Questions raised by the cytokine hypothesis of depression

Hippocampal Volume Reduction in Major Depression

2000 • 1,645 citations

Limbic-cortical dysregulation: a proposed model of depression

1997 • 1,542 citations

Depression Duration But Not Age Predicts Hippocampal Volume Loss in Medically Healthy Women with Recurrent Major Depression

1999 • 1,371 citations

Life Events and Illness.

1990 • 1,160 citations

Quantitative MRI of the hippocampus and amygdala in severe depression

2000 • 377 citations

Hippocampal volume in primary unipolar major depression: a magnetic resonance imaging study

2000 • 360 citations

The Inhibitory Effect of Interleukin-1β on Long-Term Potentiation Is Coupled with Increased Activity of Stress-Activated Protein Kinases

2000 • 235 citations

Effects of Antidepressant Drugs on the Behavioral and Physiological Responses to Lipopolysaccharide (LPS) in Rodents

2001 • 216 citations

Stimulation of malignant growth in rodents by antidepressant drugs at clinically relevant doses.

1992 • 210 citations

Elevated levels of serum interleukin-1β in combat-related posttraumatic stress disorder

1997 • 205 citations

Cytokines and depression: fortuitous or causative association?

1999 • 175 citations

Chronic treatment with the atypical antidepressant tianeptine attenuates sickness behavior induced by peripheral but not central lipopolysaccharide and interleukin-1β in the rat

2001 • 131 citations

Differential effect of chronic antidepressant treatments on lipopolysaccharide-induced depressive-like behavioural symptoms in the rat

1999 • 128 citations

Effects of interleukin-1β and mild stress on alterations of norepinephrine, dopamine and serotonin neurotransmission: a regional microdialysis study

1997 • 127 citations

Cytokine production in major depressed patients before and after clomipramine treatment

1994 • 124 citations

Behavioral effects of lipopolysaccharide in rats: involvement of endogenous opioids

1994 • 110 citations

First and second phases of biphasic fever: two sequential stages of the sickness syndrome?

1996 • 110 citations

Mood and Cognitive Disorders in Cancer Patients Receiving Cytokine Therapy

1999 • 99 citations

Cognitive functioning in cancer patients

1992 • 86 citations

Cross-Sensitization Between Immune And Non-Immune Stressors

1999 • 72 citations

Memory Disorders in Psychiatric Practice

2000 • 69 citations

Induction of cytokine synthesis and fever suppresses REM sleep and improves mood in patients with major depression

1995 • 67 citations

Light Treatment in Depressive Illness

1986 • 65 citations

Stress, Depression, and The Role of Cytokines

1999 • 61 citations

Comparative, behavioural and electrocortical effects of tumor necrosis factor-α and interleukin-1 microinjected into the locus coeruleus of rat

1997 • 60 citations

Interleukin-1 induces changes in sleep, brain temperature, and serotonergic metabolism

1997 • 52 citations

Is life stress more likely to provoke depressive episodes in women than in men?

1997 • 39 citations

The interaction between cytokines and neurotransmitters in depression and stress: possible mechanism of antidepressant treatments

2000 • 31 citations

Reversible neurotoxicity of interleukin-2 and tumor necrosis factor: correlation of SPECT with neuropsychological testing

1994 • 26 citations

Influence of acute tryptophan depletion on mood and immune measures in healthy males

1999 • 25 citations

Interleukin-1β and calcitonin, but not corticotropin-releasing factor, alter sleep cycles when injected into the rat hypothalamic lateral paraventricular area

1999 • 13 citations

Memory in functional psychosis

2000 • 8 citations