumption

1979 • 157 citations

Rapid development of tolerance to the hypothermic effect of ethanol in mice.

1979 • 150 citations

Tetrahydroisoquinolines in vivo. I. Rat brain formation of salsolinol, a condensation product of dopamine and acetaldehyde, under certain conditions during ethanol intoxication

1975 • 149 citations

Acquisition and loss of tolerance to ethanol by the rat.

1969 • 148 citations

The ß-adrenergic receptor and adenylate cyclase

1976 • 148 citations

The effect of ethanol on the activity of central catecholamine neurones in rat brain

1966 • 144 citations

BRAIN LEVELS AND TURNOVER RATES OF PRESUMPTIVE NEUROTRANSMITTERS AS INFLUENCED BY ADMINISTRATION AND WITHDRAWAL OF ETHANOL IN MICE¹

1974 • 143 citations

Ethanol-induced fluidization of brain lipid bilayers: required presence of cholesterol in membranes for the expression of tolerance.

1979 • 142 citations

THE GAMMA‐AMINOBUTYRIC ACID (GABA) SYSTEM IN BRAIN DURING ACUTE AND CHRONIC ETHANOL INTOXICATION

1975 • 141 citations

Biogenic Amine-Aldehyde Condensation Products: Tetrahydroisoquinolines and Tryptolines (szlig-Carbolines)

1980 • 140 citations

EFFECTS OF ETHANOL ON THE ACTIVITY OF ADENOSINE TRIPHOSPHATASE AND ACETYLCHOLINESTERASE IN SYNAPTOSOMES ISOLATED FROM GUINEA-PIG BRAIN

1970 • 139 citations

Cognitive performance measured on the ascending and descending limb of the blood alcohol curve

1972 • 139 citations

Behavioral augmentation of tolerance to ethanol in the rat

1973 • 139 citations

Effect of ethanol on the metabolism of brain catecholamines

1973 • 137 citations

On the supersensitivity of dopamine receptors, induced by neuroleptics

1976 • 135 citations

The acetaldehyde content in rat brain during ethanol metabolism

1974 • 133 citations

BRAIN CONCENTRATIONS OF BIOGENIC AMINE METABOLITES IN ACUTELY TREATED AND ETHANOL‐DEPENDENT RATS

1976 • 131 citations

Ethanol-induced alterations of norepinephrine metabolism in man.

1967 • 131 citations

Naloxone-induced inhibition of ethanol dependence in mice

1977 • 130 citations

PREVENTION OF EFFECTS OF ALCOHOL INTOXICATION BY NALOXONE

1979 • 129 citations

Alterations in β-adrenergic receptor binding during ethanol withdrawal

1978 • 128 citations

Effects of lower alcohols on potassium transport and microsomal adenosine-triphosphatase activity of rat cerebral cortex

1966 • 127 citations

Changes in cation transport and (Na + K)-activated adenosine triphosphatase produced by chronic administration of ethanol.

1970 • 125 citations

The effects of 6-hydroxydopamine on tolerance to and dependence on ethanol.

1977 • 125 citations

Modifications in the response to alcohol following the establishment of physical dependence

1971 • 124 citations

Uncoupling of Catecholamine Activation of Pigeon Erythrocyte Membrane Adenylate Cyclase by Filipin

1974 • 124 citations

New Concepts in Neurotransmitter Regulation

1973 • 123 citations

Serum Cortisol Levels in Alcoholic and Nonalcoholic Subjects During Experimentally Induced Ethanol Intoxication

1966 • 121 citations

An animal model for testing effects of drugs on alcohol withdrawal reactions.

1972 • 118 citations

Aminophospholipid Asymmetry in Murine Synaptosomal Plasma Membrane

1980 • 117 citations

Metabolic Aspects of Alcoholism

1976 • 115 citations

Development of functional dependence on ethanol in dopaminergic systems.

1979 • 113 citations

CHANGES IN MONOAMINE CONCENTRATIONS IN MOUSE BRAIN ASSOCIATED WITH ETHANOL DEPENDENCE AND WITHDRAWAL

1974 • 112 citations

Modification of environmentally cued tolerance to ethanol in mice.

