Infra-red and Raman spectroscopic studies of enzyme structure and function

Enzyme structure and mechanism

1978 • 2,897 citations

Vibrational spectra and structure

1981 • 610 citations

The Spectrophotometric Determination of the Operational Normality of an α-Chymotrypsin Solution

1961 • 407 citations

Applications of infrared, Raman and Resonance Raman spectroscopy in biochemistry

1984 • 355 citations

Laser-excited Raman spectroscopy of biomolecules

1970 • 355 citations

PHOTOPHYSICS OF LIGHT TRANSDUCTION IN RHODOPSIN AND BACTERIORHODOPSIN

1981 • 301 citations

Biochemical Applications of Raman and Resonance Raman Spectroscopies

1983 • 298 citations

Resonance Raman spectroscopy of rhodopsin in retinal disk membranes

1974 • 274 citations

Determination of the secondary structure of proteins by laser Raman spectroscopy

1976 • 272 citations

Photoisomerization, energy storage, and charge separation: A model for light energy transduction in visual pigments and bacteriorhodopsin

1979 • 270 citations

Free-energy profile for the reaction catalyzed by triosephosphate isomerase

1976 • 241 citations

Protein control of porphyrin conformation. Comparison of resonance Raman spectra of heme proteins with mesoporphyrin IX analogs

1976 • 236 citations

The Mechanism of the Triosephosphate Isomerase Reaction

1959 • 218 citations

A reporter group delivery system with both absolute and selective specificity for thiol groups and an improved fluorescent probe containing the 7-nitrobenzo-2-oxa-1,3-diazole moiety

1975 • 206 citations

Disulfide Bond Dihedral Angles from Raman Spectroscopy

1973 • 169 citations

Current problems in mechanistic studies of serine and cysteine proteinases

1982 • 165 citations

Determination of retinal Schiff base configuration in bacteriorhodopsin

1984 • 156 citations

Resonance Raman studies of bovine metarhodopsin I and metarhodopsin II

1978 • 146 citations

Resonance Raman studies of the primary photochemical event in visual pigments

1980 • 128 citations

Potentiometric determination of ionizations at the active site of papain

1976 • 127 citations

Kinetic Resonance Raman Spectroscopy: Dynamics of Deprotonation of the Schiff Base of Bacteriorhodopsin

1977 • 122 citations

The Preparation and Properties of trans-Cinnamoyl-Papain¹

1966 • 119 citations

Laser-excited Raman spectroscopy of biomolecules. 9. Laser Raman spectroscopic studies of the thermal unfolding of ribonuclease A

1976 • 111 citations

Direct observation of substrate distortion by triosephosphate isomerase using Fourier transform infrared spectroscopy

1980 • 111 citations

Low-frequency vibrations in resonance Raman spectra of horse heart myoglobin. Iron-ligand and iron-nitrogen vibrational modes

1979 • 111 citations

Resonance Raman studies of bathorhodopsin: Evidence for a protonated Schiff base linkage

1979 • 103 citations

The molecular mechanism of excitation in visual transduction and bacteriorhodopsin

1978 • 102 citations

The Far-Infrared Spectrum of Collagen

1974 • 72 citations

Resonance Raman spectra of carbon-13- and nitrogen-15-labeled riboflavin bound to egg-white flavoprotein

1979 • 72 citations

Sulfhydryl groups in hemoglobin. New molecular probe at the α1β1 interface studied by Fourier transform infrared spectroscopy

1975 • 63 citations

Absence of heme-localized strain in T state hemoglobin: insensitivity of heme-imidazole resonance Raman frequencies to quaternary structure.

1979 • 60 citations

Polarization of substrate carbonyl groups by yeast aldolase: investigation by Fourier transform infrared spectroscopy

1983 • 59 citations

Resonance Raman investigations of chloroperoxidase, horseradish peroxidase, and cytochrome c using Soret band laser excitation

1979 • 51 citations

Resonance Raman kinetic spectroscopy of bacteriorhodopsin on the microsecond time scale

1977 • 48 citations

Sulphydryl groups as a new molecular probe at the α1β1 interface in haemoglobin using Fourier transform infrared spectroscopy

1974 • 48 citations

Mechanism of action of cysteine proteinases: oxyanion binding site is not essential in the hydrolysis of specific substrates

