The Citrate Enzymes: Their Structures, Mechanisms, and Biological Functions

[1] Citrate synthase

1969 • 1,958 citations

Adenosine Triphosphate Conservation in Metabolic Regulation

1967 • 878 citations

The specification of asymmetric configuration in organic chemistry

1956 • 784 citations

The Citrate Condensing Enzyme of Pigeon Breast Muscle and Moth Flight Muscle.

1963 • 534 citations

Mitochondria and Glyoxysomes from Castor Bean Endosperm

1969 • 465 citations

Determination of citrate with citrate lyase

1966 • 438 citations

Interpretation of Experiments on Metabolic processes, using Isotopic Tracer Elements

1948 • 425 citations

The Citrate Cleavage Enzyme

1959 • 391 citations

The kinetic properties of citrate synthase from rat liver mitochondria

1969 • 346 citations

β Oxidation in Glyoxysomes from Castor Bean Endosperm

1969 • 329 citations

Association of the glyoxylate cycle enzymes in a novel subcellular particle from castor bean endosperm

1967 • 321 citations

Mitochondrial citric acid cycle and related enzymes: Adaptive response to exercise

1970 • 307 citations

The relative significance of acetate and glucose as precursors for lipid synthesis in liver and adipose tissue from ruminants

1967 • 294 citations

The Role of Citric Acid in Intermediate Metabolism in Animal Tissues

1968 • 292 citations

Isotope effects on reaction rates

1960 • 281 citations

ENZYMATIC SYNTHESIS OF CITRIC ACID

1951 • 281 citations

The Supply of Precursors for the Synthesis of Fatty Acids

1962 • 277 citations

Tricarballylate and hydroxycitrate: Substrate and inhibitor of ATP: Citrate oxaloacetate lyase

1969 • 259 citations

Regulation of phosphofructokinase activity by citrate in normal and diabetic muscle

1963 • 254 citations

The citric acid content of animal tissues, with reference to its occurrence in bone and tumour

1941 • 254 citations

Citrate and the Conversion of Carbohydrate into Fat

1970 • 236 citations

Enzyme Concentrations in Tissues

1967 • 215 citations

ENZYMATIC SYNTHESIS OF CITRIC ACID

1952 • 199 citations

Inhibition of citrate-synthase by palmityl-coenzyme A

1963 • 199 citations

CITRATE AND THE CONVERSION OF CARBOHYDRATE INTO FAT. THE ACTIVITIES OF CITRATE-CLEAVAGE ENZYME AND ACETATE THIOKINASE IN LIVERS OF STARVED AND RE-FED RATS

1965 • 197 citations

Feedback Interactions in the Control of Citric Acid Cycle Activity in Rat Heart Mitochondria

1972 • 179 citations

Metabolic Roles of Citrate

1967 • 168 citations

ENZYMATIC SYNTHESIS OF CITRIC ACID

1951 • 164 citations

The Purification of Citrate-condensing Enzyme

1961 • 157 citations

Comparable and specific proportions in the mitochondrial enzyme activity pattern

1962 • 151 citations

Synthesis of mitochondrial proteins: Demonstration of a transfer of proteins from microsomes into mitochondria

1967 • 149 citations

Resolution of the Dissociation Constants of Citric Acid at 0 to 50°, and Determination of Certain Related Thermodynamic Functions

1949 • 148 citations

Palmityl-coenzyme a inhibition of the citrate-condensing enzyme

1965 • 137 citations

Molecular asymmetry in biology

1969 • 129 citations

[27] ATP citrate lyase (citrate-cleavage enzyme)

1969 • 124 citations

Kinetics of regulatory enzymes: Effect of adenosine triphosphate on yeast citrate synthase

1965 • 123 citations

Citrate-condensing Enzyme-Oxalacetate Binary Complex

1966 • 121 citations

The Molecular Physiology of Citrate

1965 • 120 citations

ENZYMATIC SYNTHESIS OF CITRIC ACID BY CONDENSATION OF ACETATE AND OXALACETATE

1949 • 118 citations

Biosynthesis of fatty acids and cholesterol considered as chemical processes

1959 • 116 citations

Regulation of Citrate Synthase and Microbial Taxonomy

1968 • 114 citations

The Utilization by Yeasts of Acids of the Tricarboxylic Acid Cycle

1960 • 108 citations

Citric acid cycle

1969 • 104 citations

Escherichia coli citrate synthase. Purification and the effect of potassium on some properties