1981 • 111 citations

Naloxone blocks the excitatory effect of ethanol and chlordiazepoxide on lateral hypothalamic self-stimulation behavior

1978 • 110 citations

Stimulation of dopamine release by GABA in rat striatal slices

1978 • 109 citations

Alteration of cortical and reticular acetylcholine release by ethanol in vivo.

1973 • 108 citations

The dopamine-releasing actions of neuroleptics and ethanol.

1974 • 107 citations

Activation of adenylate cyclase by ethanol in mouse striatal tissue.

1981 • 106 citations

Microsomal Ethanol Oxidizing System (MEOS): Current Status of Its Characterization and Its Role

1977 • 105 citations

Characterization of Acute and Chronic Tolerance in Mice Selected for Inherent Differences in Sensitivity to Ethanol

1980 • 104 citations

Adenylate cyclase-coupled beta adrenergic receptors effect of membrane lipid-perturbing agents on receptor binding and enzyme stimulation by catecholamines.

1976 • 101 citations

Phospholipid unsaturation and plasma membrane organization

1975 • 100 citations

In Vitro Study of beta-Adrenergic Receptors

1977 • 99 citations

Effects of ethanol administration and withdrawal on neurotransmitter receptor systems in C57 mice.

1980 • 99 citations

Antagonism of the enhanced susceptibility to audiogenic seizures during alcohol withdrawal in the rat by gamma-aminobutyric acid (GABA) and "GABA-mimetic" agents.

1979 • 98 citations

Effects of acute and chronic ethanol intake on synaptosomal glutamate binding activity

1978 • 97 citations

Opiate-receptor mediated changes in monoamine synthesis in rat brain

1978 • 97 citations

Formation of 1-methyl-6-methoxy-1,2,3,4-tetrahydro-2-carboline under physiological conditions

1961 • 96 citations

Inherited Differences in Intensity of Alcohol Withdrawal Reactions in Mice

1973 • 95 citations

Alcohol drinking in the rat induced by acute intracerebral infusion of two tetrahydroisoquinolines and a β-carboline

1977 • 95 citations

Effect of acute and chronic administration of ethanol on the 5-hydroxytryptamine turnover and tryptophan hydroxylase activity of the mouse brain

1971 • 92 citations

Alterations in Phospholipid Composition in Ethanol Tolerance and Dependence

1979 • 90 citations

Reduction of striatal dopamine release during an ethanol withdrawal syndrome

1977 • 89 citations

Chronic ethanol feeding produces an increase in muscarinic cholinergic receptors in mouse brain

1979 • 89 citations

Participation of an endogenous Ca++-blinding protein activator in the development of drug-induced supersensitivity of striatal dopamine receptors.

1977 • 88 citations

The role of free serum tryptophan in the biphasic effect of acute ethanol administration on the concentrations of rat brain tryptophan, 5-hydroxytryptamine and 5-hydroxyindol-3-ylacetic acid

1976 • 87 citations

Opioid peptides

1980 • 86 citations

Experimentally induced ethanol dependence in rhesus monkeys.

1970 • 85 citations

Acute recovery and tolerance to low doses of alcohol: Differences in cognitive and motor skill performance

1979 • 85 citations

EFFECTS OF ETHANOL ON SEROTONIN METABOLISM IN BRAIN

1974 • 85 citations

Sodium-potassium-activated adenosine triphosphatase activity as a measure of neuronal membrane characteristics in ethanol-tolerant mice.

1980 • 84 citations

Dissociation of alcohol tolerance and dependence

1976 • 83 citations

The effects of subhypnotic doses of ethanol on regional catecholamine turnover.

1978 • 83 citations

Ethanol dependence and tolerance: a nutritionally controlled experimental model in the rat.

1973 • 82 citations

Alcohol Tolerance in a Cholinergic Nerve Terminal: Relation to the Membrane Expansion-Fluidization Theory of Ethanol Action

1977 • 82 citations

Alterations in dopamine receptor sensitivity by chronic ethanol treatment

1977 • 82 citations

Effects of chlorimipramine and lysergic acid diethylamide on efflux of precursor-formed 3-H-serotonin: correlations with serotonergic impulse flow.

