Regulation of heme synthesis in erythroid cells: hemin inhibits transferrin iron utilization but not protoporphyrin synthesis

Porphyrins and Metalloporphyrins

1978 • 1,741 citations

Cleavage of the haem-protein link by acid methylethylketone

1959 • 1,226 citations

Transferrin, biochemistry, physiology and clinical significance

1981 • 310 citations

Effects by heme, insulin, and serum albumin on heme and protein synthesis in chick embryo liver cells cultured in a chemically defined medium, and a spectrofluorometric assay for porphyrin composition.

1975 • 303 citations

Control of Porphyrin Biosynthesis through a Negative-Feedback Mechanism. STUDIES WITH PREPARATIONS OF δ-AMINOLAEVULATE SYNTHETASE AND δ-AMINOLAEVULATE DEHYDRATASE FROM RHODOPSEUDOMONAS SPHEROIDES

1963 • 294 citations

A study of intracellular iron metabolism using pyridoxal isonicotinoyl hydrazone and other synthetic chelating agents

1979 • 192 citations

Succinylacetone, a potent inhibitor of heme biosynthesis: Effect on cell growth, heme content and δ-aminolevulinic acid dehydratase activity of malignant murine erythroleukemia cells

1979 • 151 citations

Studies of the Transferrin Receptor on both Human Reticulocytes and Nucleated Human Cells in Culture

1982 • 136 citations

THE RELATION OF ERYTHROCYTE COPROPORPHYRIN AND PROTOPORPHYRIN TO ERYTHROPOIESIS

1952 • 112 citations

Control of heme synthesis by feedback inhibition

1965 • 104 citations

Iron utilization in rabbit reticulocytes

1982 • 92 citations

Hemin control of heme biosynthesis in mouse Friend virus-transformed erythroleukemia cells in culture

1978 • 83 citations

Regulation of Iron Entry into Reticulocytes. I. Feedback Inhibitory Effect of Heme on Iron Entry into Reticulocytes and on Heme Synthesis

1969 • 73 citations

Ferric pyridoxal isonicotinol hydrazone can provide iron for heme synthesis in reticulocytes

1982 • 71 citations

The role of haem biosynthetic and degradative enzymes in erythroid colony development: the effect of haemin

1982 • 58 citations

Evidence for erythroid and nonerythroid forms of δ-aminolevulinate synthetase

1981 • 56 citations

Purification and some properties of δ-aminolevulinate(ALA) synthetase in rabbit reticulocytes

1971 • 52 citations

SOLUBLE HEPATIC δ-AMINOLEVULINIC ACID SYNTHETASE: END-PRODUCT INHIBITION OF THE PARTIALLY PURIFIED ENZYME

1969 • 46 citations

The Use of Reticulocytes with High Non‐haem Iron Pool for Studies of Regulation of Haem Synthesis*

1970 • 45 citations

δ-Aminolevulinate synthase isozymes in the liver and erythroid cells of chicken

1983 • 44 citations

Studies on the role of heme in the regulation of delta-aminolevulinic acid synthetase during fetal hepatic development.

1974 • 44 citations

Transferrin and iron uptake by human lymphoblastoid and K-562 cells

1981 • 41 citations

Permeability properties of mitochondrial membranes and the regulation of haem biosynthesis

1970 • 35 citations

Evidence for the presence of free and protein-bound nonhemoglobin heme in rabbit reticulocytes

1972 • 34 citations

Electrogenic sodium-dependent glycine transport in sheep reticulocytes

1978 • 33 citations

The reticulocyte-mediated release of iron and bicarbonate from transferrin: Effect of metabolic inhibitors

1974 • 32 citations

delta-Aminolevulinic acid synthetase from rat liver mitochondria. Purification and properties.

1979 • 30 citations

Hemin feedback inhibition at reticulocyte δ-aminolevulinic acid synthetase and δ-aminolevulinic acid dehydratase

1978 • 30 citations

Studies on the ferrochelatase activity of mitochondria and submitochondrial particles with special reference to the regulatory function of the mitochondrial inner membrane

1977 • 29 citations

The Role of Heme in the Release of Iron from Transferrin in Reticulocytes

1974 • 27 citations

Regulation of iron entry into reticulocytes

1971 • 26 citations

The effect of hemin on globin synthesis and iron uptake by reticulocytes of the Belgrade rat

1978 • 26 citations

A Radiochemical Assay for Heme Synthase Activity

1982 • 23 citations

Regulation of Hemoglobin Synthesis, Iron Metabolism, and Maturation of Friend Leukemic Cells by 5-Amino Levulinic Acid and Hemin

1979 • 22 citations

The Role of Heme in the Regulation of δ‐Aminolevulinic Acid and Heme Synthesis in Rabbit Reticulocytes

1969 • 19 citations

Evidence supporting a physiological role for the hemin-controlled translational repressor of globin synthesis in reticulocytes

1975 • 17 citations

The use of exogenous δ-aminolaevulinic acid for the studies of the regulation of haem synthesis in rabbit reticulocytes

1973 • 17 citations

Benzene Inhibition of in Vitro Rabbit Reticulocyte Haem Synthesis at Delta Aminolaevulinic Acid Synthetase: Reversal of Benzene Toxicity by Pyridoxine

1977 • 16 citations

The role of hemin in the regulation of heme synthesis by fetal mouse liver erythroblasts in culture.

1979 • 14 citations

The regulation of chlorophyll and porphyrin biosynthesis

1980 • 12 citations

Transferrin receptors and iron utilization in DMSO-inducible and -uninducible friend erythroleukemia cells

1984 • 12 citations

The effect of plasma and transferrin on the hemin inhibition of iron uptake by reticulocytes

1972 • 5 citations

Inhibition of certain mitochondrial oxidative enzymes by porphyrins and metalloporphyrins

1962 • 4 citations