Formation of Thyroid Hormones

Superoxide and Superoxide Dismutases

1978 • 754 citations

Purification of horse-radish peroxidase and comparison of its properties with those of catalase and methaemoglobin

1951 • 579 citations

PLASMA INORGANIC IODIDE AS A HOMEOSTATIC REGULATOR OF THYROID FUNCTION

1948 • 569 citations

Catalysis of iodination by lactoperoxidase

1970 • 300 citations

The chemical nature of the second hydrogen peroxide compound formed by cytochrome c peroxidase and horseradish peroxidase. 1. Titration with reducing agents

1953 • 300 citations

The kinetics and stoichiometry of the transition from the primary to the secondary peroxidase peroxide complexes

1952 • 281 citations

The Mechanism of Action of the Thioureylene Antithyroid Drugs

1976 • 245 citations

Evidence for superoxide generation by NADPH-cytochrome C reductase of rat liver microsomes

1972 • 193 citations

The Isolation and Purification of Thyroid Peroxidase

1967 • 165 citations

CYTOCHEMICAL LOCALIZATION OF ENDOGENOUS PEROXIDASE IN THYROID FOLLICULAR CELLS

1970 • 158 citations

Thyroid Peroxidase and Thyroxine Biosynthesis

1970 • 157 citations

Chemical Nature of the Secondary Hydrogen Peroxide Compound Formed by Cytochrome-C Peroxidase and Horseradish Peroxidase

1952 • 153 citations

A spectrophotometric assay for iodide oxidation by thyroid peroxidase

1962 • 147 citations

Purification and Iodinating Activity of Hog Thyroid Peroxidase

1967 • 137 citations

pH Dependence of the oxidation of iodide by compound I of horseradish peroxidase

1972 • 134 citations

Reaction of peroxidase with reduced nicotinamide-adenine dinucleotide and reduced nicotinamide-adenine dinucleotide phosphate

1965 • 129 citations

The peroxidase-catalyzed oxidation of tyrosine

1972 • 119 citations

Peroxidase Activity in Thyroid Gland and Partial Purification of the Enzyme

1962 • 116 citations

Evidence for a Catalytic Role for Thyroid Peroxidase in the Conversion of Diiodotyrosine to Thyroxine*

1972 • 106 citations

Mechanism of the Inhibition of Enzymatic Halogenation by Antithyroid Agents

1966 • 102 citations

The iodination of tyrosine by beef thyroid preparations

1962 • 95 citations

Hog thyroid peroxidase: Physical, chemical, and catalytic properties of the highly purified enzyme

1979 • 89 citations

Improvements in the isolation procedure for thyroid peroxidase: Nature of the heme prosthetic group

1970 • 88 citations

Enzymatic Iodination of Tyrosine and Thyroglobulin with Chloroperoxidase

1966 • 87 citations

Superoxide anion involvement in NBT reduction catalyzed by nadph‐cytochrome P‐450 reductase: A pitfall

1978 • 87 citations

Iodine Metabolism in Thyroid Slices: Effects of TSH, Dibutyryl Cyclic 3 ′,5′-AMP, NaF and Prostaglandin E¹

1970 • 81 citations

The Oxidation of 3,5-Diiodotyrosine to Thyroxine

1942 • 80 citations

Effect of Iodide Concentration on Thyroxine Synthesis Catalysed by Thyroid Peroxidase

1973 • 78 citations

Thyroid hormone synthesis in thyroglobulin. The mechanism of the coupling reaction.

1981 • 78 citations

Comparison of Lactoperoxidase- and Thyroid Peroxidase-Catalyzed Iodination and Coupling*

1974 • 76 citations

Chromatographic Fractionation of Hog Thyroglobulin

1961 • 75 citations

Thyroglobulin iodoamino acids estimation after digestion with pronase and leucylaminopeptidase

1970 • 69 citations

Enzymatic Iodination of Protein

1973 • 63 citations

Ultrastructural Localization of Peroxidase on Pseudopods and Other Structures of the Typical Thyroid Epithelial Cell

1974 • 62 citations

Iodide Binding in Thyroid Cellular Fractions

1960 • 62 citations

Nuclear magnetic resonance studies of hemoproteins. Binding of aromatic donor molecules to horseradish peroxidase.

1979 • 61 citations

Formation of dehydroalanine residues during thyroid hormone synthesis in thyroglobulin.

