Rheumatoid Arthritis and the Virus Hypothesis

The Immunopathology of Joint Inflammation in Rheumatoid Arthritis

1973 • 561 citations

The biological basis of medicine

1968 • 381 citations

Cytotoxins in Disease

1970 • 358 citations

Glycolipids of hamster fibroblasts and derived malignant-transformed cell lines.

1968 • 336 citations

Human Immunoglobulins: Classes, Subclasses, Genetic Variants, and Idiotypes

1973 • 333 citations

THE VIRAL ENVELOPE GLYCOPROTEIN OF MURINE LEUKEMIA VIRUS AND THE PATHOGENESIS OF IMMUNE COMPLEX GLOMERULONEPHRITIS OF NEW ZEALAND MICE

1974 • 277 citations

The Pathogenesis of Arthritis Associated with Viral Hepatitis

1971 • 271 citations

Immunglobulin classes, subclasses and complexes of IgG rheumatoid factor in rheumatoid plasma cells.

1972 • 205 citations

THE PATHOGENESIS OF CHRONIC INFLAMMATION IN EXPERIMENTAL ANTIGEN-INDUCED ARTHRITIS

1972 • 203 citations

Identification of immunoglobulins and complement in rheumatoid articular collagenous tissues

1975 • 196 citations

HISTOLOGICAL AND SEROLOGICAL SEQUENCES IN EXPERIMENTAL HYPERSENSITIVITY

1947 • 181 citations

Relative T‐Cell Specificity of Lymphocytotoxins from Patients with Systemic Lupus Erythematosus

1973 • 170 citations

Immunology for Students of Medicine.

1964 • 164 citations

INFECTION AND TRANSFORMATION OF MOUSE PERITONEAL MACROPHAGES BY SIMIAN VIRUS 40

1971 • 155 citations

The pathogenesis of chronic inflammation in experimental antigen‐induced arthritis. I. The role of antigen on the local immune response

1972 • 152 citations

Infection and Immunology in the Rheumatic Diseases

1977 • 149 citations

Another Look at Immunologic Surveillance

1975 • 141 citations

Electron microscopic observations on the rheumatoid synovial membrane

1966 • 129 citations

The simultaneous occurrence of rheumatoid arthritis and agammaglobulinemia.

1957 • 128 citations

Type-C RNA Virus Gene Expression in Human Tissue

1974 • 122 citations

Antigen related to mammalian type-C RNA viral p30 proteins is located in renal glomeruli in human systemic lupus erythematosus.

1976 • 122 citations

Altered reactivity in mixed lymphocyte culture of lymphocytes from patients with rheumatoid arthritis

1969 • 121 citations

Participation of Lymphocytes in Viral Infections

1973 • 121 citations

Extrahepatic manifestations of viral hepatitis

1975 • 113 citations

Chronic Active ("Lupoid") Hepatitis

1965 • 110 citations

PROSTAGLANDINS IN THE RHEUMATIC DISEASES*

1975 • 110 citations

Arthritis of Hepatitis Associated with Australia Antigen

1971 • 106 citations

In vivo synthesis of IgG by rheumatoid synovium.

1970 • 95 citations

SYNOVIAL MEMBRANE AND FLUID MORPHOLOGIC ALTERATIONS IN EARLY RHEUMATOID ARTHRITIS: MTCROVASCULAR INJURY AND VIRUS‐LIKE PARTICLES

1975 • 93 citations

Early joint lesions of rheumatoid arthritis; report of eight cases, with knee biopsies of lesions of less than one year's duration.

1955 • 90 citations

Proliferation of synovial lining cells and fibroblasts.

