Selective Delivery of Antigens by Recombinant Bacteria

Peptidoglycan types of bacterial cell walls and their taxonomic implications

1972 • 3,772 citations

Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines

1981 • 2,042 citations

Peptidoglycan types of bacterial cell walls and their taxonomic implications.

1972 • 1,888 citations

Construction of Biologically Functional Bacterial Plasmids In Vitro

1973 • 1,699 citations

Positive selection for loss of tetracycline resistance

1980 • 704 citations

THE ROUTE OF ENTERIC INFECTION IN NORMAL MICE

1974 • 661 citations

Phage P22-mutants with increased or decreased transduction abilities

1972 • 656 citations

Genetic engineering in Vivo using translocatable drug-resistance elements

1977 • 625 citations

Selection for loss of tetracycline resistance by Escherichia coli

1981 • 585 citations

Isolation and Characterization of Gal E Mutant Ty 21a of Salmonella typhi: A Candidate Strain for a Live, Oral Typhoid Vaccine

1975 • 521 citations

Cyclic Adenosine Monophosphate in Bacteria

1970 • 503 citations

Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin.

1984 • 445 citations

Salmonella typhimurium deletion mutants lacking adenylate cyclase and cyclic AMP receptor protein are avirulent and immunogenic

1987 • 434 citations

‘ATG vectors’ for regulated high-level expression of cloned genes in Escherichia coli

1985 • 392 citations

Plasmid-associated virulence of Salmonella typhimurium

1987 • 376 citations

Construction of an ASD+ Expression-Cloning Vector: Stable Maintenance and High Level Expression of Cloned Genes in a Salmonella Vaccine Strain

1988 • 342 citations

Cyclic adenosine 5'-monophosphate in Escherichia coli

1976 • 324 citations

Association of adhesive, invasive, and virulent phenotypes of Salmonella typhimurium with autonomous 60-megadalton plasmids

1982 • 269 citations

Organ and Isotype Distribution of Plasma Cells Producing Specific Antibody after Oral Immunization: Evidence for A Generalized Secretory Immune System

1979 • 254 citations

Requirement of Adenosine 3′, 5′-Cyclic Phosphate for Flagella Formation in Escherichia coli and Salmonella typhimurium

1970 • 200 citations

Effect of different purine auxotrophic mutations on mouse-virulence of a Vi-positive strain of Salmonella dublin and of two strains of Salmonella typhimurium

1987 • 195 citations

Construction of a potential bivalent vaccine strain: introduction of Shigella sonnei form I antigen genes into the galE Salmonella typhi Ty21a typhoid vaccine strain

1981 • 193 citations

Transport of antibiotics and metabolite analogs by systems under cyclic AMP control: positive selection of Salmonella typhimurium cya and crp mutants

1978 • 190 citations

A galE via (Vi antigen-negative) mutant of Salmonella typhi Ty2 retains virulence in humans

1988 • 187 citations

Safety, infectivity, immunogenicity, and in vivo stability of two attenuated auxotrophic mutant strains of Salmonella typhi, 541Ty and 543Ty, as live oral vaccines in humans.

1987 • 185 citations

Aromatic-dependent Salmonella typhimurium as modified live vaccines for calves.

1984 • 182 citations

Prevention of Shigellosis by a Salmonella typhi-Shigella sonnei Bivalent Vaccine

1987 • 175 citations

Production of immunity and unresponsiveness in the mouse by feeding contact sensitizing agents and the role of suppressor cells in the Peyer's patches, mesenteric lymph nodes and other lymphoid tissues

1977 • 173 citations

Cyclic adenosine 5'-monophosphate in Escherichia coli.

1976 • 172 citations

A Common Mucosal Immunologic System Involving the Bronchus, Breast and Bowel

1978 • 163 citations

Cyclic AMP in Prokaryotes

1974 • 158 citations

Salmonella typhimurium infection in calves: protection and survival of virulent challenge bacteria after immunization with live or inactivated vaccines

1983 • 151 citations

Contribution of Salmonella gallinarum large plasmid toward virulence in fowl typhoid

1987 • 141 citations

Galactose-sensitive mutants of Salmonella I. Metabolism of galactose

1961 • 140 citations

Immunity to Salmonella typhimurium infection in C3H/HeJ and C3H/HeNCrlBR mice: studies with an aromatic-dependent live S. typhimurium strain as a vaccine

1985 • 140 citations

An Attenuated aroA Salmonella typhimurium Vaccine Elicits Humoral and Cellular Immunity to Cloned -Galactosidase in Mice

1987 • 131 citations

Cyclic nucleotides in procaryotes

1981 • 130 citations

The effects of biochemical mutation on the virulence of Bacterium typhosum; the loss of virulence of certain mutants.

