The Interaction of Lipids and Lipoproteins with the Intercellular Matrix of Arterial Tissue: Its Possible Role in Atherogenesis

The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.

1981 • 1,325 citations

The Biochemistry of Glycoproteins and Proteoglycans

1980 • 1,231 citations

The Pathogenesis of Atherosclerosis

1976 • 1,169 citations

Structurally Distinct Collagen Types

1980 • 1,078 citations

Physiological function of connective tissue polysaccharides.

1978 • 995 citations

Chemistry and molecular biology of the intercellular matrix

1970 • 836 citations

Glycosaminoglycans and Their Binding to Biological Macromolecules

1978 • 835 citations

Proteinpolysaccharide Complex from Bovine Nasal Cartilage

1969 • 655 citations

The biochemistry of glycoproteins and proteoglycans

1980 • 651 citations

THE ELASTIC FIBER

1969 • 643 citations

Chemistry and molecular biology of the intercellular matrix

1970 • 626 citations

Isolation and characterization of proteoglycans from the swarm rat chondrosarcoma.

1975 • 581 citations

The role of the monocyte in atherogenesis: II. Migration of foam cells from atherosclerotic lesions.

1981 • 468 citations

The Interaction between Human Plasma Lipoproteins and Connective Tissue Glycosaminoglycans

1972 • 467 citations

The role of link-protein in the structure of cartilage proteoglycan aggregates

1979 • 374 citations

Physicochemical Properties of Cartilage in the Light of Ion Exchange Theory

1968 • 369 citations

The Relationship Between Plasma and Tissue Lipids in Human Atherosclerosis

1974 • 356 citations

Coupling of glycosaminoglycans to agarose beads (Sepharose 4B)

1971 • 320 citations

Lipoprotein-Polyanion-Metal Interactions1 1This investigation was supported in part by U. S. Public Health Service Research Grant HE-02965, and Training Grant TI HE-5273 and PO-AM 13430.

1973 • 272 citations

Molecular complexes in the isolation and characterization of plasma lipoproteins

1961 • 267 citations

Lipid in the aortic intima the correlation of morphological and chemical characteristics

1967 • 266 citations

Histological and immunofluorescent studies on the evolution of the human atheromatous plaque

1968 • 239 citations

On the interaction between polysaccharides and other macromolecules

1963 • 227 citations

Collagen characterisation and cell transformation in human atherosclerosis

1975 • 223 citations

RELATIONSHIP BETWEEN LOW-DENSITY LIPOPROTEIN IN AORTIC INTIMA AND SERUM-LIPID LEVELS

1972 • 210 citations

Characterization of bovine aorta proteoglycan extracted with guanidine hydrochloride in the presence of protease inhibitors.

1979 • 207 citations

Proteoglycans in primate arteries. I. Ultrastructural localization and distribution in the intima.

1975 • 205 citations

New Molecular Model for the Long-range Elasticity of Elastin

1970 • 194 citations

Suppression of experimental atherosclerosis by the Ca++-antagonist lanthanum. Possible role of calcium in atherogenesis.

1980 • 187 citations

The Protein and Lipid Composition of Arterial Elastin and Its Relationship to Lipid Accumulation in the Atherosclerotic Plaque

1971 • 187 citations

The formation of fibrils from collagen solutions. 2. A mechanism for collagen-fibril formation

1960 • 187 citations

The glycosaminoglycans of the human artery and their changes in atherosclerosis.

1976 • 186 citations

Atherosclerosis: Prevention by Agents Not Affecting Abnormal Levels of Blood Lipids

1981 • 182 citations

The effect of chondroitin sulphate–protein on the formation of collagen fibrils in vitro

1968 • 181 citations

ISOLATION OF A MUCOPROTEIN FROM CARTILAGE

1954 • 181 citations

The distribution of labeled low-density lipoproteins across the rabbit thoracic aorta in vivo

1977 • 176 citations

A study of the immunohistochemical localization of serum lipoproteins and other plasma proteins in human atherosclerotic lesions

1965 • 176 citations

Characterization of the collagen synthesized by endothelial cells in culture.

