Back to search

Treatment discontinuation with selective serotonin reuptake inhibitors (SSRIs) versus tricyclic antidepressants (TCAs)

Data up to Jan 2025

Published2000
Citations81
References157

Total Citations Per Year

Abstract

References (157)

Meta-analysis in clinical trials

1986 • 36,193 citations

Diagnostic Criteria for Use in Psychiatric Research

1972 • 5,688 citations

Depression, Disability Days, and Days Lost From Work in a Prospective Epidemiologic Survey

1990 • 1,203 citations

Trials to assess equivalence: the importance of rigorous methods

1996 • 1,022 citations

Recognition and management of depression in general practice: consensus statement.

1992 • 556 citations

Selective serotonin reuptake inhibitors: meta-analysis of efficacy and acceptability.

1993 • 403 citations

Paroxetine: A selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study

1990 • 390 citations

Treatment discontinuation with selective serotonin reuptake inhibitors compared with tricyclic antidepressants: a meta-analysis

1995 • 313 citations

Effectiveness of antidepressants

1999 • 274 citations

Initial antidepressant choice in primary care. Effectiveness and cost of fluoxetine vs tricyclic antidepressants

1996 • 271 citations

Selective serotonin reuptake inhibitors

1994 • 261 citations

Antidepressant efficacy of sertraline: a double-blind, placebo- and amitriptyline-controlled, multicenter comparison study in outpatients with major depression.

1990 • 261 citations

A Comparison of Fluoxetine Imipramine and Placebo in Patients with Bipolar Depressive Disorder

1989 • 256 citations

A review of multicenter controlled studies of fluoxetine vs. imipramine and placebo in outpatients with major depressive disorder.

1985 • 244 citations

What Price Depression?

1994 • 226 citations

[Biological psychiatry].

1992 • 220 citations

A Comparison of Paroxetine, Imipramine and Placebo in Depressed Out-patients

1991 • 175 citations

The Treatment of Chronic Depression, Part 2

1998 • 165 citations

Initial Antidepressant Choice in Primary Care

1996 • 163 citations

The compliance with antidepressants in general practice

1994 • 149 citations

Discontinuation rates of SSRIs and tricyclic antidepressants: a meta-analysis and investigation of heterogeneity

1997 • 145 citations

Fluvoxamine and clomipramine in depressed patients A DOUBLE‐BLIND CLINICAL STUDY

1981 • 136 citations

Putting trials on trial--the costs and consequences of small trials in depression: a systematic review of methodology.

1997 • 133 citations

A comparison of fluoxetine, imipramine, and placebo in patients with major depressive disorder.

1985 • 131 citations

A Double-Blind, Placebo-Controlled Study Comparing the Effects of Sertraline Versus Amitriptyline in the Treatment of Major Depression

1997 • 126 citations

A comparative clinical trial of fluoxetine, mianserin and placebo in depressed outpatients

1988 • 112 citations

Double-blind comparison of bupropion and fluoxetine in depressed outpatients.

1991 • 109 citations

Are SSRIs a Cost-Effective Alternative to Tricyclics?

1996 • 107 citations

Longitudinal patterns of antidepressant prescribing in primary care in the UK: comparison with treatment guidelines

1999 • 103 citations

Comparison of the tolerability and efficacy of citalopram and?amitriptyline in elderly depressed patients treated in general practice

1998 • 93 citations

Acute, Subchronic and Withdrawal Sleep EEG Changes During Treatment With Paroxetine and Amitriptyline: A Double-Blind Randomized Trial in Major Depression

1995 • 91 citations

Paroxetine in the treatment of depression ‐ a randomized comparison with amitriptyline

1985 • 86 citations

Selective serotonin reuptake inhibitors have broadened the utilisation of antidepressant treatment in accordance with recommendations

1999 • 84 citations

The cost of treatment dropout in depression A cost-benefit analysis of fluoxetine vs. tricyclics

1994 • 84 citations

Treatment of chronic depression with sertraline or imipramine: preliminary blinded response rates and high rates of undertreatment in the community.

1995 • 83 citations

Fluoxetine, a Selective Serotonin Uptake Inhibitor, for the Treatment of Outpatients with Major Depression

1988 • 80 citations

A double‐blind placebo‐controlled study of fluvoxamine and imipramine in out‐patients with primary depression.

