Chemical Nature and Pharmacological Actions of Quaternary Ammonium Salts

THE AUTONOMIC NERVOUS SYSTEM

1903 • 1,674 citations

The use of chemical potentials as indices of toxicity

1939 • 550 citations

A powerful reactivator of alkylphosphate-inhibited acetylcholinesterase

1955 • 502 citations

Enzymatic Metabolism of Drugs and other Foreign Compounds

1958 • 501 citations

Choline esters in tissue extracts

1933 • 490 citations

Amine oxidase and amine metabolism.

1952 • 355 citations

THE ULTRASTRUCTURE OF A REPTILIAN MYONEURAL JUNCTION

1956 • 262 citations

Depolarization of the motor end‐plate by decamethonium and acetylcholine

1951 • 246 citations

THE PHARMACOLOGY OF FLAXEDIL, WITH OBSERVATIONS ON CERTAIN ANALOGS

1951 • 200 citations

Biochemical Evidence for the Neural Function of Acetylcholine

1957 • 193 citations

Oxygen Exchange as Evidence for the Existence of an Intermediate in Ester Hydrolysis

1951 • 190 citations

ACETYLCHOLINESTERASE

1950 • 190 citations

Die konfiguration der carbonestergruppe und die sondereigenschaften der lactone

1959 • 172 citations

Imidazole Catalysis. I. The Catalysis of the Hydrolysis of Phenyl Acetates by Imidazole

1957 • 146 citations

The Imidazole-catalyzed Hydrolysis of p-Nitrophenyl Acetate¹

1957 • 141 citations

A HORMONAL NEUROGENIC VASOPRESSOR MECHANISM

1951 • 115 citations

330. Curare alkaloids. Part I. Tubocurarine

1935 • 115 citations

Acetylcholinesterase studies on molecular complementariness

1958 • 113 citations

Localization of Cholinesterases at Neuromuscular Junctions

1955 • 112 citations

Steric Effects on the Base Strengths of Cyclic Amines¹

1957 • 98 citations

The occurrence of homologues of acetylcholine in ox spleen

1953 • 90 citations

The Autonomic Nervous System

1953 • 90 citations

New Potent Reactivators of Acetocholinesterase Inhibited by Tetraethyl Pyrophosphate

1958 • 87 citations

Curare Alkaloids from Chondodendron tomentosum

1943 • 80 citations

The Structure-Action Relationships of the Choline Group

1949 • 76 citations

REACTIVATION OF ACETYLCHOLINESTERASE¹ INHIBITED BY ALKYLPHOSPHATES

1953 • 74 citations

MECAMYLAMINE AND ITS MODE OF ACTION

1957 • 61 citations

Über die Konstitution der Calebassen‐Alkaloide C‐Dihydrotoxiferin und C‐Toxiferin‐I und des Alkaloids Caracurin‐V aus Strychnos toxifera. Synthetische Versuche mit W<scp>IELAND</scp>‐G<scp>UMLICH</scp>‐Aldehyd als Ausgangsstoff. 36. Mitteilung über Calebassen‐Alkaloide

1958 • 58 citations

The curariform action of quaternary ammonium salts

1931 • 54 citations

Pyridine-2-Aldoxime Methiodide and Poisoning by Anticholinesterases

1957 • 53 citations

Polyalkylpiperidines: a New Series of Ganglion-blocking Agents

1958 • 51 citations

Reactivation of alkylphosphate inhibited acetylcholinesterase by bis quaternary derivatives of 2-PAM and 4-PAM

1959 • 50 citations

Effect of Inorganic Complex Ions on Transmission at a Neuromuscular Junction

1957 • 50 citations

GANGLIONIC BLOCKING AGENTS

1950 • 49 citations

Protection by Oximes of bis-Pyridinium Ions against Lethal Diisopropyl Phosphonofluoridate Poisoning

1958 • 45 citations

Identification of Murexine as β-[Imidazolyl-(4)]-Acryl-Choline

1953 • 44 citations

Mode of action of an inhibitor of acetylcholine synthesis

1958 • 38 citations

Amino- and Ammonium-alkylaminobenzoquinones as Curarimimetic Agents

1950 • 38 citations

Motor End-Plate Differences as a Determining Factor in the Mode of Action of Neuro-Muscular Blocking Substances

