Role of Specific Chromosomal Proteins and DNA Sequences in the Nuclear Binding Sites for Steroid Receptors

A two-step mechanism for the interaction of estradiol with rat uterus.

1968 • 1,013 citations

Female Steroid Hormones and Target Cell Nuclei

1974 • 946 citations

Mechanism of Action of the Female Sex Hormones

1972 • 763 citations

Current Models of Steroid Hormone Action: A Critique

1976 • 707 citations

Steroid Receptors: Elements for Modulation of Eukaryotic Transcription

1976 • 688 citations

A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization.

1966 • 680 citations

Monoclonal antibodies to human estrogen receptor.

1980 • 545 citations

Hormone Receptors: Studies on the Interaction of Estrogen with the Uterus

1968 • 537 citations

Nonhistone Chromosomal Proteins and Gene Regulation

1974 • 439 citations

Reversible Denaturation of Enzymes by Sodium Dodecyl Sulfate

1971 • 438 citations

Progesterone-binding Components of Chick Oviduct

1971 • 389 citations

Progesterone-binding Components of Chick Oviduct

1972 • 372 citations

Studies on the Mechanism of Steroid Hormone Regulation of Synthesis of Specific Proteins

1969 • 352 citations

Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA fragment whose transcription is regulated by glucocorticoids in vivo.

1981 • 341 citations

Progesterone-binding Components of Chick Oviduct

1970 • 321 citations

The specific binding of estrogens and androgens to the nuclear matrix of sex hormone responsive tissues.

1980 • 304 citations

Acidophilic activation of steroid hormone receptors

1973 • 260 citations

Early Events in Glucocorticoid Action

1973 • 257 citations

Chicken oviduct progesterone receptor: Location of specific regions of high-affinity binding in cloned DNA fragments of hormone-responsive genes

1982 • 256 citations

Role of DNA and Specific Cytoplasmic Receptors in Glucocorticoid Action

1972 • 248 citations

Receptors and mechanism of action of steroid hormones

1977 • 247 citations

Mechanisms of Interaction of a Hormone—Receptor Complex with the Genome of a Eukaryotic Target Cell

1972 • 245 citations

Oestrogen receptors and antagonism of steroid hormone action

1974 • 242 citations

Proteins of chromatin in template restriction

1971 • 228 citations

A significant lag in the induction of ovalbumin messenger RNA by steroid hormones: A receptor translocation hypothesis

1976 • 219 citations

Use of a specific probe for ovalbumin messenger RNA to quantitate estrogen-induced gene transcripts

1975 • 215 citations

Specific Sites of Interaction Between Histones and DNA in Chromatin

1974 • 204 citations

Genetic Approaches to Steroid Hormone Action

1976 • 203 citations

The Molecular Mechanism of the in Vitro 4 S to 5 S Transformation of the Uterine Estrogen Receptor

1974 • 199 citations

Estrogen receptor binding to isolated nuclei. Nonsaturable process

1974 • 193 citations

Progesterone-binding Components of Chick Oviduct

1972 • 178 citations

Immunochemical analysis of the glucocorticoid receptor: identification of a third domain separate from the steroid-binding and DNA-binding domains.

1982 • 178 citations

Equilibrium: the intracellular distribution of steroid receptors

1979 • 176 citations

Progesterone-binding Protein of Chick Oviduct

1972 • 173 citations

Equilibrium binding of estradiol by uterine cell suspensions and whole uteri in vitro

1974 • 169 citations

Estrogen binding proteins of calf uterus. Molecular and functional characterization of the receptor transforming factor: A Ca2+-activated protease.

1977 • 167 citations

Receptors from Glucocorticoid-Sensitive Lymphoma Cells and Two Classes of Insensitive Clones: Physical and DNA-Binding Properties

1974 • 166 citations

Synthesis of very low density lipoproteins in the cockerel. Effects of estrogen.

1976 • 166 citations

Rates of Induction of Specific Translatable Messenger RNAs for Ovalbumin and Avidin by Steroid Hormones

1973 • 161 citations

The biology and mechanism of steroid hormone receptor interaction with the eukaryotic nucleus

1976 • 158 citations

Progesterone in uterus and plasma. IV — Progesterone receptor(s) in guinea pig uterus cytosol

1970 • 157 citations

Antibodies to estrogen receptor: Immunochemical similarity of estrophilin from various mammalian species

1977 • 156 citations

Kinetic aspects of conformational changes in proteins. I. Rate of regain of enzyme activity from denatured proteins

1971 • 156 citations

Interaction of glucocorticoid receptor-steroid complexes with acceptor sites.