1951 • 128 citations

Salmonella typhimuriumaroA mutants as carriers of the Escherichia coli heat-labile enterotoxin B subunit to the murine secretory and systemic immune systems

1987 • 127 citations

Galactose-sensitive mutants of Salmonella II. Bacteriolysis induced by galactose

1961 • 126 citations

STUDIES ON INFECTION AND IMMUNITY IN EXPERIMENTAL TYPHOID FEVER

1960 • 122 citations

Possible relationship of a 36-megadalton Salmonella enteritidis plasmid to virulence in mice

1985 • 121 citations

Immunity in Experimental Salmonellosis II. Basis for the Avirulence and Protective Capacity of gal E Mutants of Salmonella typhimurium

1971 • 121 citations

Correlation between the presence of a fifty-megadalton plasmid in Salmonella dublin and virulence for mice

1983 • 115 citations

F + , Hfr, and F' strains of Salmonella typhimurium and Salmonella abony

1972 • 114 citations

Sites of allosteric shift in the structure of the cyclic AMP receptor protein

1985 • 114 citations

Origin and Differentiation of Lymphocytes Involved in the Secretory IgA Response

1977 • 112 citations

Virulence associated plasmids of Salmonella serotype typhimurium in experimental murine infection

1986 • 109 citations

Construction of a potential live oral bivalent vaccine for typhoid fever and cholera-Escherichia coli-related diarrheas

1984 • 108 citations

Natural History of Oral Salmonella dublin Infection in BALB/c Mice: Effect of an 80-Kilobase-Pair Plasmid on Virulence

1987 • 108 citations

Oral immunization of mice with attenuated Salmonella enteritidis containing a recombinant plasmid which codes for production of the B subunit of heat-labile Escherichia coli enterotoxin

1986 • 103 citations

Live oral Salmonella vaccines: potential use of attenuated strains as carriers of heterologous antigens to the immune system

1987 • 103 citations

Plasmid-mediated virulence in Salmonella dublin demonstrated by use of a Tn5-oriT construct

1985 • 102 citations

Mediation of Serum Resistance in Salmonella typhimurium by an 11-Kilodalton Polypeptide Encoded by the Cryptic Plasmid

1987 • 98 citations

Cloning and transposon insertion mutagenesis of virulence genes of the 100-kilobase plasmid of Salmonella typhimurium

1988 • 94 citations

The Colonization of Peyer's Patches by a Strain of Salmonella typhimurium Cured of the Cryptic Plasmid

1986 • 90 citations

Genetic Analysis of Streptococcus mutans Virulence

1985 • 86 citations

Avirulent Salmonella typhimurium Δcya Δcrp oral vaccine strains expressing a streptococcal colonization and virulence antigen

1988 • 86 citations

Protection against experimental salmonellosis in mice and sheep by immunisation with aromatic-dependent Salmonella typhimurium

1987 • 84 citations

Adenosine 3′:5′-Cyclic Monophosphate Control of the Enzymes of Glutamine Metabolism in Escherichia coli

1972 • 83 citations

The role of cAMP in flagellation of Salmonella typhimurium

1975 • 82 citations

Contruction of Defined galE Mutants of Salmonella for Use as Vaccines

1987 • 81 citations

Salmonellosis in Orally Infected Specific Pathogen-Free C57B1 Mice

1972 • 76 citations

Galactose-sensitive Mutants of Salmonella

1959 • 75 citations

Cyclic nucleotides in procaryotes.

1981 • 75 citations

The effects of biochemical mutation on the virulence of Bacterium typhosum: the virulence of mutants.

1950 • 74 citations

Molecular Cloning of Recombinant DNA

1978 • 72 citations

Recombinant molecules : impact on science and society

1977 • 65 citations

Salmonella typhimurium infection in calves: cell-mediated and humoral immune reactions before and after challenge with live virulent bacteria in calves given live or inactivated vaccines

1983 • 65 citations

Interactions of cAMP receptor protein with the ompA gene, a gene for a major outer membrane protein of Escherichia coli

1981 • 64 citations

Isolation of stable aroA mutants of Salmonella typhi Ty2: Properties and preliminary characterisation in mice

1987 • 60 citations

Interrelationships between lysine and α∈-diaminopimelic acid and their derivatives and analogues in mutants of Escherichia coli

1957 • 59 citations

Safety and Antigenicity of Typhoid-Shigella sonnei Vaccine (Strain 5076-1C)

1984 • 57 citations

Studies on Infection and Immunity in Experimental Typhoid Fever: VII. The Distribution of Salmonella typhi in Chimpanzee Tissue Following Oral Challenge, and the Relationship Between the Numbers of Bacilli and Morphologic Lesions

1968 • 57 citations

The role of plasmid genes in the pathogenicity of Salmonella dublin

1986 • 56 citations

Expression of Streptococcus mutans Aspartate-Semialdehyde Dehydrogenase Gene Cloned into Plasmid pBR322