1975 • 82 citations

Neuroamine Condensations in Human Subjects

1980 • 81 citations

Mechanism of ethanol-induced changes in lipid composition of Escherichia coli: inhibition of saturated fatty acid synthesis in vivo

1978 • 80 citations

On the functional role of pre- and postsynaptic catecholamine receptors in brain.

1975 • 79 citations

ALCOHOL AND OPIATES: A REVIEW OF COMMON NEUROCHEMICAL AND BEHAVIORAL MECHANISMS

1977 • 79 citations

INHIBITION OF THE TRANSPORT OF 5‐HYDROXYINDOLEACETIC ACID FROM BRAIN BY ETHANOL¹

1975 • 79 citations

The effect of long-term ethanol treatment on the sensitivity of the dopamine receptors in the nucleus accumbens

1976 • 78 citations

Effect of Ethanol Dependence and Withdrawal on the Catecholamines in Rat Brain and Heart

1975 • 78 citations

Depression of Serotonin and Norepinephrine Levels in Brain Stem of Rabbit by Ethanol.

1960 • 78 citations

The binding of Ca2+ to the cell membrane increased by volatile anesthetics (alcohols, acetone, ether) which induce sensitization of nerve or muscle

1971 • 76 citations

Commentary on Ethanol Tolerance

1982 • 76 citations

Noradrenergic sensitivity of the cerebral cortex after chronic ethanol ingestion and withdrawal.

1975 • 75 citations

Biosynthesis of the Morphine Alkaloids

1967 • 74 citations

Effects of acute and chronic ethanol on the γ-aminobutyric acid system in rat brain

1973 • 74 citations

Effects of acute and chronic ethanol administration on whole mouse brain synaptosomal calcium influx

1980 • 73 citations

Perturbation of membrane fluidity

1975 • 70 citations

Formation of Tetrahydropapaveroline from Dopamine in vitro

1964 • 70 citations

Dopamine receptor function after chronic ingestion of ethanol

1978 • 70 citations

CATECHOLAMINE‐SENSITIVE ADENYLATE CYCLASES IN NERVOUS TISSUES

1977 • 69 citations

Effects of the Diet on Brain Neurotransmitters

2009 • 68 citations

Acute and chronic ethanol ingestion and serotonin metabolism in rat brain.

1978 • 67 citations

Regulation of nigrostriatal and tuberoinfundibular-hypophyseal dopaminergic neurons

1979 • 67 citations

Tetrahydropapaveroline: an alkaloid metabolite of dopamine in vitro.

1970 • 67 citations

Biochemical regulation and physiological significance of cyclic nucleotides in the nervous system.

1977 • 67 citations

The effect of ethanol on the amino acids of the rat brain with a reference to the administration of glutamine

1961 • 66 citations

SELECTIVE ACTION OF ALCOHOLS ON CEREBRAL CALCIUM LEVELS

1976 • 66 citations

Effect of ethanol administration on cyclic 3',5'-adenosine monophosphate metabolism in brain

1973 • 65 citations

Ethanol: Modifications of Acute Intoxication by Divalent Cations

1978 • 64 citations

Effect of acute ethanol treatment on transmitter synthesis and metabolism in central dopaminergic neurons

1976 • 64 citations

Ethanol and caffeine: A complex interaction with respect to locomotor activity and central catecholamines

1974 • 64 citations

Noradrenergic involvement in the acute effects of ethanol.