1969 • 103 citations

THE ABSOLUTE STEREOCHEMICAL COURSE OF CITRIC ACID BIOSYNTHESIS

1963 • 103 citations

Inhibition of citrate synthase by succinyl‐CoA and other metabolites

1971 • 99 citations

Subunit Structure and Chemical Characteristics of Pig Heart Citrate Synthase

1970 • 97 citations

CITRATE AND THE CONVERSION OF CARBOHYDATE INTO FAT. ACTIVITIES OF CITRATE-CLEAVAGE ENZYME AND ACETATE THIOKINASE IN LIVERS OF NORMAL AND DIABETIC RATS

1965 • 95 citations

SUBCELLULAR DISTRIBUTION OF ACETYL‐CoA SYNTHETASE, ATP CITRATE LYASE, CITRATE SYNTHASE, CHOLINE ACETYLTRANSFERASE, FUMARATE HYDRATASE AND LACTATE DEHYDROGENASE IN MAMMALIAN BRAIN TISSUE

1967 • 95 citations

Acetate-nonutilizing Mutants of Neurospora crassa II. Biochemical Deficiencies and the Roles of Certain Enzymes

1968 • 94 citations

Enzyme Variants in Thermal Acclimation

1970 • 94 citations

AN ENZYMATIC REACTION BETWEEN CITRATE, ADENOSINE TRIPHOSPHATE AND COENZYME A¹

1953 • 94 citations

Regulation of citrate synthase activity in Escherichia coli

1966 • 91 citations

FLUOROACETYL COENZYME A

1955 • 86 citations

The inhibition of citrate synthase by adenosine triphosphate

1968 • 86 citations

Incorporation of radioactive citrate into fatty acids

1962 • 85 citations

The incorporation of citrate carbon into fatty acids

1963 • 84 citations

Studies on Specific Enzyme Inhibitors

1964 • 81 citations

Purification of Rat Heart and Rat Liver Citrate Synthases

1971 • 81 citations

Citrate Cleavage Enzyme and Fatty Acid Synthesis

1968 • 80 citations

The Citrate Cleavage Enzyme

1964 • 80 citations

ROLE OF CITRITASE IN ACETOIN FORMATION BY STREPTOCOCCUS DIACETILACTIS AND LEUCONOSTOC CITROVORUM

1961 • 79 citations

Der Wirkungsmechanismus der Citrat-Lyase ausKlebsiella aerogenes

1971 • 78 citations

The sulfhydryl groups of citrate cleavage enzyme

1969 • 78 citations

Purification and Kinetic Studies of the Citrate Cleavage Enzyme

1967 • 78 citations

THE EFFECT OF pH ON FUMARASE ACTIVITY IN ACETATE BUFFER

1955 • 77 citations

Studies on ATP Citrate Lyase of Rat Liver

1966 • 77 citations

X-ray crystal analysis of the substrates of aconitase. V. Magnesium citrate decahydrate [Mg(H₂O)₆][MgC₆H₅O₇(H₂O)]₂.2H₂O

1965 • 77 citations

Biosynthesis of Asymmetric Citric Acid: a Substantiation of the Ogston Concept

1949 • 77 citations

Effect of Divalent Metal Ions on Nucleotide Inhibition of Pig Heart Citrate Synthase

1966 • 75 citations

Synthesis of Glutamate and Citrate by Clostridium kluyveri. A New Type of Citrate Synthase^*

1966 • 74 citations

Dietary response of various key enzymes related to glucose metabolism in normal and diabetic rat liver

1967 • 74 citations

The Citrate Cleavage Enzyme

1961 • 73 citations

Allosteric regulation of the activity of citrate synthetase of Escherichiacoli by α-ketoglutarate

1967 • 70 citations

Uber das Katalyseprinzip der Malat-synthase

1967 • 70 citations

Citrate synthases: Allosteric regulation and molecular size

1969 • 69 citations

Particulate enzymes of the glyoxylate cycle in Neurospora crassa

1969 • 67 citations

Physicochemical Characterization of Citrate Synthase and Its Subunits

1970 • 66 citations

[88] Citrate-cleavage enzyme

1962 • 64 citations

Dissimilation of Citric Acid by Bacterial Extracts

1953 • 62 citations

Citridesmolase: Its properties and mode of action

1955 • 62 citations

Coarse and fine control of citrate synthase from Bacillus subtilis

1969 • 61 citations

Fluorocitrate Inhibition of Aconitase: Relative Configuration of Inhibitory Isomer by X-ray Crystallography

1970 • 61 citations

Kinetic Studies on the Citrate-condensing Enzyme

1961 • 61 citations

[3] Citrate synthase from yeast

1969 • 60 citations

ON THE ORIGIN OF THE ACETYL MOIETY OF ACETYLCHOLINE IN BRAIN STUDIED WITH A DIFFERENTIAL LABELLING TECHNIQUE USING ³H‐¹⁴C‐MIXED LABELLED GLUCOSE AND ACETATE

