Activation, Aggregation, Inhibition and The Mechanism of Phospholipase A2

Phospholipase A2 and its zymogen from porcine pancreas. VI. Histidine at the active site of phospholipase A2

1974 • 465 citations

Localization of red cell membrane constituents

1973 • 431 citations

Kinetic analysis of phospholipase A2 activity toward mixed micelles and its implications for the study of lipolytic enzymes

1975 • 278 citations

Phospholipase A2 and its zymogen from porcine pancreas. VII. Zymogen-catalyzed hydrolysis of monomeric substrates and the presence of a recognition site for lipid-water interfaces in phospholipase A2

1974 • 271 citations

The critical micelle concentration of l-α-dipalmitoylphosphatidylcholine in water and water/methanol solutions

1972 • 227 citations

Physical chemical studies of short-chain lecithin homologues. I.

1974 • 214 citations

The refined crystal structure of dimeric phospholipase A2 at 2.5 A. Access to a shielded catalytic center.

1985 • 213 citations

Chemical modification of the histidine residue in phospholipase A2 (Naja naja naja). A case of half-site reactivity.

1977 • 210 citations

Enzymes of Lipid Metabolism II

1986 • 208 citations

Kinetic dependence of phospholipase A2 activity on the detergent Triton X-100

1973 • 205 citations

Studies on phospholipase a and its zymogen from porcine pancreas IV. The influence of chemical modification of the lecithin structure on substrate properties

1972 • 192 citations

Catalysis by Adsorbed Enzymes

1973 • 172 citations

Phospholipid exchange between bilayer membrane vesicles

1976 • 171 citations

Three-dimensional structure and disulfide bond connections in bovine pancreatic phospholipase A2

1978 • 167 citations

Cobra venom phospholipase A2 inhibition by manoalide. A novel type of phospholipase inhibitor.

1985 • 156 citations

Kinetic study of the phospholipase A₂ (Crotalus adamanteus) catalyzed hydrolysis of 1,2-dibutyryl-sn-glycero-3-phosphorylcholine

1972 • 151 citations

Regulation of Eicosanoid Production: Role of Phospholipases and Inhibitors

1987 • 129 citations

Dual role of interfacial phospholipid in phospholipase A2 catalysis.

1977 • 127 citations

Pancreatic colipase: chemistry and physiology.

1979 • 126 citations

Classification of phospholipases A₂ according to sequence. Evolutionary and pharmacological implications

1983 • 119 citations

Conformational properties of phospholipases A₂

1983 • 111 citations

Inhibition Studies on the Membrane-associated Phospholipase A2 in vitro and Prostaglandin E2 Production in vivo of the Macrophage-like P388D1 Cell

1989 • 107 citations

[6] Molecular weight determinations from radiation inactivation

1985 • 107 citations

Activation, aggregation, and product inhibition of cobra venom phospholipase A2 and comparison with other phospholipases.

1985 • 98 citations

Biomolecular Structure and Function

1979 • 93 citations

The 2.5 A crystal structure of a dimeric phospholipase A2 from the venom of Crotalus atrox.

1981 • 91 citations

Specific transformations at the N-terminal region of phospholipase A₂

1975 • 84 citations

Photoactivated heterobifunctional cross-linking reagents which demonstrate the aggregation state of phospholipase A₂

1977 • 82 citations

Phospholipid activation of cobra venom phospholipase A2. 1. Lipid-lipid or lipid-enzyme interaction

1979 • 82 citations

Chemical modification of lysine and histidine residues in phospholipase A2 from the venom of Naja naja atra (Taiwan cobra)

1981 • 81 citations

Role of the N-terminus in the interaction of pancreatic phospholipase A2 with aggregated substrates. Properties and crystal structure of transaminated phospholipase A2

1984 • 81 citations

Studies of the use of dihexanoyllecithin and other lecithins as substrates for phospholipase A

1961 • 80 citations

Characterization and physical properties of the major form of phospholipase A2 from cobra venom (Naja naja naja) that has a molecular weight of 11,000

1975 • 77 citations

Physicochemical studies on the interaction of pancreatic phospholipase A2 with a micellar substrate analog

1981 • 76 citations

Effects of chemical modification on the activity of Crotalus adamanteus phospholipase A₂. Evidence for an essential amino group

1973 • 76 citations

Hydrolysis of monomeric substrates by porcine pancreatic (pro)phospholipase A₂. The use of a spectrophotometric assay

1979 • 66 citations

Phospholipid activation of cobra venom phospholipase A2. 2. Characterization of the phospholipid-enzyme interaction

1979 • 63 citations

Phospholipase A2 inhibition and modification by manoalogue

1988 • 62 citations

Magnetic nonequivalence within the fatty acyl chains of phospholipids in membrane models: proton nuclear magnetic resonance studies of the α-methylene groups

1978 • 60 citations

Interaction of Phospolipase A₂ form Naja melanoleuca Sanke Venom with Meoomeric Substrate Analogs

1983 • 56 citations

Activation of porcine pancreatic phospholipase A2 by the presence of negative charges at the lipid-water interface

1986 • 53 citations

Chemical modification of the .alpha.-amino group in snake venom phospholipases A2. A comparison of the interaction of pancreatic and venom phospholipases with lipid-water interfaces

1981 • 50 citations

Purification and characterization of a lysophospholipase from human amnionic membranes.

