Mucus Hypersecretion and Its Role in the Airway Obstruction of Asthma and Chronic Obstructive Pulmonary Disease

The natural history of chronic airflow obstruction.

1977 • 2,340 citations

The Electrophoretic α;₁-Globulin Pattern of Serum in α;₁-Antitrypsin Deficiency

1963 • 1,400 citations

Site and Nature of Airway Obstruction in Chronic Obstructive Lung Disease

1968 • 1,357 citations

Damage of the Airway Epithelium and Bronchial Reactivity in Patients with Asthma

1985 • 1,315 citations

Oxidants in Cigarette Smoke Radicals, Hydrogen Peroxide, Peroxynitrate, and Peroxynitritea

1993 • 1,142 citations

An introduction to free radical biochemistry

1993 • 1,122 citations

THE PATHOLOGY OF ASTHMA, WITH SPECIAL REFERENCE TO CHANGES IN THE BRONCHIAL MUCOSA

1960 • 1,014 citations

Bronchial Biopsies in Asthma: An Ultrastructural, Quantitative Study and Correlation with Hyperreactivity

1989 • 973 citations

Textbook of Respiratory Medicine.

1988 • 847 citations

The Mechanics of Airway Narrowing in Asthma

1989 • 805 citations

Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Copenhagen City Heart Study Group.

1996 • 730 citations

A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema

1969 • 704 citations

ASTHMA AS AN AXON REFLEX

1986 • 676 citations

Bacterial Infection in Chronic Obstructive Pulmonary Disease

1992 • 575 citations

The Propulsion of Mucus by Cilia

1988 • 548 citations

Terminology, Definitions, and Classification of Chronic Pulmonary Emphysema and Related Conditions: A REPORT OF THE CONCLUSIONS OF A CIBA GUEST SYMPOSIUM

1959 • 541 citations

Generation and metabolism of 5-lipoxygenase pathway leukotrienes by human eosinophils: predominant production of leukotriene C4.

1983 • 484 citations

Major Problems in Pathology

1980 • 462 citations

The Course and Prognosis of Different Forms of Chronic Airways Obstruction in a Sample from the General Population

1987 • 453 citations

INCREASED ALVEOLAR EPITHELIAL PERMEABILITY IN CIGARETTE SMOKERS

1980 • 453 citations

The Relevance in Adults of Air-flow Obstruction, but not of Mucus Hypersecretion, to Mortality from Chronic Lung Disease

1983 • 420 citations

Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro.

1982 • 419 citations

Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease

1993 • 408 citations

TEXTBOOK OF RESPIRATORY MEDICINE

1995 • 405 citations

Intraluminal Airway Inflammation in Chronic Bronchitis: Characterization and Correlation with Clinical Parameters

1989 • 377 citations

Possible mechanisms of emphysema in smokers. In vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants.

1978 • 364 citations

Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects.

1983 • 348 citations

URINARY LEUKOTRIENE E4 AFTER ANTIGEN CHALLENGE AND IN ACUTE ASTHMA AND ALLERGIC RHINITIS

1989 • 344 citations

Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells.

1990 • 325 citations

Quantitative Structural Analysis of Peripheral Airways and Arteries in Sudden Fatal Asthma

1991 • 321 citations

Effects of Human Neutrophil Elastase and Pseudomonas aeruginosa Proteinases on Human Respiratory Epithelium

1991 • 301 citations

Oxidants, antioxidants, and respiratory tract lining fluids.

1994 • 295 citations

In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes.

1979 • 293 citations

Renewal of the terminal bronchiolar epithelium in the rat following exposure to NO2 or O3.

1976 • 289 citations

PATHOLOGY OF CHRONIC BRONCHITIS

1954 • 283 citations

Occupational Exposures: Evidence for a Causal Association with Chronic Obstructive Pulmonary Disease

1989 • 282 citations

Goblet Cells Secretion and Mucogenesis

1990 • 271 citations

Effects of Arachidonic Acid, Monohydroxyeicosatetraenoic Acid and Prostaglandins on the Release of Mucous Glycoproteins from Human Airways In Vitro

1981 • 252 citations

Immunologic and Neuropharmacologic Stimulation of Mucous Glycoprotein Release from Human Airways In Vitro

1980 • 235 citations

Mitotic rates, goblet cell increase and histochemical changes in mucus in rat bronchial epithelium during exposure to sulphur dioxide

1968 • 227 citations

Tumor necrosis factor-alpha induces mucin hypersecretion and MUC-2 gene expression by human airway epithelial cells.

1995 • 223 citations

Relation of ventilatory impairment and of chronic mucus hypersecretion to mortality from obstructive lung disease and from all causes.

1990 • 219 citations

Chronic Airflow Obstruction in Lung Disease.