1975 • 64 citations

Benzodiazepine receptors remain unchanged after chronic ethanol administration

1980 • 63 citations

Addiction and Brain Damage

1981 • 63 citations

Changes in the Sensitivity of Dopamine Receptors in the Nucleus Accumbens and in the Striatum Induced by Chronic Ethanol Administration

1978 • 63 citations

Determination of tetrahydroisoquinoline alkaloids in biological materials with high performance liquid chromatography

1977 • 63 citations

Turnover rates and steady-state levels of brain serotonin in alcohol-dependent rats

1974 • 62 citations

Pharmacological aspects of physical dependence on ethanol

1976 • 62 citations

Accelerated development of tolerance during repeated cycles of ethanol exposure

1978 • 61 citations

Alcohol Dependence and Opiate Dependence: Lack of Relationship in Mice

1971 • 61 citations

ELECTROENCEPHALOGRAPHIC CHANGES ASSOCIATED WITH CHRONIC ALCOHOLIC INTOXICATION AND THE ALCOHOL ABSTINENCE SYNDROME

1956 • 61 citations

Effect of p-chlorophenylalanine on the acquisition of tolerance to ethanol and pentobarbital

1975 • 61 citations

The role of phosphatidylserine in the hormonal control of adenylate cyclase of rat liver plasma membranes

1972 • 60 citations

ALTERATIONS IN RECEPTORS CONTROLLING DOPAMINE SYNTHESIS AFTER CHRONIC ETHANOL INGESTION

1978 • 60 citations

Effects of acute and chronic ethanol administration and withdrawal on adenosine 3':5'-monophosphate and guanosine 3':5'-monophosphate levels in the rat brain.

1977 • 60 citations

Regional brain acetylcholine levels in rats acutely treated with ethanol or rendered ethanol-dependent

1976 • 59 citations

Guanyl nucleotide regulation of hormonally-responsive adenylyl cyclases

1979 • 59 citations

Alcohol withdrawal reactions and reserpine effects in inbred strains of mice

1974 • 58 citations

Pavlovian control of cross-tolerance between pentobarbital and ethanol

1981 • 57 citations

THE EFFECT OF ETHANOL ON ACETYLCHOLINE SYNTHESIS, RELEASE, AND DEGRADATION IN BRAIN

1967 • 57 citations

Metabolic Effects of Alcohol on the Liver

1977 • 57 citations

Identification of an Isoquinoline Alkaloid after Chronic Exposure to Ethanol

1978 • 55 citations

Catecholamine synthesis in rat brain after axotomy: Interaction between apomorphine and haloperidol

1977 • 53 citations

Changes in activity and hormonal sensitivity of brain adenyl cyclase following chronic ethanol administration

1972 • 52 citations

The Chimpanzee as an Animal Model for Investigating Alcoholism

1972 • 52 citations

PYRIDOXAL PHOSPHATE AND GLUTAMATE DECARBOXYLASE IN SUBCELLULAR PARTICLES OF MOUSE BRAIN AND THEIR RELATIONSHIP TO CONVULSIONS¹

1973 • 52 citations

The Formation, Degradation, and Function of Cyclic Nucleotides in the Nervous System

1977 • 52 citations

Biogenic Amines, Biogenic Aldehydes, and Alcohol

1964 • 51 citations

Effects of ethanol, arecoline, atropine and nicotine, alone and in various combinations, on rat cerebellar cyclic guanosine 3′,5′-monophosphate

1979 • 51 citations

Effect of acute and chronic ethanol administration on serotonin turnover in rat brain

1974 • 51 citations

Effect of ethanol tolerance on release of acetylcholine and norepinephrine by rat cerebral cortex slices

1977 • 50 citations

Calcium binding to brain synaptosomes

1979 • 50 citations

Modification of glycoprotein residues as Ca2+ receptor sites after chronic ethanol exposure

1977 • 49 citations

Stimulation of dopamine synthesis and release by morphine and D-Ala2-D-Leu5-enkephalin in the mouse striatum

1981 • 47 citations

An inborn alcohol tolerance in alcohol-preferring rats. The lack of relationship between tolerance to ethanol and the brain microsomal (Na+K+) ATPase activity

1977 • 47 citations

Correlation between drug-induced supersensitivity of dopamine dependent striatal mechanisms and the increase in striatal content of the Ca2+ regulated protein activator of cAMP phosphodiesterase

1977 • 46 citations

Massive benzodiazepine requirements during acute alcohol withdrawal

1979 • 46 citations

Adrenal glucocorticoids as a required factor in the development of ethanol withdrawal seizures in mice

1974 • 45 citations

Regional distribution of ethanol in the rat brain

1978 • 45 citations

Reduction in brain gamma-aminobutyric acid and in barbital narcosis during ethanol withdrawal.

