Cell Death in Normal and Malignant Tissues

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

1955 • 2,174 citations

PRACTICAL STEREOLOGICAL METHODS FOR MORPHOMETRIC CYTOLOGY

1966 • 1,821 citations

ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS

1971 • 1,643 citations

TECHNIQUES FOR THE PRESERVAATION OF THREE‐DIMENSIONAL STRUCTURE IN PREPARING SPECIMENS FOR THE ELECTRON MICROSCOPE*

1951 • 1,477 citations

Shrinkage necrosis: A distinct mode of cellular death

1971 • 1,448 citations

Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.

1968 • 1,363 citations

CELL DEATHS IN NORMAL VERTEBRATE ONTOGENY

1951 • 1,194 citations

Identification of human chromosomes by DNA-binding fluorescent agents

1970 • 989 citations

Method for the Quantitative Morphologic Analysis of Tissues

1943 • 979 citations

Death in Embryonic Systems

1966 • 943 citations

Dynamics of Tumor Growth

1964 • 815 citations

MULTIPOTENTIALITY OF SINGLE EMBRYONAL CARCINOMA CELLS.

1964 • 773 citations

The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour

1968 • 764 citations

“Lymphokines”: Non-Antibody Mediators of Cellular Immunity generated by Lymphocyte Activation

1969 • 575 citations

DNA synthesis and myogenesis

1961 • 557 citations

The Theory of Branching Processes.

1964 • 546 citations

A MICROASSAY FOR CELL-MEDIATED IMMUNITY

1970 • 486 citations

ESTABLISHMENT OF FUNCTIONAL CLONAL LINES OF NEURONS FROM MOUSE NEUROBLASTOMA

1969 • 486 citations

Blocking of cell‐mediated tumor immunity by sera from patients with growing neoplasms

1971 • 423 citations

Nigrosin as a dye for differentiating live and dead ascites cells

1958 • 422 citations

CHANGES IN SURFACE MORPHOLOGY OF CHINESE HAMSTER OVARY CELLS DURING THE CELL CYCLE

1973 • 403 citations

Phagocytosis

1974 • 392 citations

Analytical Review: The Kinetics of Granulopoiesis in Normal Man

1964 • 392 citations

Counting actively metabolizing tissue cultured cells

1957 • 334 citations

Determination of Cell Viability

1958 • 327 citations

Specific in vitro Cytotoxicity of Thymus-derived Lymphocytes sensitized to Alloantigens

1970 • 318 citations

Relation between the pathological nature and the growth rate of human tumors

1971 • 310 citations

Differentiation of malignant to benign cells

1971 • 306 citations

CELL LOSS FROM EXPERIMENTAL TUMOURS

1968 • 290 citations

Tumor Angiogenesis: Transfilter Diffusion Studies in the Hamster by the Transparent Chamber Technique<xref ref-type="fn" rid="FN2">2</xref>

1968 • 288 citations

Cell loss as a factor in the growth rate of human tumours

1967 • 281 citations

Autoradiographic Analysis of Cell Proliferation in Spontaneous Breast Cancer of C3H Mouse. III. The Growth Fraction<xref ref-type="fn" rid="fn1"><sup>2</sup></xref>

1962 • 279 citations

Possible host resistance in carcinoma of the breast: a histological study

1968 • 268 citations

Population kinetics of carcinoma cells, capillary endothelial cells, and fibroblasts in a transplanted mouse mammary tumor.

1970 • 243 citations

Cellular Radiation Biology

1965 • 234 citations

A suggested explanation for the paradoxically slow growth rate of basal‐cell carcinomas that contain numerous mitotic figures

1972 • 227 citations

Stochastic Model for Abnormal Clone Spread through Epithelial Basal Layer

1972 • 225 citations

The Modulating Influence of Stromal Environment on Epithelial Cells Studied in Human Autotransplants11From the Dermatology Service, General Medicine Branch, National Cancer Institute, National Institutes of Health, Public Health Service, Department of Health, Education and Welfare, Bethesda, Maryland.Presented at the Twenty-first Annual Meeting of The Society for Investigative Dermatology, Inc., Miami Beach, Florida, June 13, 1960.