1977 • 199 citations

Lysosomal enzymes from polymorphonuclear leukocytes and proteinase inhibitors in patients with cystic fibrosis.

1986 • 198 citations

Clinically Important Respiratory Effects of Dust Exposure and Smoking in British Coal Miners

1988 • 188 citations

Reduction of ciliary beat frequency in vitro by sputum from patients with bronchiectasis: a serine proteinase effect.

1984 • 185 citations

The effects of chronic bronchitis and chronic air-flow obstruction on lung cell populations recovered by bronchoalveolar lavage.

1985 • 184 citations

Protease and elastase of Pseudomonas aeruginosa: inactivation of human plasma alpha 1-proteinase inhibitor

1979 • 178 citations

Relationship of smoking history and pulmonary function tests to tracheal mucous velocity in nonsmokers, young smokers, ex-smokers, and patients with chronic bronchitis.

1978 • 172 citations

Longitudinal Lung Function Decline in Subjects with Respiratory Symptoms

1992 • 167 citations

The Dutch hypothesis (chronic non-specific lung disease) revisited

1991 • 162 citations

Goblet and Clara cells of human distal airways: evidence for smoking induced changes in their numbers.

1984 • 162 citations

Respiratory symptoms and pulmonary function as predictors of 10-year mortality from respiratory disease, cardiovascular disease, and all causes in the whitehall study

1988 • 157 citations

Continuity of airway goblet cells and intraluminal mucus in the airways of patients with bronchial asthma

1996 • 150 citations

Tracheal mucous velocity in normal man and patients with obstructive lung disease: effects of terbutaline.

1974 • 149 citations

Human neutrophil elastase releases cell surface mucins from primary cultures of hamster tracheal epithelial cells.

1987 • 146 citations

A DESIGN FOR GENERAL PRACTICE

1963 • 143 citations

Mucus transport in the tracheobronchial tree of normal and bronchitic rats

1972 • 138 citations

Goblet Cell Increase in Rat Bronchial Epithelium after Exposure to Cigarette and Cigar Tobacco Smoke

1969 • 136 citations

Levels of Elastase Activity in Bronchoalveolar Lavage Fluids of Healthy Smokers and Nonsmokers^1–3

1983 • 131 citations

Nucleotide Regulation of Goblet Cells in Human Airway Epithelial Explants: Normal Exocytosis in Cystic Fibrosis

1993 • 127 citations

Twelve Years Spirometric Changes Among Paris Area Workers

1979 • 126 citations

Chronic Obstructive Pulmonary Disease Mortality in Six U.S. Cities

1989 • 125 citations

Analysis of respiratory mucus glycoproteins in asthma: a detailed study from a patient who died in status asthmaticus.

1995 • 123 citations

Ultrastructural localization of bronchial antileukoprotease in central and peripheral human airways by a gold-labeling technique using monoclonal antibodies.

1986 • 122 citations

Cigarette Smoke Oxidation of Human Plasma Constituentsa

1993 • 121 citations

Reflex tracheal gland secretion evoked by stimulation of bronchial C-fibers in dogs

1982 • 120 citations

OPIOID INHIBITION OF NEURALLY MEDIATED MUCUS SECRETION IN HUMAN BRONCHI

1989 • 118 citations

Quantitative Structural Alterations in Long-Standing Allergic Asthma

1984 • 116 citations

Inactivation of human α1-proteinase inhibitor by thiol proteinases

1977 • 112 citations

An index of risk for obstructive airways disease.

1982 • 111 citations

Abnormal cilia in human bronchial epithelium.

1976 • 110 citations

Mucus Secretion in the Trachea

1932 • 105 citations

Mucociliary Transport in Allergic Patients with Antigen-Induced Bronchospasm^1–3

1978 • 104 citations

Markers of Mucus Secretion and DNA Levels in Induced Sputum from Asthmatic and from Healthy Subjects

1993 • 104 citations

Goblet cell degranulation in isolated canine tracheal epithelium: response to exogenous ATP, ADP, and adenosine

1992 • 104 citations

Biochemistry of airway mucus secretions.

1980 • 103 citations

Effect of human leukocyte enzymes on tracheal mucosa and its mucociliary activity.

1979 • 102 citations

The effects of irritation at various levels of the airway upon tracheal mucus secretion in the cat.

1976 • 96 citations

Proteinases of Pseudomonas aeruginosa evoke mucin release by tracheal epithelium.

1984 • 95 citations

Impaired tracheobronchial clearance in patients with mild stable asthma.

1983 • 94 citations

Criteria for mucus transport in the airways by two-phase gas-liquid flow mechanism

1986 • 93 citations

Short term morphologic effects of high ambient levels of ozone on lungs of rhesus monkeys.