1976 • 156 citations

Progesterone-binding Components of Chick Oviduct

1971 • 149 citations

Purified glucocorticoid receptor-hormone complex from rat liver cytosol binds specifically to cloned mouse mammary tumor virus long terminal repeats in vitro.

1982 • 147 citations

In Vitro Conversion of Estradiol-Receptor Protein to Its Nuclear Form: Dependence on Hormone and DNA

1972 • 145 citations

On the Specificity of the Binding of the Estradiol Receptor Protein to Deoxyribonucleic Acid

1974 • 144 citations

The interaction of estradiol-receptor protein with the genome: an argument for the existence of undetected specific sites

1975 • 144 citations

Tissue-specific stimulation of RNA synthesis by transformed estradiol-receptor complex

1972 • 140 citations

Nonhistone Proteins Control Gene Expression in Reconstituted Chromatin

1974 • 140 citations

THE BINDING OF ESTRADIOL IN THE UTERUS: A MECHANISM FOR DEREPRESSION OF RNA SYNTHESIS

1964 • 134 citations

Binding of glucocorticoid receptors to DNA.

1975 • 133 citations

Studies on the mechanism of action of estrogens.

1958 • 132 citations

Activation of the rat liver glucocorticoid-receptor complex

1977 • 130 citations

Deoxyribonucleoproteins and the tissue-specific restriction of the deoxyribonucleic acid in chromatin

1970 • 121 citations

Unstable nuclear RNA synthesis following estrogen stimulation

1970 • 113 citations

A low molecular weight inhibitor of steroid receptor activation.

1977 • 113 citations

Involvement of a low molecular weight component(s) in the mechanism of action of the glucocorticoid receptor

1976 • 110 citations

Ribonucleoprotein Binding of Steroid-“Receptor” Complexes

1973 • 104 citations

Characterization of the 4 S and 5 S Forms of the Estradiol Receptor Protein and Their Interaction with Deoxyribonucleic Acid

1974 • 103 citations

Nature of Nuclear Acceptor Sites for Glucocorticoid- and Estrogen-Receptor Complexes

1973 • 102 citations

Chemical modification of the avian progesterone receptor by pyridoxal 5'-phosphate.

1979 • 98 citations

Progesterone Receptors of Chick Oviduct: Identification of 6S Receptor Dimers

1975 • 98 citations

Involvement of DNA in the Acceptor Mechanism for Uterine Oestradiol Receptor

1972 • 96 citations

Seasonal changes in the molecular species and nuclear binding of the chick oviduct progesterone receptor

1979 • 96 citations

Progesterone-binding components of chick oviduct. Receptor B subunit protein purified to apparent homogeneity from laying hen oviducts.

1977 • 93 citations

On the mechanism of hormone actionXV. Subcellular distribution and binding of [1,2-3H]cortisol in rat liver

1969 • 91 citations

Effect of estrogen on gene expression in the chick oviduct. V. Changes in the number of RNA polymerase binding and initiation sites in chromatin.

1975 • 91 citations

Concepts related to salt resistant estradiol receptors in rat uterine nuclei: Nuclear matrix

1977 • 87 citations

The Role of Estrophilin in Estrogen Action

1975 • 84 citations

The interaction of uterine estrogen receptors with DNA

1972 • 81 citations

Estrophilic binding sites of the uterus. Relation to uptake and retention of estradiol in vitro

1973 • 75 citations

Inhibition of the binding of progesterone receptor to nuclei: Effects of o-phenanthroline and rifamycin AF/013

1975 • 74 citations

Nuclear binding of progesterone in hen oviduct. Role of acidic chromatin proteins in high-affinity binding

1976 • 72 citations

Nuclear binding of progesterone in hen oviduct. Binding to multiple sites in vitro

1976 • 72 citations

The synthesis of ribonucleic acid in immature rat uterus responding to oestradiol-17β

1971 • 71 citations

Nuclear Receptor · Estrogen Complexes of Rat Uteri:

1973 • 69 citations

In vivo effect of anti-estrogens on the localisation and replenishment of estrogen receptor

1975 • 69 citations

Evidence for fidelity of chromatin reconstitution

1975 • 67 citations

Cytoplasmic Estradiol “Receptors” Associated with the “Microsomal” Fraction of Pig Uterus

1972 • 66 citations

Identification of a High Affinity Nuclear Acceptor Site for Estrogen Receptor of Calf Uterus

1974 • 66 citations

Acidic proteins of the nucleus

1975 • 66 citations

Acceptor proteins in rat androgenic tissue chromatin.