1952 • 37 citations

Eine neue Klasse Cholinester

1932 • 36 citations

ELECTRIC POTENTIAL AND ACTIVITY OF CHOLINE ESTERASE IN THE ELECTRIC ORGAN OF ELECTROPHORUS ELECTRICUS (LINNAEUS)

1941 • 36 citations

Gamma-Aminobutyrylcholine

1958 • 35 citations

PHARMACOLOGY AND CLINICAL USE OF PEMPIDINE IN THE TREATMENT OF HYPERTENSION

1958 • 34 citations

Dicholinesters of alpha, omega-dicarboxylic acids and related substances.

1956 • 33 citations

The Pharmacology of Tropane Compounds in Relation to Their Steric Structure

1957 • 32 citations

Über Muscarin. III

1957 • 32 citations

Struktur und Wirkung des Muscarins, des Muscarons und ihrer Stereoisomeren

1958 • 32 citations

Inter-quaternary distance and ganglion-blocking activity in bis-quaternary compounds

1959 • 31 citations

1 : 2 : 2 : 6 : 6-Pentamethylpiperidine: a New Hypotensive Drug

1958 • 31 citations

Some Derivatives of 3-Pyridol with Parasympathomimetic Properties¹

1951 • 31 citations

SYNTHETIC CURARE SUBSTITUTES FROM ALIPHATIC DICARBOXYLIC ACID AMINOETHYL ESTERS

1949 • 30 citations

Über die stufenweise Quaternisierung von aliphatischen Polyaminen. Neue Verbindungen mit ganglienblockierender Wirkung

1951 • 30 citations

Polycyclic Quaternary Ammonium Salts. III

1954 • 30 citations

Über die Bruttoformeln der Curare‐Alkaloide aus Calebassen und Strychnos‐Arten. 19. Mitteilung über Curare‐Alkaloide aus Calebassen

1956 • 30 citations

SYNTHETIC DRUGS INFLUENCING NEUROMUSCULAR ACTIVITY

1951 • 28 citations

Nature of the Acetyl Cholinesterase Surface. I. Some Potent Competitive Inhibitors of the Enzyme^1a,b

1954 • 25 citations

Indirekter Konstitutionsbeweis für Muscarin durch synthetische Versuche. 5. Mitteilung über Muscarin

1957 • 24 citations

Cardiovascular Innervation

1956 • 23 citations

Bis-ammonium Salts. Derivatives of Fluorene, Carbazole and Phenothiazine

1954 • 22 citations

Curare

1948 • 22 citations

Synthetic Hypotensive Agents. III. Some 4,4'-Bipiperidines

1955 • 21 citations

OBSERVATIONS ON THE POTENCY OF NEUROMUSCULAR BLOCKING AGENTS WITH PARTICULAR REFERENCE TO SUCCINYLCHOLINE

1955 • 21 citations

Neuromuscular Block caused by Acetylcholine

1955 • 20 citations

Pyridazine Derivatives. III.^1,2 Some 3,6-Disubstituted Pyridazines Having Neuromuscular Blocking Activity

1954 • 19 citations

Further studies on the pharmacological properties of onium salts

1933 • 19 citations

Preparation and Properties of Acetyl Dextro-and Acetyl Levo-β-methylcholine Chloride

1935 • 19 citations

Pharmacological Activity of the Carbon Analogue of Acetylcholine

1951 • 19 citations

Effect of γ-Aminobutyryl-Choline upon the Electrical Activity of the Cerebral Cortex

1958 • 18 citations

Autonomic Blocking Agents. I. Branched Aliphatic Quaternary Ammonium and Analogous Cyclic Ammonium Salts

1951 • 18 citations

44. Some new curarising agents

1950 • 18 citations

Synthetic neuromuscular‐ and ganglion‐blocking agents. N‐Alkylated bipyridyls, bipiperidyls, and their methylene and ethylene “homologues”

