A model for the microtubule organizing activity of the centrosomes and kinetochores in mammalian cells

Promotion of microtubule assembly in vitro by taxol

1979 • 3,521 citations

Taxol binds to polymerized tubulin in vitro

1981 • 618 citations

THE ULTRASTRUCTURE OF A MAMMALIAN CELL DURING THE MITOTIC CYCLE

1964 • 567 citations

The effects of methyl (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl) carbamate, (R 17934; NSC 238159), a new synthetic antitumoral drug interfering with microtubules, on mammalian cells cultured in vitro.

1976 • 422 citations

Interaction of oncodazole (R 17934), a new anti-tumoral drug, with rat brain tubulin

1976 • 366 citations

THE CENTRIOLE CYCLE IN SYNCHRONIZED HELA CELLS

1968 • 316 citations

Microtubule treadmills—possible molecular machinery

1981 • 279 citations

Head-to-tail polymerization of microtubules in vitro. Electron microscope analysis of seeded assembly.

1980 • 279 citations

COLD‐LABILE AND COLD‐STABLE MICROTUBULES IN THE MITOTIC SPINDLE OF MAMMALIAN CELLS*

1975 • 253 citations

Mitotic mechanism based on intrinsic microtubule behaviour

1978 • 232 citations

Implications of treadmilling for the stability and polarity of actin and tubulin polymers in vivo.

1980 • 232 citations

Initiation and growth of microtubules from mitotic centers in lysed mammalian cells.

1975 • 219 citations

The ultrastructure and spatial organization of the metaphase kinetochore in mitotic rat cells

1967 • 207 citations

Light and electron microscopy of rat kangaroo cells in mitosis

1973 • 175 citations

Human chromosomes and centrioles as nucleating sites for the in vitro assembly of microtubules from bovine brain tubulin.

1975 • 164 citations

Polarity of microtubules nucleated by centrosomes and chromosomes of Chinese hamster ovary cells in vitro

1980 • 155 citations

Tubulin assembly sites and the organization of cytoplasmic microtubules in cultured mammalian cells.

1981 • 154 citations

Decoration of spindle microtubules with Dynein: evidence for uniform polarity.

1981 • 126 citations

Origin of kinetochore microtubules in Chinese hamster ovary cells

1980 • 119 citations

Head-to-tail polymerization of microtubules in vitro

1981 • 115 citations

Immunofluorescence localization of HeLa cell microtubule-associated proteins on microtubules in vitro and in vivo.

1980 • 102 citations

Effects of nocodazole on structures of calf brain tubulin

1980 • 100 citations

Cell cycle-dependent, in vitro assembly of microtubules onto pericentriolar material of HeLa cells.

1979 • 93 citations

Specific visualization of the distribution of the calcium dependent regulatory protein of cyclic nucleotide phosphodiesterase (modulator protein) in tissue culture cells by immunofluorescence microscopy: mitosis and intercellular bridge.

1978 • 92 citations

Electron microscopy of spermatocytes previously studied in life: methods and some observations on micromanipulated chromosomes

1979 • 76 citations

The distribution of tau and HMW microtubule-associated proteins in different cell types

1980 • 68 citations

Quantitative initiation of microtubule assembly by chromosomes from Chinese hamster ovary cells

1978 • 63 citations

Polarity of microtubules of the mitotic spindle

1978 • 58 citations

ASPECTS OF SPINDLE EVOLUTION

1975 • 56 citations

The attachment of kinetochores to the pro-metaphase spindle in PtK1 cells

1981 • 56 citations

Localization of tubulin in the mitotic apparatus of mammalian cells by immunofluorescence and immunoelectron microscopy

1977 • 53 citations

DIRECTIONALITY AND RATE OF ASSEMBLY OF CHICK BRAIN TUBULIN ONTO PIECES OF NEUROTUBULES, FLAGELLAR AXONEMES, AND BASAL BODIES

1975 • 53 citations

Characteristics of sea-urchin mitotic apparatus isolated using a dimethyl sulphoxide/glycerol medium

1974 • 47 citations

Distribution of microtubules during centriole separation in rat kangaroo (Potorous) cells.

1976 • 44 citations

Immunoelectron microscopic localization of the 210,000-mol wt microtubule-associated protein in cultured cells of primates.

1981 • 33 citations

ROLE OF INTERMEDIATES IN MICROTUBULE ASSEMBLY IN VIVO AND IN VITRO*

1975 • 17 citations