1983 • 80 citations

A double‐blind, multicentre study of paroxetine versus clomipramine in depressed elderly patients

1989 • 77 citations

A Placebo-controlled Inpatient Comparison of Fluvoxamine Maleate and Imipramine in Major Depression

1989 • 77 citations

A study comparing paroxetine placebo and imipramine in depressed patients

1993 • 76 citations

Compliance in depressed patients treated with fluoxetine or amitriptyline

1998 • 72 citations

A Double-Blind, Multicenter Study in Primary Care Comparing Paroxetine and Clomipramine in Patients With Depression and Associated Anxiety

1997 • 71 citations

A comparative trial of fluoxetine and amitriptyline in patients with major depressive disorder.

1985 • 69 citations

Fluoxetine in depressed patients: a comparison with imipramine.

1984 • 69 citations

Fluoxetine Versus Trazodone in Depressed Geriatric Patients

1989 • 68 citations

Fluoxetine and Desipramine in Major Depressive Disorder

1993 • 66 citations

A double‐blind controlled clinical trial comparing fluvoxamine with imipramine.

1983 • 66 citations

Paroxetine in the Treatment of Elderly Depressed Patients in General Practice

1992 • 64 citations

A double-blind placebo-controlled study of fluvoxamine and imipramine in depression.

1985 • 64 citations

A double-blind, placebo-controlled comparison of sertraline and dothiepin in the treatment of major depression in general practice

1994 • 62 citations

Comparative effects of fluoxetine and amitriptyline on cardiac function.

1988 • 62 citations

Fluoxetine Compared with Imipramine in the Treatment of Inpatient Depression A Multicenter Trial

1993 • 62 citations

Depression: An Integrative Approach

1991 • 61 citations

Citalopram and imipramine in the treatment of depressive patients in general practice. A Nordic multicentre clinical study

1994 • 60 citations

Multicenter double blind study of paroxetine and amitriptyline in elderly depressed inpatients

1995 • 59 citations

Citalopram versus mianserin

1985 • 58 citations

Clinical trials of fluvoxamine vs chlorimipramine with single and three times daily dosing.

1983 • 58 citations

Treatment of major affective disorder with fluvoxamine.

1987 • 58 citations

A Double-Blind Comparison of Fluoxetine, Imipramine and Placebo in Outpatients with Major Depression

1989 • 57 citations

Response to Total Sleep Deprivation Before and During Treatment with Fluvoxamine or Maprotiline in Patients with Major Depression - Results of a Double-Blind Study

1990 • 54 citations

Fluoxetine compared with amitriptyline in elderly depression: a controlled clinical trial.

1989 • 52 citations

Double-Blind Multicenter Study of Paroxetine and Amitriptyline in Depressed Inpatients

1993 • 50 citations

Should Anxiety and Insomnia Influence Antidepressant Selection

1998 • 49 citations

Is Baseline Agitation a Relative Contraindication for a Selective Serotonin Reuptake Inhibitor

1994 • 49 citations

A double-blind comparison of fluvoxamine, imipramine and placebo in depressed patients

1984 • 48 citations

A comparison of the effect of flouxetine and trazodone on the cognitive functioning of depressed outpatients

1990 • 48 citations

Double‐blind comparative multicentre study of fluvoxamine and mianserin in the treatment of major depressive episode in elderly people

1991 • 47 citations

High-Dose Fluoxetine

1991 • 46 citations

A double-blind, randomised comparison of fluvoxamine with dothiepin in the treatment of depression in elderly patients.

1991 • 46 citations

A Comparison of Fluoxetine and Amitriptyline in the Treatment of Major Depression

1991 • 46 citations

Citalopram versus maprotiline: A controlled, clinical multicentre trial in depressed patients

1987 • 45 citations

The role of neuropharmacologic selectivity in antidepressant action: fluvoxamine versus desipramine.

1990 • 45 citations

Fluvoxamine, imipramine, and placebo in the treatment of depressed outpatients: effects on depression.

1989 • 45 citations

A Double-blind Parallel Study Comparing Fluoxetine with Imipramine in the Treatment of Atypical Depression

1991 • 43 citations

A Controlled Comparison of Fluoxetine and Amitriptyline in Depressed Out-patients

1987 • 42 citations

A comparative trial of fluoxetine versus trazodone in outpatients with major depression.

1989 • 42 citations

A double-blind comparison of fluvoxamine, desipramine and placebo in outpatients with depression

1990 • 42 citations

A Double-Blind Multicentre Study of Paroxetine and Amitriptyline in Depressed Outpatients

1992 • 41 citations

Paroxetine and imipramine in the treatment of depressive patients in psychiatric practice

1992 • 41 citations

A double‐blind comparative study of the clinical efficacy of fluvoxamine and chlorimipramine.

