The Transforming Protein of Avian Sarcoma Viruses and Its Homologue in Normal Cells

The Fluid Mosaic Model of the Structure of Cell Membranes

1972 • 8,835 citations

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus

1970 • 2,061 citations

Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses

1970 • 1,992 citations

DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA

1976 • 1,290 citations

Protein kinase activity associated with the avian sarcoma virus src gene product.

1978 • 1,137 citations

Phosphorylated Proteins as Physiological Effectors

1978 • 975 citations

Identification of a transformation-specific antigen induced by an avian sarcoma virus

1977 • 931 citations

Protein Phosphorylation

1975 • 762 citations

Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein

1978 • 673 citations

Characteristics of an assay for Rous sarcoma virus and Rous sarcoma cells in tissue culture

1958 • 555 citations

Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine

1980 • 539 citations

The fibronexus: a transmembrane association of fibronectin-containing fibers and bundles of 5 nm microfilaments in hamster and human fibroblasts

1979 • 536 citations

Avian sarcoma virus-transforming protein, pp60src shows protein kinase activity specific for tyrosine

1980 • 510 citations

Fibrinolysis Associated with Oncogenic Transformation

1974 • 444 citations

Rous Sarcoma Virus: a Function required for the Maintenance of the Transformed State

1970 • 444 citations

Relationships between fibronectin (LETS protein) and actin

1978 • 428 citations

Proteases and biological control

1975 • 412 citations

The effects of reciprocal changes in temperature on the transformed state of cells infected with a Rous sarcoma virus mutant

1971 • 411 citations

Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src).

1979 • 378 citations

Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts.

1977 • 371 citations

Characterization of Rous sarcoma virus src gene products synthesized in vitro

1978 • 352 citations

Structural analysis of the avian sarcoma virus transforming protein: sites of phosphorylation

1979 • 319 citations

Retroviruses

1978 • 311 citations

The outer boundary of the cytoskeleton: a lamina derived from plasma membrane proteins

1979 • 298 citations

Cell Transformation by RNA Tumor Viruses

1977 • 298 citations

Comprehensive Virology

1976 • 288 citations

Localization of the ASV src gene product to the plasma membrane of transformed cells by electron microscopic immunocytochemistry

1979 • 276 citations

Identification of a polypeptide encoded by the avian sarcoma virus src gene.

1978 • 266 citations

Differences between the Ribonucleic Acids of Transforming and Nontransforming Avian Tumor Viruses

1970 • 262 citations

Purification of DNA complementary to nucleotide sequences required for neoplastic transformation of fibroblasts by avian sarcoma viruses

1976 • 252 citations

Characterization of a normal avian cell protein related to the avian sarcoma virus transforming gene product

1978 • 251 citations

Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates.

1978 • 245 citations

Mapping RNase T1-resistant oligonucleotides of avian tumor virus RNAs: sarcoma-specific oligonucleotides are near the poly(A) end and oligonucleotides common to sarcoma and transformation-defective viruses are at the poly(A) end

1975 • 241 citations

Location and identification of the genes for adenovirus type 2 early polypeptides

1976 • 239 citations

Evidence that the avian sarcoma virus transforming gene product is a cyclic AMP-independent protein kinase.

1979 • 232 citations

Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo

1978 • 229 citations

Chromatographic Separation and Antigenic Analysis of Proteins of the Oncornaviruses II. Mammalian Leukemia-Sarcoma Viruses

1972 • 227 citations

Size and Genetic Content of Viral RNAs in Avian Oncovirus-Infected Cells

1977 • 221 citations

Spontaneous segregation of nontransforming viruses from cloned sarcoma viruses

1971 • 212 citations

The size and genetic composition of virus-specific RNAs in the cytoplasm of cells producing avian sarcoma-leukosis viruses

1977 • 207 citations

Chromatographic Separation and Antigenic Analysis of Proteins of the Oncornaviruses

1971 • 199 citations

Role of surface alterations in cell transformation: the importance of proteases and surface proteins

1974 • 192 citations

A normal cell protein similar in structure and function to the avian sarcoma virus transforming gene product.

1979 • 187 citations

Genetics of RNA Tumor Viruses

1977 • 185 citations

The molecular biology of tumour viruses

1973 • 183 citations

SPECIFIC COMPLEMENT-FIXING VIRAL ANTIGENS IN HAMSTER AND GUINEA PIG TUMORS INDUCED BY THE SCHMIDT-RUPPIN STRAIN OF AVIAN SARCOMA

1964 • 175 citations

Temperature sensitive mutants of an avian sarcoma virus

1969 • 160 citations

Recovery of avian sarcoma virus from tumors induced by transformation-defective mutants.

1977 • 151 citations

USE OF HYBRID ANTIBODY WITH ANTI-γG AND ANTI-FERRITIN SPECIFICITIES IN LOCATING CELL SURFACE ANTIGENS BY ELECTRON MICROSCOPY

1968 • 142 citations

Immunofluorescence on avian sarcoma virus-transformed cells: Localization of the src gene product

1979 • 133 citations

Cellular information in the genome of recovered avian sarcoma virus directs the synthesis of transforming protein.

