Effects of epidermal growth factor and dimethylhydrazine on crypt size, cell proliferation, and crypt fission in the rat colon. Cell proliferation and crypt fission are controlled independently.

A possible explanation for the differential cancer incidence in the intestine, based on distribution of the cytotoxic effects of carcinogens in the murine large bowel

1992 • 152 citations

Intravenous but not intragastric urogastrone-EGF is trophic to the intestine of parenterally fed rats.

1987 • 146 citations

Crypt fission in the small intestine and colon. A mechanism for the emergence of G6PD locus-mutated crypts after treatment with mutagens.

1995 • 145 citations

Whole population cell kinetics and postnatal development of the mouse intestinal epithelium

1985 • 144 citations

The crypt cycle. Crypt and villus production in the adult intestinal epithelium

1987 • 142 citations

The effect of epidermal growth factor (EGF) on cell proliferation of the gastrointestinal mucosa in rodents

1982 • 130 citations

Significance of the labeling index and labeling distribution as kinetic parameters in colorectal mucosa of cancer patients and DMH treated animals

1982 • 128 citations

The effect of growth and of fasting on the number of villi and crypts in the small intestine of the albino rat.

1972 • 118 citations

Effect of luminal growth factor preservation on intestinal growth

1993 • 117 citations

FISSION OF CRYPTS IN THE SMALL INTESTINE OF THE IRRADIATED MOUSE

1975 • 113 citations

Specific receptors for epidermal growth factor in rat intestinal microvillus membranes

1988 • 107 citations

Crypt production in normal and diseased human colonic epithelium

1986 • 95 citations

Chemical synthesis and cloning of a gene for human β-urogastrone

1982 • 89 citations

Production of transforming growth factor-alpha by normal rat small intestine

1991 • 87 citations

Histogenesis of Symmetrical 1,2-Dimethylhydrazine-Induced Neoplasms of the Colon in the Mouse 2

1978 • 77 citations

Crypt fission and crypt number in the small and large bowel of postnatal rats*

1985 • 66 citations

KINETICS OF TISSUE PROLIFERATION IN COLORECTAL MUCOSA DURING POST‐NATAL GROWTH

1981 • 63 citations

Cell proliferation in the small intestine and colon of intravenously fed rats: effects of urogastrone‐epidermal growth factor

1992 • 61 citations

The number of villi in rat's jejunum and ileum: effect of normal growth, partial enterectomy, and tube feeding.

1972 • 59 citations

Histogenesis of colon glands during postnatal growth

1978 • 58 citations

The kinetics of villus cell populations in the mouse small intestine.

1982 • 48 citations

A test of the stochastic theory of stem cell differentiation

1986 • 43 citations

Proliferation of human colon cancer cells: Role of epidermal growth factor and transforming growth factorα

1992 • 42 citations

A stochastic branching model with formation of subunits applied to the growth of intestinal crypts

1991 • 42 citations

Cell proliferation and ageing in mouse colon. II. Late effects of repeated X-irradiation in young and old mice

1980 • 19 citations

Abnormal DNA content as a biomarker of large bowel cancer risk and prognosis

1992 • 15 citations

Effects of EGF and PMA on the growth and proliferation of IEC-6 cells.

1989 • 13 citations

Acute changes occurring in the intestinal mucosae of rats given a single injection of 1,2 dimethylhydrazine

1981 • 11 citations