1961 • 219 citations

A Method for Counting the Viable Cells in Normal and in Malignant Cell Suspensions

1936 • 201 citations

Proliferation Kinetics of X-irradiated Mouse L Cells Studied with Time-lapse Photography. II

1969 • 182 citations

CELLS MEDIATING SPECIFIC IN VITRO CYTOTOXICITY

1972 • 177 citations

The proliferation of capillary endothelial cells.

1972 • 174 citations

CYTOKINETIC ANALYSIS OF TUMOR GROWTH

1966 • 171 citations

A colony inhibition (CI) technique for demonstration of tumor cell destruction by lymphoid cells in vitro

1967 • 164 citations

CHROMOSOMES IN CANCER TISSUE

1956 • 162 citations

The relationship between growth rate, labelling index and histological type of human solid tumours

1973 • 160 citations

CELLS MEDIATING SPECIFIC IN VITRO CYTOTOXICITY

1971 • 157 citations

Chromosome aberrations and radiation-induced cell death

1973 • 156 citations

The growth rate of human tumours.

1966 • 156 citations

Histology and prognosis in malignant melanoma

1969 • 152 citations

Microcirculation of tumors Part I: Anatomy, function, and necrosis

1966 • 152 citations

CELL PHYSIOLOGY OF NEOPLASIA

1961 • 151 citations

Analysis of the cell population kinetics of transplanted tumours of widely-differing growth rate.

1966 • 151 citations

HETEROLOGOUS TRANSPLANTATION OF MAMMALIAN TUMORS

1941 • 149 citations

A Mathematical Model of the Mitotic Cycle and Its Application to the Interpretation of Percentage Labeled Mitoses Data<xref ref-type="fn" rid="FN2">2</xref>

1966 • 148 citations

Structural Representations of Tumor-Host Relationships in Mammary Carcinoma: Biologic and Prognostic Significance

1956 • 147 citations

Chromosomal Abnormalities in Human Neoplasia

1970 • 147 citations

Kinetics of cell proliferation of an experimental tumor.

1967 • 145 citations

Theoretical basis for cell cycle analysis

1968 • 145 citations

Membrane Dynamics in the Action of Dibutyryl Adenosine 3′:5′-Cyclic Monophosphate and Testosterone on Mammalian Cells

1972 • 144 citations

Proliferation and ultrastructure of papillary transitional cell carcinoma of the human bladder

1971 • 140 citations

Cell proliferation kinetics in five human solid tumors

1968 • 139 citations

A comparison of methods for estimating the viable count of a suspension of tumour cells

1956 • 138 citations

Cultivation of neurons from the adult human cerebral and cerebellar cortex

1951 • 134 citations

Glucose consumption by transplanted tumors in vivo.

1967 • 133 citations

Human Chromosome Damage by Chemical Agents

1970 • 132 citations

Quantitative Techniques for Study of the Anatomy and Function of Small Blood Vessels in Tumors

1969 • 132 citations

Cytological and cytochemical studies on cell death and digestion in the foetal rat foot: The role of macrophages and hydrolytic enzymes

1968 • 129 citations

Cinemicrography in Cell Biology

1963 • 128 citations

CELL DEATH IN THE EMBRYONIC CHICK SPINAL CORD

1974 • 127 citations

Role of macrophages in tumour immunity. I. Co-operation between macrophages and lymphoid cells in syngeneic tumour immunity.

1972 • 126 citations

Ultrastructure of human testicular tumors

1966 • 125 citations

Death and Metastatic Distribution of Tumor Cells in Mice Monitored With <sup>125</sup>I-Iododeoxyuridine<xref ref-type="fn" rid="FN2">2</xref>

1969 • 122 citations

Homograft Target Cells: Contact Destruction in vitro by Immune Macrophages

1966 • 118 citations

Cure of Murine Leukemia With Drug and Interferon Treatment

1973 • 115 citations

The Significance of Lymphocytic Infiltration in Neuroblastoma

1972 • 111 citations

In vitro studies of cell proliferation in tumours—I

1965 • 110 citations

Studies on the mechanism of lymphocyte-mediated cytolysis. II. The use of various target cell markers to study cytolytic events.

