Topoisomerase-I-Inhibitor mit potentiell strahlensensibilisierender Wirkung

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

DNA Topoisomerases: Essential Enzymes and Lethal Targets

1994 • 722 citations

Phase II study of intravenous topotecan as a 5-day infusion for refractory epithelial ovarian carcinoma.

1996 • 248 citations

Activity of Topotecan, a New Topoisomerase I Inhibitor, Against Human Tumor Colony-Forming Units In Vitro

1992 • 174 citations

Topoisomerase Inhibitors

1995 • 173 citations

Phase I trial of low-dose continuous topotecan infusion in patients with cancer: an active and well-tolerated regimen.

1994 • 166 citations

Inhibition of potentially lethal DNA damage repair in human tumor cells by beta-lapachone, an activator of topoisomerase I.

1989 • 165 citations

Synergistic cell killing by ionizing radiation and topoisomerase I inhibitor topotecan (SK&F 104864).

1991 • 154 citations

Cerebrospinal fluid pharmacokinetics and penetration of continuous infusion topotecan in children with central nervous system tumors

1995 • 141 citations

Potentiation of radiation response in human carcinoma cells in vitro and murine fibrosarcoma in vivo by topotecan, an inhibitor of DNA topoisomerase I

1992 • 108 citations

Pediatric phase I trial and pharmacokinetic study of topotecan administered as a 24-hour continuous infusion.

1993 • 93 citations

Phase II study of topotecan in patients with recurrent malignant glioma

1996 • 74 citations

Phase II and pharmacologic study of topotecan administered as a 21-day continuous infusion to patients with colorectal cancer.

1996 • 66 citations

Schedule-dependent cytotoxicity of topotecan alone and in combination chemotherapy regimens.

1994 • 60 citations

A pharmacokinetic model of topotecan clearance from plasma and cerebrospinal fluid.

1994 • 54 citations

Interaction of topoisomerase I inhibitors with radiation in cis‐diamminedichloroplatinum(II)‐sensitive and ‐resistantcells In Vitro and in the fsaiic fibrosarcoma In Vivo

1993 • 47 citations

Interaction of ionizing radiation with topotecan in two human tumor cell lines

1996 • 44 citations

926 Pharmacokinetics (PK), clinical pharmacodynamics (PD) and safety of chronic oral topotecan (T), in a phase I study

1995 • 5 citations

Deleted Work

1955 • 0 citations