1970 • 59 citations

The free energy change associated with the hydrolysis of the thiol ester bond of acetyl coenzyme A

1955 • 59 citations

Stereochemistry of Enzymic Citrate Synthesis and Cleavage

1970 • 58 citations

The fate of acetyl groups derived from glucose in the isolated perfused goat udder

1966 • 55 citations

Regulatory Mechanisms Involving Nicotinamide Adenine Nucleotides as Allosteric Effectors

1971 • 54 citations

Citrate and the conversion of carbohydrate into fat. Citrate cleavage in obesity and lactation

1966 • 54 citations

The Stereospecificity of the Citrate Synthase in Sulfate‐Reducing and Photosynthetic Bacteria

1968 • 53 citations

[5] Citrate synthase from Escherichia coli

1969 • 53 citations

Control of DPN-specific isocitric dehydrogenase activity by precursor activation and end product inhibition

1963 • 53 citations

A Coenzyme A analogue, Desulpho-CoA; Preparation and effects on various enzymes

1966 • 53 citations

Regulation of citrate synthase activity by α‐ketoglutarate. Metabolic and taxonomic significance

1969 • 52 citations

Nature of the phosphorylated residue in citrate cleavage enzyme

1969 • 52 citations

Mechanisms of acetylcholine synthesis in the blowfly

1956 • 51 citations

The Ionization of Citric Acid Studied by the Nuclear Magnetic Resonance Technique¹

1960 • 51 citations

Mechanism of aconitase action deduced from crystallographic studies of its substrates

1968 • 51 citations

Control of citrate formation in rat liver mitochondria

1967 • 50 citations

Occurrence and Significance of Citric Acid in the Animal Organism

1953 • 50 citations

OBSERVATIONS ON THE SUBCELLULAR DISTRIBUTION OF CHOLINE ACETYLTRANSFERASE IN THE BRAIN TISSUE OF MAMMALS AND COMPARISONS OF ACETYLCHOLINE SYNTHESIS FROM ACETATE AND CITRATE IN HOMOGENATES AND NERVE‐ENDING FRACTIONS

1967 • 50 citations

Synthesis and Breakdown of Citric Acid with Crystalline Condensing Enzyme

1950 • 49 citations

Reduced Nicotinamide-Adenine Dinucleotide as an Allosteric Effector of Citrate-Synthase Activity in Escherichia coli

1966 • 49 citations

Requirement for Sodium in the Anaerobic Growth of Aerobacter aerogenes on Citrate

1969 • 48 citations

THE ENZYMATIC FORMATION OF CITRIC ACID STUDIED WITH C14-LABELED OXALACETATE

1950 • 48 citations

Glutamate Biosynthesis in Anaerobic Bacteria. I. The Citrate Pathways of Glutamate Synthesis in Clostridium kluyveri^*

1966 • 47 citations

Studies on ATP Citrate Lyase of Rat Liver

1968 • 46 citations

Acetyl-CoA carboxylase and citrate cleavage enzymein the rat mammary gland

1965 • 44 citations

Citrate cleavage and acetate activation in livers of normal and diabetic rats

1964 • 44 citations

Studies of the Mechanism of Action of the Condensing Enzyme

1959 • 43 citations

CITRITASE, THE CITRATE-SPLITTING ENZYME FROM ESCHERICHIA COLI

1955 • 41 citations

CITRITASE, THE CITRATE-SPLITTING ENZYME FROM ESCHERICHIA COLI

1955 • 41 citations

Fate of Chiral Acetates in the Citric Acid Cycle

1970 • 40 citations

Citryl Phosphate and the Mode of Action of the Citrate Cleavage Enzyme

1969 • 40 citations

Oxalacetate Keto-Enol Tautomerase

1969 • 39 citations

Naturally Occurring Lactones and Lactames. III. The Absolute Configuration of the Hydroxycitric Acid Lactones: Hibiscus Acid and Garcinia Acid.