1973 • 107 citations

Cell death and the development of limb form and skeletal pattern in normal andwingless(ws) chick embryos

1973 • 106 citations

THE EFFECT OF CELL-TO-CELL CONTACT ON THE SURFACE MORPHOLOGY OF CHINESE HAMSTER OVARY CELLS

1973 • 106 citations

On the permeability to lissamine green and other dyes in the course of cell injury and cell death

1961 • 105 citations

Analyses of dna content, nuclear size and cell proliferation of transitional cell carcinoma in man

1969 • 105 citations

Cell proliferation in human melanoma

1970 • 103 citations

An Experimental Method for Comparing Treatments of Intact Malignant Tumours in Animals and its Application to the Use of Oxygen in Radiotherapy

1960 • 103 citations

IRRADIATION OF PARTS OF INDIVIDUAL CELLS. III. EFFECTS OF CHROMOSOMAL AND EXTRACHROMOSOMAL IRRADIATION ON CHROMOSOME MOVEMENTS

1955 • 102 citations

Some Characteristics of DNA Synthesis and the Mitotic Cycle in Ehrlich Ascites Tumor Cells

1960 • 102 citations

The cellular proliferation kinetics of animal tumors.

1970 • 98 citations

Terminal lens cell differentiation I. Histological and microspectrophotometric analysis of nuclear Degeneration

1970 • 97 citations

Chromosome aberrations in cultured cells deprived of single essential amino acids

1969 • 97 citations

Graft reaction in tissue culture. II. Quantification of the lytic action on mouse fibroblasts by rat lymphocytes sensitized on mouse embryo monolayers.

1969 • 96 citations

CELL CYCLE CHARACTERISTICS OF HUMAN SOLID TUMORS IN VIVO

1970 • 93 citations

Autoradiographic Analysis of Cell Proliferation in Spontaneous Breast Cancer of C3H Mouse. I. Typical Cell Cycle and Timing of DNA Synthesis<xref ref-type="fn" rid="FN1">2</xref>

1960 • 90 citations

Proliferation characteristics of the various classes of cells in Hodgkin's disease

1969 • 89 citations

In vitro uptake of tritiated thymidine by carcinoma of the human colon.

1966 • 88 citations

The micromorphology of zeiotic blebs in cultured human epithelial (HEp) cells

1967 • 85 citations

Spermatocytic seminoma.II. Ultrastructural study

1969 • 85 citations

Cell proliferation in Burkitt tumours

1966 • 82 citations

Growth rate and radiosensitivity of human tumours—II

1966 • 81 citations

Cell loss in malignant tumours in man

1967 • 79 citations

Kinetics of cellular proliferation and cell loss in human carcinomas

1967 • 78 citations

Studies on possible mechanisms of programmed cell death in the chick embryo

1970 • 75 citations

Autoradiographic studies of in vitro incorporation of uridine and thymidine by human tumor tissue.

1962 • 74 citations

Cellular proliferation patterns in an experimental Rhabdomyosarcoma in the rat

1967 • 74 citations

Observations on the ultrastructure of two hamster lymphomas with particular reference to infiltrating macrophages

1972 • 73 citations

Demonstration of H-2 isoantigens and polyoma specific tumor antigens by measuring colony formation in vitro

1965 • 70 citations

PROLIFERATION KINETICS OF AN EXPERIMENTAL ASCITES TUMOUR OF THE MOUSE

1969 • 70 citations

Statistical inference from the fraction labelled mitoses curve

1970 • 70 citations

Percentage labeled mitoses curves in exponentially growing cell populations

1968 • 68 citations

Effects of X-Irradiation on the Mitotic Cycle of Ehrlich Ascites Tumor Cells

1964 • 65 citations

Cell proliferation in rectal carcinoma and rectal mucosa. A stathmokinetic study

1973 • 62 citations

Zellproliferation in normalen und malignen Geweben:3H-Thymidin-Einbau in vitro unter Standardbedingungen

1966 • 62 citations

Cellular kinetics of invasive squamous carcinoma of the human cervix.