1973 • 45 citations

Acetaldehyde occurrence in cerebrospinal fluid during ethanol oxidation in rats and its dependence on the blood level and on dietary factors

1977 • 44 citations

Drug-induced changes in lipid composition of and of mammalian cells in culture: Ethanol, pentobarbital, and chlorpromazine

1978 • 44 citations

Preferential inhibition of the low Km aldehyde dehydrogenase activity by pargyline

1977 • 44 citations

Potentiation of leptazol seizures by 6-hydroxydopamine

1973 • 43 citations

Absence of formation of brain salsolinol in ethanol-dependent mice.

1977 • 42 citations

Catecholamine stimulated myocardial adenylate cyclase: Effects of phospholipase digestion and the role of membrane lipids

1975 • 41 citations

Alteration of alcohol effects by calcium and other inorganic cations

1979 • 41 citations

Alterations in brain cyclic guanosine 3':5'-monophosphate levels after acute and chronic treatment with ethanol.

1977 • 41 citations

Synaptosomal transport and acetylation of choline

1977 • 41 citations

Physical dependence on alcohol in mice.

1975 • 41 citations

Effect of chronic administration of ethanol on (Na + K)‐activated ATPase activity in six areas of the cat brain

1972 • 40 citations

Effects of ethanol withdrawal, stress and amphetamine on rat brain (Na+ + K+-ATPase

1978 • 40 citations

Endogenous opiates: Through 1978

1979 • 40 citations

Adenylate cyclase from various dopaminergic areas of the brain and the action of antipsychotic drugs

1977 • 38 citations

Lack of alteration in regional brain adenosine-3′, 5′-cyclic monophosphate levels after acute and chronic treatment with ethanol

1976 • 37 citations

Effect of p-chlorophenylalanine on the acquisition of tolerance to the hypothermic effects of ethanol

1978 • 37 citations

Adaptative Changes in Ca++-Membrane Interactions Following Chronic Ethanol Exposure

1977 • 37 citations

TOLERANCE AS ADAPTATION: INTERACTIONS WITH BEHAVIOR AND PARALLELS TO OTHER ADAPTIVE PROCESSES

1977 • 36 citations

Acquisition of behavioral tolerance to ethanol as a function of reinforced practice in rats

1979 • 36 citations

Dopamine levels in the striatum and the effect of alcohol and reserpine

1977 • 36 citations

Involvement of the dopamine nigrostriatal system in the picrotoxin effect on striatal acetylcholine levels

1977 • 35 citations

Possible role of GABA in the development of tolerance to alcohol

1977 • 35 citations

Interaction of ethanol and catecholamines on rat brain (Na⁺ + K⁺)-ATPase

1979 • 35 citations

Effects of ethanol on mouse brain (Na+K)-activated adenosine triphosphatase.

1972 • 35 citations

Studies on plasma membranes. VI. Differences in the effect of temperature on the ATPase and (Na+-K+)-ATPase activities of plasma membranes isolated from rat liver and hepatoma

1968 • 35 citations

Cerebrospinal fluid homovanillic acid in male alcoholics: effects of disulfiram.

1977 • 34 citations

Role of impulse flow in the short-term regulation of norepinephrine biosynthesis

1979 • 34 citations

Effect of Ethanol on Membranes: A Fluorescent Probe Study

1979 • 34 citations

Neurochemical correlates of ethanol withdrawal: alterations in serotoninergic function

1977 • 33 citations

Effect of Ethanol on 5-Hydroxytryptamine Turnover in Rat Brain

1970 • 33 citations

Effect of 5,7-dihydroxytryptamine on the development of tolerance to ethanol

1980 • 33 citations

Effect of chronic ethanol administration on phospholipid acyl groups of synaptic plasma membrane fraction isolated from guinea pig brain.

