Long-Term Murine Hemopoietic Cultures as Model Systems for Analysis of B Lymphocyte Differentiation

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

Conditions controlling the proliferation of haemopoietic stem cells in vitro

1977 • 2,157 citations

IL3-dependent mouse clones that express B-220 surface antigen, contain ig genes in germ-line configuration, and generate B lymphocytes in vivo

1985 • 718 citations

Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/W mice

1985 • 663 citations

Long-term culture of B lymphocytes and their precursors from murine bone marrow.

1982 • 612 citations

Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors

1985 • 598 citations

Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse

1984 • 527 citations

HEMOPOIETIC COLONY STUDIES

1968 • 329 citations

The ultrastructure of the hemopoietic environment of the marrow: a review.

1981 • 308 citations

Differentiation of lymphocytes in mouse bone marrow

1974 • 305 citations

Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease.

1984 • 229 citations

BIRPS deep seismic reflection studies of the British Caledonides

1983 • 224 citations

Murine B cell lymphopoiesis in long term culture

1984 • 222 citations

Retrovirus transfer of a bacterial gene into mouse haematopoietic progenitor cells

1983 • 214 citations

Interleukin-3 supports growth of mouse pre-B-cell clones in vitro

1984 • 213 citations

Sequential Expression of Immunoglobulin on Developing Mouse B Lymphocytes: A Systematic Survey That Suggests a Model for the Generation of Immunoglobulin Isotype Diversity

1978 • 211 citations

In vitro generation of B lymphocytes in mouse foetal liver, a mammalian ‘bursa equivalent’

1974 • 210 citations

Cellular Interrelationships during in vitro Granulopoiesis

1976 • 193 citations

Mediators in cell growth and differentiation.

1984 • 166 citations

Evidence for structured variation in self-renewal capacity within long-term bone marrow cultures.

1980 • 153 citations

Regulation of megakaryopoiesis in long-term murine bone marrow cultures

1978 • 144 citations

Maintenance of hemopoietic stem cells and production of differentiated progeny in allogeneic and semiallogeneic bone marrow chimeras in vitro.

1977 • 144 citations

Differentiation of lymphocytes in mouse bone marrow

1974 • 141 citations

[[Long-term bone marrow culture].

1998 • 133 citations

Cultured mouse marrow stromal cell lines. II. Distinct subtypes differing in morphology, collagen types, myelopoietic factors, and leukemic cell growth modulating activities

1985 • 126 citations

Myelogenous production and maturation of B lymphocytes in the mouse.

1981 • 126 citations

Efficient insertion of genes into the mouse germ line via retroviral vectors.

1985 • 126 citations

Transmural Cellular Passage in Vascular Sinuses of Rat Bone Marrow

1970 • 111 citations

Differentiation of cloned populations of immature B cells after transformation with abelson murine leukemia virus

1983 • 108 citations

Defective colony formation by B lymphocytes from CBA/N and C3H/HeJ mice.

1977 • 89 citations

Clonal preadipocyte cell lines with different phenotypes derived from murine marrow stroma: Factors influencing growth and Adipogenesis in vitro

1982 • 83 citations

Effect of src infection on long-term marrow cultures: Increased self-renewal of hemopoietic progenitor cells without leukemia

1984 • 81 citations

Potentials for lymphoid differentiation by cells from long term cultures of bone marrow.

1980 • 78 citations

B lymphocyte development in fetal liver

1977 • 78 citations

Small Lymphocyte and Transitional Cell Populations of the Bone Marrow; Their Role in the Mediation of Immune and Hemopoietic Progenitor Cell Functions

1976 • 76 citations

Phenotypic and functional characterization of murine B lymphocyte precursors isolated from fetal and adult tissues.

1983 • 76 citations

Stromal cells in myeloid and lymphoid long-term bone marrow cultures can support multiple hemopoietic lineages and modulate their production of hemopoietic growth factors

1986 • 75 citations

In vitro differentiation of B lymphocytes from primitive hemopoietic precursors present in long-term bone marrow cultures.

