Biological Mechanisms and Toxicological Consequences of the Methylation of Arsenic

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

The Pharmacological Basis of Therapeutics

1976 • 8,675 citations

Modern Nutrition in Health and Disease.

1988 • 3,468 citations

The Pharmacological Basis of Therapeutics

1971 • 1,765 citations

Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper–transporting ATPase

1993 • 1,395 citations

DNA METHYLATION AND GENE ACTIVITY

1983 • 1,115 citations

Cancer risks from arsenic in drinking water.

1992 • 1,069 citations

Prevalence of Skin Cancer in an Endemic Area of Chronic Arsenicism in Taiwan<xref ref-type="fn" rid="FN2">2</xref>

1968 • 804 citations

The Pharmacological Basis of Therapeutics

1941 • 778 citations

Isolation of a partial candidate gene for Menkes disease by positional cloning

1993 • 690 citations

DOSE-RESPONSE RELATION BETWEEN ARSENIC CONCENTRATION IN WELL WATER AND MORTALITY FROM CANCERS AND VASCULAR DISEASES

1989 • 640 citations

Malignant neoplasms among residents of a blackfoot disease-endemic area in Taiwan: high-arsenic artesian well water and cancers.

1985 • 618 citations

Biological Methylation.

1945 • 562 citations

Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethylarsonate, or dimethylarsinate in man

1981 • 536 citations

Methylated Forms of Arsenic in the Environment

1973 • 466 citations

Reactions of arsenic(III) and arsenic(V) species with glutathione

1993 • 456 citations

Biosynthesis of dimethylarsine by methanobacterium

1971 • 390 citations

Isolation, crystal structure and synthesis of arsenobetaine, the arsenical constituent of the western rock lobster panulirus longipes cygnus George

1977 • 335 citations

Changes in the chemical speciation of arsenic following ingestion by man.

1977 • 330 citations

Advances in Mercury Toxicology

1991 • 322 citations

Reduction and binding of arsenate and dimethylarsinate by glutathione: a magnetic resonance study

1994 • 294 citations

Atherogenicity and carcinogenicity of high-arsenic artesian well water. Multiple risk factors and related malignant neoplasms of blackfoot disease.

1988 • 279 citations

Reduction of arsenate to arsenite by the ArsC protein of the arsenic resistance operon of Staphylococcus aureus plasmid pI258.

1992 • 273 citations

Urinary excretion of inorganic arsenic and its metabolites after repeated ingestion of sodium metaarsenite by volunteers

1981 • 271 citations

Evaluation of certain food additives and contaminants

1989 • 252 citations

Metabolism of arsenobetaine in mice, rats and rabbits

1983 • 243 citations

Metabolism of inorganic arsenic (74As) in humans following oral ingestion

1979 • 223 citations

A chemical hypothesis for arsenic methylation in mammals

1993 • 220 citations

Induction of DNA damage by dimethylarsine, a metabolite of inorganic arsenics, is for the major part likely due to its peroxyl radical

1990 • 219 citations

Biotransformation of trivalent and pentavalent inorganic arsenic in mice and rats

1981 • 217 citations

Study of inorganic arsenic methylation by rat liver in vitro: relevance for the interpretation of observations in man

1985 • 205 citations

Effects of low dietary intake of methionine, choline or proteins on the biotransformation of arsenite in the rabbit

1987 • 202 citations

Microbial formation and transformation of organometallic and organometalloid compounds

1993 • 192 citations

Survey of Arsenic in Total Diet Food Composites and Estimation of the Dietary Intake of Arsenic by Canadian Adults and Children

1993 • 187 citations

Cellular response to oxidative damage in lung induced by the administration of dimethylarsinic acid, a major metabolite of inorganic arsenics, in mice

1991 • 185 citations

Metalloregulated expression of the ars operon.

1993 • 181 citations

Labile Methyl Groups and the Promotion of Cancer

1986 • 169 citations

Human retention studies with 74As

1980 • 166 citations

Human Studies Do Not Support the Methylation Threshold Hypothesis for the Toxicity of Inorganic Arsenic

1993 • 163 citations

Isolation, crystal structure and synthesis of arsenobetaine, a constituent of the western rock lobster, the dusky shark, and some samples of human urine

1981 • 161 citations

Biotransformation of dimethylarsinic acid in mouse, hamster and man

1987 • 160 citations

In vivo reduction of arsenate in mice and rabbits

1983 • 154 citations

The role of the methylation in the detoxication of arsenate in the rabbit

1985 • 152 citations

The speciation of the chemical forms of arsenic in the biological monitoring of exposure to inorganic arsenic

1984 • 151 citations

Role of thiols in the in-vitro methylation of inorganic arsenic by rat liver cytosol

1988 • 151 citations

Dimethylated arsenics induce DNA strand breaks in lung via the production of active oxygen in mice

