Clinical use of lipids to control inflammatory disease.

The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil

1996 • 867 citations

Effect of an Enteric-Coated Fish-Oil Preparation on Relapses in Crohn's Disease

1996 • 780 citations

Early enteral administration of a formula (Impact Registered Trademark) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients

1995 • 601 citations

The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells.

1994 • 467 citations

Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan

1996 • 441 citations

Dietary Supplementation with Fish Oil in Ulcerative Colitis

1992 • 405 citations

Dietary omega-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils.

1993 • 348 citations

Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial.

1992 • 306 citations

A role for phospholipid polyunsaturation in modulating membrane protein function

1996 • 280 citations

Dietary (n-3) Polyunsaturated Fatty Acids Suppress Murine Lymphoproliferation, Interleukin-2 Secretion, and the Formation of Diacylglycerol and Ceramide , ,

1997 • 240 citations

Effects of high‐dose fish oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs clinical and immune correlates

1995 • 239 citations

Gamma‐linolenic acid treatment of rheumatoid arthritis. A randomized, placebo‐controlled trial

1996 • 199 citations

Effect of Dietary Fish Oil on Renal Function and Rejection in Cyclosporine-Treated Recipients of Renal Transplants

1993 • 195 citations

Fish oil supplementation inhibits the expression of major histocompatibility complex class II molecules and adhesion molecules on human monocytes

1996 • 192 citations

Docosahexaenoic Acid Selectively Attenuates Induction of Vascular Cell Adhesion Molecule–1 and Subsequent Monocytic Cell Adhesion to Human Endothelial Cells Stimulated by Tumor Necrosis Factor–α

1995 • 187 citations

Nuclear Factor kB Is Activated by Arachidonic Acid but Not by Eicosapentaenoic Acid

1996 • 185 citations

Control of endothelial leukocyte adhesion molecules by fatty acids

1996 • 158 citations

Participation of thromboxane and other eicosanoid synthesis in the course of experimental inflammatory colitis

1990 • 147 citations

Inhibitory Effect of Fish Oil N-3 Polyunsaturated Fatty Acids on the Expression of Endothelial Cell Adhesion Molecules

1996 • 133 citations

(n-3) Polyunsaturated Fatty Acids Modulate the Expression of Functionally Associated Molecules on Human Monocytes in Vitro

1996 • 131 citations

N-3 fatty acids only delay early relapse of ulcerative colitis in remission

1996 • 129 citations

Effects of eicosapentaenoic and gamma-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats

1997 • 108 citations

Dietary Fish Oil Reduces Survival and Impairs Bacterial Clearance in C3H/Hen Mice Challenged with Listeria Monocytogenes

1997 • 107 citations

Effects of modulation of inflammatory and immune parameters in patients with rheumatic and inflammatory disease receiving dietary supplementation of n-3 and n-6 fatty acids

1996 • 105 citations

The ratio of n‐6 to n‐3 polyunsaturated fatty acids in the rat diet alters serum lipid levels and lymphocyte functions

1996 • 103 citations

Inability of skin enzyme preparations to biosynthesize arachidonic acid from linoleic acid

1984 • 90 citations

Dietary marine lipids suppress continuous expression of interleukin‐1β gene transcription¹

1996 • 84 citations

Immunologic effects of marine- and plant-derived n-3 polyunsaturated fatty acids in nonhuman primates

1996 • 79 citations

Effects of different polunsaturated fatty acids on growth‐related early gene expression and cell growth

1996 • 75 citations

Impact of arachidonic versus eicosapentaenoic acid on exotonin-induced lung vascular leakage: relation to 4-series versus 5-series leukotriene generation.