1976 • 174 citations

Lipoprotein-acid mucopolysaccharide complexes of human atherosclerotic lesions

1975 • 156 citations

Human aorta collagens: Evidence for three distinct species

1974 • 156 citations

Cellular Mechanisms for Lipid Deposition in Atherosclerosis

1977 • 155 citations

Synthesis of types I and III procollagen and collagen by monkey aortic smooth muscle cells in vitro

1977 • 152 citations

Mucopolysaccharides of Aorta at Various Ages.

1960 • 150 citations

Complexing of serum pre-β- and β-lipoproteins and acid mucopolysaccharides

1970 • 146 citations

The interaction between polysaccharides and other macromolecules. 9. The exclusion of molecules from hyaluronic acid gels and solutions

1964 • 145 citations

Collagen αB Chain: Increased Proportion in Human Atherosclerosis

1981 • 139 citations

Low Density Lipoproteins

1977 • 138 citations

The Interaction of Serum and Arterial Lipoproteins with Elastin of the Arterial Intima and Its Role in the Lipid Accumulation in Atherosclerotic Plaques

1973 • 138 citations

Proteoglycans in primate arteries. II. Synthesis and secretion of glycosaminoglycans by arterial smooth muscle cells in culture.

1975 • 136 citations

Connective tissue. Macromolecular structure and evolution.

1975 • 136 citations

Isolation of lipoprotein-acid mucopolysaccharide complexes from fatty streaks of human aortas

1972 • 131 citations

Metabolism of sulfated glycosaminoglycans in cultured endothelial cells and smooth muscle cells from bovine aorta

1978 • 128 citations

Isolation and preliminary characterization of proteoglycans dissociatively extracted from human aorta.

1981 • 128 citations

Cholesterol vehicle in experimental atherosclerosis Part II. Peanut oil

1971 • 127 citations

Unified concept on the role of acid mucopolysaccharides and connective tissue proteins in the accumulation of lipids, lipoproteins, and calcium in the atherosclerotic plaque

1976 • 125 citations

Stimulation of proliferation in stationary primary cultures of monkey and rabbit aortic smooth muscle cells

1976 • 120 citations

Very low density lipoproteins in normal and cholesterol-fed rabbits: lipid and protein composition and metabolism

1976 • 108 citations

The Influence of Chemical and Physicochemical Nature of Macromolecular Polyanions on Their Interaction with Human Serum β-Lipoproteins

1960 • 107 citations

The release of an immobilized lipoprotein fraction from atherosclerotic lesions by incubation with plasmin

1976 • 101 citations

Glycoproteins of the Connective Tissue Matrix

1976 • 100 citations

The synthesis of connective tissue protein in smooth muscle cells

1976 • 99 citations

Early changes in plasma lipoprotein structure and biosynthesis in cholesterol-fed rabbits

1973 • 94 citations

Characterization of low density lipoprotein-like particle in the human aorta from grossly normal and atherosclerotic regions

1979 • 91 citations

Very low density lipoproteins in normal and cholesterol-fed rabbits: lipid and protein composition and metabolism

1976 • 89 citations

The interaction of low density lipoproteins with arterial proteoglycans

1980 • 87 citations

Quantitative studies on the complexes formed between aortic mucopolysaccharides and serum lipoproteins

1967 • 87 citations

INTERACTION OF HUMAN SERUM β-LIPOGLOBULIN WITH POLYANIONS

1957 • 87 citations

Pathogenetic mechanisms in atherosclerosis

1975 • 85 citations

The precipitation of serum lipoproteins by mucopolysaccharides extracted from aortic tissue.

1960 • 85 citations

High-performance liquid chromatographic determinations of disaccharides resulting from enzymatic degradation of isomeric chondroitin sulfates

1979 • 83 citations

Amino acid composition and calcification of human aortic elastin

1974 • 80 citations

Production of Mucopolysaccharides by Normal and Transformed Cells

1973 • 79 citations

Increased arterial collagen synthesis in experimental canine atherosclerosis

1974 • 78 citations

The interaction of human plasma glycoaminoglycans with plasma lipoproteins.