1976 • 64 citations

An antiserum to the rat liver glucocorticoid receptor.

1980 • 63 citations

Chromosomal proteins regulate steroid binding to chromatin

1976 • 61 citations

Specific Binding of the Oestradiol-Receptor Complex to DNA

1972 • 60 citations

Nonfunctioning Progesterone Receptors in the Developed Oviducts from Estrogen-Withdrawn Immature Chicks and in Aged Nonlaying Hens*

1982 • 60 citations

Role of zinc(II) in the refolding of guanidine hydrochloride denatured bovine carbonic anhydrase

1972 • 60 citations

Characterization of two 8 S forms of chick oviduct progesterone receptor.

1982 • 59 citations

Nuclear components responsible for the retention of steroid–receptor complexes, especially from the standpoint of the specifcity of hormonal responses

1976 • 59 citations

Selective binding of chicken progesterone receptor a subunit to a DNA fragment containing ovalbumin gene sequences

1982 • 59 citations

Circannual Rhythms in Steroid Receptor Concentration and Nuclear Binding in the Chick Oviduct*

1980 • 57 citations

An Insoluble Receptor for Oestrogens in the “Residual” Nuclear Proteins of Chick‐Liver

1973 • 57 citations

The Globin Gene: Structure and Expression

1974 • 56 citations

Progesterone-binding components of chick oviduct. In vitro effect of receptor subunits on gene transcription.

1976 • 56 citations

Nuclear binding of progesterone in chick oviduct. Multiple binding sites in vivo and transcriptional response

1976 • 55 citations

Interaction of the estradiol receptor from calf uterus with its nuclear acceptor sites

1975 • 55 citations

Retention of an androgen-protein complex by nuclear chromatin aggregates: Heat-labile factors,

1971 • 54 citations

Factors affecting the binding of chick oviduct progesterone receptor to deoxyribonucleic acid: evidence that deoxyribonucleic acid alone is not the nuclear acceptor site

1980 • 54 citations

Hormone-Mediated Dimerization of Microsomal Estradiol Receptor

1973 • 53 citations

Denaturation and reactivation of human carbonic anhydrases in guanidine hydrochloride and urea

1973 • 51 citations

Structural recognitions in the interactions of androgens and receptor proteins and in their association with nuclear acceptor components

1972 • 51 citations

Reversible unfolding of the major fraction of ovalbumin by guanidine hydrochloride

1976 • 51 citations

Binding of hydrocortisone to rat liver histones

1966 • 49 citations

Analysis of the molecular species of the chick oviduct progesterone receptor using isoelectric focusing

1979 • 48 citations

Progesterone Binding to Hen Oviduct Genome: Specific Versus Nonspecific Binding

1976 • 48 citations

Alterations in liver chromatin during perinatal development of the rat

1974 • 48 citations

Effects of estrogen and progesterone on transcription, chromatin and ovalbumin gene expression in the chick oviduct

1976 • 46 citations

Nuclear Binding of Steroid Receptors: Comparison in Intact Cells and Cell-Free Systems

1973 • 46 citations

Assessment of specificity of oestrogen receptor-DNA interaction by a competitive assay

1978 • 44 citations

The binding of [3H]oestradiol-receptor complexes to calf uterine chromatin

1981 • 43 citations

Role of nuclear proteins as high affinity sites (“acceptors”) for progesterone in the avian oviduct

1976 • 43 citations

Interaction of steroid hormones with histones in vitro

1969 • 42 citations

Isolation and Characterization of the Estrogen Receptor in Hen Oviduct: Evidence for Two Molecular Species*

1980 • 42 citations

In vitro binding of the estrogen receptor to DNA: Absence of saturation at equilibrium

1975 • 42 citations

Regulation of Specific Protein Synthesis in Eucaryotic Cells

1970 • 42 citations

In vitro assembly of aldolase. Kinetics of refolding, subunit reassociation, and reactivation

1972 • 42 citations

Estrogen receptor has enhanced affinity for bromodeoxyuridine-substituted DNA.