1969 • 61 citations

Tetrazolium salt and electron-microscopic studies of cellular degeneration and necrosis in the interdigital areas of the developing chick limb

1971 • 59 citations

RELATION BETWEEN WATER PERMEABILITY AND INTEGRITY OF SULFHYDRYL GROUPS IN MALIGNANT AND NORMAL CELLS

1961 • 59 citations

Proliferation Kinetics of X-irradiated Mouse L Cells Studied with Time-lapse Photography

1968 • 57 citations

Surface Responses in Cultured Fibroblasts Elicited by Ethylenediaminetetraacetic Acid

1958 • 52 citations

AN EVALUATION OF RADIOIODINE‐LABELED 5‐IODO‐2′‐DEOXYURIDINE AS A TRACER FOR MEASURING CELL LOSS FROM SOLID TUMORS*

1971 • 51 citations

Chromosome constitution of transitional cell carcinoma of the urinary bladder

1972 • 50 citations

The Acridine Orange Viability Test Applied to Bone Marrow Cells I. Correlation with Trypan Blue and Eosin Dye Exclusion and Tissue Culture Transformation

1964 • 50 citations

Evaluation of the mode of cell death in ehrlich ascites tumor

1972 • 47 citations

Variations in the mitotic cycle in vitro

1961 • 46 citations

HETEROGENEITY OF THE EFFECTOR CELLS IN THE CYTOTOXIC REACTION AGAINST ALLOGENEIC LYMPHOMA CELLS

1973 • 45 citations

Pharmacological Treatment in Organ and Tissue Transplantation

1971 • 44 citations

Growth in vitro and induction of differentiation in cells of basal cell cancer.

1972 • 43 citations

Studies on homotransplantable lymphomas in hamsters. I. Histologic responses in lymphoid tissues and their relationship to metastasis.

1966 • 43 citations

Increased numbers of a characteristic type of reticular cell in the thymus and lymph nodes of leukemic mice: an electron microscope study.

1968 • 42 citations

Specific Antigens of Tumors and Leukemias of Experimental Animals

1966 • 42 citations

The role of ribonuclease in regression of lymphosarcoma P1798.

1966 • 42 citations

Cellular Reaction in Trophoblastic Tumours

1973 • 42 citations

Lysosomal enzyme changes in growing and regressing mammary tumours

1969 • 41 citations

Tumour growth and anti-mitotic action. The role of spontaneous cell losses

1968 • 41 citations

Time-Lapse Cinemicrographic Studies of X-Irradiated HeLa S3 Cells

1969 • 40 citations

PATHOLOGY AND PROGNOSIS FOLLOWING TOTAL CYSTECTOMY FOR CARCINOMA OF BLADDER

1972 • 39 citations

The pattern of cell growth in reticulum cell sarcoma and lymphosarcoma

1970 • 37 citations

Activities and quantities of lysosomal enzymes during mammary tumor regression.

1972 • 37 citations

Proliferation and differentiation of normal and neoplastic cells in the colon of man

1971 • 37 citations

The use of trypsin for the determination of cellular viability

1965 • 37 citations

Electron Microscopy of Milk Secretion in the Mammary Gland of the C3H/Crgl Mouse. III. Cytomorphology of the Involuting Gland<xref ref-type="fn" rid="fn1">2</xref>

1963 • 37 citations

CYTOLOGICAL VARIABILITY IN HUMAN CARCINOMATOSIS

1956 • 36 citations

STUDY OF METASTASIS WITH THE AID OF LABELED ASCITES TUMOR CELLS

1956 • 35 citations

Bactericidal function of human polymorphonuclear leukocytes. E. Mead Johnson Award Address.

1972 • 34 citations

Electron‐microscope investigation of experimental rhabdomyosarcoma

1969 • 32 citations

Membrane specialization and synchronized cell death in developing rat transitional epithelium.

1972 • 32 citations

Death in normal and neoplastic cells

1974 • 30 citations

Mitomycin C induced increases in the activities of the deoxyribonucleases of HeLa cells

1966 • 28 citations

The determination of cell-cycle parameters from measurements of the fraction of labeled mitoses

1972 • 28 citations

Ultrastructural studies relating to the surface morphology of cultured cells

1970 • 27 citations

Random walk and the spread of cancer

1970 • 25 citations

Metachromatic differential fluorochroming of living and dead ascites tumor cells with acridine orange.