1975 • 77 citations

Characterization and properties of a lipoprotein-complexing proteoglycan from human aorta

1980 • 75 citations

Increased vascular collagen and elastin synthesis in experimental atherosclerosis in the rabbit Variation in synthesis among major vessels

1980 • 74 citations

Acid mucopolysaccharides of human aorta

1967 • 73 citations

Nature of the Interaction of Dextran Sulfate with Low Density Lipoproteins of Plasma

1970 • 73 citations

Isolation of proteoglycan-hyaluronate complexes from bovine aorta.

1979 • 72 citations

Synthesis of collagens Types I and III by pig medial smooth muscle cells in culture

1976 • 71 citations

Characterization of cell populations isolated from aortas of rhesus monkeys with experimental atherosclerosis.

1980 • 70 citations

Non‐Aggregated Tropocollagen at Physiological pH and Ionic Strength

1972 • 69 citations

Interactions between mucopolysaccharides and cationic polypeptides in aqueous solution: Hyaluronic acid, heparitin sulfate, and keratan sulfate

1974 • 69 citations

Lipoproteins in human atherosclerotic vessels

1979 • 69 citations

Nature of the interaction of chondroitin 4-sulphate and chondroitin sulphate–proteoglycan with collagen

1971 • 68 citations

Role of intimal mucoid substances in the pathogenesis of atherosclerosis. I. Complex formation in vitro between mucopolysaccharides from atherosclerotic aortic intimas and plasma β-lipoprotein and fibrinogen

1961 • 67 citations

Chemical and Metabolic Heterogeneity of a Bovine Aorta Chondroitin Sulfate-Dermatan Sulfate Proteoglycan

1971 • 67 citations

Characterization of Lipids Associated with Macromolecules of the Intercellular Matrix of Human Aorta

1976 • 66 citations

Mucopolysaccharides in the atheromatous aorta

1962 • 66 citations

Role of Mucoid Substances of the Aorta in the Deposition of Lipids

1960 • 65 citations

Connective tissue components in normal and atherosclerotic human coronary arteries

1978 • 64 citations

Effects of anticalcifying and antifibrobrotic drugs on pre-established atherosclerosis in the rabbit

1979 • 62 citations

The participation of aortic proteins in the formation of complexes between low density lipoproteins and intima-media extracts

1975 • 62 citations

Isolation of a chondroitin sulfate-dermatan sulfate proteoglycan from bovine aorta

1975 • 60 citations

Distribution and composition of acid mucopolysaccharides in normal and atherosclerotic human aortas

1967 • 60 citations

Preparation and properties of soluble, immunoreactive apoLDL.

1979 • 57 citations

Flux of plasma lipoproteins into human arterial intima Comparison between grossly normal and atheromatous intima

1981 • 57 citations

Model connective tissue system: The effect of proteoglycans on the distribution of small non‐electrolytes and micro‐ions

1972 • 56 citations

A macromolecule transport model for the arterial wall and endothelium based on the ultrastructural specialization observed in electron microscopic studies

1976 • 56 citations

Molecular interactions in human atherosclerotic plaques.

1977 • 55 citations

Composition and structure of the pericellular environment. Physiological function and chemical composition of pericellular proteoglycan (an evolutionary view)

1975 • 53 citations

Interaction of aortic endothelial and smooth muscle cells in culture Effect on glycosaminoglycan levels

1981 • 53 citations

Connective tissue: Macromolecular structure and evolution

1976 • 53 citations

Electron microscopy of cartilage proteoglycans

1977 • 52 citations

Lipoprotein-hyaluronate associations in human aorta fibrous plaque lesions

1980 • 51 citations

Flotational Lipoproteins Extracted from Human Atherosclerotic Aortas

1956 • 50 citations

Increased synthesis of aortic collagen and elastin in experimental atherosclerosis

1981 • 50 citations

Further investigations on complex formation in vitro between aortic mucopolysaccharides and β-lipoproteins

1964 • 50 citations

RECENT STUDIES ON VASCULAR ENDOTHELIUM

1976 • 49 citations

Interactions between mucopolysaccharides and cationic polypeptides in aqueous solution: Chondroitin 4‐sulfate and dermatan sulfate