1989 • 149 citations

Transfer of arsenite from glutathione to dithiols: A model of interaction

1993 • 148 citations

The effect of methyltransferase inhibition on the metabolism of [74As]arsenite in mice and rabbits

1984 • 141 citations

Blackfoot Disease in Taiwan: A 30-Year Follow-up Study

1989 • 140 citations

Special report on ingested inorganic arsenic : skin cancer, nutritional essentiality

1988 • 127 citations

Reduction and binding of arsenate in marmoset monkeys

1985 • 124 citations

Separation of arsenic metabolites in dog plasma and urine following intravenous injection of 74As

1978 • 119 citations

Elevation of glutathione levels and glutathione S-transferase activity in arsenic-resistant chinese hamster ovary cells

1989 • 117 citations

Carcinomas of the respiratory tract in hamsters given arsenic trioxide and/or benzo[a]pyrene by the pulmonary route

1984 • 114 citations

Metabolism and excretion of orally administered dimethylarsinic acid in the hamster

1984 • 113 citations

Tissue distribution and subcellular binding of arsenic in Marmoset monkeys after injection of 74As-Arsenite

1982 • 109 citations

Evidence for the presence of arsenobetaine and another organoarsenical in shrimps

1982 • 104 citations

Towards an understanding of the genetics of bacterial metal resistance

1991 • 102 citations

Toxicity of Arsenic Compounds

1963 • 101 citations

Biotransformation and intracellular binding of arsenic in tissues of rabbits after intraperitoneal administration of 74As labelled arsenite

1981 • 100 citations

Production of trimethylarsine gas from various arsenic compounds by three sewage fungi

1973 • 99 citations

Biological Monitoring of Arsenic exposure of Gallium Arsenide- and Inorganic Arsenic-Exposed Workers by Determination of Inorganic Arsenic and Its Metabolites in Urine and Hair

1989 • 99 citations

Metabolism in the Rat of the Naturally Occurring Arsenic of Shrimp as Compared with Arsenic Trioxide

1935 • 92 citations

Metabolism and excretion of orally administrated arsenic trioxide in the hamster

1985 • 90 citations

Study of factors influencing the in vivo methylation of inorganic arsenic in rats

1987 • 89 citations

Biomethylation of inorganic arsenic by the rat and some laboratory animals

1980 • 88 citations

New Evidence for the presence of arsenocholine in shrimps (Pandalus borealis) by use of pyrolysis gas chromatography — atomic absorption spectrometry/mass spectrometry

1983 • 88 citations

Arsenicals in biology--retrospect and prospect.

1967 • 86 citations

Occurrence of arsenic in plaice (Pleuronectes platessa), nature of organo-arsenic compound present and its excretion by man.

1982 • 85 citations

Glutathione-dependent biliary excretion of arsenic

1991 • 84 citations

Metabolism of arsenocholine in mice, rats and rabbits

1984 • 82 citations

RADIOACTIVE TRACER STUDIES ON ARSENIC INJECTED AS POTASSIUM ARSENITE I. EXCRETION AND LOCALIZATION IN TISSUES

1942 • 82 citations

Arsenic intake and excretion by Japanese adults: A 7-day duplicate diet study

1990 • 81 citations

Intake of different chemical species of dietary arsenic by the japanese, and their blood and urinary arsenic levels

1992 • 79 citations

The metabolism of arsenite and arsenate by the rat

1983 • 78 citations

Human Menkes X‐chromosome disease and the staphylococcal cadmium‐resistance ATPase: a remarkable similarity in protein sequences

1993 • 76 citations

Orphan enzyme or patriarch of a new tribe: the arsenic resistance ATPase of bacterial plasmids

1993 • 73 citations

The rate of transmethylation in mouse liver as measured by trapping S-adenosylhomocysteine

1980 • 72 citations

Methylation of inorganic arsenic by mammals

1975 • 71 citations

The Metabolism of Arsenic in Humans Acutely Intoxicated by AS2O3. Its Significance for the Duration of BAL Therapy

1981 • 71 citations

Gene Damage Induced in Human Alveolar Type II (L-132) Cells by Exposure to Dimethylarsinic Acid

1993 • 69 citations

Glutathione as a cellular defence against arsenite toxicity in cultured Chinese hamster ovary cells

1993 • 67 citations

Dose-Dependent Disposition of Sodium Arsenate in Mice Following Acute Oral Exposure

1994 • 66 citations

Inorganic arsenic methylation by rat tissue slices

1990 • 65 citations

Pharmacogenetics of methylation: Relationship to drug metabolism

1988 • 64 citations

Identification of arsenobetaine in sole, lemon sole, flounder, dab, carb and shrimps by field desorption and fast atom bombardment mass spectrometry