1984 • 50 citations

Aggregation studies on fluorescein-coupled cobra venom phospholipase A2

1985 • 46 citations

Role of monomeric activators in cobra venom phospholipase A2 action

1982 • 41 citations

The inhibition of phospholipase A2 by manoalide and manoalide analogues

1987 • 39 citations

Aggregation of porcine pancreatic phospholipase A2 and its zymogen induced by submicellar concentration of negatively charged detergents

1983 • 38 citations

Short-chain phosphatidylethanolamines: physical properties and susceptibility of the monomers to phospholipase A2 action

1985 • 37 citations

Kinetic behavior of porcine pancreatic phospholipase A2 on zwitterionic and negatively charged single-chain substrates

1985 • 37 citations

Probing the role of substrate conformation in phospholipase A2 action on aggregated phospholipids using constrained phosphatidylcholine analogues.

1988 • 34 citations

Comparative studies of tyrosine modification in pancreatic phospholipases. 2. Properties of the nitrotyrosyl, aminotyrosyl, and dansylaminotyrosyl derivatives of pig, horse, and ox phospholipases A2 and their zymogens

1979 • 34 citations

Exploring the action and specificity of cobra venom phospholipase A2 toward human erythrocytes, ghost membranes, and lipid mixtures.

1978 • 32 citations

A further examination of the active form of crotalus adamanteus phospholipase A2

1981 • 32 citations

Immobilized phospholipase A2 from cobra venom. Prevention of substrate interfacial and activator effects.

1985 • 28 citations

Histidine and lysine residues and the activity of phospholipase A2 from the venom of Bitis Gabonica

1977 • 27 citations

Proton nuclear magnetic resonance demonstration of conformationally nonequivalent phospholipid fatty acid chains in mixed micelles

1977 • 26 citations

Effects of substitution of the absolutely invariant Gln-4 and Phe-5 in bovine pancreatic phospholipase A2 on enzymic activity and substrate binding properties

1982 • 25 citations

Comparative studies of tyrosine modification in pancreatic phospholipases. 1. Reaction of tetranitromethane with pig, horse, and ox phospholipases A2 and their zymogens

1979 • 25 citations

Carbamylation with cyanate of basic phospholipase A2 from the venom of Naja nigricollis (Spitting cobra)

1981 • 24 citations

Use of short-chain cyclopentano-phosphatidylcholines to probe the mode of activation of phospholipase A2 from bovine pancreas and bee venom.

1988 • 23 citations

Unusual kinetic behavior of porcine pancreatic (pro)phospholipase A2 on negatively charged substrates at submicellar concentrations

1983 • 22 citations

Magnetic nonequivalence of two fatty acid chains in phospholipids of small unilamellar vesicles and mixed micelles

1981 • 21 citations

Lipid-induced aggregation of phospholipase A2: sucrose density gradient ultracentrifugation and crosslinking studies

1988 • 20 citations

Rate-determining step in phospholipase A2 mechanism. 18O isotope exchange determined by 13C NMR.

1986 • 18 citations

Chemical Modification of Lys‐6 in Phospolipase A₂ from Naja melanoleuca Snake Venom

1983 • 18 citations

Differences in the pattern of attack of acidic, neutral, and basic phospholipases A2 of A. halys blomhofii on human erythrocyte membranes: Problems in interpretation of phospholipid location

1981 • 17 citations

Characterization of crystals of two venom phospholipases A2

1975 • 16 citations

Kinetic behavior of porcine pancreatic phospholipase A2 on zwitterionic and negatively charged double-chain substrates

1985 • 15 citations

Studies on the status of tyrosyl residues in phospholipases A2 fromNaja naja atra andNaja nigricollis snake venoms

1985 • 15 citations

Phosphatidylserine decarboxylase: Analysis of its action towards unsaturated and saturated phosphatidylserine and the effect of triton X-100 on activity

1975 • 15 citations

Isolation of rhodopsin by the combined action of cardiotoxin and phospholipase A2 on rod outer segment membranes

1981 • 12 citations

Interaction of Monodispersed and Micellar Phospholipids with an Agkistrodon halys blomhoffii Phospholipase A2, in which the α-Amino Group Had Been Modified to an α-Keto Group1

1986 • 9 citations

Effect of phospholipids on fluorescence polarization and lifetimes of fluorescein-labeled phospholipase A2

1988 • 6 citations

18O isotope exchange experiments on phospholipase A2 determined by 13C-NMR: monomeric phosphatidylcholine and micellar phosphatidylethanolamine substrates

1989 • 3 citations

NMR STUDIES ON THE ORGANIZATION AND CONFORMATION OF PHOSPHOLIPIDS IN MIXED MICELLES AS MODEL MEMBRANES

1978 • 1 citations

Comparison of the Activation of Soluble and Immobilized Phospholipase A2

1986 • 1 citations