1969 • 37 citations

Citrate cleavage enzyme in mango fruit

1970 • 37 citations

Studies on ATP Citrate Lyase of Rat Liver

1969 • 36 citations

Location of the structural gene for citrate synthase on the chromosome of Escherichia coli K12

1965 • 36 citations

Dietary and hormonal regulation of the hepatic citrate-cleavage enzyme

1964 • 36 citations

A COMPLETE IONIZATION SCHEME FOR CITRIC ACID

1961 • 36 citations

The role of ATP citrate lyase in the transfer of acetyl groups in rat liver

1968 • 35 citations

[77] Isolation and properties of hydroxycitric acid

1969 • 35 citations

Citryl-CoA and the citrate condensing enzyme

1963 • 35 citations

Isotope effects on reaction rates

1961 • 35 citations

ENZYMATIC REACTIONS OF FLUOROACETATE AND FLUOROACETYL COENZYME A

1956 • 35 citations

The Reaction Inactivation of Citrate Lyase from Aerobacter aerogenes

1971 • 34 citations

On the proposed relation of citrate enzymes to fatty acid synthesis and ketosis in starvation

1967 • 34 citations

Role of ATP in the ATP citrate lyase reaction

1967 • 34 citations

The Citritase of Streptococcus diacetilactis

1963 • 34 citations

ON THE MECHANISM OF THE ANAEROBIC SYNTHESIS OF ACETYLCHOLINE

1946 • 34 citations

The inhibition of lemon citrate-condensing enzyme by ATP

1966 • 34 citations

Control of citrate and acetoacetate synthesis in rat liver

1968 • 33 citations

A magnetic resonance study of the citrate synthase reaction

1967 • 32 citations

Citritase and isocitritase reactions: equilibria-energetics

1956 • 32 citations

Influence of thyroxine and luteinizing hormone on some enzymes concerned with lopogenesis in adipose tissue, testis and adrenal gland

1966 • 32 citations

Citryl-CoA. An substrate for the citrate-cleavage enzyme

1963 • 32 citations

Utilization of citric acid carbon for the biosynthesis of long-chain fatty acids

1962 • 31 citations

Acid anhydride-free acid equilibria in water in some substituted succinic acid systems and their interaction with aniline

1967 • 31 citations

Enzymatic Synthesis of Monofluorocitrate from β-Fluoro-oxaloacetate

1962 • 30 citations

Citryl-CoA. An substrate for the citrate-cleavage enzyme

1963 • 30 citations

Development of a Journal

1959 • 29 citations

Citrate Synthase

1970 • 28 citations

Some complexities of metabolic regulation

1969 • 28 citations

Mechanisms of acetylcholine synthesis

1952 • 27 citations

Stereochemistry of the interconversions of citrate and acetate catalyzed by citrate synthase, adenosine triphosphate citrate lyase, and citrate lyase

1971 • 26 citations

Citrate lyase: Molecular weight and subunit structure

1968 • 26 citations

Effect of Alloxan-Diabetes on the Activity of Citrate Cleavage Enzyme in Adipose Tissue

1965 • 26 citations

Studies with Acetyl Coenzyme A and Condensing Enzyme in D2O

1958 • 26 citations

Acetyl group transfer in lipogenesis

1968 • 26 citations

Effects of Salts and Organic Solvents on the Activity of Citrate Synthase

1970 • 26 citations

THE EQUILIBRIUM OF THE REACTION CATALYSED BY CITRATE OXALOACETATE-LYASE

1965 • 25 citations

Properties of (R)-Citrate Synthase fromClostridium acidi-urici

1970 • 25 citations

A magnetic resonance study on the citrate lyase of Streptococcus diacetilactis

1965 • 24 citations

Citrate synthase interaction with polyphosphate derivatives

1967 • 23 citations

Purification and some properties of yeast citrate synthase

1968 • 23 citations

Ueber eine Synthese der Aconitsäure

1891 • 23 citations

Studies on the Mechanism of the Citrate Condensing Enzyme Reaction

1959 • 23 citations

The sulfhydryl groups of citrate-condensing enzyme

1965 • 22 citations

Enzymatic Analysis of the Requirement for Sodium in Aerobic Growth of Salmonella typhimurium on Citrate

1969 • 22 citations

Studies on ATP Citrate Lyase of Rat Liver

1969 • 22 citations

Purification of citrase from Aerobacter aerogenes

1961 • 21 citations

Glutamate Biosynthesis in Anaerobic Bacteria. II. Stereospecificity of Aconitase and Citrate Synthetase of Clostridium kluyveri^*

1966 • 20 citations

Effect of thyroidectomy on pathways of glucose metabolism in lactating rat mammary gland

1967 • 20 citations

Conformation changes in citrate-condensing enzyme

1965 • 19 citations

Absolute configurations of the naturally occurring hydroxycitric acids

1969 • 19 citations

Intramolecular Nucleophilic Catalysis on the Hydrolysis of Citryl-CoA

1969 • 19 citations

Die enzymatische analyse von coenzym A

1963 • 18 citations

[85] Citratase and isocitratase

1962 • 18 citations

Role of Sodium in Determining Alternate Pathways of Aerobic Citrate Catabolism in Aerobacter aerogenes