1956 • 25 citations

Distribution and properties of lysosomal enzymes in untreated and in irradiated mouse mammary-gland carcinomas.

1969 • 24 citations

Distributions associated with cell populations

1969 • 23 citations

ROLE OF SOLUBLE LYMPHOCYTE MEDIATORS IN MALIGNANT-TUMOUR DESTRUCTION

1971 • 22 citations

A STUDY OF THE METASTATIC DISTRIBUTION OF ERLICH ASCITES TUMOUR CELLS IN MICE

1959 • 22 citations

51 Cr leakage from and uptake of trypan blue by target cells undergoing cell-mediated destruction.

1972 • 22 citations

Changes in phospholipid metabolism of a tumor target cell during a cell-mediated cytotoxic reaction

1971 • 21 citations

Acid hydrolase activity during the growth, necrosis, and regression of the Jensen sarcoma.

1968 • 21 citations

Enzyme levels in the growing and spontaneously regressing Flexner-Jobling carcinoma. I. Catheptic activity and phosphatases

1955 • 20 citations

Cr LEAKAGE FROM AND UPTAKE OF TRYPAN BLUE BY TARGET CELLS UNDERGOING CELL-MEDIATED DESTRUCTION

1972 • 19 citations

Ultrastructural, cytochemical and biochemical changes occurring during syngeneic macrophage-lymphoma interaction in vitro

1972 • 17 citations

STUDIES ON THE MECHANISM OF HUMAN TUMOR RESISTANCE TO THE FLUORINATED PYRIMIDINES.

1964 • 17 citations

The composition of branching populations: A mathematical result and its application to determine the incidence of death in cell proliferation

1970 • 17 citations

[In vivo determination of the cell loss rate in experimental neoplasms using radioactively marked idoxuridine].

1969 • 16 citations

Untersuchungen zur prognostischen Bedeutung der ?Stromareaktion? beim malignen Melanom

1973 • 16 citations

Cell Mediated Immunity

1971 • 16 citations

A quantitative measurement of cell damage by means of 51Cr-binding

1967 • 15 citations

The naphthylamidase reaction as a diagnostic tool for the demonstration of cellular injury and autophagy

1969 • 14 citations

Prednisolone induced surface alterations in HeLa cells

1971 • 12 citations

A kinetic analysis of death and survival in HeLa cells following exposure to methylazoxymethanol acetate

1974 • 12 citations

Radiotherapy and Chemotherapy for Colorectal Cancer [Abridged]

1973 • 11 citations

THE GROWTH KINETICS OF SOLID TUMORS: SUMMARY REPORT OF MEETING

1970 • 11 citations

Proliferation in an established cell line

1967 • 10 citations

ESTIMATION OF THE MEAN AND VARIANCE OF CYCLE TIMES IN CINEMICROGRAPHICALLY RECORDED CELL POPULATIONS DURING BALANCED EXPONENTIAL GROWTH

1974 • 10 citations

Cell Kinetic Analysis of a Human Melanoma &lt;italic&gt;In Vitro&lt;/italic&gt; and &lt;italic&gt;In Vivo-Vitro&lt;/italic&gt;&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;

1971 • 10 citations

ABNORMAL CYCLE PHASE DURATIONS IN POLYPLOID CELLS OR CELLS WITH IRREGULAR MITOSIS IN A HELA CELL POPULATION

1970 • 9 citations

The Effect of Cyclophosphamide on the Growth and Cellular Kinetics of a Transplantable Rat Fibrosarcoma

1972 • 8 citations

THE FATE OF Cr⁵¹ LABELLED EHRLICH ASCITES TUMOUR CELLS

1964 • 8 citations

Disappearance of Chromosomal Abnormalities in Megaloblastic Anaemia after Treatment

1970 • 6 citations

Parity models of cell proliferation

1974 • 6 citations

Application of a mathematical model to a clinical study of the local spread of endometrial cancer

1971 • 5 citations

Monte carlo simulation of PLM-curves and collection functions

1970 • 5 citations

A Quantitative Morphological Analysis of the Response of a Transplantable Rat Fibrosarcoma to Cyclophosphamide

1973 • 3 citations

Chapter 7 Staging of the Cell Cycle with Time-Lapse Photography

1969 • 2 citations