1980 • 58 citations

Peroxydase particulaire thyroïdienne

1972 • 58 citations

The horseradish peroxidase − catalyzed oxidation of iodide. Outline of the mechanism

1970 • 57 citations

Newer knowledge of the biochemistry of the thyroid gland

1944 • 55 citations

Preferential Synthesis of Thyroxine from Early Iodinated Tyrosyl Residues in Thyroglobulin

1974 • 55 citations

Opposite Effects of Thiocyanate on Tyrosine Iodination and Thyroid Hormone Synthesis

1980 • 55 citations

APPEARANCE AND FUNCTION OF ENDOGENOUS PEROXIDASE IN FETAL RAT THYROID

1971 • 54 citations

Sequential reactivity of tyrosyl residues of thyroglobulin upon iodination catalyzed by thyroid peroxidase.

1977 • 53 citations

Free Diiodotyrosine Effects on Protein Iodination and Thyroid Hormone Synthesis Catalyzed by Thyroid Peroxidase

1975 • 52 citations

[In vitro biosynthesis of double-labelled hormones in thyroid slices. II. Biosynthesis of non-iodinated pre-thyroglobulin].

1965 • 51 citations

OBSERVATIONS CONCERNING THE HETEROGENEITY OF OVINE THYROGLOBULIN¹

1959 • 51 citations

THE ROLE OF INTERMEDIARY CARBOHYDRATE METABOLISM IN REGULATING ORGANIC IODINATIONS IN THE THYROID GLAND*

1961 • 51 citations

Purification of Bovine Thyroid Peroxidase*

1977 • 50 citations

Thyroid peroxidase-catalyzed iodination of thyroglobulin; inhibition by excess iodide

1970 • 49 citations

Biosynthesis of uniodinated pre-thyroglobulin

1965 • 49 citations

Solubilization, isolation and identification of a peroxidase from the microsomal fraction of beef thyroid

1968 • 49 citations

Acute and Chronic Effects of Iodide on Thyroid Radioiodine Metabolism in Iodine-Deficient Rats¹

1968 • 48 citations

Specificity of thyroid hormone synthesis The role of thyroid peroxidase

1978 • 48 citations

Nuclear magnetic resonance studies of hemoproteins

1977 • 47 citations

Iodoamino acid composition of the thyroglobulin of normal and diseased thyroid glands comparison with in vitro iodinated thyroglobulin

1972 • 47 citations

The Importance of Thyroglobulin Structure in Thyroid Peroxidase-Catalyzed Conversion of Diiodotyrosine to Thyroxine¹

1977 • 47 citations

Electronic structure of the peroxidase-peroxide complexes

1952 • 46 citations

Kinetics of Iodination. I. A Comparison of the Kinetics of Iodination of N-Acetyl-L-Tyrosine and N-Acetyl-3-iodo-L-Tyrosine

1964 • 46 citations

Kinetics of Thyroglobulin Iodination and of Hormone Synthesis Catalyzed by Thyroid Peroxidase

1976 • 46 citations

Studies on an Iodinating Enzyme from Calf Thyroid

1965 • 45 citations

Spatial requirement for coupling of iodotyrosine residues to form thyroid hormones.

1977 • 43 citations

The Properties of Thyroglobulin

1967 • 40 citations

Localization of peroxidase and other microsomal enzymes in thyroid cells

1971 • 40 citations

Studies on the Biosynthesis of Iodotyrosines

1961 • 39 citations

Iodation des protéines par voie enzymatique

1969 • 39 citations

Comparison of the iodoamino acid distribution in various preparations of hog thyroglobulin with different iodine content and subunit structure

1974 • 37 citations

The Amino Acid Neighbors of Thyroxine in Thyroglobulin

1970 • 37 citations

Relationship between iodination and the polypeptide chain composition of thyroglobulin.

1975 • 37 citations

Evidence that thyroglobulin contains nonidentical half molecule subunits.

1978 • 36 citations

Further observations on the oxidation of di-iodotyrosine derivatives

1958 • 34 citations

Thyroid Peroxidase

1971 • 32 citations

Maximal Number of Hormonogenic Iodotyrosine Residues in Thyroglobulin Iodinated by Thyroid Peroxidase

1976 • 32 citations

A Defective Thyroid Peroxidase Solubilized from a Familial Goiter with Iodine Organification Defect

1974 • 30 citations

Iodide binding and regulation of lactoperoxidase activity toward thyroid goitrogens

1979 • 30 citations

Participation of NADPH-Cytochrome C Reductase in Thyroid Hormone Biosynthesis

1975 • 29 citations

Subcellular Distribution of Peroxidase Activity in Human Thyroid Tissue

1973 • 28 citations

Relationship between iodination and conformation of thyroglobulin

1966 • 28 citations

The fate of the “lost side chain” during thyroid hormonogenesis.