1979 • 33 citations

Behavioural changes during withdrawal from desmethylimipramine (DMI)

1981 • 33 citations

Acute and chronic ethanol-induced alterations in brain norepinephrine metabolites in the rat

1976 • 33 citations

The regulation of the kinetic state of striatal tyrosine hydroxylase and the role of postsynaptic dopamine receptors

1975 • 31 citations

ALTERATIONS IN HIGH-AFFINITY CHOLINE UPTAKE IN BRAIN AFTER ACUTE AND CHRONIC ETHANOL TREATMENT

1978 • 31 citations

<scp>Part</scp> 2. Psychophysiological Findings

1964 • 31 citations

Ethanol Alters Kinetic Characteristics and Function of Striatal Morphine Receptors

1981 • 30 citations

Effects of disulfiram and chloral hydrate on the metabolism of catecholamines in rat liver and brain

1977 • 30 citations

Experimental Ethanol Ingestion: Sleep Variables and Metabolites of Dopamine and Serotonin in the Cerebrospinal Fluid

1975 • 29 citations

The effects of ethanol ingestion on cyclic AMP, homovanillic acid and 5-hydroxyindoleacetic acid in human cerebrospinal fluid

1976 • 28 citations

Ethanol-induced increase in the penetration of exogenously administered L-dopa through the blood-brain barrier

1979 • 28 citations

Quantitative Changes of Signs and Symptoms Associated with Acute Alcohol Withdrawal: Incidence, Severity and Circadian Effects in Experimental Studies of Alcoholics

1975 • 28 citations

EFFECTS OF DRUGS AFFECTING ENDOGENOUS AMINES OR CYCLIC NUCLEOTIDES ON ETHANOL WITHDRAWAL HEAD TWITCHES IN MICE

1976 • 28 citations

Modification of ethanol intoxication by dopamine agonists and antagonists

1979 • 27 citations

Effect of Modification of Brain Serotonin (5‐HT) on Ethanol Tolerance

1979 • 27 citations

The Pharmacology of Sedative/Hypnotics, Alcohol, and Anesthetics: Sites and Mechanisms of Action

1977 • 27 citations

Acute tolerance to ethanol on the release of acetylcholine from the cat cerebral cortex

1978 • 27 citations

ELECTROENCEPHALOGRAPHIC AND OTHER EVIDENCE FOR MIXED DEPRESSANT AND STIMULANT ACTIONS OF ALCOHOLIC BEVERAGES

1973 • 26 citations

Dopamine-receptor binding and adenylate-cyclase activity in mouse striatal tissue in the supersensitivity phase after neuroleptic treatment

1978 • 26 citations

Inhibition of sodium, potassium, and magnesium activated ATPases by acetaldehyde and "biogenic" aldehydes.

1974 • 26 citations

Ethanol-Induced Changes in Cation-Stimulated Adenosine Triphospha-Tase Activity and Lipid-Proteolipid Labeling of Brain Microsomes

1975 • 26 citations

Effects of chemical injection into the reticular formation of rats.

1964 • 26 citations

Addiction and Brain Damage

2016 • 26 citations

Effect of ethanol on the cyclic AMP system in rat brain.

1977 • 24 citations

Ethanol-induced spontaneous norepinephrine release from the rat vas deferens.

1979 • 24 citations

Involvement of the lipid and protein components of (Na+ + K+)-adenosine triphosphatase in the inhibitory action of alcohol

1980 • 23 citations

Enhancement of ethanol-induced withdrawal convulsions by blockade of 5-hydroxytryptamine receptors

1976 • 23 citations

Requirement for adrenal glucocorticoid in the ethanol-induced increase of tryptophan hydroxylase activity in mouse brain

1974 • 23 citations

Functional tolerance to ethanol in mice: relationship to lipid metabolism

1979 • 22 citations

Effect of ethanol and stress on gamma-aminobutyric acid and guanosine 3′, 5′-monophosphate levels in the rat brain

1979 • 22 citations

Use of Single Unit Recording in Correlating Transmitter Turnover with Impulse Flow in Monoamine Neurons

1973 • 21 citations

Ethanol-induced conformational changes in rat brain microsomal membranes

1977 • 21 citations

Ethanol inhibition of transport of 5-hydroxyindoleacetic acid from cerebrospinal fluid

