Back to search

The orexin system regulates alcohol‐seeking in rats

Data up to Jan 2025

Published2006
Citations384
References56

Total Citations Per Year

Abstract

References (56)

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

1998 • 3,711 citations

Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB 1 Receptor Knockout Mice

1999 • 3,597 citations

Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

1998 • 3,381 citations

Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions

1991 • 3,177 citations

Narcolepsy in orexin Knockout Mice

1999 • 3,014 citations

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

1999 • 2,583 citations

Naltrexone in the Treatment of Alcohol Dependence

1992 • 1,875 citations

The reinstatement model of drug relapse: history, methodology and major findings

2002 • 1,586 citations

Naltrexone and Coping Skills Therapy for Alcohol Dependence

1992 • 1,510 citations

Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity

2001 • 1,387 citations

A role for lateral hypothalamic orexin neurons in reward seeking

2005 • 1,266 citations

Orexin A activates locus coeruleus cell firing and increases arousal in the rat

1999 • 1,182 citations

Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons

2005 • 830 citations

Corticostriatal-hypothalamic circuitry and food motivation: Integration of energy, action and reward

2005 • 741 citations

Orexin A in the VTA Is Critical for the Induction of Synaptic Plasticity and Behavioral Sensitization to Cocaine

2006 • 704 citations

Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system

1999 • 587 citations

Excitation of Ventral Tegmental Area Dopaminergic and Nondopaminergic Neurons by Orexins/Hypocretins

2003 • 569 citations

Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior

2005 • 507 citations

Hypocretin-1 Modulates Rapid Eye Movement Sleep through Activation of Locus Coeruleus Neurons

2000 • 506 citations

Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations

1999 • 502 citations

Direct Involvement of Orexinergic Systems in the Activation of the Mesolimbic Dopamine Pathway and Related Behaviors Induced by Morphine

2006 • 501 citations

Anatomical substrates of orexin–dopamine interactions: lateral hypothalamic projections to the ventral tegmental area

2002 • 499 citations

Ethanol consumption and resistance are inversely related to neuropeptide Y levels

1998 • 477 citations

Interaction between the Corticotropin-Releasing Factor System and Hypocretins (Orexins): A Novel Circuit Mediating Stress Response

2004 • 445 citations

Additive Effect of Stress and Drug Cues on Reinstatement of Ethanol Seeking: Exacerbation by History of Dependence and Role of Concurrent Activation of Corticotropin-Releasing Factor and Opioid Mechanisms

2002 • 357 citations

Overlapping distributions of orexin/hypocretin‐ and dopamine‐β‐hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress

2003 • 343 citations

Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor

1999 • 276 citations

SB‐334867, a selective orexin‐1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin‐A in rats

2001 • 230 citations

Hypocretin/Orexin Selectively Increases Dopamine Efflux within the Prefrontal Cortex: Involvement of the Ventral Tegmental Area

2005 • 180 citations

Hypocretin/orexin depolarizes and decreases potassium conductance in locus coeruleus neurons

2000 • 166 citations

Voluntary Alcohol Consumption Is Controlled via the Neuropeptide Y Y1 Receptor

2002 • 160 citations

Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholism

2004 • 152 citations

Stress and Arousal: The Corticotrophin-Releasing Factor/Hypocretin Circuitry

2005 • 137 citations

Ethanol-Induced Conditioned Place Preference Is Expressed Through a Ventral Tegmental Area Dependent Mechanism.

2005 • 125 citations

The role of opioid-dopamine interactions in the induction and maintenance of ethanol consumption

1999 • 124 citations

The Metabotropic Glutamate 5 Receptor Antagonist 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine Reduces Ethanol Self-Administration in Multiple Strains of Alcohol-Preferring Rats and Regulates Olfactory Glutamatergic Systems

2005 • 121 citations

The GABAB receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats

2006 • 117 citations

Blockade of central neuropeptide Y (NPY) Y2 receptors reduces ethanol self-administration in rats

2002 • 92 citations

Neurobiological responses to ethanol in mutant mice lacking neuropeptide Y or the Y5 receptor

2000 • 85 citations

The acute anti‐craving effect of acamprosate in alcohol‐preferring rats is associated with modulation of the mesolimbic dopamine system

2005 • 81 citations

Neuropeptide Y Reduces Oral Ethanol Intake in Alcohol‐Preferring (P) Rats Following a Period of Imposed Ethanol Abstinence

2003 • 78 citations

The CRF1 receptor antagonist antalarmin reduces volitional ethanol consumption in isolation-reared fawn-hooded rats

2003 • 72 citations

Alterations in Central Preproenkephalin mRNA Expression After Chronic Free‐Choice Ethanol Consumption by Fawn‐Hooded Rats

2001 • 66 citations

Neuropeptide Y and Alcoholism: Genetic, Molecular, and Pharmacological Evidence

2003 • 57 citations

Orexin, drugs and motivated behaviors

2005 • 49 citations

Satiety enhancement by selective orexin-1 receptor antagonist SB-334867: influence of test context and profile comparison with CCK-8S

2004 • 41 citations

Neuropeptides: implications for alcoholism

2004 • 40 citations

Actions of nitric oxide and expression of the mRNA encoding nitric oxide synthase in rat vagal afferent neurons

1996 • 36 citations

The role of NPY in the mediation of orexin-induced hypothermia

2002 • 34 citations

Orexin Expression and Function: Glucocorticoid Manipulation, Stress, and Feeding Studies

2005 • 34 citations

The Corticotropin-Releasing Factor-Hypocretin Connection: Implications in Stress Response and Addiction

2005 • 31 citations

Comparative analysis of the central CCK system in Fawn Hooded and Wistar Kyoto rats: extended localisation of CCK-A receptors throughout the rat brain using a novel radioligand

2001 • 26 citations

Cholecystokinin and Bombesin Inhibit Ethanol and Food Intake in Rats Selectively Bred for Ethanol Sensitivity

1993 • 24 citations

Sensitized effects of neuropeptide Y on multiple ingestive behaviors in P rats following ethanol abstinence

2005 • 14 citations

Exogeneous and endogenous CCK inhibit ethanol ingestion in Sardinian alcohol-preferring rats

2004 • 7 citations

Cited By (0)

Loading...