1978 • 41 citations

The selective isolation of the uterine oestradiol-receptor complex by binding to oligo(dT)-cellulose. The mediation of an essential activator in the transformation of cytosol receptor

1976 • 41 citations

Evidence for glucocorticoid transport through the target cell membrane

1974 • 41 citations

Early estrogen action: nuclear synthesis and accumulation of protein correlated with enhancement of two DNA-dependent RNA polymerase activities.

1968 • 40 citations

Reconstitution of Chromatin Subunits

1977 • 39 citations

Inhibition of estrogen-receptor-DNA interaction by intercalating drugs

1976 • 39 citations

Bindung von [³H]Cortison an Histone aus Rattenleber

1965 • 37 citations

Progesterone-binding components of chick oviduct. In vitro effects of purified hormone-receptor complexes on the initiation of RNA synthesis in chromatin.

1976 • 36 citations

Nuclear Binding Sites (“Acceptors”) for Progesterone in Avian Oviduct: Characterization of the Highest‐Affinity Sites^*

1977 • 36 citations

Reconstitution of chromatin. Mode of reassociation of chromosomal proteins

1975 • 32 citations

Glucocorticoid receptor-steroid complex binding to DNA competition between DNA and DNA-cellulose

1977 • 30 citations

The binding of 3H-labelled oestradiol- and progesterone-receptor complexes to hypothalamic chromatin of male and female sheep

1978 • 29 citations

Support for chromatin acidic proteins as acceptors for progesterone in the chick oviduct

1979 • 28 citations

Comparison of glucocorticoid-receptor complex binding to nuclei and DNA cellulose Evidence for different forms of interaction

1978 • 28 citations

Estradiol-receptors of the rat uterus: Interaction of the cytoplasmic estrogen-receptor with DNA in vitro

1972 • 27 citations

Drug Receptors and Their Effectors

1981 • 26 citations

THE ASSOCIATION OF [6,7-3H]OESTRADIOL WITH A NUCLEAR PROTEIN

1967 • 26 citations

In vitro binding of the estrogen receptor to DNA: Absence of saturation at equilibrium

1975 • 25 citations

Interaction of estradiol- and progesterone-receptors with nucleoprotein: Heat-labile acceptor factors

1972 • 24 citations

Glucocorticoid-Receptor Complex Binds to Nonhistone Protein and DNA in Rat Liver Chromatin1

1978 • 23 citations

Mode of reconstitution of chicken erythrocyte and reticulocyte chromatin

1976 • 21 citations

Selective binding of mouse estradiol.receptor complexes to oligo(dT)-cellulose

1978 • 20 citations

Intracellular distribution of estrogen receptors: A function of preparation

1980 • 20 citations

The Interaction of Uterine Estrogen Receptors with DNA

1973 • 19 citations

Binding of the partially purified glucocorticoid receptor of rat liver to chromatin and DNA

1977 • 19 citations

Transformed estrogen receptor in the regulation of RNA synthesis in uterine nuclei

1973 • 18 citations

Solubilization of the Chromatin‐Bound Estrogen Receptor from Chicken Liver and Fractionation on Hydroxylapatite

1976 • 18 citations

Estradiol‐receptor‐DNA interaction: Liquid polymer phase partition

1976 • 18 citations

Direct binding of corticosterone and estradiol to rat liver nuclear non-histone proteins

1974 • 17 citations

Isolation and characterization of the nuclear acceptor that binds the progesterone‐receptor complex in hen oviduct

1977 • 15 citations

[15] Immunochemical characteristics of chromosomal proteins

1975 • 15 citations

Steroid receptor binding to nuclei: Effect of assay conditions on the integrity of chromatin

1979 • 14 citations

Dissociation and reconstitution of human ferroxidase II

1977 • 13 citations

Steroid hormone receptor fraction stimulation of RNA synthesis: A caution

1976 • 12 citations

Distribution of Binding Sites for the Progesterone Receptor Within Chick Oviduct Chromatin

1976 • 12 citations