1985 • 47 citations

Calculation and use of protein‐derived conformation‐related spectra for the estimate of the secondary structure of proteins from their infrared spectra

1977 • 37 citations

Time-resolved resonance Raman spectroscopy of bacteriorhodopsin

1977 • 35 citations

A STUDY OF SOME THIOL ESTER HYDROLYSES AS MODELS FOR THE DEACYLATION STEP OF PAPAIN-CATALYSED HYDROLYSES

1965 • 34 citations

Evidence for two acyl group conformations in some furylacryloyl- and thienylacryloylchymotrypsins: resonance Raman studies of enzyme-substrate intermediates at pH 3.0

1981 • 32 citations

Resonance Raman studies on some carbonic anhydrase-aromatic sulfonamide complexes

1976 • 32 citations

Charge effects in the active site of papain: resonance Raman and absorption evidence for electron polarization occurring in the acyl group of some acylpapains

1978 • 31 citations

Evidence for a structural change in the substrate preceding hydrolysis of a chymotrypsin acyl enzyme: Application of the resonance Raman labelling technique to a dynamic biochemical system

1976 • 30 citations

Resonance Raman evidence for substrate reorganization in the active site of papain

1976 • 28 citations

Infrared and raman spectroscopy of biological molecules

1980 • 28 citations

Ligand-dependent heme-protein interactions in human hemoglobin studied by Fourier transform infrared spectroscopy. Effects of quaternary structure on alpha chain tertiary structure measured at the alpha-104(G11) cysteine-SH.

1980 • 28 citations

A Study by the Hydrogen-Exchange Method of the Complex Formed between the Basic Pancreatic Trypsin Inhibitor and Trypsin

1974 • 27 citations

Characterization of Transient Enzyme-Substrate Bonds by Resonance Raman Spectroscopy

1984 • 27 citations

Time-resolved resonance Raman characterization of the bO640 intermediate of bacteriorhodopsin. Reprotonation of the Schiff base

1979 • 25 citations

Vibrational spectra of scissile bonds in enzyme active sites: a resonance Raman study of dithioacylpapains

1982 • 24 citations

Conformational states of N-acylglycine dithioesters in solution: resonance Raman studies of isotopically substituted models for enzyme-substrate complexes

1983 • 24 citations

Resonance Raman spectroscopy of chemically modified retinals: Assigning the carbon-methyl vibrations in the resonance Raman spectrum of rhodopsin

1978 • 24 citations

Relaxed and perturbed substrate conformations in enzyme active sites: evidence from multichannel resonance Raman spectra

1983 • 22 citations

The existence of an electrophilic component in the reaction catalysed by triose phosphate isomerase

1974 • 22 citations

The pK of Schiff base deprotonation in bacteriorhodopsin

1978 • 19 citations

Picosecond absorption studies on rhodopsin and isorhodopsin in detergent and native membrane

1984 • 17 citations

Infrared spectroscopy of the water vapor sorption process of caseins

1975 • 16 citations

Resonance Raman carbonyl frequencies and ultraviolet absorption maxima as indicators of the active site environment in native and unfolded chromophoric acyl-.alpha.-chymotrypsin

1984 • 16 citations

A laser Raman study of lysozyme denaturation

1978 • 16 citations

Determination of ionization state by resonance Raman spectroscopy. Sulfonamide binding to carbonic anhydrase

1977 • 15 citations

Identity of acyl group conformations in the active sites of papain and cathepsin B by resonance Raman spectroscopy.

1984 • 11 citations

Resonance Raman and electronic absorption spectral studies of some .beta.-(2-furyl)acryloylglyceraldehyde-3-phosphate dehydrogenases

1981 • 11 citations

Tunable laser resonance Raman spectroscopic investigations of the transduction process in vertebrate rod cells.

1976 • 9 citations

Neoprontosil binding to carbonic anhydrase. Resonance Raman and other studies on the ionization behavior of the sulfonamide

1979 • 8 citations

Physicochemical studies of a branched polypeptide antigen: poly(l-Tyr,l-Glu)-poly(dl-Ala)--poly(l-Lys)

1977 • 3 citations

Fourier transform infrared absorption studies of the sulfhydryl groups in heavy meromyosin

1981 • 3 citations