1973 • 46 citations

Arterial influx of esterified cholesterol from two plasma lipoprotein fractions and its hydrolysis in vtvo in hype rcholesterolemic rabbits

1981 • 46 citations

The role of hyperlipidemic serum on the proliferation and necrosis of aortic medial cells in vitro

1977 • 44 citations

Aortic glycosaminoglycans in atherosclerosis-susceptible and -resistant pigeons

1977 • 43 citations

Lipoprotein concentrations in serum and in biopsy samples of arterial intima A quantitative comparison

1976 • 43 citations

Interactions between chondroitin‐6‐sulfate and poly‐<scp>L</scp>‐lysine in aqueous solution: Circular dichroism studies

1973 • 42 citations

Sequestration of Serum Low-Density Lipoproteins in the Arterial Intima by Complex Formation.

1965 • 41 citations

Nature of the interaction of dextran sulfate with high and low density lipoproteins in the presence of Ca2+.

1979 • 41 citations

Enhanced synthesis of collagen and total protein by smooth muscle cells from atherosclerotic rabbit aortas in culture

1980 • 40 citations

Isolation and partial characterization of basement membrane-like collagens from bovine thoracic aorta.

1980 • 40 citations

The very low density lipoproteins of cholesterol-fed rabbits

1974 • 40 citations

Elastin—lipid interaction in the arterial wall part 2. In vitro binding of lipoprotein-lipids to arterial elastin and the inhibitory effect of high density lipoproteins on the process

1981 • 38 citations

The affinity of low density lipoproteins for an arterial macromolecular complex A study in ischemic heart disease and controls

1976 • 37 citations

Interaction of Proteoglycans and Chondroitin Sulfates with Calcium or Phosphate Ions

1971 • 37 citations

Effect of hyperlipidemic rat serum on the synthesis of collagen by chick embryo fibroblasts

1975 • 36 citations

Distribution of Acid Mucopolysaccharides in Inner and Outer Layers of Bovine Aorta

1959 • 36 citations

Nature of interaction of dextran sulfate with lecithin dispersions and lysolecithin micelles.

1977 • 35 citations

Interaction between chondroitin‐6‐sulfate and poly‐<scp>L</scp>‐arginine in aqueous solution

1973 • 35 citations

Elastin sub-fraction as binding site for lipids

1977 • 34 citations

Enzymatic studies of chondroitin sulphates in human arterial tissue

1968 • 34 citations

INFLUENCE OF LIPID CONCENTRATIONS AND AGE ON TRANSFER OF PLASMA LIPOPROTEIN INTO HUMAN ARTERIAL INTIMA

1977 • 34 citations

Structural investigation of loose connective tissue by using a series of dextran fractions as non-interacting macromolecular probes

1977 • 34 citations

Composition of connective tissue in aortas from rhesus monkeys during regression of diet-induced fatty streaks.

1975 • 33 citations

Control of chondroitin sulphate biosynthesis. β-<scp>d</scp>-Xylopyranosides as substrates for UDP-galactose: <scp>d</scp>-xylose transferase from embryonic-chicken cartilage

1981 • 32 citations

Culture of rat and pig aortic endothelial cells Differences in their isolation, growth rate and glycosaminoglycan synthesis

1981 • 32 citations

Cross-linking of elastin in human atherosclerotic aortas. I. A preliminary study.

1971 • 31 citations

Aortic glycosaminoglycans in genetically selected WC-2 pigeons with increased atherosclerosis susceptibility.

1981 • 31 citations

Proton magnetic resonance studies on water in the presence of various macromolecular substances

1959 • 30 citations

Electron microscopic features of lipoprotein-glycosaminoglycan complexes from human atherosclerotic plaques.