1979 • 27 citations

Regulatory Effects of Iodide and Thiocyanate on Tyrosine Oxidation Catalyzed by Thyroid Peroxidase

1980 • 27 citations

Electron microscopy of low iodinated thyroglobulin molecules

1975 • 26 citations

Appearance of Serine upon Alkaline Incubation of Iodinated Polytyrosine

1956 • 26 citations

An electron microscopic study of the thyroglobulin molecule

1973 • 26 citations

Solubilization of thyroid peroxidase by nonionic detergents.

1976 • 25 citations

Chemistry and Biosynthesis of Thyroid Iodoproteins

1973 • 25 citations

Thyroid Iodine Organification Defects: A Case With Lack of Thyroglobulin Iodination and a Case Without Any Peroxidase Activity

1976 • 25 citations

Dissociation between Degree of Iodination and Iodoamino Acid Distribution in Thyroglobulin*

1978 • 25 citations

The possible role of thyroid monoamine oxidase in iodothyronine synthesis

1966 • 20 citations

[Biogenesis of thyroglobulin: changes during halogenation].

1966 • 19 citations

Model Reactions for the Biosynthesis of Thyroxine. II. The Fate of the Aliphatic Side Chain in the Conversion of 3,5-Diiodophloretic Acid to 3,5,3',5'-Tetraiodothyropropionic Acid¹

1960 • 19 citations

The iodination of tyrosine by myeloperoxidase and beef thyroids. The possible involvement of free radicals

1966 • 19 citations

Studies on the Biosynthesis of Thyroid Hormone: Reconstruction of a Definedin VitroIodinating System

1971 • 19 citations

Changes in the structure of thyroglobulin following the administration of thyroid-stimulating hormone.

1975 • 19 citations

Iodation enzymatique de protéines

1965 • 18 citations

Comparison of the iodoamino acid distribution in thyroglobulins obtained from various animal species

1974 • 18 citations

Kinetics of the oxidation of iodide ion by lactoperoxidase compound II. 5

1972 • 18 citations

Biogénèse de la thyroglobuline: Les transitions d'halogénation

1966 • 17 citations

FAMILIAL GOITRE WITH PARTIAL IODINE ORGANIFICATION DEFECT, LACK OF THYROGLOBULIN, AND HIGH LEVELS OF THYROID PEROXIDASE

1977 • 15 citations

Interaction of thyroid peroxidase with concanavalin A covalently coupled to agarose.

1977 • 14 citations

Dissociation of Thyroglobulin Iodination and Hormone Synthesis Catalyzed by Peroxidases

1979 • 14 citations

Partial Purification and Some Properties of Thyroid Peroxidase Solubilized by Alkaline Treatment

1973 • 13 citations

Involvement of free radicals in the iodination of tyrosine and thyroglobulin by myeloperoxidase and a purified beef thyroid peroxidase

1967 • 13 citations

The specificity of thyroid peroxidase toward tyrosine peptides

1971 • 13 citations

The heterogeneity of human thyroglobulin

1965 • 13 citations

Partial Purification and Some Properties of Thyroid Peroxidase Solubilized by Extraction with n-Butanol

1973 • 13 citations

Métabolisme de l'iode de la thyroïde chez le rat

1964 • 11 citations

Hydrogen peroxide generating system in hog thyroid microsomes

1973 • 10 citations

Perkussion und Auscultation

1924 • 9 citations

Relation entre teneur en iode et propriétés de thyroglobulines obtenues par la méthode d'equilibrage isotopique

1971 • 9 citations

[Relation between iodine content and properties of thyroglobulins obtained by isotopic equilibration].

1971 • 9 citations

STUDIES ON THE MECHANISM OF IODINATION SUPPORTED BY THYROIDAL NADPH-CYTOCHROME c REDUCTASE

1973 • 8 citations

Dissociation into subunits of thyroglobulin iodinated by thyroid and horse radish peroxidase

1973 • 8 citations

"In Vivo" and "In Vitro" Regulation by Iodide of Thyroglobulin lodination and Thyroxine Synthesis

1975 • 7 citations

Pyridine Nucleotide and odination Reaction in the Thyroid Gland

1966 • 5 citations

Deleted Work

1955 • 0 citations