1969 • 18 citations

[4] Citrate synthase from lemon fruit

1969 • 18 citations

Deuterium Isotope Rate Effects with Citrate-condensing Enzyme

1961 • 17 citations

[74] Stereospecifically labeled citric acid cycle intermediates

1969 • 17 citations

Allosteric changes in citrate synthase observed by electron microscopy

1969 • 16 citations

Reversal of the stereospecificity of the citrate synthase of Clostridiumkluyveri by p-chloromercuribenzoate

1969 • 16 citations

Rôle modeste du citrate comme transporteur d'acétyl‐CoA chez l'animal vivant.

1971 • 14 citations

On the regulation of the regulatory enzyme, citrate synthase, by salt

1971 • 14 citations

The stereospecificity of the (R)-citrate synthase in the presence of p-chloromercuribenzoate

1969 • 14 citations

The effect of thyroxine on citrate cleavage enzyme and NADP linked dehydrogenase activities

1965 • 13 citations

Crystallization and some properties of the citrate cleavage enzyme of rat liver

1965 • 13 citations

The product inhibition of citrate-oxaloacetate lyase from A.aerogenes

1963 • 13 citations

An unusual citrate synthase from mango fruit

1971 • 13 citations

THE STATE OF IONIZATION OF CRYSTALLINE SODIUM DIHYDROGEN CITRATE¹

1960 • 12 citations

Citrate Condensing Enzyme in Citrus Fruit

1966 • 12 citations

STUDIES ON CHOLINE ACETYLASE (II)

1954 • 12 citations

Immunochemical studies with citrate-condensing enzyme

1963 • 12 citations

Inactivation of citrate lyase by oxaloacetate and its structural analogues

1966 • 12 citations

The Isomer of Oxaloacetate Produced by the Action of Citrate Lyase on Citrate

1964 • 11 citations

Physicochemical studies on citrate-oxaloacetate lyase from Aerobacter aerogenes

1963 • 11 citations

Citryl 1-Phosphate and the Citrate Cleavage Reaction

1968 • 11 citations

Studies on ATP Citrate Lyase of Rat Liver

1967 • 11 citations

The synthesis of acetyl-coenzyme A and scetylcholine from citrate and acetate in the nerve endings of mammalian brain

1966 • 11 citations

Reversible Inactivation of Citrate Lyase: Effect of Metal Ions and Adenine Nucleotides

1967 • 10 citations

Evidence against an allosteric effect of indole-3-acetic acid on citrate synthase

1968 • 9 citations

On the site of synthesis of enzymes tightly bound to mitochondrial structure in rat liver

1968 • 9 citations

Hormonal modifications of plant citrate synthase in vitro

1970 • 9 citations

Reversible Inactivation of Citrate Lyase: Effect of Metal Ions and Adenine Nucleotides

1967 • 9 citations

¹⁸O‐Studies with Citrate Synthase and Malate Synthase

1969 • 8 citations

Dietary Response of the Hepatic Citrate-Cleavage Enzyme in Hypophysectomized Rats

1966 • 8 citations

The citrate cleavage enzyme: Release of phosphate from the phosphoenzyme

1971 • 8 citations

Confirmation of the effect of indole-3-acetic acid on citrate synthase

1969 • 8 citations

Starch-gel electrophoresis of citrate-condensing enzyme from pig heart

1963 • 8 citations

Oxygen-18 studies with citrate synthase

1967 • 7 citations

Activation of Citrate Synthetase by Indoleacetic Acid

1969 • 7 citations

General discussion

1966 • 6 citations

Pathway and Enzymes of Conversion of Citric Acid into Acetyl Phosphate in Animal Tissues

1966 • 5 citations

Condensing Enzyme from Higher Plants

1962 • 5 citations

Adenosine triphosphate citrate lyase of rat liver. Binding site of citrate

1971 • 5 citations

Condensing Enzyme in Garcinia Leaves (Xanthochymus guttiferae)

1959 • 4 citations

Molecular models of metal chelates to illustrate enzymatic reactions

1968 • 4 citations

Initial Velocity Studies of the Reverse Citrate Cleavage Reaction

1971 • 3 citations

Isotopic Exchange Studies of the Citrate Cleavage Reaction

1971 • 2 citations

MECHANSM AND ENZYMES IN THE PRODUCTION OF ACETYL PHOSPHATE DURING THE CONVERSION OF CITRIC ACID IN THE ANIMAL TISSUE

1964 • 2 citations