1977 • 92 citations

Sympathomimetic Drugs Stimulate the Output of Secretory Glycoproteins from Human Bronchi In Vitro

1982 • 92 citations

Deposition and clearance of inhaled particles.

1980 • 91 citations

On the transport of mucus and its rheologic simulants in ciliated systems.

1974 • 90 citations

BRONCHIAL MUCUS IN HEALTH AND DISEASE

1978 • 89 citations

The morphologic features of the bronchi, bronchioles, and alveoli in chronic airway obstruction: a clinicopathologic study.

1976 • 89 citations

Disease of the Small Airways in Chronic Bronchitis^1–3

1973 • 89 citations

Alpha,-antitrypsin and leukocyte elastase in infected and noninfected sputum.

1979 • 86 citations

Inhibition by Oral N-Acetylcysteine of Cigarette Smoke-Induced “Bronchitis” in the Rat

1986 • 85 citations

alpha1-Antitrypsin deficiency in nonsmokers.

1978 • 82 citations

Mucus transport in the airways by two-phase gas-liquid flow mechanism: continuous flow model

1986 • 81 citations

Mucociliary Clearance in Adult Asthma

1992 • 79 citations

Autonomic regulation of viscoelasticity of cat tracheal gland secretions

1984 • 76 citations

Tracheal submucosal gland serous cells stimulated in vitro with adrenergic and cholinergic agonists A morphometric study

1981 • 76 citations

The Radioimmunoassay of Pulmonary Surface Active Material in Sheep Lung^1–3

1974 • 75 citations

The sputum in bronchial asthma: Pathognomonic patterns

1965 • 74 citations

A Distribution Curve for Chronic Bronchitis

1964 • 74 citations

The Effect of Bacterial Products on Ciliary Function

1988 • 72 citations

Purification, properties, and analysis of human asthmatic bronchial mucin

1979 • 70 citations

Gas exchange, expiratory flow obstruction and the clinical spectrum of asthma

1996 • 70 citations

Inhibition by vasoactive intestinal peptide of glycoconjugate and lysozyme secretion by human airways in vitro.

1981 • 69 citations

Major Problems in Pathology

1980 • 64 citations

Abnormal mucociliary transport in allergic patients with antigen-induced bronchospasm: role of slow reacting substance of anaphylaxis.

1981 • 63 citations

Nervous control of mucin secretion into human bronchi.

1985 • 63 citations

A quantitative study of bronchial mucous gland volume, emphysema and smoking in a necropsy population

1971 • 61 citations

Evidence for non‐cholinergic, non‐adrenergic nervous control of mucus secretion into the cat trachea.

1983 • 61 citations

Neutrophil elastase stimulates tracheal submucosal gland secretion that is inhibited by ICI 200,355

1992 • 60 citations

Histologic changes in bronchial tubes of cigarette-smoking dogs

1967 • 59 citations

Sulfur-Dioxide-Induced Bronchitis in Dogs

1987 • 58 citations

Quantitative study of secretory cell metaplasia induced by human neutrophil elastase in the large bronchi of hamsters.

1985 • 58 citations

A comparative study of cell renewal after exposure to ozone or oxygen. Response of terminal bronchiolar epithelium in the rat.

1978 • 56 citations

Respiratory Tract Mucus

1979 • 54 citations

Experimental chronic bronchitis. Pathology in the dog.

1974 • 54 citations

Effects of 0.5 ppm ozone on glycoprotein secretion, ion and water fluxes in sheep trachea

1986 • 52 citations

DRUG IDENTIFICATION

1975 • 49 citations

Oxidant-Mediated Ciliary Dysfunction

1986 • 46 citations

Mechanism of Hydrogen Peroxide-induced Inhibition of Sheep Airway Cilia

1992 • 44 citations

The aminergic innervation of the human bronchus: a light and electron microscopic study.

1984 • 42 citations

Relationships among the composition of mucus, epithelial lining liquid, and adhesion of microorganisms.

1995 • 41 citations

Endothelin regulation of mucus glycoprotein secretion from feline tracheal submucosal glands

1992 • 41 citations

Cigarette smoke-induced airway goblet cell secretion: dose-dependent differential nerve activation

1992 • 41 citations

Long-Term Effect of Cigarette Smoke on Mucociliary Function in Animals

1974 • 40 citations

Mucociliary Clearance in Patients with Chronic Bronchitis and Bronchial Carcinoma

1983 • 39 citations

Human monocyte-derived mucus secretagogue.

1985 • 39 citations

The control of mucin secretion into the lumen of the cat trachea by α- and β-adrenoceptors, and their relative involvement during sympathetic nerve stimulation

1982 • 39 citations

Experimental induction of chronic bronchitis in dogs: effects on airway obstruction and responsiveness.