1982 • 56 citations

Galactose epimeraseless (GalE) mutant G30 ofSalmonella typhimuriumis a good potential live oral vaccine carrier for fimbrial antigens

1985 • 55 citations

A new method for the physical and genetic mapping of large plasmids: application to the localisation of the virulence determinants on the 90 kb plasmid of Salmonella typhimurium

1987 • 54 citations

Genetic Analysis of Streptococcus mutans Virulence and Prospects for an Anticaries Vaccine

1986 • 50 citations

CONSTRUCTION AND USE OF SAFER BACTERIAL HOST STRAINS FOR RECOMBINANT DNA RESEARCH

1977 • 49 citations

Nucleotide sequence of the asd gene of Streptococcus mutans. Identification of the promoter region and evidence for attenuator-like sequences preceding the structural gene.

1987 • 48 citations

In vivo properties of a cloned K88 adherence antigen determinant

1986 • 47 citations

METABOLISM OF GALACTOSE

1933 • 47 citations

Biological Containment and Cloning Vector Transmissibility

1978 • 46 citations

Selection of Auxotrophic Bacterial Mutants through Diaminopimelic Acid or Thymine Deprival

1957 • 45 citations

Introduction of Shigella flexneri 2a type and group antigen genes into oral typhoid vaccine strain Salmonella typhi Ty21a

1987 • 42 citations

Intestinal Toxicology

1985 • 41 citations

Molecular of Cloning of Recombinant DNA

1977 • 40 citations

Some galE mutants of Salmonella choleraesuis retain virulence

1986 • 39 citations

Cyclic AMP-dependent synthesis of fimbriae in Salmonella typhimurium: effects of cya and pts mutations

1978 • 39 citations

Mutation in the crp gene of Salmonella typhimurium which interferes with inducer exclusion

1980 • 39 citations

ROLE OF α,ε-DIAMINOPIMELIC ACID IN THE CELLULAR INTEGRITY OF ESCHERICHIA COLI

1957 • 35 citations

Cyclic AMP and the production of sex pili by E. coli K-12 carrying derepressed sex factors

1975 • 34 citations

Double negative and positive control of tsx expression in Escherichia coli

1988 • 33 citations

Contribution of cyclic adenosine 3':5'-monophosphate to the regulation of bacterial glycogen synthesis in vivo. Effect of carbon source and cyclic adenosine 3':5'-monophosphate on the quantitative relationship between the rate of glycogen synthesis and the cellular concentrations of glucose 6-phosphate and fructose 1,6-diphosphate in Escherichia coli.

1979 • 31 citations

MOLECULAR CLONING OF BACTERIAL ANTIGENS AND VIRULENCE DETERMINANTS

1984 • 31 citations

Isolation and characterization of cAMP suppressor mutants of Escherichia coli K12

1981 • 28 citations

F + , Hfr, and F' strains of Salmonella typhimurium and Salmonella abony.

1972 • 26 citations

LIVE ATTENUATED BACTERIAL VACCINES: NEW APPROACHES FOR SAFETY AND EFFICACY

1985 • 26 citations

Vaccines : new concepts and developments

1988 • 26 citations

Evidence for the regulation of bacterial glycogen synthesis by cyclic AMP

1977 • 23 citations

Use of Attenuated Mutants of <i>Salmonella </i>as Carriers for Delivery of Heterologous Antigens to the Secretory Immune System

1987 • 23 citations

Plasmid-cured Salmonella enteritidis AL1192 as a candidate for a live vaccine

1985 • 19 citations

Vaccines: New concepts and developments

1987 • 18 citations

Correlation of macrophage migration-inhibition factor and protection from challenge exposure in calves vaccinated with Salmonella typhimurium.

1985 • 18 citations

Differential growth characteristics and immunogenicity of tight and coasting temperature-sensitive mutants of Pseudomonas aeruginosa

1987 • 15 citations

Immune system of the gastrointestinal tract.

1983 • 15 citations

Vaccines 86: New Approaches to Immunization : Developing Vaccines Against Parasitic, Bacterial, and Viral Diseases

1986 • 11 citations

Genetic Approaches to Microbial Pathogenicity

1985 • 10 citations

Temperature‐Sensitive Growth Mutants as Live Vaccines against Experimental Murine Salmonellosis

1987 • 9 citations

Specific Pulmonary Defences against Pseudomonas aeruginosa after Local Immunization with Temperature-sensitive Mutants

1987 • 8 citations

ESCHERICHIA COLI STRAINS PRODUCING STREPTOCOCCUS MUTANS PROTEINS RESPONSIBLE FOR COLONIZATION AND VIRULENCE*

1983 • 7 citations

[Properties of 2 gal+ derivatives of the vaccine mutant gal E Ty21a strain of Salmonella typhi].

1985 • 4 citations