1975 • 90 citations

Studies of isolated synovial lining cells of rheumatoid and nonrheumatoid synovial membranes

1970 • 87 citations

Infection and Immunology in the Rheumatic Diseases

1976 • 85 citations

Immunological Characterization of Lymphocytes in Synovial Fluid from Patients with Rheumatoid Arthritis

1973 • 78 citations

Arthritis in acute hepatitis and chronic active hepatitis

1974 • 76 citations

Electron microscopic demonstration of immunoglobulin deposition in rheumatoid cartilage

1975 • 75 citations

Viruses and Systemic Lupus Erythematosus

1975 • 70 citations

DECREASED PERCENTAGE OF POLYMORPHONUCLEAR NEUTROPHILS IN MOUSE PERIPHERAL BLOOD AFTER INOCULATION WITH MATERIAL FROM MULTIPLE SCLEROSIS PATIENTS

1972 • 70 citations

On the role of mononuclear phagocytes in immunity against viruses.

1974 • 64 citations

Lysosomal enzymes in synovial membrane in rheumatoid arthritis. Relationship to joint damage.

1972 • 62 citations

Collagen disease in patients with congenital agammaglobulinemia.

1956 • 62 citations

Immunoglobulin and receptors for C3 on lymphocytes from patients with rheumatoid arthritis

1972 • 60 citations

Viral Arthritis

1967 • 59 citations

The Arthritis of Viral Hepatitis

1971 • 59 citations

THE ROLE OF THE LYMPHOCYTE AND ITS PRODUCTS IN THE PROPAGATION OF JOINT DISEASE *

1975 • 57 citations

Response of the rheumatoid synovial membrane to exogenous immunization

1971 • 47 citations

Immunoglobulin and Specific Antibody Synthesis in a Chronic Inflammatory Focus: Antigen-Induced Synovitis

1969 • 46 citations

HUMAN SYNOVIAL-CELL CULTURE USE OF A NEW METHOD IN A STUDY OF RHEUMATOID ARTHRITIS

1961 • 46 citations

Multiple sclerosis-associated agent: transmission to animals and some properties of the agent

1975 • 46 citations

Control mechanisms of lymphocyte traffic. Modification of the traffic of ⁵¹ Cr‐Labeled mouse lymph node cells by treatment with plant lectins in intact and splenectomized hosts

1975 • 44 citations

Rheumatoid arthritis—etiologic considerations

1964 • 43 citations

Epidemic Polyarthritis: A Cytological, Viroiogical and Immunochemical Study

1975 • 43 citations

Antinuclear Factors in Synovia

1966 • 42 citations

Search for infectious agents in rheumatoid arthritis

1966 • 42 citations

Significance of persistent differences between normal and rheumatoid synovial membrane cells in culture

1969 • 42 citations

Virologic Studies on Rheumatoid Arthritis

1973 • 40 citations

Lupoid Hepatitis

1964 • 36 citations

Properties of synovial cells in culture.

1971 • 33 citations

LOCALIZATION OF ANTIGEN‐ANTIBODY COMPLEXES IN INTRAARTICULAR COLLAGENOUS TISSUES*

1975 • 32 citations

Rubella virus and rheumatoid arthritis.

1977 • 32 citations

PROPERTIES OF SYNOVIAL CELLS IN CULTURE

1971 • 32 citations

Multiple sclerosis-associated agent: neutralization of the agent by human sera

1975 • 31 citations

STUDIES ON MONONUCLEAR CELLS OBTAINED FROM SYNOVIAL FLUID OF PATIENTS WITH DIFFERENT TYPES OF ARTHRITIS. CYTOTOXIC EFFECT ON TISSUE‐CULTURED HUMAN FIBROBLASTS

1964 • 30 citations

Australia Antigen Immune Complexes in Patients with Different Forms of Hepatitis

1971 • 30 citations

Concentration of Rubella Virus Antigen in Chondrocytes of Congenitally Infected Rabbits

1970 • 30 citations

PATHOGENIC MECHANISMS OF TISSUE INJURY IN PERSISTENT VIRAL INFECTIONS*

1975 • 29 citations

The effect of gold salts on tumour immunity and its stimulation by Corynebacterium Parvum

1975 • 27 citations

Antiviral antibodies in rheumatoid synovial fluid and cryoprecipitates.

1974 • 26 citations

Cytology of rheumatoid synovial cells in culture. I. Composition and sequence of cell populations in cultures of rheumatoid synovial fluid.

