Genetic Susceptibility to the Development of Autoimmune Disease

Mapping of a susceptibility locus for Crohn's disease on chromosome 16

1996 • 961 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

A revised estimate of twin concordance in systemic lupus erythematosus

1992 • 765 citations

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

1995 • 749 citations

A full genome search in multiple sclerosis

1996 • 666 citations

A Population-Based Study of Multiple Sclerosis in Twins

1986 • 644 citations

A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22

1996 • 638 citations

A genetic basis for familial aggregation in multiple sclerosis

1995 • 626 citations

Identification of a Major Susceptibility Locus on Chromosome 6p and Evidence for Further Disease Loci Revealed by a Two Stage Genome-Wide Search in Psoriasis

1997 • 523 citations

CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population.

1995 • 426 citations

21-hydroxylase, a major autoantigen in idiopathic Addison's disease

1992 • 403 citations

Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome llq

1994 • 397 citations

Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease

1996 • 371 citations

Concordance rates of insulin dependent diabetes mellitus: a population based study of young Danish twins

1995 • 357 citations

Multiple sclerosis. Updated risks for relatives

1988 • 330 citations

A genetic association between juvenile rheumatoid arthritis and a novel interleukin‐1α polymorphism

1995 • 327 citations

Gene Interaction at HLA-DQ Enhances Autoantibody Production in Primary Sjögren's Syndrome

1986 • 263 citations

A CTLA‐4 gene polymorphism is associated with both Graves' disease and autoimmune hypothyroidism

1997 • 261 citations

Evidence that a locus for familial psoriasis maps to chromosome 4q

1996 • 226 citations

A genetic association between systemic lupus erythematosus and tumor necrosis factor alpha

1994 • 220 citations

Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31–q33

1995 • 211 citations

HLA-DRB1*0401/0404 genotype and rheumatoid arthritis: increased association in men, young age at onset, and disease severity.

1995 • 201 citations

Two ro (ss‐a) autoantibody responses in systemic lupus erythematosus

1988 • 199 citations

Susceptibility locus for inflammatory bowel disease on chromosome 16 has a role in Crohn's disease, but not in ulcerative colitis

1996 • 192 citations

Juvenile chronic arthritis

1998 • 174 citations

Inherited Susceptibility to Autoimmune Addison's Disease Is Linked to Juman Leukocyte Antigens-DR3 and/or DR4, except when Associated with Type I Autoimmune Poluglandular Syndrome*

1986 • 155 citations

The Genetics of Graves’ Disease: HLA and Disease Susceptibility*

1985 • 146 citations

Genetics of autoimmune thyroid disease: lack of evidence for linkage to HLA within families.

1992 • 125 citations

The application of genetic epidemiology to systemic lupus erythematosus.

1987 • 123 citations

Sardinian multiple sclerosis is associated with HLA‐DR4

1988 • 116 citations

A population genetic study of psoriasis

1994 • 116 citations

Linkage disequilibrium between TAP2 variants and HLA class II alleles; no primary association between TAP2 variants and insulin‐dependent diabetes mellitus

1993 • 90 citations

Association of HLA‐DQA1*0501 with Graves’ disease in English Caucasian men and women

1996 • 90 citations

Linkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35.

1996 • 90 citations

Association of LMP2 and LMP7 genes within the major histocompatibility complex with insulin-dependent diabetes mellitus: population and family studies.

1995 • 89 citations

Gm ALLOTYPES IN MYASTHENIA GRAVIS

1980 • 82 citations

Influence of the HLA-DRB1 locus on susceptibility and severity in rheumatoid arthritis

1996 • 80 citations

Involvement of human muscle acetylcholine receptor alpha-subunit gene (CHRNA) in susceptibility to myasthenia gravis.

1994 • 78 citations

HLA-linked rheumatoid arthritis.

1994 • 77 citations

Genetics of Insulin-Dependent Diabetes Mellitus.

1996 • 76 citations

Scanning Chromosome 17 for Psoriasis Susceptibility: Lack of Evidence for a Distal 17q Locus

1995 • 71 citations

Hla class ii alleles and heterogeneity of juvenile rheumatoid arthritis. drb1*0101 may define a novel subset of the disease

1993 • 68 citations

Analysis of the thyrotropin receptor as a candidate gene in familial Graves' disease.

1996 • 68 citations

Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus in southern chinese

1992 • 65 citations

The HLA association with Graves' disease is sex‐specific in Hong Kong Chinese subjects

1994 • 62 citations

HLA-DP/DR interaction in early onset pauciarticular juvenile chronic arthritis

1993 • 60 citations

Reduced expression of a human V beta 6.1 T-cell receptor allele.

1993 • 43 citations

Confirmation of genetic heterogeneity in familial psoriasis.

1995 • 41 citations

Family study of linkage disequilibrium between TAP2 transporter and HLA class II genes absence of TAP2 contribution to association with insulin-dependent diabetes mellitus

1995 • 40 citations

The 8.5-kb PstI allele of the stress protein gene, Hsp70-2

1996 • 37 citations

Myasthenia gravis in identical twins

1986 • 36 citations

Human Muscle Acetylcholine Receptor Alpha-subunit Gene (CHRNA1) Association with Autoimmune Myasthenia Gravis in Black, Mixed-Ancestry and Caucasian Subjects

1996 • 34 citations

Genetic factors in myasthenia gravis

1988 • 34 citations

HLA-DR and -DQ DNA genotyping in multiple sclerosis patients in Northern Ireland

1991 • 32 citations

HLA Class II Alleles in Japanese Patients with Graves' Disease: Weak Associations of HLA-DR and -DQ.

1994 • 30 citations

No Independent Associations of LMP2 and LMP7 Polymorphisms With Susceptibility to Develop IDDM

1997 • 29 citations

Synergy between T cell receptor β gene polymorphism and HLA–DR4 in susceptibility to rheumatoid arthritis

1996 • 29 citations

Genetic mapping of susceptibility loci in the genes involved in rheumatoid arthritis.

1997 • 29 citations

HLA‐DQ polymorphisms do not explain HLA class II associations with multiple sclerosis in two Canadian patient groups

1993 • 23 citations

The onset of disease in twins and siblings with systemic lupus erythematosus.

1984 • 23 citations

DNA analysis of HLA-DR, DQ, and DP alleles in children with polyarticular juvenile rheumatoid arthritis.

1992 • 20 citations

HLA‐DPB1 polymorphisms on the MHC‐extended haplotypes of families of patients with Graves' disease: two distinct HLA‐DR17 haplotypes

1994 • 16 citations

A repetitive DNA sequence 5′ to the human myelin basic protein gene may be linked to MS in Danes

2009 • 13 citations

Contemporaneous diagnosis of Crohn's disease and adenocarcinoma of the jejunum.

1996 • 13 citations

Genetic susceptibility to multiple sclerosis may be linked to polymorphism of the myelin basic protein gene

1995 • 8 citations

Genetic susceptibility to multiple sclerosis in the Shanghai Chinese is not linked to the myelin basic protein gene microsatellite

1995 • 2 citations