1955 • 18 citations

Hypotensive Agents. IV.¹ Hydrogenated Dialkylaminoalkyl Isoindole Derivatives²

1953 • 17 citations

On the Bjerrum Relation and the Formation of Ion Pairs

1956 • 17 citations

Bis-Ammonium Salts. Unsymmetric Derivatives of Substituted Pyridine Bases that Are Potent and Selective Hypotensive Agents¹

1957 • 17 citations

Substituierte t-Hexylamine als neuer Typ hypotensiv wirksamer Verbindungen

1959 • 17 citations

Quantitative Untersuchungen über die Wirksamkeit homologer quartärer Ammoniumbasen

1922 • 16 citations

Ganglionic Blocking Activity of Bis‐trialkylammoniumethyl Ether Salts and their Branched Homologues*).

1957 • 15 citations

Autonomic Blocking Agents. II. Alkamine Esters and their Quaternaries

1951 • 15 citations

The Comparative Anticholinergic Activity of a Series of Derivatives of 3-Hydroxy Piperidine

1954 • 15 citations

Bis Ammonium Salts. Derivatives of Some Carboline and Related Heterocyclic Bases¹

1954 • 15 citations

THE NEUROMUSCULAR BLOCKING ACTIVITY OF ETHYL ANALOGUES OF DECAMETHONIUM

1953 • 15 citations

Anticholinesterase activities of some bis-quaternary ammonium salts

1959 • 14 citations

Curare-Like Activity of Some Bis-Fluorenyl-Bis-Quaternary Ammonium Compounds

1954 • 14 citations

Quaternary Derivatives of Benzoyltropine and Benzoyl-ψ-tropine with Anticholinergic and Local Anæsthetic Properties

1953 • 13 citations

Hypotensive and Ganglion blocking action of methyl substituted 3-amino-norcamphanes

1958 • 13 citations

Handbuch der experimentellen Pharmakologie. Begründet von A. Heffter; Ergänzungswerk. Herausgegeben von W. Heubner und I. Schüller. Band IV. Mit 79 Abbildungen. Verlag Julius Springer, Berlin 1937. Preis geh. RM. 24,–

1937 • 13 citations

Quantitative Evaluation of Ganglionic Blocking Agents.

1954 • 13 citations

Das Vorkommen von Imidazyl-Essigs�ure-Cholinester im Gehirn von Warmbl�tern

1955 • 13 citations

Bis-ammonium Salts. Unsymmetrical Derivatives of Some Isoquinolines and Related Heterocyclic Bases¹

1955 • 12 citations

620. Diacid bases. Part I. Compounds related to 1: 5-diphenyl-pentane-pp′-bis(trialkylammonium) salts as anti-cholinesterases

1953 • 12 citations

SYNERGISMS AND ANTAGONISMS OF ACETYLCHOLINE BY QUATERNARY AMMONIUM SALTS

1937 • 12 citations

Optically Active Amino Aldehydes. II. Preparation of Cyclic Acetals of Quaternary Amino Aldehydes; Contribution to the Knowledge of the Stereospecificity of Muscarinic Activity¹

1956 • 12 citations

Neuromuscular Blocking Agents of Short Duration

1959 • 11 citations

THE PHARMACOLOGICAL ACTIONS OF A SERIES OF PHENYL ALKANE p‐ω;‐BIS(TRIALKYLAMMONIUM) COMPOUNDS*

1953 • 11 citations

Bolaform Electrolytes. V. Conductance of Some Bisquaternary Salts in Methanol and in Ethanol.

1956 • 11 citations

Ganglionic Blocking Activity of Homologues and Analogues of bis‐Choline Ether Salts.*)

1957 • 11 citations

N ‐substituierte 2.5‐Dimethyl‐pyrrole und ‐pyrrolidine (Über 1.4‐Diketone, II. Mitteil.)