1982 • 38 citations

Release of Mucus Glycoconjugates by Pseudomonas aeruginosa Rhamnolipids into Feline Trachea In Vivo and Human Bronchus In Vitro

1992 • 38 citations

Effects of leukotriene D4 on mucociliary and respiratory function in allergic and nonallergic sheep

1985 • 36 citations

Mediator Release from Human Basophils and Mast Cells from Lung and Intestinal Mucosa

1985 • 36 citations

Platelet-activating factor stimulates secretion of respiratory glycoconjugate from human airways in culture

1989 • 35 citations

The Role of Mucus in Chronic Obstructive Pulmonary Disease

1990 • 34 citations

Hypoxemia reflexly increases secretion from tracheal submucosal glands in dogs

1982 • 33 citations

Chronic Effects of Nitrogen Dioxide on Cilia in Hamster Bronchioles

1986 • 32 citations

Mechanisms and modulation of airway plasma exudation after direct inhalation of cigarette smoke.

1995 • 32 citations

A possible role for PAF in allergen-induced late responses: modification by a selective antagonist

1989 • 31 citations

Airways Smooth Muscle : Structure, Innervation and Neurotransmission

1994 • 31 citations

Chronic Exposure to Sulfur Dioxide

1987 • 31 citations

The bronchographic appearances of early chronic bronchitis

1969 • 31 citations

The action of dust in the airways on secretion into the trachea of the cat.

1983 • 31 citations

Effects of prostaglandins E1, E2, and F2 alpha on mucin secretion from human bronchi in vitro.

1984 • 27 citations

Tracheobronchial deposition and clearance in small airways in asthmatic subjects

1996 • 27 citations

Morphological study of the effects of ozone on rat lung

1989 • 26 citations

Stimulation of secretion into human and feline airways by Pseudomonas aeruginosa proteases

1991 • 24 citations

A morphological study of the effects of ozone on rat lung

1987 • 22 citations

The effect of tobacco smoke upon airway secretion in the cat

1986 • 22 citations

Distribution of bronchial gland measurements in a Jamaican population

1969 • 22 citations

Biochemical characteristics of bronchial secretions in chronic obstructive pulmonary disease.

1974 • 21 citations

Hydrogen peroxide-induced epithelial damage increases terbutaline transport in guinea-pig tracheal wall: Implications for drug delivery

1991 • 20 citations

Lung mucociliary transport in asymptomatic asthma: effects of inhaled histamine.

1989 • 19 citations

Antigen stimulates glycoprotein secretion and alters ion fluxes in sheep trachea

1983 • 19 citations

Hydrogen peroxide-scavenging properties of sheep airway mucus.

1995 • 18 citations

The effect of airflow on mucus secretion into the trachea of the cat.

1986 • 18 citations

The functional significance of the sympathetic innervation of mucous glands in the bronchi of man.

1988 • 18 citations

Airway Mucosal Permeability in Chronic Bronchitics and Bronchial Asthmatics with Hypersecretion

1988 • 17 citations

The effect of serum on the secretion of radiolabeled mucous macromolecules into the lumen of the cat trachea.

1982 • 17 citations

Action of serum on the output of secretory glycoproteins from human bronchi in vitro.

1983 • 16 citations

In VivoDetection of a Novel Macrophage-derived Protein Involved in the Regulation of Mucus-like Glycoconjugate Secretion

1992 • 16 citations

Goblet-Cell Density in Human Bronchus in Chronic Bronchitis

1983 • 16 citations

Regulation of Secretion from Serous and Mucous Cells in the Trachea

1984 • 15 citations

Rheological requirements for optimal clearance of secretions: ciliary transport versus cough.

1980 • 15 citations

Bronchiolar aerosol deposition and clearance

1996 • 12 citations

Characterization of airway mucus from a fatal case of status asthmaticus

1988 • 11 citations

The effect of hydrogen peroxide on smooth muscle tone, mucus secretion and epithelial albumin transport of the ferret trachea in vitro

1991 • 11 citations

NANC nerve pathways controlling mucus glycoconjugate secretion into feline trachea

1992 • 11 citations

Nitrogen Dioxide-Induced Eosinophilia and Mucosal Injury in the Trachea of the Guinea Pig

1993 • 10 citations

The pathophysiological consequences of smoking on the respiratory system.

1981 • 10 citations

Inflammatory Indices in Chronic Bronchitis

1990 • 9 citations

Leukocyte function and chronic bronchitis.

1988 • 9 citations

Vagal Reflexes

1994 • 6 citations

Evidence for, and characterization of, a lipopolysaccharide‐inducible adenosine A2 receptor in human tracheal gland serous cells

1995 • 5 citations

Criteria for Evaluating Mucus Functions and Their Disorders in Chronic Bronchitis

1978 • 5 citations

A Critical Look at Mucus Markers

1990 • 1 citations