1974 • 26 citations

Rubella and Rheumatoid Arthritis: Hyaluronic Acid and Susceptibility of Cultured Rheumatoid Synovial Cells to Viruses

1975 • 25 citations

Arthritis and HB Ag-Positive Hepatitis

1973 • 24 citations

A search for viruses and mycoplasmas in connective tissue diseases

1973 • 23 citations

Attempts to identify viruses in rheumatoid synovial cells.

1976 • 22 citations

RESPONSE OF RHEUMATOID-SYNOVIAL-FLUID LYMPHOCYTES TO NON-SPECIFIC MITOGENS

1973 • 22 citations

Murine Leukemialike Virus and the Immunopathological Disorders of New Zealand Black Mice

1969 • 22 citations

A clinico-immunological study of serum and synovial fluid antinuclear factors in rheumatoid arthritis and other arthritides.

1968 • 20 citations

Mammalian Type C RNA Viruses

1975 • 20 citations

Anicteric Hepatitis Presenting as Polyarthritis

1972 • 19 citations

The reaction of blood lymphocytes from patients with rheumatoid arthritis against human connective tissue cells in vitro.

1968 • 19 citations

HEPATITIS AND ARTHRITIS WITH HEPATITIS-ASSOCIATED ANTIGEN IN SERUM AND SYNOVIAL FLUID

1971 • 18 citations

Immune-Complex Arthritis in Viral Hepatitis?

1971 • 17 citations

A segregated antigen in cartilage matrix.

1972 • 16 citations

Possible relationships between an infectious agent and the immune reactions of rheumatoid synovitis

1973 • 16 citations

EVIDENCE FOR AN INFECTIOUS ETIOLOGY OF RHEUMATOID ARTHRITIS*

1975 • 15 citations

Transformation of human lymphocytes in vitro by autologous and allogeneic rheumatoid synovial fluids.

1976 • 15 citations

Lymphocytes in rheumatoid arthritis. I. Responses to allogeneic cells and to phytomitogens.

1974 • 15 citations

Cytology of rheumatoid synovial cells in culture. II. Association of polykarocytes with rheumatoid and other forms of arthritis.

1974 • 14 citations

Uridine Incorporation into the Media and RNA of Cultured Rheumatoid Synovial Cells

1973 • 14 citations

Persistent Rubella Virus Production in Embryonic Rabbit Chondrocyte Cell Cultures

1973 • 12 citations

Current Topics In Connective Tissue Disease

1975 • 12 citations

DNA polymerase activity in rheumatoid synovial membranes.

1975 • 11 citations

Cancer—A comprehensive treatise. Etiology: Viral carcinogenesis

1976 • 10 citations

CHARACTERIZATION OF A HUMAN ACUTE PHASE PROTEIN FOUND IN ASSOCIATION WITH RUBELLA VIRUS INFECTION

1974 • 9 citations

Lymphocytes in rheumatoid arthritis.

1969 • 9 citations

Interaction of tumor cells and activated macrophages in vitro: modulation by Corynebacterium parvum and gold salt.

1976 • 8 citations

Continuous Culture of a B‐Immunocyte from Rheumatoid Synovium

1973 • 8 citations

Ultrastructural aspects of lymphoreticular cells in rheumatoid synovium.

1973 • 8 citations

Cytology of rheumatoid synovial cells in culture. III. Significance of isolates of epithelial cell lines.

1974 • 8 citations

[Antibodies against a fetorenal antigen in hepatitis B patients, in patients with kidney tumors, and in healthy individuals].

1974 • 6 citations

Relationships between rheumatoid cells in culture.

1975 • 6 citations

RUBELLA AND RHEUMATOID ARTHRITIS

1970 • 6 citations

II. Comparison in Rheumatoid and Normal Sera

1966 • 5 citations

Current topics in connective tissue disease

1975 • 5 citations

Arthritis and Hepatitis

1971 • 5 citations

Lymphocytes in rheumatoid arthritis. II. Quantitative binding of phytomitogens.

1974 • 5 citations

Co-cultivation of human cell lines with synovial fluids of patients with rheumatoid arthritis.

1975 • 3 citations