Target antigens for prostate cancer immunotherapy.

Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts.

1998 • 1,013 citations

A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase

1999 • 983 citations

Peptides Naturally Presented by MHC Class I Molecules

1993 • 803 citations

Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature.

1999 • 777 citations

A kallikrein-like serine protease in prostatic fluid cleaves the predominant seminal vesicle protein.

1985 • 752 citations

Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers

1999 • 687 citations

Prostate stem cell antigen: A cell surface marker overexpressed in prostate cancer

1998 • 672 citations

Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues.

1990 • 640 citations

PROSTATE SPECIFIC ANTIGEN: A DECADE OF DISCOVERY-WHAT WE HAVE LEARNED AND WHERE WE ARE GOING

1999 • 618 citations

HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells.

1995 • 599 citations

BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes

1995 • 598 citations

A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.

1995 • 591 citations

From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells

1999 • 587 citations

Human prostate-specific antigen: structural and functional similarity with serine proteases.

1986 • 580 citations

Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2.

1999 • 526 citations

Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen.

1993 • 510 citations

Monoclonal antibodies to the extracellular domain of prostate-specific membrane antigen also react with tumor vascular endothelium.

1997 • 509 citations

Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model.

1997 • 488 citations

Isolation of High Avidity Melanoma-Reactive CTL from Heterogeneous Populations Using Peptide-MHC Tetramers

1999 • 423 citations

Constitutive and antibody-induced internalization of prostate-specific membrane antigen.

1998 • 419 citations

Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice

1997 • 400 citations

Molecular cloning of human prostate specific antigen cDNA

1987 • 399 citations

Phase I clinical trial: T-cell therapy for prostate cancer using autologous dendritic cells pulsed with HLA-A0201-specific peptides from prostate-specific membrane antigen

1996 • 398 citations

Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs

1998 • 380 citations

Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research

1995 • 374 citations

Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice

1997 • 369 citations

Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase.

1996 • 360 citations

Significance of Increased Phosphatase Activity of Bone at the Site of Osteoplastic Metastases Secondary to Carcinoma of the Prostate Gland

1936 • 333 citations

Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy.

1999 • 329 citations

Phase II study of weekly intravenous trastuzumab (Herceptin) in patients with HER2/neu-overexpressing metastatic breast cancer.

1999 • 300 citations

Overview of the trastuzumab (Herceptin) anti-HER2 monoclonal antibody clinical program in HER2-overexpressing metastatic breast cancer. Herceptin Multinational Investigator Study Group.

1999 • 296 citations

Monoclonal antibody therapy of human cancer: Taking the HER2 protooncogene to the clinic

1991 • 296 citations

In Vitro Generation of Human Cytotoxic T Lymphocytes Specific for Peptides Derived From Prostate-Specific Antigen

1997 • 267 citations

Cloning of the TMPRSS2 Gene, Which Encodes a Novel Serine Protease with Transmembrane, LDLRA, and SRCR Domains and Maps to 21q22.3

1997 • 258 citations

The Biologic Effects of C225, A Chimeric Monoclonal Antibody to the EGFR, on Human Prostate Carcinoma

1996 • 243 citations

Infusion of dendritic cells pulsed with HLA-A2-specific prostate-specific membrane antigen peptides: A phase II prostate cancer vaccine trial involving patients with hormone-refractory metastatic disease

1999 • 242 citations

Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression

1999 • 221 citations

Recombinant vaccinia-PSA (PROSTVAC) can induce a prostate-specific immune response in androgen-modulated human prostate cancer

1999 • 206 citations

Phase II prostate cancer vaccine trial: Report of a study involving 37 patients with disease recurrence following primary treatment

1999 • 191 citations

Loss of HLA class I expression in prostate cancer: Implications for immunotherapy

1995 • 189 citations

Combination therapy with trastuzumab (Herceptin) and cisplatin for chemoresistant metastatic breast cancer: evidence for receptor-enhanced chemosensitivity.

1999 • 182 citations

Alternatively spliced variants of prostate-specific membrane antigen RNA: ratio of expression as a potential measurement of progression.

1995 • 179 citations

HER-2/neu Protein: A Target for Antigen-Specific Immunotherapy of Human Cancer

1997 • 173 citations

p53, c-erbB-2 and the Epidermal Growth Factor Receptor in the Benign and Malignant Prostate

1992 • 169 citations

Expression of the c-erbB-2 (Her-2/neu) Oncoprotein in Human Prostatic Carcinoma

1993 • 159 citations

Location of prostate-specific membrane antigen in the LNCaP prostate carcinoma cell line

1997 • 158 citations

Hepsin, a cell surface serine protease identified in hepatoma cells, is overexpressed in ovarian cancer.

1997 • 149 citations

Discovery of three genes specifically expressed in human prostate by expressed sequence tag database analysis

1998 • 148 citations

Identification of a positive regulatory element responsible for tissue-specific expression of prostate-specific antigen.

1997 • 140 citations

Prostase/KLK-L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated.

1999 • 128 citations

Induction of tissue-specific autoimmune prostatitis with prostatic acid phosphatase immunization: implications for immunotherapy of prostate cancer.

1997 • 128 citations

Generation of Human Cytolytic T Lymphocyte Lines Directed Against Prostate-Specific Antigen (PSA) Employing a PSA Oligoepitope Peptide

1998 • 126 citations

Follow-up evaluation of prostate cancer patients infused with autologous dendritic cells pulsed with PSMA peptides

1997 • 126 citations

Presentation of prostate tumor antigens by dendritic cells stimulates T-cell proliferation and cytotoxicity

1996 • 120 citations

Isolation and Characterization of Two Specific Antigens of Human Seminal Plasma

1973 • 120 citations

Coamplification of prostate stem cell antigen (PSCA) andMYC in locally advanced prostate cancer

2000 • 118 citations

Induction of prostate tumor-specific CD8+ cytotoxic T-lymphocytes in vitro using antigen-presenting cells pulsed with prostatic acid phosphatase peptide

1998 • 114 citations

RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell.

