Induction of the p16INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

Revised Criteria for the Classification of Rheumatoid Arthritis

1990 • 7,730 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

1987 • 2,539 citations

Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment

1993 • 2,182 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

1997 • 1,651 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

1996 • 944 citations

Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome

1997 • 753 citations

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

1994 • 731 citations

Regulation of p16^CDKN2 Expression and Its Implications for Cell Immortalization and Senescence

1996 • 713 citations

Novel INK4 Proteins, p19 and p18, Are Specific Inhibitors of the Cyclin D-Dependent Kinases CDK4 and CDK6

1995 • 657 citations

Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase

1995 • 612 citations

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging

1997 • 555 citations

Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

1998 • 481 citations

Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization.

1994 • 418 citations

Apoptosis in rheumatoid arthritis synovium.

1995 • 378 citations

The role of T cells in the immunopathogenesis of rheumatoid arthritis. New perspectives

1997 • 295 citations

Upregulation of integrins alpha v beta 3 and alpha v beta 5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery

1995 • 292 citations

Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor α soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects

1998 • 285 citations

Multiple adenovirus serotypes use alpha v integrins for infection

1994 • 284 citations

Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death

1997 • 234 citations

Anti-Tumor Necrosis Factor-α Therapy of Rheumatoid Arthritis

1997 • 233 citations

Adenovirus-Mediated Transfer of Viral IL-10 Gene Inhibits Murine Collagen-Induced Arthritis

1998 • 200 citations

Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer.

1997 • 196 citations

Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy.

1996 • 188 citations

Prevention of murine collagen‐induced arthritis in the knee and ipsilateral paw by local expression of human interleukin‐1 receptor antagonist protein in the knee

1997 • 186 citations

Adenoviral-mediated gene transfer to rabbit synovium in vivo.

1993 • 186 citations

Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins.

1995 • 185 citations

Monoclonal anti‐TNFα Antibody as a Probe of Pathogenesis and Therapy of Rheumatoid Disease

1995 • 182 citations

Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells

1997 • 139 citations

Plasmid DNA encoding transforming growth factor-beta1 suppresses chronic disease in a streptococcal cell wall-induced arthritis model.

1998 • 134 citations

Induction of senescence in human malignant glioma cells by p16INK4A

1997 • 131 citations

Suppression of collagen‐induced arthritis through adenovirus‐mediated transfer of a modified tumor necrosis factor α receptor gene

1997 • 100 citations

Adenovirus-mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells.

1996 • 84 citations

Features of replicative senescence induced by direct addition of antennapedia‐p16^INK4A fusion protein to human diploid fibroblasts

1998 • 84 citations

Accumulation of p16CDKN2A in response to ultraviolet irradiation correlates with late S-G(2)-phase cell cycle delay.

1996 • 59 citations

Overexpression of cell cycle inhibitors (p16INK4 and p21Cip1) and cyclin D1 using adenovirus vectors regulates proliferation of rat mesangial cells.

1997 • 54 citations

Expression of the p16 and p15 cyclin-dependent kinase inhibitors in lymphocyte activation and neuronal differentiation.

1995 • 48 citations

Fractionated Total Lymphoid Irradiation: A Promising New Treatment for Rheumatoid Arthritis? Yes, No, Maybe

1987 • 18 citations