1953 • 11 citations

595. Thia- and dithia-alkanebis(quaternary ammonium) salts as neuromuscular- and ganglion-blocking agents

1953 • 10 citations

Hypotensive Agents. VI.¹ Substituted 3-Azabicyclo[3.2.1]octane Derivatives²

1957 • 10 citations

Distinction between Sodium and Potassium in Change in Permeability effected by Lipid-soluble Analogues of Acetylcholine

1959 • 10 citations

Bisammonium Salts. Unsymmetrical Derivatives of Tropane and Related Bases¹

1956 • 10 citations

Some New Neuromuscular Blocking Agents

1958 • 10 citations

Reaction of Ethylene Bromide with Trimethylamine and the Neuromuscular Blocking Activity of Ethylenebis-(Trimethylammonium)

1958 • 10 citations

The Synthesis of N-Substituted Choline Carbamates and Trimethyl-β-phenylaminoethylammonium Chloride

1941 • 10 citations

Bis-ammonium Salts. Unsymmetrical Derivatives of Some β-Carbolines¹

1955 • 9 citations

Hypotensive Agents. X. 3-Azabicyclo[3.3.0]octane Derivatives^1,2

1959 • 9 citations

The inhibitory action of acetylcholine with special reference to small doses

1951 • 9 citations

INFLUENCE OF ANESTHESIA ON THE NEUROMUSCULAR BLOCKING ACTIVITY OF MYLAXEN®

1956 • 9 citations

PRESENT CONCEPTS AND RECENT ADVANCES IN ACUTE POLIOMYELITIS

1952 • 9 citations

Some Further Comments on the Properties of Bolaform Electrolytes

1958 • 8 citations

Hypotensive Agents. IX. 3-Azabicyclo[3.3.1]nonane Derivatives¹

1958 • 8 citations

The Effects of Decamethonium and Its Ethyl Analogues on Neuromuscular Transmission.

1955 • 8 citations

Hypotensive Agents. VII.¹ Azabicyclo[3.2.0]heptane Derivatives²

1957 • 7 citations

N‐Oxyde und N.N′‐Dioxyde tertiärer Amine

1952 • 7 citations

SOME BIS- AND TRIS-AMINO AND AMMONIUM DERIVATIVES OF SYMMETRICAL-TRIAZINE

1954 • 7 citations

Hydrolyse enzymatique de la propionylcholine, de l'acétylthiocholine et de la butyrylthiocholine par le rectus de grenouille

1958 • 7 citations

Muscarinic Action of Murexine and Some Related Choline Esters

1957 • 6 citations

Hypotensive Agents. II. Aminoalkyl Esters of Piperidinecarboxylic Acids and Their “Reversed” Ester Derivatives

1957 • 6 citations

Physiologische und pharmakologische Bedeutung der Cholinesterasen und Anticholinesterasen

1958 • 6 citations

Esters of Basically Substituted 3-Pyridols with Physostigmine-like Activity¹

1952 • 6 citations

The Polymerization of Pharmacophoric Moieties and Its Effect Upon Biologic Activity I. Polymeric Quaternary Ammonium Salts**Department of Pharmacology, College of Medicine, State University of Iowa, Iowa City

1956 • 6 citations

An Evaluation of Certain Hypotensive Agents II**Department of Pharmacology, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pa.

1957 • 6 citations

Ganglion‐Blocking Action of Some Substituted Choline Phenyl Ethers.

1958 • 5 citations

The Ganglionic Blocking Activity of a Series of 4-Aminoethylpiperidine Derivatives**Wellcome Research Laboratories, Tuckahoe, N. Y.

1956 • 5 citations

Autonomic Nervous System: Introduction

1957 • 5 citations

Bis-ammonium Salts. Unsymmetric Derivatives of Decahydroquinoline and of Decahydroisoquinoline

1959 • 5 citations

Hypotensive Activity of a New Ganglionic Blocking Agent and Its Comparative Effectiveness on Normotensive Unanesthetized Dogs**Georgetown University Medical Center, Department of Pathology, Washington 7, D. C.