1976 • 29 citations

Amidated carboxyl groups in elastin

1976 • 29 citations

The binding of chondroitin 6-sulfate to plasma low density lipoprotein

1981 • 28 citations

Mucopolysaccharide-polypeptide interactions: Effect of the position of the sulfate group

1973 • 28 citations

Changes in the physical behavior of low density lipoprotein in the presence of glycosaminoglycans and high density lipoprotein

1981 • 28 citations

Aortic collagen, elastin and non-fibrous protein synthesis in rabbits fed cholesterol and peanut oil

1980 • 27 citations

Age Dependence of the Biosynthesis of Intercellular Matrix Macromolecules of Rabbit Aorta in Organ Culture and Cell Culture

1976 • 27 citations

Model connective tissue systems. A physical study of gelatin gels containing proteoglycans

1971 • 26 citations

SIGNIFICANCE OF MACRORHEOLOGY AND MICRORHEOLOGY IN ATHEROGENESIS*

1976 • 25 citations

Reaction Patterns of Intimal Mesenchyme to Injury, and Repair in Atherosclerosis

1974 • 25 citations

The Rotational Diffusion of Albumin in Solutions of Connective‐Tissue Polysaccharides

1973 • 24 citations

The ground substance of the arterial wall Part 2. Electron-microscopic studies

1976 • 24 citations

Factors Modulating the Interaction of LDL with an Arterial Lipoprotein Complexing Proteoglycan: The Effect of HDL

1980 • 24 citations

A Simple Nephelometric Method for the Determination of Human Serum Beta-Lipoprotein1

1957 • 24 citations

Lipoprotein-elastin interactions in human aorta fibrous plaque lesions

1981 • 23 citations

Synthesis of glycosaminoglycans by cultured rabbit smooth muscle cells

1980 • 22 citations

The binding of total low density lipoproteins in human arterial intima affected and unaffected by atherosclerosis

1979 • 21 citations

Studies on the passage of plasma proteins across arterial endothelium in relation to atherogenesis.

1977 • 21 citations

Effect of phospholipase A treatment of low density lipoproteins on the dextran sulfate-lipoprotein interaction

1968 • 20 citations

Changes in the content of human aortic glycoproteins and acid mucopolysaccharides in atherosclerosis

1973 • 20 citations

Cortisol decreases the synthesis of hyaluronic acid by human aortic smooth muscle cells in culture

1980 • 20 citations

Sequential study of biochemical changes during regression of swine aortic atherosclerotic lesions.

1981 • 20 citations

DIFFERENCES IN THE STRUCTURE OF PLASMA LOW‐DENSITY LIPOPROTEINS AND THEIR RELATIONSHIP TO THE EXTENT OF INTERACTION WITH ARTERIAL WALL COMPONENTS*

1976 • 19 citations

The Macromolecules of the Intercellular Matrix of the Arterial Wall: Collagen, Elastin, Proteoglycans, and Glycoproteins

1974 • 19 citations

Characterization of free and tightly bound lipoprotein in intima by thin layer isoelectric focusing

1979 • 18 citations

Acidic glycosaminoglycans in three layers of human aorta: their different constitution and anticoagulant function.

1975 • 18 citations

Metabolism of glycosaminoglycans and lipids in smooth muscle cells from atherosclerotic rabbit aortas in culture

1980 • 18 citations

Reduction of Ischemic Coronary Heart Disease By Chondroitin Sulfate a

1971 • 18 citations

Interaction of isolated Lp(a) lipoprotein with calcium ions and glycosaminoglycans in vitro

1977 • 17 citations

Investigation by immunofluorescence of arterial lesions in rabbits on two different lipid supplements and treated with pyridinol carbamate

1976 • 17 citations

The Role of Connective Tissue in Atherosclerosis

1978 • 17 citations

Effect of low density lipoprotein on proteoglycan synthesis by aorta cells in culture

1978 • 17 citations

Chemical changes in the arterial wall during regression of atherosclerosis in monkeys.

1981 • 17 citations

The distribution of intravenously administered [3H]Chole-sterol in the arteries and other tissues

1967 • 16 citations

Distribution of glycosaminoglycans in consecutive layers of the rabbit aorta.

1979 • 16 citations

Small-angle x-ray scattering and differential scanning calorimetry studies on reversibly modified human-serum low density lipoproteins

1978 • 16 citations

Action of human hyperlipemic sera on the biosynthesis of intercellular matrix macromolecules in aorta organ cultures.