1996 • 112 citations

ProstaScint scan may enhance identification of prostate cancer recurrences after prostatectomy, radiation, or hormone therapy: analysis of 136 scans of 100 patients.

1998 • 111 citations

A recombinant vaccinia virus expressing human prostate‐specific antigen (PSA): Safety and immunogenicity in a non‐human primate

1995 • 109 citations

Identification of Her-2/Neu CTL epitopes using double transgenic mice expressing HLA-A2.1 and human CD.8

1997 • 107 citations

Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database.

1999 • 104 citations

HER-2/neu gene amplification status in prostate cancer by fluorescence in situ hybridization

1997 • 102 citations

Molecular cloning and sequence analysis of cDNA encoding human prostatic acid phosphatase

1988 • 100 citations

Induction of human cytotoxic T lymphocytes specific for prostate-specific antigen

1997 • 99 citations

Identification, purification, and subcellular localization of prostate-specific membrane antigen PSM' protein in the LNCaP prostatic carcinoma cell line.

1998 • 97 citations

A recombinant, fully human monoclonal antibody with antitumor activity constructed from phage-displayed antibody fragments

1999 • 96 citations

Expression of Transforming Growth Factor-α and the Epidermal Growth Factor Receptor in Human Prostate Tissues

1994 • 95 citations

Molecular and cellular biology of prostate cancer.

1997 • 93 citations

PAGE-1 , an X chromosome-linked GAGE- like gene that is expressed in normal and neoplastic prostate, testis, and uterus

1998 • 91 citations

Gene expression and prostate specificity of human prostatic acid phosphatase (PAP): evaluation by RNA blot analyses

1990 • 90 citations

Molecular and immunological analysis of genetic prostate specific antigen (PSA) vaccine

1998 • 85 citations

Immunohistochemical detection of c-erbB-2 protein in human benign and neoplastic prostate

1991 • 84 citations

Immunologic approaches to the treatment of prostate cancer.

1999 • 83 citations

Isolation and Characterization of PAGE-1 andGAGE-7

1998 • 81 citations

Tissue-specific expression of the human prostate-specific antigen gene in transgenic mice: Implications for tolerance and immunotherapy

1997 • 80 citations

Clinical use of tumor markers in oncology

1991 • 68 citations

ISOLATION AND CHARACTERIZATION OF MONOCLONAL ANTIBODIES SPECIFIC FOR THE EXTRACELLULAR DOMAIN OF PROSTATE SPECIFIC MEMBRANE ANTIGEN

1998 • 62 citations

Fluorescence in Situ Hybridization Study of HER-2/neu Oncogene Amplification in Prostate Cancer

1999 • 58 citations

Prostate-specific membrane antigen: current and future utility.

1998 • 52 citations

Improved immunohistochemical detection of prostatic acid phosphatase by a monoclonal antibody

1989 • 51 citations

Monoclonal antibody 7E11.C5 staining of viable LNCaP cells

1997 • 49 citations

Identification of rat prostatic steroid-binding protein as a target antigen of experimental autoimmune prostatitis: implications for prostate cancer therapy.

1997 • 45 citations

Antibodies come back from the brink

1998 • 37 citations

Effect of methotrexate-monoclonal anti-prostatic acid phosphatase antibody conjugate on human prostate tumor.

1986 • 33 citations

Immunological approaches for the treatment of prostate cancer.

1998 • 23 citations

Adjuvant immunotherapy (BCG) in Stage D prostate cancer

1982 • 23 citations

THE ROLE OF MONOCLONAL ANTIBODY IN THE MANAGEMENT OF PROSTATE ADENOCARCINOMA

1998 • 23 citations

Diagnostic markers of prostate cancer: Utility of prostate‐specific antigen in diagnosis and staging

1995 • 21 citations

Expression of human prostate-specific antigen (PSA) in a mouse tumor cell line reduces tumorigenicity and elicits PSA-specific cytotoxic T lymphocytes

1996 • 20 citations

Intravenous injection of an immunoconjugate (anti-PSA-IgG conjugated to 5-fluoro-2'-deoxyuridine) selectively inhibits cell proliferation and induces cell death in human prostate cancer cell tumors grown in nude mice.

1999 • 19 citations

Potential Therapeutic Effect of Adriamycin-Monoclonal Anti-prostatic Acid Phosphatase Antibody Conjugate on Human Prostate Tumor

1987 • 17 citations

Adjuvant immunotherapy with bacillus Calmette-Guérin in prostatic cancer

1979 • 13 citations

Expression and Purification of Prostate-Specific Membrane Antigen in the Baculovirus Expression System and Recognition by Prostate-Specific Membrane Antigen-Specific T Cells

1999 • 12 citations

Antibody immunoglobulin G (IgG) against human prostatic specific antigen (PSA) as a carrier protein for chemotherapeutic drugs to human prostate tumors: Part 1. A double immunofluorescence analysis

1996 • 8 citations

Immunocytochemical localization of an immunoconjugate (antibody IgG against prostatic acid phosphatase conjugated to 5-fluoro-2'-deoxyuridine) in human prostate tumors.

1998 • 7 citations

MONOCLONAL ANTIBODIES AGAINST PROSTATE STEM CELL ANTIGEN (PSCA) DETECT HIGH LEVELS OF PSCA EXPRESSION IN PROSTATE CANCER BONE METASTASES

1999 • 1 citations

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