1957 • 5 citations

Hypotensives. III. Reaction Products of Acetylenic Diamines

1958 • 5 citations

Alkoxytrimethylammonium salts and muscarine

1953 • 5 citations

Cholinesterasehemmwirkung und neuromuskul�re Wirksamkeit von Bischolin-Polymethylendicarbamins�ureestern

1954 • 5 citations

A Simple Model of Molecular Specificity in Enzyme-Substrate Systems. II. The Correlation of the Michaelis Constant with the Inhibition Constant

1955 • 5 citations

Synthetic Curare Substitutes from Stilbazoline Bis-quaternary Ammonium Salts

1952 • 4 citations

Effect of the Anion on R F Values of Quaternary Ammonium Salts

1956 • 4 citations

The Pharmacology of Some Bis-Quaternary Ammonium Compounds * *Department of Pharmacology, University of Pittsburgh School of Pharmacy, Pittsburgh, Pa.

1958 • 4 citations

Hypotensive Agents. VIII. Azabicyclo[3.2.1] octane Derivatives¹

1957 • 4 citations

236. Synthetic neuromuscular blocking agents. Part III. Miscellaneous quaternary ammonium salts

1952 • 4 citations

Dimethyl‐(β‐acetoxyäthyl)‐sulfonium‐chlorid, das Schwefel‐analogon des Acetyl‐cholin‐chlorids

1942 • 4 citations

Über nikotinartige Wirkungen auf die Skelettmuskulatur

1951 • 4 citations

Pharmacological Properties of some Hydrazonium and Trimethylammoniumbenzyl Analogues related to the Di‐eholine Esters,

1957 • 3 citations

A Curarimimetic Analog of Decamethylene Ditrimethylammonium (C₁₀)¹

1952 • 3 citations

The Synthesis and Pharmacology of Some Polymethylene Bisonium Compounds

1956 • 3 citations

Sulfonium Analogs of Pharmacologically Active Amines. The Synthesis of ι-(10-Phenothiazinyl)-alkyl-dialkylsulfonium Halides and 2'-(10-Phenothiazinecarboxy)-ethyldialkylsulfonium Halides

1958 • 3 citations

522. Bisquaternary ammonium salts. Part III. 4-Alkylbenzene-1 : ω-bistrialkylammonium salts

1957 • 3 citations

Verbindungen mit kurareähnlicher Wirkung

1952 • 2 citations

[Pharmacological studies on a new ganglionic blocking agent with prolonged effect, N-(gamma-trimethylammoniumpropyl)-N-methyl-camphidinium dimethyl sulfate (Ha-106)].

1957 • 2 citations

Synthetic Hypotensive Agents. IV. dialkylaminoalkyl Esters of N-Methylnipecotic and N-Methylisonipecotic Acids and Some Bis-quaternary Ammonium Salts

1956 • 2 citations

IN THE ESTATE OF WILLIAMS

1914 • 2 citations

The Neuromuscular Activity of a Series of Bis(3-hydroxydimethylpiperidinium Bromide) Ethers * *Department of Pharmacology, College of Medicine, State University of Iowa, Iowa City

1958 • 2 citations

Quaternary Salts of 2,4,6-(Dialkylaminoalkoxy)-1,3,5-Triazines and 2, 4-(Dialkylaminoalkoxy)-Quinazolines as Curare Agents

1954 • 2 citations

Basic Ethers of Some Piperidine Alcohols

1954 • 2 citations

Branched-chain thia-alkanebis(quaternary ammonium) salis as ganglion-blocking agents

1954 • 1 citations

[New hypotensive heterocyclic methonium compounds; preliminary report].

1954 • 1 citations

Propriétés antiacétylcholinestérasiques du diiodométhylate debis-(diméthylamino-3-phénoxy)-1-3 propane, de ses dérivés phénoliques et des esters carbamiques correspondants

1957 • 1 citations

[Pharmacology of diquaternary basic alkylethers].

1957 • 1 citations

[Cyclocatdecane-1, 10-bis(trimethylammonium iodide) a synthetic agent with the ring size and effects of d-tubocurarine].

1957 • 1 citations

[Comparative studies on the muscarine-like effects of acetylcholine, nitrocholine, furtrethonium and other quaternary ammonium bases].

1956 • 1 citations