1979 • 132 citations

Discrete foci of altered chicken embryo cells associated with Rous sarcoma virus in tissue culture

1956 • 131 citations

Translation of 35S and of subgenomic regions of avian sarcoma virus RNA.

1977 • 125 citations

Mapping of biological functions on RNA of avian tumor viruses: location of regions required for transformation and determination of host range.

1975 • 119 citations

Uninfected avian cells contain RNA related to the transforming gene of avian sarcoma viruses

1978 • 114 citations

Reversion from transformed to normal phenotype by inhibition of protein synthesis in rat kidney cells infected with a temperature-sensitive mutant of Rous sarcoma virus.

1976 • 113 citations

src gene product from different strains of avain sarcoma virus: Kinetics and possible mechanism of heat inactivation of protein kinase activity from cells infected by transformation-defective, temperature-sensitive mutant and wild-type virus

1979 • 101 citations

Surface ruffles as markers for studies of cell transformation by Rous sarcoma virus.

1975 • 98 citations

Protein Phosphorylation Mediated by Partially Purified Avian Sarcoma Virus Transforming-gene Product

1980 • 98 citations

Recombination between viral and cellular sequences generates transforming sarcoma virus

1978 • 94 citations

Genetic Variation in the RNA Transcripts of Endogenous Virus Genes in Uninfected Chicken Cells

1977 • 89 citations

Peptide analysis of the transformation-specific antigen from avian sarcoma virus-transformed cells

1978 • 85 citations

Rous sarcoma virus activates embryonic globin genes in chicken fibroblasts.

1975 • 80 citations

In vitro synthesis of a functional avian sarcoma virus transforming-gene product

1978 • 80 citations

Transformation-defective mutants of Rous sarcoma virus with src gene deletions of varying length

1977 • 78 citations

Chromatographic separation and antigenic analysis of proteins of the oncornaviruses

1975 • 78 citations

Differential expression of Rous Sarcoma virus-specific transformation parameters in enucleated cells

1978 • 76 citations

Product of in vitro translation of the Rous sarcoma virus src gene has protein kinase activity

1979 • 72 citations

Heteroduplex analysis of avian RNA tumor viruses.

1977 • 71 citations

In vitro translation yields a possible Rous sarcoma virus src gene product.

1977 • 65 citations

Characterization of the avian sarcoma virus protein p60src

1978 • 63 citations

Common tumor-Specific surface antigens on cells of different species transformed by avian RNA tumor viruses

1972 • 46 citations

Cell-surface antigens induced by RNA tumour viruses

1979 • 43 citations

Transformation-defective mutants of avian sarcoma viruses: The genetic relationship between conditional and nonconditional mutants

1976 • 43 citations

Chromatographic and Electrophoretic Analysis of Viral Proteins from Hamster and Chicken Cells Transformed by Rous Sarcoma Virus

1973 • 43 citations

Occurrence of partial deletion and substitution of the src gene in the RNA genome of avian sarcoma virus

1977 • 42 citations

Detection of the Viral Sarcoma Gene Product in Cells Infected with Various Strains of Avian Sarcoma Virus and of a Related Protein in Uninfected Chicken Cells

1979 • 41 citations

Group-specific antigen of avian leukosis viruses. Virus specificity and relation to an antigen contained in Rous mammalian tumor cells

1967 • 40 citations

Restitution of fibroblast-transforming ability in srcdeletion mutants of avian sarcoma virus during animal passage

1979 • 39 citations

Assay for early cytoplasmic effects of the src gene product of Rous sarcoma virus

1978 • 37 citations

Transformation by a Temperature Sensitive Mutant of Rous Sarcoma Virus in the Absence of Serum

1975 • 37 citations

Rous-sarcoma-virus-transformed fibroblasts having low levels of plasminogen activator.

1976 • 35 citations

Reversion of transformed glycolysis to normal by inhibition of protein synthesis in rat kidney cells infected with temperature-sensitive mutant of Rous sarcoma virus.

1978 • 33 citations

Polymorphism of avian sarcoma virus src proteins

1979 • 32 citations

Regulation of sugar transport in chick embryo fibroblasts infected with a temperature-sensitive mutant of RSV

1975 • 29 citations

Cell-free synthesis of two proteins unique to RNA of transforming virions of Rous sarcoma virus.

1977 • 28 citations

Multiple forms of sarc gene proteins from Rous sarcoma virus RNA.

1978 • 25 citations

Antibody to virion structural proteins in mammals bearing avian sarcoma virus-induced tumors

1978 • 22 citations

Effects of the src gene product on microfilament and microtubule organization in avian and mammalian cells infected with the same temperature-sensitive mutant of rous sarcoma virus

1979 • 20 citations

The Role of Cell Surface Changes in RNA Tumor Virus-transformed Cells

1974 • 19 citations

Rous Sarcoma Virus-Induced Tumors in Marmosets: Characteristics of Tumor Cells and Host Cell-Virus Interrelationships2

1973 • 8 citations