1983 • 41 citations

Fluoxetine vs Amitriptyline in the Treatment of Depressed Out-patients

1988 • 41 citations

A double‐blind comparison of citalopram (Lu 10–171) and amitriptyline in depressed patients

1987 • 41 citations

Double-Blind, Multicenter Comparative Study of Sertraline and Amitriptyline in Hospitalized Patients with Major Depression

1998 • 40 citations

Antidepressant efficacy in relation to item analysis and severity of depression

1995 • 40 citations

A Comparative Trial of a New Antidepressant, Fluoxetine

1987 • 40 citations

A Comparison of the Antidepressant Action of Citalopram and Amitriptyline

1986 • 40 citations

A placebo- and imipramine-controlled study of paroxetine.

1990 • 39 citations

Paroxetine in the treatment of depression

1988 • 39 citations

The short- and long-term efficacy of paroxetine HCl: A. Data from a 6-week double-blind parallel design trial vs. imipramine and placebo.

1989 • 38 citations

A Double-Blind Comparative Clinical Trial of Citalopram vs Maprotiline in Hospitalized Depressed Patients

1987 • 38 citations

A Double-blind Comparative Study of Fluoxetine and Dothiepin in the Treatment of Depression in General Practice

1989 • 37 citations

Comparative efficacy and safety of nortriptyline and fluoxetine in the treatment of major depression: a clinical study.

1991 • 37 citations

A double-blind comparison of sertraline and clomipramine in the treatment of major depressive disorder and associated anxiety in general practice

1994 • 37 citations

Fluvoxamine and imipramine in the treatment of depressive patients: A double-blind controlled study

1990 • 37 citations

Response to treatment in minor and major depression: results of a double-blind comparative study with paroxetine and maprotiline

1997 • 36 citations

A Randomized, Double-Blind Study of Fluoxetine and Maprotiline in the Treatment of Major Depression

1991 • 36 citations

Orthostatic side effects of clomipramine and citalopram during treatment for depression

1985 • 35 citations

A double-blind comparison of paroxetine, imipramine, and placebo in major depression.

1992 • 34 citations

A comparison of fluoxetine and imipramine in the treatment of outpatients with major depressive disorder

1993 • 34 citations

Fluoxetine versus amitriptyline in the treatment of major depression

1993 • 33 citations

A double-blind, randomized comparison of fluvoxamine with mianserin in depressive illness

1990 • 33 citations

Paroxetine and amitriptyline in the treatment of depression in general practice

1996 • 33 citations

Health economics of depression

1994 • 33 citations

A double-blind controlled comparison of fluoxetine and lofepramine in major depressive illness

1994 • 33 citations

The impact of sertraline, desipramine, and placebo on psychomotor functioning in depression

1995 • 32 citations

Double-Blind Comparative Study of Paroxetine and Amitriptyline in Depressed Patients of a University Psychiatric Outpatient Clinic (Pilot Study)

1985 • 32 citations

A 12‐week double‐blind multi‐centre study of paroxetine and imipramine in hospitalized depressed patients

1994 • 32 citations

A double‐blind study of the comparative antidepressant effect of paroxetine and amitriptyline

1989 • 32 citations

Antidepressant Response and Plasma Concentrations of Fluoxetine

1991 • 31 citations

Antidepressant Use Over Time in a Rural Older Adult Population: The MoVIES Project

1997 • 31 citations

TREATMENT OF MAJOR DEPRESSION IN GENERAL PRACTICE: A DOUBLE‐BLIND COMPARISON OF PAROXETINE AND LOFEPRAMINE

1996 • 30 citations

Randomized Double-Blind Study of Fluvoxamine and Maprotiline in Treatment of Depression

1991 • 30 citations

The Risk-Benefit Assessment of Antidepressant Drugs

1987 • 29 citations

Controlling Acute Episodes of Depression

1991 • 29 citations

A double‐blind study to compare the effectiveness and tolerability of paroxetine and amitriptyline in depressed patients

1989 • 28 citations

Fluoxetine vs. clomipramine in depressed patients: a controlled multicentre trial

1991 • 27 citations

A double‐blind clinical trial of fluvoxamine and imipramine in patients with primary depression

1984 • 27 citations

A double‐blind comparison of fluvoxamine and dothiepin in the treatment of major affective disorder

1988 • 26 citations

Inadequate dosaging in general practice of tricyclic vs. other antidepressants for depression

1998 • 25 citations

A Multicentre Double Blind Trial of Fluoxetine versus Amitriptyline in the Treatment of Depressive Illness

1993 • 25 citations

Does placebo help establish equivalence in trials of new antidepressants?