1983 • 62 citations

Metabolism and excretion of orally and intraperitoneally administered gallium arsenide in the hamster

1986 • 61 citations

Glutathione S-Transferase π Facilitates the Excretion of Arsenic from Arsenic-Resistant Chinese Hamster Ovary Cells

1993 • 61 citations

The Teratogenic Potential of Cacodylic Acid in the Rat and Mouse

1981 • 59 citations

マウス,ラット,ウサギ中でのアルセノコリンの代謝

1984 • 57 citations

Excretion of a single oral dose of fish-arsenic in man

1982 • 56 citations

In vitro metabolism of inorganic arsenic by the gastro‐intestinal microflora of the rat

1981 • 54 citations

Metabolism and disposition of inorganic arsenic in laboratory animals and humans

1992 • 52 citations

Effects of glutathione depletion on the acute nephrotoxic potential of arsenite and on arsenic metabolism in hamsters

1990 • 49 citations

DNA methylation and differentiation.

1989 • 48 citations

Relation between airborne arsenic trioxide and urinary excretion of inorganic arsenic and its methylated metabolites.

1992 • 48 citations

Crosslink Formation between DNA and Nuclear Proteins by in Vivo and in Vitro Exposure of Cells to Dimethylarsinic Acid

1993 • 46 citations

Effect of arsenicals on biliary excretion of endogenous glutathione and xenobiotics with glutathione-dependent hepatobiliary transport

1991 • 46 citations

ENVIRONMENTAL AND OCCUPATIONAL EXPOSURE TO INORGANIC ARSENIC

1986 • 45 citations

Metabolism and excretion of orally ingested trimethylarsenic in man

1984 • 44 citations

Metabolism and excretion of orally and intraperitoneally administered methylarsonic acid in the hamster

1988 • 43 citations

Renal lesions induced in F344/DuCrj rats by 4-weeks oral administration of dimethylarsinic acid

1993 • 42 citations

On the pulmonary tumorigenicity of arsenic trisulfide and calcium arsenate in hamsters

1985 • 42 citations

The metabolism of 4-hydroxy-3-nitrophenylarsonic acid in hens

1964 • 41 citations

The influence of liver disease on the methylation of arsenite in humans

1984 • 40 citations

The metabolism of arsenic in laboratory animals using As74 as a tracer.

1950 • 38 citations

Review of Arsenical Pesticides

1975 • 36 citations

Human carcinogenesis by arsenic

1992 • 35 citations

Abnormal methylation capacity in human liver cirrhosis.

1988 • 34 citations

Dimercaptan metal-binding agents influence the biotransformation of arsenite in the rabbit

1985 • 32 citations

GSH release in bile as influenced by arsenite

1982 • 30 citations

Toxicity and metabolism of trimethylarsine in mice and hamsters

1990 • 30 citations

Arsenic metabolites in hair, blood and urine in workers exposed to arsenic trioxide.

1980 • 29 citations

Concentration of inorganic and total arsenic in fish from industrially polluted water

1985 • 28 citations

Molecular analysis of an anion pump: Purification of the ArsC protein

1991 • 27 citations

Conversion of arsenite and arsenate to methylarsenic and dimethylarsenic compounds by homogenates prepared from livers and kidneys of rats and mice

1989 • 27 citations

Detection of arsenobetaine in human blood

1994 • 25 citations

[Urinary inorganic arsenic and methylarsenic excretion following arsenate-rich seaweed ingestion (author's transl)].

1979 • 24 citations

The fate of 4-nitrophenylarsonic acid in hens

1964 • 21 citations

Individual Difference of Methylmercury Metabolism in Animals and Its Significance in Methylmercury Toxicity

1991 • 19 citations

THE EFFECT OF DIETARY AND CHEMICALLY INDUCED METHYLATION DEFICIENCY ON THE METABOLISM OF ARSENATE IN THE RABBIT.

1986 • 19 citations

Glutathione and methylation of inorganic arsenic in hamsters

1988 • 18 citations

The acute inhalation toxicology of the technical grade organoarsenical herbicides, cacodylic acid and disodium methanearsonic acid; a route comparison

1979 • 17 citations

Feed Additives, Metabolic Stability of Radioactive Arsanilic Acid in Chickens

1963 • 16 citations

Metabolism of arsanilic acid

1965 • 13 citations

Arsenic toxicity in humans: Research problems and prospects

1994 • 13 citations

Metabolism of arsanilic acid

1965 • 9 citations

Effect of S-adenosylmethionine on methylation of inorganic arsenic.

1990 • 8 citations

Arsenic contamination: Metabolic effects and localization in rats

1981 • 7 citations

Methylation of arsenic trioxide in hamsters with liver damage induced by long‐term administration of carbon tetrachloride

1988 • 6 citations

Deleted Work

1955 • 0 citations