Pivotal role of plasminogen-activator inhibitor 1 in vascular disease

Molecular Bases of the Acute Coronary Syndromes

1995 • 2,049 citations

Increased Plasma Levels of a Rapid Inhibitor of Tissue Plasminogen Activator in Young Survivors of Myocardial Infarction

1985 • 1,364 citations

Plasminogen activator inhibitors

1987 • 957 citations

The plasminogen activation system in tumor growth, invasion, and metastasis

2000 • 930 citations

Plasminogen activator inhibitors

1987 • 764 citations

Role of the Matrix Metalloproteinase and Plasminogen Activator–Plasmin Systems in Angiogenesis

2001 • 754 citations

Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants.

1985 • 555 citations

Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries.

1992 • 547 citations

Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells. A potential link between the renin-angiotensin system and thrombosis.

1995 • 539 citations

Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin).

1988 • 484 citations

Generation in plasma of a fast-acting inhibitor of plasminogen activator in response to endotoxin stimulation.

1985 • 405 citations

Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells.

1983 • 400 citations

Diurnal variation of tissue-type plasminogen activator and its rapid inhibitor (PAI-1).

1989 • 390 citations

Demonstration of a fast-acting inhibitor of plasminogen activators in human plasma

1984 • 382 citations

Detection and partial characterization of an inhibitor of plasminogen activator in human platelets.

1984 • 365 citations

cDNA cloning of human plasminogen activator-inhibitor from endothelial cells.

1986 • 350 citations

Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family.

1986 • 343 citations

Demonstration of a fast-acting inhibitor of plasminogen activators in human plasma

1984 • 303 citations

Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo

1988 • 300 citations

Plasminogen Activator Inhibitors - A Review

1988 • 299 citations

Effect of Activation and Inhibition of the Renin-Angiotensin System on Plasma PAI-1

1998 • 273 citations

Purification and characterization of a plasminogen activator inhibitor from the histiocytic lymphoma cell line U-937.

1986 • 249 citations

Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo

1988 • 232 citations

Molecular cloning and characterization of a full‐length cDNA clone for human plasminogen

1987 • 229 citations

Bleeding diathesis due to decreased functional activity of type 1 plasminogen activator inhibitor.

1989 • 208 citations

Sp1 Sites Mediate Activation of the Plasminogen Activator Inhibitor-1 Promoter by Glucose in Vascular Smooth Muscle Cells

1998 • 207 citations

Inhibition of plasminogen activator inhibitor-1 activity results in promotion of endogenous thrombolysis and inhibition of thrombus extension in models of experimental thrombosis.

1992 • 198 citations

Purification of a Protein from Bovine Plasma That Binds to Type 1 Plasminogen Activator Inhibitor and Prevents Its Interaction with Extracellular Matrix

1989 • 197 citations

The Urokinase-type Plasminogen Activator Receptor Mediates Tyrosine Phosphorylation of Focal Adhesion Proteins and Activation of Mitogen-activated Protein Kinase in Cultured Endothelial Cells

1998 • 162 citations

Selective Stimulation of Tissue-Type Plasminogen Activator (t-PA) In Vivo by Infusion of Bradykinin

1997 • 149 citations

Stability of Plasminogen Activator Inhibitor 1 (PAI-1)

1989 • 148 citations

Identification of a conformationally distinct form of plasminogen activator inhibitor-1, acting as a noninhibitory substrate for tissue-type plasminogen activator.

1992 • 142 citations

Fibrinolytic System of Vascular Endothelial Cells

1988 • 138 citations

Inhibition of plasminogen activators by conditioned medium of human hepatocytes and hepatoma cell line Hep G2.

1985 • 132 citations

Circadian Variation in the Efficacy of Tissue-Type Plasminogen Activator

1995 • 118 citations

Structure of the human plasminogen activator inhibitor 1 gene: nonrandom distribution of introns

1987 • 109 citations

The dexamethasone-induced inhibitor of fibrinolytic activity in hepatoma cells. A cellular product which specifically inhibits plasminogen activation.

1982 • 95 citations

Different induction of two plasminogen activator inhibitor 1 mRNA species by phorbol ester in human hepatoma cells.

1991 • 63 citations

High Concentrations of Active Plasminogen Activator Inhibitor-1 in Porcine Coronary Artery Thrombi

1996 • 55 citations

Plasminogen activator inhibitor-1: a common denominator in cardiovascular disease.

1998 • 52 citations

A Kinetic Model of the Circulatory Regulation of Tissue Plasminogen Activator

1991 • 47 citations

XR5967, a novel modulator of plasminogen activator inhibitor-1 activity, suppresses tumor cell invasion and angiogenesis in vitro

2004 • 32 citations

Plasminogen activator inhibitor-1 (PAI-1) content in platelets from healthy individuals genotyped for the 4G/5G polymorphism in the PAI-1 gene

1997 • 30 citations

Structure and expression of the human gene encoding plasminogen activator inhibitor, PAI-1

1989 • 22 citations

Crystallization and X‐ray diffraction data of the cleaved form of plasminogen activator inhibitor‐1

1995 • 19 citations