2000 • 24 citations

Is Anxious-Agitated Major Depression Responsive to Fluoxetine? A Double-Blind Comparison with Amitriptyline

1998 • 24 citations

Paroxetine and imipramine treatment of depressive patients in a controlled multicentre study with plasma amino acid measurements

1991 • 24 citations

THE EFFECTS OF PSYCHOMOTOR PERFORMANCE OF FLUVOXAMINE VERSUS MIANSERIN IN DEPRESSED PATIENTS IN GENERAL PRACTICE

1991 • 24 citations

Fluoxetine versus clomipramine in major depressive disorders.

1989 • 23 citations

Antidepressant agents: from tricyclics to serotonin uptake inhibitors

1998 • 23 citations

Fluoxetine 40 mg vs maprotiline 75 mg in the treatment of out-patients with depressive disorders.

1989 • 22 citations

Fluvoxamine and clomipramine in depressed hospitalised patients: results from a randomised, double-blind study.

1995 • 22 citations

Double-blind comparison of fluvoxamine and imipramine in depressed patients

1989 • 21 citations

Depression and associated anxiety in primary care: A double-blind comparison of paroxetine and amitriptyline

1993 • 21 citations

A double‐blind comparative study of sertraline and amitriptyline in outpatients with major depressive episodes

1994 • 21 citations

Selective serotonin reuptake inhibitors for depression?

1993 • 20 citations

Meta‐analysis of early phase I1 studies with paroxetine in hospitalized depressed patients

1989 • 20 citations

Management of depression in real-life settings

1994 • 20 citations

[Multicenter double-blind study comparing the efficacy and tolerance of paroxetine and clomipramine in reactive depression in the elderly patient].

1993 • 20 citations

Perspectives in Clinical Psychopharmacology of Amitriptyline and Fluvoxamine

1992 • 19 citations

Clinical multicentre study of citalopram compared double-blindly with mianserin in depressed patients in Finland

1988 • 19 citations

A double-blind study of fluoxetine and imipramine in major depression.

1989 • 18 citations

A Double-blind Multi-centre Trial of Fluoxetine and Dothiepin in Major Depressive Illness

1988 • 18 citations

An Italian multicenter experience with fluvoxamine, a new antidepressant drug, versus imipramine

1988 • 17 citations

Comparison of fluoxetine and desipramine in depressed outpatients

1993 • 17 citations

A comparative trial of a new antidepressant, fluoxetine.

1989 • 16 citations

A double-blind parallel study to compare fluoxetine with doxepin in the treatment of major depressive disorders.

1989 • 16 citations

Fluoxetine versus imipramine.

1989 • 16 citations

Comparison of fluvoxamine and amitriptyline in depressed outpatients

1994 • 16 citations

A Double-Blind Comparison of Sertraline and Imipramine in Outpatients with Major Depression: Acute (8 Weeks) and Continuation (16 Weeks) Treatment

1997 • 16 citations

The efficacy of fluoxetine versus maprotiline in depressed patients and by dose

1991 • 15 citations

Cost-effectiveness of newer antidepressants

1997 • 15 citations

[Double-blind study of mianserin and fluoxetine in ambulatory therapy of depressed patients].

1993 • 14 citations

Selektive Re-uptake-Hemmung und ihre Bedeutung für die Depression

1991 • 13 citations

[Efficacy and safety of fluoxetine versus clomipramine in ambulatory patients with a depressive syndrome in a clinical trial with private practitioners].

1991 • 12 citations

[Comparative study of the efficacy and acceptability of amineptine and fluoxetine in patients with major depression].

1992 • 11 citations

Fluvoxamine versus imipramine and placebo: a double-blind comparison in depressed patients

1996 • 10 citations

An overview of studies comparing the efficacy, safety, and tolerability of paroxetine and clomipramine

1992 • 7 citations

Fluoxetine and moclobemide versus amitriptyline in major depression: A single blind randomized clinical trial in Zimbabwe

1997 • 6 citations

Paroxetine and imipramine treatment of depressed patients in a controlled, multicentre study with plasma amino acid measurements

1992 • 3 citations

Paroxetine in the treatment of Chinese patients with depressive episode: a double-blind randomized comparison with imipramine.

1996 • 3 citations

Cited By (0)

Loading...