1975 • 20 citations

THE RAPID ONSET OF FUNCTIONAL TOLERANCE TO ETHANOL—ROLE OF DIFFERENT NEUROTRANSMITTERS AND SYNAPTOSOMAL MEMBRANE LIPIDS

1980 • 20 citations

Relationship between 3,4‐Dihydroxyphenylacetaldehyde Levels and Tetrahydropapaveroline Formation

1978 • 20 citations

Receptor‐Mediated Dopaminergic Function After Ethanol Withdrawal

1980 • 19 citations

Sensitivity to alcohol in mice with an altered brain fatty acid composition

1981 • 19 citations

Disposition of Catecholamine-Derived Alkaloids in Mammalian Systems

1975 • 19 citations

Effect of depletion of brain catecholamines on ethanol tolerance and dependence

1979 • 19 citations

Ethanol intoxication and the activities of glutamate decarboxylase and γ‐aminobutyrate aminotransferase in rat brain

1979 • 18 citations

Ethanol-induced changes in activities of adenylate cyclase, guanylate cyclase and cyclic adenosine 3′,5′-monophosphate dependent protein kinase in the brain and liver

1977 • 16 citations

Noradrenaline receptor sensitivity after chronic ethanol administration

1978 • 16 citations

The effects of alcohol on cyclic AMP in mouse brain

1976 • 15 citations

Is serotonin or are its metabolites responsible for induction of hypothermia?

1976 • 14 citations

Effects of enkephalins and two enzyme resistant analogues on monoamine synthesis and metabolism in rat brain

1980 • 14 citations

ETHANOL AND ACETALDEHYDE METABOLISM DURING ETHANOL CONSUMPTION

1977 • 14 citations

The influence of mouse genotype on the changes in brain cyclic nucleotide levels induced by acute alcohol administration

1979 • 14 citations

Effect of depletion of brain 5-hydroxytryptamine by 5,7-dihydroxytryptamine on ethanol tolerance and dependence in the rat

1980 • 14 citations

EFFECTS OF CHRONIC CONSUMPTION OF ETHANOL AND SUCROSE ON RAT WHOLE BRAIN 5‐HYDROXYTRYPTAMINE

1975 • 13 citations

Na,K‐ATPase: The role of state of lipids and Mg ions in activity regulation

1977 • 13 citations

Alcohol withdrawal effects on brain serotonin in mice behaviorally attracted to alcohol.

1976 • 10 citations

Cyclic adenosine 3′,5′-monophosphate, adenylate cyclase and physical dependence on ethanol: Studies with tranylcypromine

1977 • 10 citations

Alterations of fast-reacting sulfhydryl groups of rat brain microsomes by ethanol

1976 • 10 citations

Ethanol and the metabolic interrelations of carbohydrates and amino acids in brain preparations

1972 • 10 citations

Induction of Alcohol Withdrawal Symptoms by Nalorphine in Chronic Alcoholic Patients

1978 • 10 citations

Chronic ethanol and neural C-AMP

1978 • 8 citations

γ‐Aminobutyric Acid in Alcohol, Barbiturate and Morphine Dependence: A review*

1977 • 8 citations

Cellular Tolerance to Ethanol as Membrane Adaptation: A Review

1979 • 8 citations

Alteration in serum tyrosine and tryptophan concentrations associated with the induction of physical dependence on ethanol in mice

1978 • 5 citations

Effect of tolerance to morphine, ethanol and barbiturate on amphetamine circling in rats with a striatal dopamine lesion

1978 • 4 citations

Some biochemical effects of ethanol on CNS.

1974 • 3 citations

Altered activation of tyrosine hydroxylation by γ-butyrolactone following chronic ethanol treatment

1979 • 2 citations

Ethanol and glutamate receptor function

1979 • 2 citations

Failure to detect conversion of 3H-dopamine to tetrahydroisoquinoline derivatives in the brains of rats treated with alcohol or chloral hydrate

1980 • 1 citations

Deleted Work

1955 • 0 citations