1997 • 70 citations

Inhibition of Lymphocyte Protein Kinase C by Unsaturated Fatty Acids

1993 • 69 citations

The significance of polyunsaturated fatty acids in cutaneous biology

1996 • 67 citations

Eicosapentaenoic acid suppressed the proliferation of vascular smooth muscle cells through modulation of various steps of growth signals

1996 • 63 citations

DOCOSAHEXAENOIC AND EICOSAPENTAENOIC ACIDS INHIBIT IN VITRO HUMAN LYMPHOCYTE-ENDOTHELIAL CELL ADHESION

1996 • 63 citations

Effects of new fish oil derivative on fatty acid phospholipid-membrane pattern in a group of Crohn's disease patients

1994 • 61 citations

Effects of Dietary Lipid Manipulation upon Graft vs Host and Host vs Graff Responses in the Rat

1995 • 60 citations

N‐3 but not N‐6 fatty acids reduce the expression of the combined adhesion and scavenger receptor CD36 in human monocytic cells

1995 • 57 citations

Effects of variations in the proportions of saturated, monounsaturated and polyunsaturated fatty acids in the rat diet on spleen lymphocyte functions

1997 • 57 citations

MARKERS FOR PREDICTING THE DEVELOPMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME

1997 • 54 citations

Hypertension Prophylaxis With Omega-3 Fatty Acids in Heart Transplant Recipients

1997 • 51 citations

The effect of highly purified eicosapentaenoic and docosahexaenoic acids on monocyte phagocytosis in man

1997 • 49 citations

Effects of a Fish Oil Diet on Pigs' Cardiopulmonary Response to Bacteremia

1991 • 43 citations

ω-3 Lipid Infusion in a Heart Allotransplant Model

1996 • 40 citations

Polyunsaturation in cell membranes and lipid bilayers and its effects on membrane proteins

1996 • 40 citations

Can n — 3 polyunsaturated fatty acids be used as immunomodulatory agents?

1996 • 39 citations

Polyunsaturated fatty acids and signalling via phospholipase C-β and A2 in myocardium

1996 • 37 citations

Lipid mediators, free fatty acids and psoriasis

1995 • 34 citations

Dietary n-3 fatty acids increase spleen size and postendotoxin circulating TNF in mice; role of macrophages, macrophage precursors, and colony-stimulating factor-1.

1996 • 32 citations

Gammalinolenic Acid and Dihomogammalinolenic Acid Suppress the CD3-Mediated Signal Transduction Pathway in Human T Cells

1997 • 31 citations

γ‐linolenic acid‐containing diet attenuates bleomycin‐induced lung fibrosis in hamsters

1997 • 31 citations

The Effect of α-Linolenic Acid-Rich Emulsion on Fatty Acid Metabolism and Leukotriene Generation of the Colon in a Rat Model with Inflammatory Bowel Disease

1996 • 28 citations

An Enteral Formula Containing Fish Oil, Indigestible Oligosaccharides, Gum Arabic and Antioxidants Affects Plasma and Colonic Phospholipid Fatty Acid and Prostaglandin Profiles in Pigs ,

1997 • 27 citations

Essential fatty acids are antagonists of the leukotriene B4 receptor

1995 • 27 citations

Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells

1995 • 25 citations

Effect of degree of unsaturation in dietary fatty acids on arachidonic acid mobilization by peritoneal macrophages

1996 • 25 citations

Effect of dietary flaxseed on fatty acid composition, superoxide, nitric oxide generation and antilisterial activity of peritoneal macrophages from female Sprague-Dawley rats

1997 • 23 citations

Synthesis of 4- and 5-series leukotrienes in the lung microvasculature challenged with Escherichia coli hemolysin: critical dependence on exogenous free fatty acid supply.

1997 • 22 citations

Quantification of distinct molecular species of platelet activating factor in ulcerative colitis

1996 • 18 citations

Sulfasalazine or Enteral Diets Containing Fish Oil or Oligosaccharides Attenuate Chronic Colitis in Rats

1996 • 11 citations

The Nutritional Effect of <i>α</i><i>-</i>Linolenic Acid-Rich Emulsion with Total Parenteral Nutrition in a Rat Model with Inflammatory Bowel Disease

1996 • 9 citations

THE EFFECTS OF ??-3 POLYUNSATULATED FATTY ACIDS ON THE RECOVERY OF CARDIAC FUNCTION FOLLOWING COLD PRESERVATION AND REPERFUSION IN HYPERLIPIDEMIC RATS1

1996 • 6 citations

Reproducible effects of intravenously administered fish oil in acute relapsing psoriasis

1996 • 3 citations