1976 • 16 citations

Collagen synthesis in organ culture of normal and atherosclerotic aortas

1981 • 15 citations

Interactions of an intact proteoglycan and its fragments with basic homopolypeptides in dilute aqueous solution

1974 • 15 citations

Connective tissue composition of aortas from non-human primates A comparative study

1978 • 15 citations

Possible relationship of cholesterol accumulation and collagen synthesis in rabbit aortic tissues

1980 • 15 citations

Covalent structure of collagen: amino acid sequence of five consecutive cyanogen bromide peptides from type III collagen of human liver

1978 • 14 citations

The effect of long-term heparin treatment in ischaemic heart disease

1965 • 14 citations

Mucopolysaccharide-Lipoprotein Complexes in Atherosclerotic Aorta

1974 • 13 citations

Effect of HDL on the interaction of hyperlipemic LDL with monkey smooth muscle cells.

1980 • 13 citations

Morphology of Mesenchymal Elements of Normal Artery, Fatty Streaks, and Plaques

1974 • 13 citations

Hypercholesterolemia and aortic collagen synthesis in rabbit aortas

1976 • 13 citations

Association of structural glycoproteins with lipids or lipoproteins

1978 • 12 citations

Lipoproteins in human atherosclerotic vessels

1979 • 12 citations

Studies on increased vascular permeability in the pathogenesis of lesions of connective tissue diseases: I. Experimental hyperlipidaemia and immune arthropathy.

1980 • 11 citations

High density lipoproteinemia due to vigorous physical work inhibits the incorporation of [3H]thymidine and the synthesis of glycosaminoglycans by human aortic smooth muscle cells in culture

1979 • 11 citations

Ultrastructure of proteoglycans in human renal arteries from end stage renal disease

1977 • 10 citations

The precipitation of serum lipoproteins by gelatin.

1960 • 10 citations

Glycoproteins from the aorta.

1978 • 10 citations

Cerebral atherosclerosis in Japanese part 6: the interaction of plasma lipoproteins with glycosaminoglycans isolated from the cerebral arteries and aortas.

1981 • 9 citations

Inhibition of collagen and non-collagen protein synthesis in cultured aortic smooth muscle cells by hyperlipoproteinemic serum.

1980 • 9 citations

Demonstration by immunofluorescence that the same cells from chick embryo aortas synthesize elastin and collagen types I and III.

1980 • 9 citations

Proteoglycan synthesis and secretion by bovine aortic tissue in organ culture.

1980 • 8 citations

Type iia hyperlipoproteinemic sera decrease the synthesis of hyaluronic acid by cultured human aortic smooth muscle cells

1981 • 7 citations

Subcellular Sites Involved in Lipid Synthesis in Saccharomyces cerevisiae

1967 • 7 citations

Small‐angle X‐ray scattering study of human serum low‐density lipoproteins with differential reactivity for an arterial proteoglycan

1977 • 6 citations

In vitro synthesis of aortic glycosaminoglycans effect of diet, lipoproteins and diabetes

1974 • 6 citations

Fibrous long spacing collagen in aortic explants of normal rabbit cultured in hypercholesterolemic serum

1977 • 6 citations

Biosynthesis of acid mucopolysaccharides by rabbit and human arteries

1967 • 6 citations

The Significance of ‘Bound’ and ‘Labile’ Fractions of Low-Density Lipoprotein and Fibrinogen in the Arterial Wall

1977 • 6 citations

Further studies on a highly purified glycoprotein from the intimal region of porcine aorta

1976 • 5 citations

Intercellular glycoproteins and low density lipoprotein binding to fibroblasts

1977 • 5 citations

Model connective tissue systems: Measurement of ion flux across gel membranes containing proteoglycan

1975 • 5 citations

Heparitin sulfates (heparan sulfates) of atherosclerosis-susceptible and atherosclerosis-resistant pigeon aortas

1977 • 4 citations

Vascular extracellular tissue and atherosclerosis.

1979 • 3 citations

The distribution of mast cells in bovine coronary arteries and their participation in the metabolism of mural glycosaminoglycans

1981 • 3 citations

Secretion and Assembly of Collagen — Present Status

1977 • 1 citations