1986 • 73 citations

Hematopoietic factor production by a cell line (TC-1) derived from adherent murine marrow cells

1985 • 73 citations

Cellular interactions affecting the maturation of murine B lymphocyte precursors in vitro.

1981 • 71 citations

In vitro studies on lymphocyte differentiation. I. Long term in vitro culture of cells giving rise to functional lymphocytes in irradiated mice.

1978 • 68 citations

Loss of immunoreactivity in long-term bone marrow culture

1978 • 61 citations

Differentiation of murine B cell precursors in agar culture. Frequency, surface marker analysis and requirements for growth of clonable pre‐B cells

1984 • 61 citations

Generation of purified stromal cell cultures that support lymphoid and myeloid precursors

1986 • 57 citations

Surface immunoglobulin-negative B-cell precursors detected by formation of antibody-secreting colonies in agar

1983 • 55 citations

Preferential but Nonexclusive Expression of Macromolecular Antigens on B‐Lineage Cells

1983 • 54 citations

Characterization of early B lymphocyte precursors present in long-term bone marrow cultures.

1983 • 49 citations

Radioresistant murine marrow stromal cells: a morphologic and functional characterization.

1984 • 47 citations

Maturational state of lymphoid cells in long-term bone marrow cultures.

1982 • 45 citations

Regulation of bone marrow lymphocyte production

1983 • 44 citations

Regulation of human B lymphopoiesis: effect of a urinary activity associated with cyclic neutropenia.

1985 • 43 citations

Morphologic analysis of long-term bone marrow cultures that support B-lymphopoiesis or myelopoiesis

1985 • 42 citations

In vitro development of B lymphocytes from long-term cultured precursor cells.

1986 • 42 citations

Precocious and enhanced functional maturation of B lineage cells in New Zealand Black mice during embryonic development.

1984 • 41 citations

Long-term cultures of murine fetal liver retain very early B lymphoid phenotype.

1984 • 39 citations

In vitro studies on lymphocyte differentiation. II. Generation of terminal deoxynucleotidyl transferase-positive cells in long-term cultures of mouse bone marrow.

1979 • 38 citations

IgG subclass, IgE, and IgA anti-trinitrophenyl antibody production within trinitrophenyl-Ficoll-responsive B cell clones. Evidence in support of three distinct switching pathways.

1983 • 35 citations

Long-term cultured B lymphocytes and their precursors reconstitute the B-lymphocyte lineage in vivo.

1984 • 32 citations

In Vitro Differentiation of B Lymphocytes from Pre-B Cells

1979 • 32 citations

Biological effects of inhibition of guanine nucleotide synthesis by mycophenolic acid in cultured neuroblastoma cells.

1977 • 31 citations

In vivo maturation of pre-B cells derived from long-term cultured bone marrow.

1985 • 18 citations

kappa gene diversity among the clonal progeny of pre-B lymphocytes.

1984 • 17 citations

Enhanced lymphoid and decreased myeloid reconstituting ability of stem cells from long-term cultures of mouse bone marrow

1980 • 17 citations

Early B cell precursors in long‐term bone marrow culture: selective development in the bone marrow of irradiated recipients

1985 • 16 citations

An investigation into the B lymphopoietic capacity of long-term bone marrow cultures.

1983 • 14 citations

Heterogeneity of bone marrow lymphocytes: Radioautographic detection of pre-B cells bearing cytoplasmic μ chains, and of B and T lymphocytes, and characterization of null lymphoid cells

1984 • 12 citations

In Vitro Studies on Lymphocyte Differentiation

1979 • 11 citations

Reconstitution of immune-deficient mice with cells from long-term bone marrow cultures.

1984 • 11 citations

Hemopoiesis in spleen and bone marrow cultures

1983 • 7 citations